Huang, Jie, Dattilo, Lisa K, Kaartinen, Vesa, Mishina, Yuji, Deng, Chu-Xia, ...
BMPs play multiple roles in development and BMP signaling is essential for lens formation. However, the mechanisms by which BMP receptors function in vertebrate development are incompletely...
Dattilo, Lisa K, Rajagopal, Ramya, Liu, Ying, Kaartinen, Vesa, Mishina, Yuji, ...
There are conflicting reports about whether BMP signaling is required for eyelid closure during fetal development. This question was addressed using mice deficient in BMP or TGF beta signaling in...
Signaling via Alk5 Controls Ontogeny of Lung Clara Cells (2009)
Yiming Xing, Changgong Li, Aimin Li, Somyoth Sridurongrit, Caterina Tiozzo, Saverio Bellusci, ...
Clara cells, together with ciliated and pulmonary neuroendocrine cells, make up the epithelium of the bronchioles along the conducting airways. Clara cells are also known as Progenitor/Stem cells...
Wang, Jikui, Nagy, Andre, Larsson, Jonas, Dudas, Marek, Sucov, Henry M, Kaartinen, Vesa
Abstract Background Congenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction,...
BMC Developmental Biology BioMed Central (2006)
Jikui Wang, Andre Nagy, Jonas Larsson, Marek Dudas, Henry M Sucov, Vesa Kaartinen
Research article Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry (2003)
Warburton, David, Bellusci, Saverio, Del Moral, Pierre-Marie, Kaartinen, Vesa, Lee, Matt, Tefft, Denise, ...
Abstract Lung morphogenesis is stereotypic, both for lobation and for the first several generations of airways, implying mechanistic control by a well conserved, genetically hardwired developmental...
Respiratory Research BioMed Central Review (2003)
David Warburton, Saverio Bellusci, Vesa Kaartinen, Matt Lee, Denise Tefft, ...
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
Kaartinen, Vesa, Williams, Julian C., Tomich, John, Hood, Leroy E., Mononen, Ilkka
The apparent active site of human leukocyte glycoasparaginase (N4-(beta-acetylglucosaminyl)-L-asparaginase EC 3.5.1.26) has been studied by labeling with an asparagine analogue,...
Enzymological aspects and molecular biology of human glycoasparaginase / (1991)
Diss. -- Kuopion yliopisto.
TGF-β3-induced Palatogenesis Requires Matrix Metalloproteinases
Blavier, Laurence, Lazaryev, Alisa, Groffen, John, Heisterkamp, Nora, DeClerck, Yves A., Kaartinen, Vesa
Cleft lip and palate syndromes are among the most common congenital malformations in humans. Mammalian palatogenesis is a complex process involving highly regulated interactions between epithelial...
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
Warburton, David, Bellusci, Saverio, Del Moral, Pierre-Marie, Kaartinen, Vesa, Lee, Matt, Tefft, Denise, ...
Lung morphogenesis is stereotypic, both for lobation and for the first several generations of airways, implying mechanistic control by a well conserved, genetically hardwired developmental program....
Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia
Cho, Young Jin, Zhang, Bin, Kaartinen, Vesa, Haataja, Leena, De Curtis, Ivan, Groffen, John, ...
Numerous studies indirectly implicate Rac GTPases in cancer. To investigate if Rac3 contributes to normal or malignant cell function, we generated rac3 null mutants through gene targeting. These mice...
Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart
Wang, Jikui, Sridurongrit, Somyoth, Dudas, Marek, Thomas, Penny, Nagy, Andre, Schneider, Michael D., ...
Developmental abnormalities in endocardial cushions frequently contribute to congenital heart malformations including septal and valvular defects. While compelling evidence has been presented to...
TGF-β3-induced Palatogenesis Requires Matrix Metalloproteinases
Blavier, Laurence, Lazaryev, Alisa, Groffen, John, Heisterkamp, Nora, DeClerck, Yves A., Kaartinen, Vesa
Cleft lip and palate syndromes are among the most common congenital malformations in humans. Mammalian palatogenesis is a complex process involving highly regulated interactions between epithelial...
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
Warburton, David, Bellusci, Saverio, Del Moral, Pierre-Marie, Kaartinen, Vesa, Lee, Matt, Tefft, Denise, ...
Lung morphogenesis is stereotypic, both for lobation and for the first several generations of airways, implying mechanistic control by a well conserved, genetically hardwired developmental program....
Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia
Cho, Young Jin, Zhang, Bin, Kaartinen, Vesa, Haataja, Leena, De Curtis, Ivan, Groffen, John, ...
Numerous studies indirectly implicate Rac GTPases in cancer. To investigate if Rac3 contributes to normal or malignant cell function, we generated rac3 null mutants through gene targeting. These mice...
Cho, Young Jin, Cunnick, Jess M., Yi, Sun-Ju, Kaartinen, Vesa, Groffen, John, Heisterkamp, Nora
Small GTPases of the Rho family are key regulators of phagocytic leukocyte function. Abr and Bcr are homologous, multidomain proteins. Their C-terminal domain has GTPase-activating protein (GAP)...
Progressive Neurodegeneration in Aspartylglycosaminuria Mice
Gonzalez-Gomez, Ignacio, Mononen, Ilkka, Heisterkamp, Nora, Groffen, John, Kaartinen, Vesa
Aspartylglycosaminuria (AGU) is one of the most common lysosomal storage disorders in humans. A mouse model for AGU has been recently generated through targeted disruption of the glycosylasparaginase...
Park, Sung O., Lee, Young Jae, Seki, Tsugio, Hong, Kwon-Ho, Fliess, Naime, Jiang, Zhigang, ...
ALK1 belongs to the type I receptor family for transforming growth factor-β family ligands. Heterozygous ALK1 mutations cause hereditary hemorrhagic telangiectasia type 2 (HHT2), a multisystemic...