Veronika Groh

IL-7 induces proliferation of CD3-/low CD4- CD8- human thymocyte precursors by an IL-2 independent pathway (1992)

Fabbi, Marina, Groh, Veronika, Strominger, Jack L.

The proliferation potential of highly purified human CD3−CD4−CD8− (triple negative) and CD3low(lo)CD4−CD8− thymocyte precursors in response to various cytokines was investigated. High in...

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

Groh, Veronika, Rhinehart, Rebecca, Secrist, Heather, Bauer, Stefan, Grabstein, Kenneth H., Spies, Thomas

Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of γδ T cells expressing the variable region Vδ1. This functional association has...

Diversification, expression, and γδ T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules

Steinle, Alexander, Groh, Veronika, Spies, Thomas

Distant relatives of major histocompatibility complex (MHC) class I molecules, human MICA and MICB, function as stress-induced antigens that are broadly recognized by intestinal epithelial γδ T...

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis

Groh, Veronika, Brühl, Anja, El-Gabalawy, Hani, Nelson, J. Lee, Spies, Thomas

Effector T cell responses can be modulated by competing positive or negative signals transduced by natural killer (NK) cell receptors. This raises the possibility that dominant T cell stimulation...

Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells

Groh, Veronika, Li, Yongqing Q., Cioca, Daniel, Hunder, Naomi N., Wang, Wei, Riddell, Stanley R., ...

Dendritic cells (DCs) have the capacity to prime tumor-specific T cell responses and are considered as potentially effective vaccines for immunotherapy of cancer. Critical parameters in the...

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

Groh, Veronika, Rhinehart, Rebecca, Secrist, Heather, Bauer, Stefan, Grabstein, Kenneth H., Spies, Thomas

Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of γδ T cells expressing the variable region Vδ1. This functional association has...

Diversification, expression, and γδ T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules

Steinle, Alexander, Groh, Veronika, Spies, Thomas

Distant relatives of major histocompatibility complex (MHC) class I molecules, human MICA and MICB, function as stress-induced antigens that are broadly recognized by intestinal epithelial γδ T...

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis

Groh, Veronika, Brühl, Anja, El-Gabalawy, Hani, Nelson, J. Lee, Spies, Thomas

Effector T cell responses can be modulated by competing positive or negative signals transduced by natural killer (NK) cell receptors. This raises the possibility that dominant T cell stimulation...

Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells

Groh, Veronika, Li, Yongqing Q., Cioca, Daniel, Hunder, Naomi N., Wang, Wei, Riddell, Stanley R., ...

Dendritic cells (DCs) have the capacity to prime tumor-specific T cell responses and are considered as potentially effective vaccines for immunotherapy of cancer. Critical parameters in the...

Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B▿

McSharry, Brian P., Burgert, Hans-Gerhard, Owen, Douglas P., Stanton, Richard J., Prod'homme, Virginie, Sester, Martina, ...

The adenovirus (Ad) early transcription unit 3 (E3) encodes multiple immunosubversive functions that are presumed to facilitate the establishment and persistence of infection. Indeed, the capacity of...

Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand

Ebert, Ellen C, Groh, Veronika

Human intestinal intraepithelial lymphocytes (IELs), which are T-cell receptor αβ+ CD8+ T cells located between epithelial cells (ECs), are likely to participate in the innate immune response...

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

Lakshmikanth, Tadepally, Burke, Shannon, Ali, Talib Hassan, Kimpfler, Silvia, Ursini, Francesco, Ruggeri, Loredana, ...

NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be determined what specific molecular interactions...

Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

Tang, Fangming, Chen, Zhangguo, Ciszewski, Cezary, Setty, Mala, Solus, Jason, Tretiakova, Maria, ...

IL-15 and NKG2D promote autoimmunity and celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional...

Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

Dai, Zhenpeng, Turtle, Cameron J., Booth, Garrett C., Riddell, Stanley R., Gooley, Theodore A., Stevens, Anne M., ...

The NKG2D receptor stimulates natural killer cell and T cell responses upon engagement of ligands associated with malignancies and certain autoimmune diseases. However, conditions of persistent NKG2D...