Haller,Florian, Kulle,Bettina, Schwager,Stefanie, Gunawan,Bastian, Von Heydebreck,Anja, Sültmann,Holger, ...
In quantitative reverse transcription–polymerase chain reaction (qRT–PCR), normalization using reference genes is a common useful approach, but the validation of suitable reference genes remains...
Differential Expression with the Bioconductor Project (2004)
Von Heydebreck,Anja, Huber,Wolfgang, Gentleman,Robert
A basic, yet challenging task in the analysis of microarray gene expression data is the identification of changes in gene expression that are associated with particular biological conditions. We...
Maximum likelihood estimation of oncogenetic tree models (2004)
Von Heydebreck,Anja, Gunawan,Bastian, Füzesi,László
We present a new approach for modelling the dependences between genetic changes in human tumours. In solid tumours, data on genetic alterations are usually only available at a single point in time,...
Error models for microarray intensities (2004)
Huber,Wolfgang, Von Heydebreck,Anja, Vingron,Martin
We derive the additive-multiplicative error model for microarray intensities, and describe two applications. For the detection of differentially expressed genes, we obtain a statistic whose variance...
Gunawan,Bastian, Schulten,Hans-Jürgen, Von Heydebreck,Anja, Schmidt,Bettina, Enders,Christina, Höer,Jörg, ...
Although the significance of tumour site for estimating malignant potential in gastrointestinal stromal tumours (GISTs) has recently been recognized, site-specific genetic patterns have not to date...
Von Heydebreck,Anja, Sperling,Silke, Kaynak,Bogac, Lehrach,Hans, Vingron,Martin
In a genome-wide gene expression study, normal and congenitally malformed human hearts were examined using cDNA arrays. Statistical and bioinformatic methods were used in order to identify tissue-...
Gunawan,Bastian, Von Heydebreck,Anja, Fritsch,Thekla, Huber,Wolfgang, Ringert,Rolf-Hermann, Jakse,Gerhard, ...
We evaluated clinical characteristics, patient outcome (mean follow-up, 47 months), and cytogenetic abnormalities in the largest as yet reported cytogenetic series of 47 primary and 11 secondary...
A genome-wide transcriptional fingerprint of normal and malformed human hearts (2003)
Kaynak,Bogac, Von Heydebreck,Anja, Mebas,Siegrun, Seelow,Dominic, Vogel,Jan, Sperling,Hans-Peter, ...
Background— We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
Genome-wide array analysis of normal and malformed human hearts (2003)
Kaynak,Bogac, Von Heydebreck,Anja, Mebus,Sigrun, Seelow,Dominik, Hennig,Steffen, Vogel,Jan, ...
Background We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
Parameter estimation for the calibration and variance stabilization of microarray data (2003)
Huber,Wolfgang, Von Heydebreck,Anja, Sültmann,Holger, Poustka,Annemarie, Vingron,Martin
We derive and validate an estimator for the parameters of a transformation for the joint calibration (normalization) and variance stabilization of microarray intensity data. With this, the variances...
Huber,Wolfgang, Von Heydebreck,Anja, Sültmann,Holger, Poustka,Annemarie, Vingron,Martin
We introduce a statistical model for microarray gene expression data that comprises data calibration, the quantification of differential expression, and the quantification of measurement error. In...
Class discovery in gene expression data: characterizing splits by support vector machines (2002)
Markowetz,Florian, Von Heydebreck,Anja
We present a variation of ISIS, a class discovery method for microarray data described by Heydebreck et al. (2001). The objective is to discover biologically relevant structures in the gene...