Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin
Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin
Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...
Crystal structures of saposins A and C
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1
Binnerts, Minke E., Tomasevic, Nenad, Bright, Jessica M., Leung, John, Ahn, Victoria E., Kim, Kyung-Ah, ...
The Wnt coreceptor LRP6 is required for canonical Wnt signaling. To understand the molecular regulation of LRP6 function, we generated a series of monoclonal antibodies against the extra cellular...