Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor (2008)
Voelter, Verena, Rufer, Nathalie, Reynard, Severine, Greub, Gilbert, Brookes, Roger, Guillaume, Philippe, ...
Melan-A specific CD8+ T cells are thought to play an important role against the development of melanoma. Their in vivo expansion is often observed with advanced disease. In recent years, low levels...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection (2004)
Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, ...
HIV-1 infection induces activation and differentiation of CD8+ T-cells, resulting in replicative senescence. This may be part of the mechanism through which HIV-1 exhausts the capacity of the immune...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection (2004)
Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Appay, Victor, Dunbar, P. Rod, Cerundolo, Vincenzo, McMichael, Andrew, Czaplewski, Lloyd, Rowland-Jones, Sarah
RANTES (regulated upon activation, normal T cell expressed and secreted) is released by cytotoxic T lymphocytes (CTL), and is a potent chemoattractant factor for monocytes and T cells, also known for...
Gillespie, Geraldine M. A., Wills, Mark R., Appay, Victor, O'Callaghan, Chris, Murphy, Mike, Smith, Neil, ...
Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
Gillespie, Geraldine M. A., Wills, Mark R., Appay, Victor, O'Callaghan, Chris, Murphy, Mike, Smith, Neil, ...
Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor
Dong, Tao, Stewart-Jones, Guillaume, Chen, Nan, Easterbrook, Philippa, Xu, Xiaoning, Papagno, Laura, ...
HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease...
Almeida, Jorge R., Price, David A., Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, ...
The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the...
HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...
Evidence of premature immune aging in patients thymectomized during early childhood
Sauce, Delphine, Larsen, Martin, Fastenackels, Solène, Duperrier, Anne, Keller, Michael, Grubeck-Loebenstein, Beatrix, ...
While the thymus is known to be essential for the initial production of T cells during early life, its contribution to immune development remains a matter of debate. In fact, during cardiac surgery...