Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity (2008)
Harju, Terttu, Mazur, Witold, Merikallio, Heta, Soini, Ylermi, Kinnula, Vuokko L
Abstract Background Oxidative stress plays a potential role in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Glutathione S-transferases (GSTs) detoxify toxic...
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients (2007)
Harju, Terttu H, Peltoniemi, Mirva J, Rytilä, Paula H, Soini, Ylermi, Salmenkivi, Kaisa M, Board, Philip G, ...
Abstract Background The major contribution to oxidant related lung damage in COPD is from the oxidant/antioxidant imbalance and possibly impaired antioxidant defence. Glutathione (GSH) is one of the...
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines (2007)
Nymark, Penny, Lindholm, Pamela M, Korpela, Mikko V, Lahti, Leo, Ruosaari, Salla, Kaski, Samuel, ...
Abstract Background Asbestos has been shown to cause chromosomal damage and DNA aberrations. Exposure to asbestos causes many lung diseases e.g. asbestosis, malignant mesothelioma, and lung cancer,...
Gene Expression Profiles in Asbestos-exposed Epithelial and Mesothelial Lung Cell Lines (2007)
Nymark, Penny, Lindholm, Pamela M., Korpela, Mikko V., Lahti, Leo, Ruosaari, Salla, Kaski, Samuel, ...
Background Asbestos has been shown to cause chromosomal damage and DNA aberrations. Exposure to asbestos causes many lung diseases e.g. asbestosis, malignant mesothelioma, and lung cancer, but the...
Peltoniemi, Mirva J, Rytilä, Paula H, Harju, Terttu H, Soini, Ylermi M, Salmenkivi, Kaisa M, Ruddock, Lloyd W, ...
Abstract Background One typical feature in chronic obstructive pulmonary disease (COPD) is the disturbance of the oxidant/antioxidant balance. Glutaredoxins (Grx) are thiol disulfide oxido-reductases...
Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD (2006)
Rytilä, Paula, Rehn, Tiina, Ilumets, Helen, Rouhos, Annamari, Sovijärvi, Anssi, Myllärniemi, Marjukka, ...
Abstract Background Chronic obstructive pulmonary disease (COPD) is associated with increased oxidative and nitrosative stress. The aim of our study was to assess the importance of these factors in...
Diminished Immunoreactivity of {gamma}-Glutamylcysteine Synthetase in the Airways of (2002)
Petra Pietarinen-runtti, Essi Lakari, Kari O. Raivio, Vuokko L. Kinnula, V L Kinnula, ...
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Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD
Rytilä, Paula, Rehn, Tiina, Ilumets, Helen, Rouhos, Annamari, Sovijärvi, Anssi, Myllärniemi, Marjukka, ...
Peltoniemi, Mirva J, Rytilä, Paula H, Harju, Terttu H, Soini, Ylermi M, Salmenkivi, Kaisa M, Ruddock, Lloyd W, ...
Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD
Rytilä, Paula, Rehn, Tiina, Ilumets, Helen, Rouhos, Annamari, Sovijärvi, Anssi, Myllärniemi, Marjukka, ...
Peltoniemi, Mirva J, Rytilä, Paula H, Harju, Terttu H, Soini, Ylermi M, Salmenkivi, Kaisa M, Ruddock, Lloyd W, ...
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
Nymark, Penny, Lindholm, Pamela M, Korpela, Mikko V, Lahti, Leo, Ruosaari, Salla, Kaski, Samuel, ...
Bone Morphogenetic Protein-4 Inhibitor Gremlin Is Overexpressed in Idiopathic Pulmonary Fibrosis
Koli, Katri, Myllärniemi, Marjukka, Vuorinen, Kirsi, Salmenkivi, Kaisa, Ryynänen, Merja J., Kinnula, Vuokko L., ...
Idiopathic pulmonary fibrosis (IPF), ie, usual interstitial pneumonia in histopathology, is a disease characterized by tissue destruction and active areas of fibroproliferation in the lung. Gremlin...
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients
Harju, Terttu H, Peltoniemi, Mirva J, Rytilä, Paula H, Soini, Ylermi, Salmenkivi, Kaisa M, Board, Philip G, ...
Gremlin-mediated Decrease in Bone Morphogenetic Protein Signaling Promotes Pulmonary Fibrosis
Myllärniemi, Marjukka, Lindholm, Pamela, Ryynänen, Merja J., Kliment, Corrine R., Salmenkivi, Kaisa, Keski-Oja, Jorma, ...
Rationale: Members of the transforming growth factor (TGF)-β superfamily, including TGF-βs and bone morphogenetic proteins (BMPs), are essential for the maintenance of tissue homeostasis and...
Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity
Harju, Terttu, Mazur, Witold, Merikallio, Heta, Soini, Ylermi, Kinnula, Vuokko L
Rajendrasozhan, Saravanan, Yang, Se-Ran, Kinnula, Vuokko L., Rahman, Irfan
Rationale: Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory...
Louhelainen, Noora, Myllärniemi, Marjukka, Rahman, Irfan, Kinnula, Vuokko L
The pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been claimed to be attributable to increased systemic and local oxidative stress. Detection of the oxidant burden and...
Matrix metalloproteinases -8, -9 and -12 in smokers and patients with Stage 0 COPD
Ilumets, Helen, Rytilä, Paula, Demedts, Ingel, Brusselle, Guy G, Sovijärvi, Anssi, Myllärniemi, Marjukka, ...
COPD is underdiagnosed and its early assessment is problematic. It has been suggested that symptomatic smokers with normal FEV1/FVC (Stage 0 COPD, GOLD criteria) can develop COPD in the future....
Persistence of oxidant and protease burden in the airways after smoking cessation
Louhelainen, Noora, Rytilä, Paula, Haahtela, Tari, Kinnula, Vuokko L, Djukanović, Ratko
Oxidative Stress in Pulmonary Fibrosis: A Possible Role for Redox Modulatory Therapy
Kinnula, Vuokko L., Fattman, Cheryl L., Tan, Roderick J., Oury, Tim D.
Idiopathic ulmonary fibrosis (histopathology of usual interstitial pneumonia) is a progressive lung disease of unknown etiology. No treatment has been shown to improve the prognosis of the patients...
Vuorinen, Kirsi, Ohlmeier, Steffen, Leppäranta, Outi, Salmenkivi, Kaisa, Myllärniemi, Marjukka, Kinnula, Vuokko L.
Oxidant burden has been suggested to be a contributor to the pathogenesis of idiopathic pulmonary fibrosis (IPF). The study focused on peroxiredoxin (Prx) II, an antioxidant that has been associated...