Vincent B. Young

Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation (2009)

Antonopoulos, Dionysios A., Huse, Susan M., Morrison, Hilary G., Schmidt, Thomas M., Sogin, Mitchell L., Young, Vincent B.

Author Posting. © American Society for Microbiology, 2009. This is the author's version of the work. It is posted here by permission of American Society for Microbiology for personal use, not for...

Streptococcus intermediuscausing infective endocarditis and abscesses: a report of three cases and review of the literature (2008)

Tran, MaryAnn P, Caldwell-McMillan, Molly, Khalife, Walid, Young, Vincent B

Abstract Background Streptococcus intermedius is a member of the Streptococcus anginosus group. Clinical disease with S. intermedius is characterized by abscess formation and rarely endocarditis....

Emerging Insights into Antibiotic-Associated Diarrhea and Clostridium difficile Infection through the Lens of Microbial Ecology (2008)

Seth T. Walk, Vincent B. Young

Antibiotics are the main, and often only, clinical intervention for prophylactic and active treatment of bacterial infections in humans. Perhaps it is not surprising that these drugs also shift the...

Emerging Insights into Antibiotic-Associated Diarrhea and Clostridium difficile Infection through the Lens of Microbial Ecology (2008)

Seth T. Walk, Vincent B. Young

Antibiotics are the main, and often only, clinical intervention for prophylactic and active treatment of bacterial infections in humans. Perhaps it is not surprising that these drugs also shift the...

Cytolethal Distending Toxin Sequence and Activity in the Enterohepatic Pathogen Helicobacter hepaticus

Young, Vincent B., Knox, Kimberly A., Schauer, David B.

Little is known about the molecular pathogenesis of hepatitis and enterocolitis caused by enterohepatic Helicobacter species. Sonicates of the murine pathogen Helicobacter hepaticus were found to...

Chronic Atrophic Gastritis in SCID Mice Experimentally Infected with Campylobacter fetus

Young, Vincent B., Dangler, Charles A., Fox, James G., Schauer, David B.

Campylobacter fetus is a cause of enteritis and invasive extraintestinal disease in humans. In order to develop an animal model of C. fetus infection, outbred ICR SCID mice were orally challenged...

Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota

Young, Vincent B., Schmidt, Thomas M.

Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document...

In Vitro and In Vivo Characterization of Helicobacter hepaticus Cytolethal Distending Toxin Mutants

Young, Vincent B., Knox, Kimberly A., Pratt, Jason S., Cortez, Jennifer S., Mansfield, Linda S., Rogers, Arlin B., ...

Helicobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family of bacterial cytotoxins. To investigate the role of CDT in the pathogenesis of H. hepaticus, transposon...

Evolutionary Genetics of a New Pathogenic Escherichia Species: Escherichia albertii and Related Shigella boydii Strains

Hyma, Katie E., Lacher, David W., Nelson, Adam M., Bumbaugh, Alyssa C., Janda, J. Michael, Strockbine, Nancy A., ...

A bacterium originally described as Hafnia alvei induces diarrhea in rabbits and causes epithelial damage similar to the attachment and effacement associated with enteropathogenic Escherichia coli....

Colonization of the Cecal Mucosa by Helicobacter hepaticus Impacts the Diversity of the Indigenous Microbiota

Kuehl, Carole J., Wood, Heather D., Marsh, Terence L., Schmidt, Thomas M., Young, Vincent B.

Establishment of mucosal and/or luminal colonization is the first step in the pathogenesis of many gastrointestinal bacterial pathogens. The pathogen must be able to establish itself in the face of...

Genetic Diversity of Campylobacter sp. Isolates from Retail Chicken Products and Humans with Gastroenteritis in Central Michigan

Fitch, Brooke R., Sachen, Kacey L., Wilder, Stacey R., Burg, Matthew A., Lacher, David W., Khalife, Walid T., ...

Multilocus sequencing was used to compare Campylobacter sp. strains isolated from retail chicken products and humans with gastroenteritis in central Michigan. Sequence comparisons demonstrated...

Modulation of Host Immune Responses by the Cytolethal Distending Toxin of Helicobacter hepaticus

Pratt, Jason S., Sachen, Kacey L., Wood, Heather D., Eaton, Kathryn A., Young, Vincent B.

Persistent murine infection with Helicobacter hepaticus leads to chronic gastrointestinal inflammation and neoplasia in susceptible strains. To determine the role of the virulence factor cytolethal...

Cytolethal Distending Toxin Sequence and Activity in the Enterohepatic Pathogen Helicobacter hepaticus

Young, Vincent B., Knox, Kimberly A., Schauer, David B.

Little is known about the molecular pathogenesis of hepatitis and enterocolitis caused by enterohepatic Helicobacter species. Sonicates of the murine pathogen Helicobacter hepaticus were found to...

Chronic Atrophic Gastritis in SCID Mice Experimentally Infected with Campylobacter fetus

Young, Vincent B., Dangler, Charles A., Fox, James G., Schauer, David B.

Campylobacter fetus is a cause of enteritis and invasive extraintestinal disease in humans. In order to develop an animal model of C. fetus infection, outbred ICR SCID mice were orally challenged...

Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota

Young, Vincent B., Schmidt, Thomas M.

Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document...

In Vitro and In Vivo Characterization of Helicobacter hepaticus Cytolethal Distending Toxin Mutants

Young, Vincent B., Knox, Kimberly A., Pratt, Jason S., Cortez, Jennifer S., Mansfield, Linda S., Rogers, Arlin B., ...

Helicobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family of bacterial cytotoxins. To investigate the role of CDT in the pathogenesis of H. hepaticus, transposon...

Evolutionary Genetics of a New Pathogenic Escherichia Species: Escherichia albertii and Related Shigella boydii Strains

Hyma, Katie E., Lacher, David W., Nelson, Adam M., Bumbaugh, Alyssa C., Janda, J. Michael, Strockbine, Nancy A., ...

A bacterium originally described as Hafnia alvei induces diarrhea in rabbits and causes epithelial damage similar to the attachment and effacement associated with enteropathogenic Escherichia coli....

Colonization of the Cecal Mucosa by Helicobacter hepaticus Impacts the Diversity of the Indigenous Microbiota

Kuehl, Carole J., Wood, Heather D., Marsh, Terence L., Schmidt, Thomas M., Young, Vincent B.

Establishment of mucosal and/or luminal colonization is the first step in the pathogenesis of many gastrointestinal bacterial pathogens. The pathogen must be able to establish itself in the face of...

Genetic Diversity of Campylobacter sp. Isolates from Retail Chicken Products and Humans with Gastroenteritis in Central Michigan

Fitch, Brooke R., Sachen, Kacey L., Wilder, Stacey R., Burg, Matthew A., Lacher, David W., Khalife, Walid T., ...

Multilocus sequencing was used to compare Campylobacter sp. strains isolated from retail chicken products and humans with gastroenteritis in central Michigan. Sequence comparisons demonstrated...

Modulation of Host Immune Responses by the Cytolethal Distending Toxin of Helicobacter hepaticus

Pratt, Jason S., Sachen, Kacey L., Wood, Heather D., Eaton, Kathryn A., Young, Vincent B.

Persistent murine infection with Helicobacter hepaticus leads to chronic gastrointestinal inflammation and neoplasia in susceptible strains. To determine the role of the virulence factor cytolethal...

Pathogenesis of Renal Disease Due to Enterohemorrhagic Escherichia coli in Germ-Free Mice▿

Eaton, Kathryn A., Friedman, David I., Francis, Gayle J., Tyler, Jessica S., Young, Vincent B., Haeger, Jennifer, ...

Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes hemorrhagic colitis and acute renal failure. We used a germ-free mouse model to investigate the role of host factors,...

Emerging Insights into Antibiotic-Associated Diarrhea and Clostridium difficile Infection through the Lens of Microbial Ecology

Walk, Seth T., Young, Vincent B.

Antibiotics are the main, and often only, clinical intervention for prophylactic and active treatment of bacterial infections in humans. Perhaps it is not surprising that these drugs also shift the...

Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation▿ †

Antonopoulos, Dionysios A., Huse, Susan M., Morrison, Hilary G., Schmidt, Thomas M., Sogin, Mitchell L., Young, Vincent B.

Shifts in microbial communities are implicated in the pathogenesis of a number of gastrointestinal diseases, but we have limited understanding of the mechanisms that lead to altered community...

Perturbation of the Small Intestine Microbial Ecology by Streptomycin Alters Pathology in a Salmonella enterica Serovar Typhimurium Murine Model of Infection▿

Garner, Cherilyn D., Antonopoulos, Dionysios A., Wagner, Bettina, Duhamel, Gerald E., Keresztes, Ivan, Ross, Deborah A., ...

The small intestine is an important site of infection for many enteric bacterial pathogens, and murine models, including the streptomycin-treated mouse model of infection, are frequently used to...