Black, Antony P.B., Ardern-Jones, Michael R., Kasprowicz, Victoria, Bowness, Paul, Jones, Louise, Bailey, Abigail S., ...
The ability of human keratinocytes to present antigen to T cells is controversial and, indeed, it has been suggested that keratinocytes may promote T cell hyporesponsiveness. Furthermore, it is...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection (2005)
Adiba Isa, Victoria Kasprowicz, Oscar Norbeck, Andrew Loughry, Katie Jeffery, Kristina Broliden, ...
Background Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The...
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
Norbeck, Oscar, Isa, Adiba, Pöhlmann, Christoph, Broliden, Kristina, Kasprowicz, Victoria, Bowness, Paul, ...
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally...
Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection
Isa, Adiba, Kasprowicz, Victoria, Norbeck, Oscar, Loughry, Andrew, Jeffery, Katie, Broliden, Kristina, ...
Although parvovirus B19 apparently causes an acute viral infection, it appears to induce a persistent activated CD8 + T cell response.
Kasprowicz, Victoria, Isa, Adiba, Tolfvenstam, Thomas, Jeffery, Katie, Bowness, Paul, Klenerman, Paul
The evolution of peptide-specific CD4+ T-cell responses to acute viral infections of humans is poorly understood. We analyzed the response to parvovirus B19 (B19), a ubiquitous and clinically...
Kasprowicz, Victoria, Ward, Scott M., Turner, Alison, Grammatikos, Alexandros, Nolan, Brian E., Lewis-Ximenez, Lia, ...
Cross-reactivity of murine and recently human CD8+ T cells between different viral peptides, i.e., heterologous immunity, has been well characterized. However, the directionality and quality of these...
Kasprowicz, Victoria, Schulze Zur Wiesch, Julian, Kuntzen, Thomas, Nolan, Brian E., Longworth, Steven, Berical, Andrew, ...
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic...
Schulze Zur Wiesch, Julian, Lauer, Georg M., Timm, Joerg, Kuntzen, Thomas, Neukamm, Martin, Berical, Andrew, ...
Chronic hepatitis C virus (HCV) infection is typically characterized by a lack of virus-specific CD4+ T-cell–proliferative responses, but strong responses have been described in a subset of persons...