Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy (2008)
Chugh, Pauline, Bradel-Tretheway, Birgit, Monteiro-Filho, Carlos MR, Planelles, Vicente, Maggirwar, Sanjay B, Dewhurst, Stephen, ...
Abstract Background Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs. Results Here, we...
Characterizing the Anti-HIV Activity of Papuamide A (2008)
Cynthia D. Andjelic, Vicente Planelles, Louis R. Barrows
Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry...
Host factors influencing susceptibility to HIV infection and AIDS progression (2007)
Lama, Juan, Planelles, Vicente
Abstract Transmission of HIV first results in an acute infection, followed by an apparently asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most patients...
HIV-1 Vpr activates the G2checkpoint through manipulation of the ubiquitin proteasome system (2007)
DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
Abstract HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G 2 and induction of apoptosis. In...
HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT (2006)
Joshua L. Andersen, Jason L. DeHart, Erik S. Zimmerman, Orly Ardon, Baek Kim, Guillaume Jacquot, ...
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage–signaling protein ATR as the cellular factor that...
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Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements
White, Sarah M., Renda, Matthew, Nam, Na-Yon, Klimatcheva, Ekaterina, Zhu, Yonghong, Fisk, Jennifer, ...
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to...
Lacasse, Rachel A., Follis, Kathryn E., Moudgil, Tarsem, Trahey, Meg, Binley, James M., Planelles, Vicente, ...
We have examined the relationship between coreceptor utilization and sensitivity to neutralization in a primary isolate of human immunodeficiency virus type 1 and its T-cell line-adapted (TCLA)...
Renda, Matthew J., Rosenblatt, Joseph D., Klimatcheva, Ekaterina, Demeter, Lisa M., Bambara, Robert A., Planelles, Vicente
Cellular tRNA\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs}...
Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente
All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration
DeHart, Jason L., Andersen, Joshua L., Zimmerman, Erik S., Ardon, Orly, An, Dong Sung, Blackett, Jana, ...
Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the...
Tripp, Adam, Banerjee, Prabal, Sieburg, Michelle, Planelles, Vicente, Li, Fengzhi, Feuer, Gerold
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, an aggressive CD4+ malignancy. Although HTLV-2 is highly homologous to HTLV-1, infection with HTLV-2...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Diamond, Tracy L., Roshal, Mikhail, Jamburuthugoda, Varuni K., Reynolds, Holly M., Merriam, Aaron R., Lee, Kwi Y., ...
Retroviruses utilize cellular dNTPs to perform proviral DNA synthesis in infected host cells. Unlike oncoretroviruses, which replicate only in dividing cells, lentiviruses, such as HIV-1 and SIV, are...
Ardon, Orly, Zimmerman, Erik S., Andersen, Joshua L., DeHart, Jason L., Blackett, Jana, Planelles, Vicente
Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the biochemical...
Dykes, Carrie, Wang, Jiong, Jin, Xia, Planelles, Vicente, An, Dong Sung, Tallo, Amanda, ...
Human immunodeficiency virus type 1 (HIV-1) replication efficiency or fitness, as measured in cell culture, has been postulated to correlate with clinical outcome of HIV infection, although this is...
Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements
White, Sarah M., Renda, Matthew, Nam, Na-Yon, Klimatcheva, Ekaterina, Zhu, Yonghong, Fisk, Jennifer, ...
Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to...
Lacasse, Rachel A., Follis, Kathryn E., Moudgil, Tarsem, Trahey, Meg, Binley, James M., Planelles, Vicente, ...
We have examined the relationship between coreceptor utilization and sensitivity to neutralization in a primary isolate of human immunodeficiency virus type 1 and its T-cell line-adapted (TCLA)...
Renda, Matthew J., Rosenblatt, Joseph D., Klimatcheva, Ekaterina, Demeter, Lisa M., Bambara, Robert A., Planelles, Vicente
Cellular tRNA\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs}...
Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente
All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration
DeHart, Jason L., Andersen, Joshua L., Zimmerman, Erik S., Ardon, Orly, An, Dong Sung, Blackett, Jana, ...
Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the...
Tripp, Adam, Banerjee, Prabal, Sieburg, Michelle, Planelles, Vicente, Li, Fengzhi, Feuer, Gerold
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, an aggressive CD4+ malignancy. Although HTLV-2 is highly homologous to HTLV-1, infection with HTLV-2...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Ardon, Orly, Zimmerman, Erik S., Andersen, Joshua L., DeHart, Jason L., Blackett, Jana, Planelles, Vicente
Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the biochemical...
Dykes, Carrie, Wang, Jiong, Jin, Xia, Planelles, Vicente, An, Dong Sung, Tallo, Amanda, ...
Human immunodeficiency virus type 1 (HIV-1) replication efficiency or fitness, as measured in cell culture, has been postulated to correlate with clinical outcome of HIV infection, although this is...
HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT
Andersen, Joshua L, DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Kim, Baek, Jacquot, Guillaume, ...
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage–signaling protein ATR as the cellular factor that...
Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo▿
Zimmerman, Erik S., Sherman, Michael P., Blackett, Jana L., Neidleman, Jason A., Kreis, Christophe, Mundt, Pamela, ...
The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G2. Vpr-expressing cells display the hallmarks of certain forms of DNA damage, specifically...
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis. In the present...
Host factors influencing susceptibility to HIV infection and AIDS progression
Lama, Juan, Planelles, Vicente
Transmission of HIV first results in an acute infection, followed by an apparently asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most patients progress into...
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
Chugh, Pauline, Bradel-Tretheway, Birgit, Monteiro-Filho, Carlos MR, Planelles, Vicente, Maggirwar, Sanjay B, Dewhurst, Stephen, ...
Characterizing the Anti-HIV Activity of Papuamide A
Andjelic, Cynthia D, Planelles, Vicente, Barrows, Louis R
Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry...
DeHart, Jason L., Bosque, Alberto, Harris, Reuben S., Planelles, Vicente
Human immunodeficiency virus type 1 (HIV-1) Vif recruits a Cullin 5 ubiquitin ligase that targets APOBEC3 proteins for degradation. Recently, Vif has also been shown to induce cell cycle disturbance...
Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
Kauder, Steven E., Bosque, Alberto, Lindqvist, Annica, Planelles, Vicente, Verdin, Eric
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T cells of infected persons treated with highly active antiretroviral therapy (HAART). This reservoir must...
Ward, Jeffrey, Davis, Zachary, DeHart, Jason, Zimmerman, Erik, Bosque, Alberto, Brunetta, Enrico, ...
Natural killer (NK) cells are stimulated by ligands on virus-infected cells. We have recently demonstrated that NK cells respond to human immunodeficiency virus type-1 (HIV-1)-infected autologous...
Jacquot, Guillaume, Le Rouzic, Erwann, Maidou-Peindara, Priscilla, Maizy, Marion, Lefrère, Jean-Jacques, Daneluzzi, Vincent, ...
Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a...