SALEM, RANEEM O., LAPOSATA, MICHAEL, RAJENDRAM, RAJKUMAR, CLUETTE-BROWN, JOANNE E., PREEDY, VICTOR R.
Aims: Skeletal muscle appears to be susceptible to chronic and acute excess alcohol intake, giving rise to alcoholic myopathy, a common disease among alcoholics. Fatty acid ethyl esters (FAEE),...
SALEM, RANEEM O., LAPOSATA, MICHAEL, RAJENDRAM, RAJKUMAR, CLUETTE-BROWN, JOANNE E., PREEDY, VICTOR R.
Aims: Skeletal muscle appears to be susceptible to chronic and acute excess alcohol intake, giving rise to alcoholic myopathy, a common disease among alcoholics. Fatty acid ethyl esters (FAEE),...
Protein adduct species in muscle and liver of rats following acute ethanol administration (2005)
Patel, Vinood B., Worrall, Simon, Emery, Peter W., Preedy, Victor R.
Aims: Previous immunohistochemical studies have shown that the post-translational formation of aldehyde-protein adducts may be an important process in the aetiology of alcohol-induced muscle disease....
Protein adduct species in muscle and liver of rats following acute ethanol administration (2005)
Patel, Vinood B., Worrall, Simon, Emery, Peter W., Preedy, Victor R.
Aims: Previous immunohistochemical studies have shown that the post-translational formation of aldehyde-protein adducts may be an important process in the aetiology of alcohol-induced muscle disease....
PROTEIN ADDUCT SPECIES IN MUSCLE AND LIVER OF RATS FOLLOWING ACUTE ETHANOL ADMINISTRATION (2005)
PATEL, VINOOD B., WORRALL, SIMON, EMERY, PETER W., PREEDY, VICTOR R.
Aims: Previous immunohistochemical studies have shown that the post-translational formation of aldehyde-protein adducts may be an important process in the aetiology of alcohol-induced muscle disease....
PROTEIN ADDUCT SPECIES IN MUSCLE AND LIVER OF RATS FOLLOWING ACUTE ETHANOL ADMINISTRATION (2005)
PATEL, VINOOD B., WORRALL, SIMON, EMERY, PETER W., PREEDY, VICTOR R.
Aims: Previous immunohistochemical studies have shown that the post-translational formation of aldehyde-protein adducts may be an important process in the aetiology of alcohol-induced muscle disease....
Recent advances in the pathology of alcoholic myopathy (2001)
Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, ...
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Victor R. Preedy and Junko Adachi. The presentations were (1) Alcoholic myopathy:...
Worrall, Simon, Richardson, Peter J., Preedy, Victor R.
Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although...
Worrall, Simon, Richardson, Peter J., Preedy, Victor R.
Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although...
COOK, ELISABETH B., GOVE, CHRISTOPHER D., PANOS, MARIOS Z., WILLIAMS, ROGER, PREEDY, VICTOR R.
This study was carried out in an attempt to differentiate between the contribution of liver impairment and direct actions of alcohol in myopathy of alcoholic liver disease. Using an animal model of...
MARWAY, JASPAUL S., PREEDY, VICTOR R.
An investigation was made into the acute effects of ethanol and acetaldehyde with or without enzyme inhibitors of alcohol dehydrogenase (4-methylpyrazole) and aldehyde dehydrogenase (cyanamide) on...
MARWAY, JASPAUL S., RODRIGUES, LORETA M., GRIFFITHS, JOHN R., PREEDY, VICTOR R.
In previous studies we have shown that ethanol-fed rats generate antibodies reactive with proteins modified by acetaldehyde in vitro and that their livers contain proteins modified by acetaldehyde....
SIDDIQ, TAHIR, RICHARDSON, PETER J., MORTON, JOHN, SMITH, BRIAN, SHERWOOD, ROY A., MARWAY, JASPAUL S., ...
The objective of study was (a) to investigate whether protein synthesis in different regions of the heart (i.e. left and right atria, left and right ventricles) expressed equal sensitivity to acute...
WASSIF, WASSIF S., PREEDY, VICTOR R., SUMMERS, BEATRICE, DUANE, PAUL, LEIGH, NIGEL, PETERS, TIMOTHY J.
The relationship between chronic ethanol consumption and muscle biopsy morphometry (i.e. atrophy factor), plasma analytes, including carnosinase activities and tissue composition was investigated. In...
SALISBURY, JONATHAN R., PREEDY, VICTOR R., ROSE, PETER E., DEVERELL, MARK H., PETERS, TIMOTHY J.
An investigation was made into the characteristics of an experimental chronic alcoholic myopathy in the young rat. Male Wistar rats were fed a diet for 6 weeks in which ethanol comprised 36%...
PREEDY, VICTOR R., COOK, ELISABETH B., SIDDIQ, TAHIR
We investigated the use of a microprocessor-controlled laser-Doppler monitor to measure blood-flow in unanaesthetised animals. The apparatus permitted real-time assessment of cutaneous blood-flow,...
Siddiq, Tahir, Richardson, Peter J, Sherwood, Roy A, Preedy, Victor R
Objective: The aim was to investigate nucleic acid composition and rates of protein synthesis in cardiopulmonary tissues and skeletal muscle in response to hypertension induced by aortic...
PREEDY, VICTOR R., PETERS, TIMOTHY J.
An investigation was made into the chronic effects of ethanol feeding on bone (represented by the tibia). Treated rats were fed a liquid diet containing ethanol as 36% of total calories, and...
IMIDAZOLE DIPEPTIDES IN EXPERIMENTAL ALCOHOL-INDUCED MYOPATHY (1992)
WARD, ROBERTA J., PREEDY, VICTOR R.
Rats were chronically fed a nutritionally complete liquid diet containing 35% of total calories as either ethanol, or (for the controls) an isocaloric amount of glucose. After 6 weeks of...
PREEDY, VICTOR R., SHERWOOD, ROY A., AKPOGUMA, CAROLINE I. O., BLACK, DARCEY
(1) The effect of chronic (6 weeks) ethanol feeding on whole-body skeletal tissue in the rat was studied by analysis of the urinary pyridinium crosslinks of collagen, pyridinoline (PYD; found...
MARWAY, JASPAUL S., PREEDY, VICTOR R.
Rats were fed a nutritionally adequate liquid diet containing 35% of the total calories as ethanol (treated), or identical amounts of the same diet in which ethanol was replaced with...
PREEDY, VICTOR R., BALDWIN, DIANNE R., KEATING, JAMES W., SALISBURY, JONATHAN R.
(1) We examined the possibility that enhanced fragility of the bony skeleton in alcohol abusers may be a consequence of a reduction in collagen composition. Male rats were fed a liquid diet...
MARWAY, JASPAUL S., PREEDY, VICTOR R., PETERS, TIMOTHY J.
An investigation was made into the effects of ethanol feeding (36% of total calories) on skeletal muscle. From 7 to 42 days, muscle weights and protein and DNA contents of alcohol-treated rats...
ALCOHOL AND SKELETAL MUSCLE DISEASE (1990)
PREEDY, VICTOR R., PETERS, TIMOTHY J.
Skeletal muscle myopathy is caused by prolonged ethanol misuse and affects between half and two-thirds of chronic alcohol misusers. This chronic myopathy is characterized by a selective reduction in...
PREEDY, VICTOR R., PETERS, TIMOTHY J.
The relative sensitivity of heart, small intestine and skeletal muscle to chronic ethanol feeding was investigated in mature Wistar rats fed ethanol as 36% of total energy intake; controls...
PREEDY, VICTOR R., GOVE, CHRISTOPHER D., PANOS, MARIOS Z., SHERWOOD, ROY, PORTMANN, BERNARD, WILLIAMS, ROGER, ...
Liver cirrhosis was induced in male rats by treatment with carbon tetrachloride and phenobarbitone for 130–142 days. Detailed histological examination showed all livers from rats treated with...
PREEDY, VICTOR R., BATEMAN, CHRISTINE J., SALISBRY, JONATHAN R., PRICE, ASHLEY B., PETERS, TIMOTHY J.
Rats were pair-fed either a nutritionally complete liquid diet containing 36% of total calories as ethanol or isovolumetric amounts of the same diet in which ethanol was substituted by...
PREEDY, VICTOR R., MARWAY, JASPAUL S., PETERS, TIMOTHY J.
This communication discusses the ways in which parameters of tissue injury in chronic ethanol-fed rats can be presented. These are: concentration (amount per unit wet weight), absolute amount (total...
PREEDY, VICTOR R., PETERS, TIMOTHY J.
1. The response of the liver to chronic ethanol feeding was investigated in sexually immature (85 g) and sexually mature (280 g) male Wistar rats. Rats received a nutritionally adequate liquid diet...
PREEDY, VICTOR R, PETERS, TIMOTHY J
An investigation was made into the chronic effects of ethanol on the subcellular protein fractions in the hearts of young rats (80–100 g body weight). Rats were fed a nutritionally adequate liquid...
PREEDY, VICTOR R., DUANE, PAUL, PETERS, TIMOTHY J.
This paper responds to the recent article by Rao et at. (Alcohol and Alcoholism 21, 369–373, 1986) which suggested that the Lieber-De Carli liquid diet for chronic ethanol-feeding studies may not...
PREEDY, VICTOR R., DUANE, PAUL, PETERS, TIMOTHY J.
(1) The acute effects of ethanol on protein synthesis by liver and skeletal muscle were investigated in young (95–100 g) rats. Rats were injected intraperitoneally with ethanol, 75 mmol/kg body...