Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice (2008)
Beertsen, W.,
Willenborg, M.,
Everts, V.,
Zirogianni, A.,
Podschun, R.,
Schroder, B.,
...
Inflammatory periodontal diseases constitute one of the most common infections in humans, resulting in the destruction of the supporting structures of the dentition. Circulating neutrophils are an...
alpha 11 beta 1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor (2007)
Popova, S. N.,
Barczyk, M.,
Tiger, C. F.,
Beertsen, W.,
Zigrino, P.,
Aszodi, A.,
...
Alpha 11 beta 1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor (2007)
Popova, S.N.,
Barczyk, M.,
Tiger, C.F.,
Beertsen, W.,
Zigrino, P.,
Aszodi, A.,
...
Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor (2007)
Popova, S.N.,
Barczyk, M.,
Tiger, C.F.,
Beertsen, W.,
Zigrino, P.,
Aszodi, A.,
...
Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts (2006)
Vries, T.J. De,
Schoenmaker, A.M.,
Wattanaroonwong, N.,
Hoonaard, M.,
Nieuwenhuijse, A.,
Beertsen, W.,
...
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone (2006)
Everts, V.,
Korper, W.,
Hoeben, K.A.,
Jansen, I.D.,
Bromme, D.,
...
Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity (2006)
Perez Amodio, S.G.,
Jansen, D.C.,
Schoenmaker, A.M.,
Vogels, I.M.,
Reinheckel, T.,
Hayman, A.R.,
...
Endocytosis of tartrate-resistant acid phosphatase by osteoblast-like cells is followed by inactivation of the enzyme (2006)
Perez-Amodio, S.,
Jansen, D.C.,
Tigchelaar-Gutter, W.,
Beertsen, W.,
Everts, V.
Tartrate-resistant acid phosphatase (TRACP) is generally used as a marker of osteoclasts. Yet, other bone-associated cells, such as osteoblasts and osteocytes, may also express activity of this...
Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity (2006)
Perez-Amodio, S.,
Jansen, D.C.,
Schoenmaker, T.,
Vogels, I.M.C.,
Reinheckel, T.,
Hayman, A.R.,
...
Bone resorption by osteoclasts depends on the activity of various proteolytic enzymes, in particular those belonging to the group of cysteine proteinases. Next to these enzymes, tartrate-resistant...
Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: Differences between calvaria and long bone (2006)
Everts, V.,
Korper, W.,
Hoeben, K.A.,
Jansen, I.D.C.,
Bromme, D.,
...
Introduction: The osteoclast resorbs bone by lowering the pH in the resorption lacuna, which is followed by secretion of proteolytic enzymes. One of the enzymes taken to be essential in resorption is...
Structure of the periodontium in cathepsin C-deficient mice (2006)
Haar, S.F. De,
Tigchelaar-Gutter, W.,
Everts, V.,
Beertsen, W.
Papillon-Lefevre syndrome is characterized by increased susceptibility to early-onset periodontitis and is caused by mutations in the cathepsin C gene. How deficiency of the enzyme relates to an...
Cementum and dentin in hypophosphatasia (2005)
Bos, T. Van Den,
Handoko, G.,
Niehof, A.,
Ryan, L.M.,
Coburn, S.P.,
Whyte, M.P.,
...
Cementum and dentin in hypophosphatasia (2005)
Bos, T. Van Den,
Handoko, G.,
Niehof, A.,
Ryan, L.M.,
Coburn, S.P.,
Whyte, M.P.,
...
Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells (2005)
Perez Amodio, S.G.,
Vogels, I.M.,
Schoenmaker, T.,
Jansen, D.C.,
Alatalo, S.L.,
Halleen, J.M.,
...
symbol: CTSC. Disease: Papillon-Lefevre syndrome (2005)
Haar, S.F. De,
Mir, M.,
Nguyen, M.,
Kazemi, B.,
Ramezani, G.H.,
Everts, V.,
...
Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells (2005)
Perez-Amodio, S.,
Vogels, I.M.C.,
Schoenmaker, T.,
Jansen, D.C.,
Atalo, S.L.,
Halleen, J.M.,
...
Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs (2004)
Haar, S.F. De,
Jansen, D.C.,
Schoenmaker, T.,
Vree, H. De,
Everts, V.,
Beertsen, W.
Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants (2004)
Brand, H.S.,
Lerner, U.B.,
Grubb, A.,
Beertsen, W.,
Nieuw Amerongen, A. Van,
Everts, V.
Involvement of matrix metalloproteinases in the onset of dentin mineralization (2004)
Fanchon, S.,
Bourd, K.,
Septier, D.,
Everts, V.,
Beertsen, W.,
Menashi, S.,
...
Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane; tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase (2004)
Nakano, Y.,
Beertsen, W.,
Bos, T. Van Den,
Kawamoto, T.,
Oda, K.,
Takano, Y.
In vitro evidence thatmatrix metalloproteinases 2, -3 and/or -9 are implicated in the onset of dentin mineralization (2004)
Fanchon, S.,
Bourd, K.,
Septier, D.,
Everts, V.,
Beertsen, W.,
Menashi, S.,
...
Involvement of matrix metalloproteinases in the onset of dentin mineralization (2004)
Fanchon, S.,
Bourd, K.,
Septier, D.,
Everts, V.,
Beertsen, W.,
Menashi, S.,
...
Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs (2004)
Haar, S.F. De,
Jansen, D.C.,
Schoenmaker, T.,
Vree, H. De,
Everts, V.,
Beertsen, W.
Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants (2004)
Brand, H.S.,
Lerner, U.H.,
Grubb, A.,
Beertsen, W.,
Nieuw Amerongen, A. Van,
Everts, V.
Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase (2003)
Tesch, W.,
Bos, T. Van Den,
Roschgr, P.,
Fratzl-Zelman, N.,
Klaushofer, K.,
Beertsen, W.,
...
Collagen type I, III and V differently modulate synthesis and activation of matrix metalloproteinases by cultured rabbit periosteal fibroblasts (2003)
Kerkvliet, E.H.M.,
Jansen, I.D.C.,
Schoenmaker, T.A.M.,
Beertsen, W.,
Everts, V.
Low molecular weight inhibitors of matrix metalloproteinases can enhance the expression of matrix metalloproteinase-2 (gelatinase A) without inhibiting its activation (2003)
Kerkvliet, E.H.M.,
Jansen, I.D.C.,
Schoenmaker, T.A.M.,
Docherty, A.J.P.,
Beertsen, W.,
Everts, V.
Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice (2003)
Beertsen, W.,
Holmbeck, K.,
Niehof, A.,
Bianco, P.,
Chrysovergis, K.,
Birkedal-Hansen, H.,
...
Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts (2003)
Everts, V.,
Hou, W.S.,
Rialland, X.,
Tigchelaar, W.,
Saftig, P.,
Bromme, D.,
...
Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue non-specific alkaline phosphatase (2003)
Tesch, W.,
Bos, T. Van Den,
Roschgr, P.,
Fratzl-Zelman, N.,
Klaushofer, K.,
Beertsen, W.,
...
Collagen type I, III and V differently modulate synthesis and activation of matrix metalloproteinases by cultured rabbit periosteal fibroblasts (2003)
Kerkvliet, E.H.M.,
Jansen, D.C.,
Schoenmaker, A.M.,
Beertsen, W.,
Everts, V.
Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts (2003)
Everts, V.,
Hou, W.S.,
Rialland, X.,
Tigchelaar, W.,
Saftig, P.,
Bromme, D.,
...
The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation (2002)
Everts, V.,
Delaisse, J.M.,
Korper, W.,
Jansen, D.C.,
Tigchelaar-Gutter, W.,
Saftig, P.,
...
On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth (2002)
Beertsen, W.,
Holmbeck, K.,
Niehof, A.,
Bianco, P.,
Chrysovergis, K.,
Birkedal-Hansen, H.,
...
On the role of MT1-MMP, a matrix metalloproteinase essential to periodontal collagen remodeling, in murine molar eruption and root growth (2002)
Beertsen, W.,
Holmbeck, K.,
Niehof, A.,
Bianco, P.,
Chrysovergis, K.,
Birkedal-Hansen, H.,
...
Functional heterogeneity of osteoclasts. Matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone (1999)
Everts, V.,
Korper, W.,
Jansen, D.C.,
Steinfort, J.,
Lammerse, I.,
Heera, S.,
...
Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone (1999)
Everts, V.,
Korper, W.,
Jansen, D.C.,
Steinfort, J.,
Lammerse, I.,
Heera, S.,
...
EGF and IL-1alpha modulate the release of collagenase, gelatinase and TIMP-1 as well as the release of calcium by rabbit calvarial bone explants (1998)
Zee, E. Van Der,
Jansen, I.D.C.,
Hoeben, K.A.,
Beertsen, W.,
Everts, V.
Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue (1998)
Creemers, L.B.,
Jansen, I.D.C.,
Docherty, A.J.P.,
Reynolds, J.J.,
Beertsen, W.,
Everts, V.
Participation of intracellular cysteine proteinases, in particular Cathepsin B, in degradation of collagen in periosteal tissue explants (1998)
Creemers, L.B.,
Hoeben, K.A.,
Jansen, D.C.,
Buttle, D.J.,
Beertsen, W.,
Everts, V.
Alkaline phosphatase induces the mineralization of sheets of collagen implanted subcutaneously in the rat.
Beertsen, W
To determine whether alkaline phosphatase (ALP) can cause the mineralization of collagenous matrices in vivo, bovine intestinal ALP was covalently bound to slices of guanidine-extracted demineralized...
Alkaline phosphatase induces the mineralization of sheets of collagen implanted subcutaneously in the rat.
Beertsen, W
To determine whether alkaline phosphatase (ALP) can cause the mineralization of collagenous matrices in vivo, bovine intestinal ALP was covalently bound to slices of guanidine-extracted demineralized...
Free and polymerized tubulin in cultured bone cells and Chinese hamster ovary cells: the influence of cold and hormones
Beertsen, W,
Heersche, JNM,
Aubin, JE
Free and polymerized tubulin were measured in bone cells and Chinese hamster ovary (CHO) cells cultured on plastic substrata. Polymerized tubulin was stabilized in a microtubule- stabilizing medium...