New biologics in the management of Crohn’s disease: focus on certolizumab pegol (2009)
Elisabetta Colombo1, Fabrizio Bossa1, Anna Latiano2, Orazio Palmieri2, Angelo Andriulli1,2, Vito Annese2,31Unit of Gastroenterology, 2Laboratory of Genetic Research, 3Unit of Endoscopy, Department of...
Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...
Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...
Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...
Renner, Marcus, Bergmann, Gaby, Krebs, Inge, End, Caroline, Lyer, Stefan, Hilberg, Frank, ...
BACKGROUND & AIMS: Impaired mucosal defense plays an important role in the pathogenesis of Crohn's disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). Deleted in malignant...
Prevalence of CARD15/NOD2 mutations in Caucasian healthy people (2007)
Zaccaria, Isabelle, Cavanaugh, Juleen, Yang, Huiying, Lappalainen, Maarit, ...
BACKGROUND: Crohn's disease (CD) has been associated with CARD15/NOD2 mutations in Caucasians. The R702W, G908R, and 1007fs mutations represent 82% of the mutated chromosomes. The relative risk of...
Yang, Huiying, Barmada, Michael M, Cavanaugh, Juleen A, Annese, Vito, Brant, Steven R, ...
BACKGROUND AND AIMS: The inflammatory bowel diseases (IBDs) Crohn's disease (CD) and ulcerative colitis are complex disorders with an important genetic determinant. One gene associated with CD has...
Zaninotto, Giovanni, Annese, Vito, Costantini, Mario, Del Genio, Alberto, Costantino, Michela, Epifani, Magdalena, ...
Eighty patients suffering from achalasia underwent either laparoscopic myotomy or botulinum toxin injections. After 2 years, 86.5% of patients were symptom free after myotomy by comparison with 42%...
Zaninotto, Giovanni, Annese, Vito, Costantini, Mario, Del Genio, Alberto, Costantino, Michela, Epifani, Magdalena, ...
Eighty patients suffering from achalasia underwent either laparoscopic myotomy or botulinum toxin injections. After 2 years, 86.5% of patients were symptom free after myotomy by comparison with 42%...
Enteropathic spondyloarthropathy: A common genetic background with inflammatory bowel disease?
Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bossa, Fabrizio, Andriulli, Angelo, Annese, Vito
The association between spondyloarthropathy and inflammatory bowel disease (IBD) is largely established, although prevalence is variable because of different population selection and diagnostic...
Latiano, Anna, Palmieri, Orazio, Valvano, Maria Rosa, D’Incà, Renata, Cucchiara, Salvatore, Riegler, Gabriele, ...
AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction...
Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease
Wang, Kai, Zhang, Haitao, Kugathasan, Subra, Annese, Vito, Bradfield, Jonathan P., Russell, Richard K., ...
Previous genome-wide association (GWA) studies typically focus on single-locus analysis, which may not have the power to detect the majority of genuinely associated loci. Here, we applied pathway...