DECOMPRESSION SICKNESS AND INERT GAS NARCOSIS. (2005)
A summary is given of research activities and results in the following areas: Effects of gases in producing decompression sickness; distribution and intensity of bubble formation as a function of...
Decompression Sickness and Inert Gas Narcosis. (1998)
The results of experiments on the following topics of research are summarized: Arterial bubbles; Decompression characteristics of various inert gases; The role of separated gas in decompression...
POTENCY OF MIXTURES OF GENERAL ANAESTHETIC AGENTS (1978)
CLARKE, R. F., DANIELS, S., HARRISON, C. B., JORDAN, M. J., PATON, W. D. M., SMITH, E. B., ...
The anaesthetic potencies of binary mixtures of the gases argon (Ar), nitrous oxide (N2O) and sulphur hexafluoride (SF6) have been measured using mice. The mixtures SF6-N2O and N2O-Ar showed additive...
PRESSURE ANTAGONISM OF ANAESTHETIC-INDUCED CONDUCTION FAILURE IN FROG PERIPHERAL NERVE (1976)
ROTH, S. H, SMITH, R. A, PATON, W. D. M
Experiments to investigate pressure-induced antagonism of the effects of general anaesthetics in isolated peripheral nerve from the frog are described. The doses of four gaseous general anaesthetic...
THE ANAESTHETIC PRESSURES OF CERTAIN FLUORINE-CONTAINING GASES (1967)
MILLER, K. W., PATON, W. D. M., SMITH, E. B.
The pressures required to abolish the righting reflex of mice have been measured for five gaseous anaesthetics. The ED50 pressures (in atmospheres) found were: N2, 35; CF4, 19; SF6, 6.9; N2O, 1.5;...
The control of the plasma choline concentration in the cat
Gardiner, J. E., Paton, W. D. M.
1. Changes in choline concentration of the blood after injections or infusions of choline were studied in cats anaesthetized with chloralose.
The mechanism of acetylcholine release from parasympathetic nerves
Paton, W. D. M., Vizi, E. S., Zar, M. Aboo
1. The output of acetylcholine from the plexus of the guinea-pig ileum longitudinal strip has been used to study the mechanism of acetylcholine release. From the effects of hexamethonium and...
The roles of striated and smooth muscle in the movement of the cat's nictitating membrane
Paton, W. D. M., Thompson, J. W.
1. When the movement of the nictitating membrane is recorded in the usual way, pulled out under load in cat, dog, or rabbit, end-plate-depolarizing drugs such as succinylcholine, decamethonium,...
Experiments on the genesis of bubbles as a result of rapid decompression
Lever, M. J., Miller, K. W., Paton, W. D. M., Smith, E. B.
1. The time course of intravascular bubble formation in mice after rapid decompression from 150 Lb/sq. in. has been followed in vivo in a flap preparation of thoracic and abdominal skin.
The margin of safety of neuromuscular transmission
1. The margin of safety for neuromuscular transmission in the tibialis and sartorius muscles of the cat has been determined by measuring the ratio by which end-plate depolarization produced by...
The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips
1. Strips of longitudinal muscle can be obtained from guinea-pig ileum either retaining or free from Auerbach's plexus.
Distribution of histamine and substance P in the wall of the dog's digestive tract
Douglas, W. W., Feldberg, W., Paton, W. D. M., Schachter, M.
Medically Qualified Preclinical Teachers
Quilliam, J. P., Bowden, Ruth M., Downham, C. B. B., Gillespie, J. S., Glenister, T. W. A., Paton, W. D. M., ...
The control of the plasma choline concentration in the cat
Gardiner, J. E., Paton, W. D. M.
1. Changes in choline concentration of the blood after injections or infusions of choline were studied in cats anaesthetized with chloralose.
The mechanism of acetylcholine release from parasympathetic nerves
Paton, W. D. M., Vizi, E. S., Zar, M. Aboo
1. The output of acetylcholine from the plexus of the guinea-pig ileum longitudinal strip has been used to study the mechanism of acetylcholine release. From the effects of hexamethonium and...
The roles of striated and smooth muscle in the movement of the cat's nictitating membrane
Paton, W. D. M., Thompson, J. W.
1. When the movement of the nictitating membrane is recorded in the usual way, pulled out under load in cat, dog, or rabbit, end-plate-depolarizing drugs such as succinylcholine, decamethonium,...
Experiments on the genesis of bubbles as a result of rapid decompression
Lever, M. J., Miller, K. W., Paton, W. D. M., Smith, E. B.
1. The time course of intravascular bubble formation in mice after rapid decompression from 150 Lb/sq. in. has been followed in vivo in a flap preparation of thoracic and abdominal skin.
The margin of safety of neuromuscular transmission
1. The margin of safety for neuromuscular transmission in the tibialis and sartorius muscles of the cat has been determined by measuring the ratio by which end-plate depolarization produced by...
The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips
1. Strips of longitudinal muscle can be obtained from guinea-pig ileum either retaining or free from Auerbach's plexus.
Distribution of histamine and substance P in the wall of the dog's digestive tract
Douglas, W. W., Feldberg, W., Paton, W. D. M., Schachter, M.
Medically Qualified Preclinical Teachers
Quilliam, J. P., Bowden, Ruth M., Downham, C. B. B., Gillespie, J. S., Glenister, T. W. A., Paton, W. D. M., ...
The action of methylpentynol and methylpentynol carbamate on the perfused superior cervical ganglion of the cat was analysed. Both drugs, in doses of 1 to 5 mg., depressed the output of...
Experiments on the pharmacology of hydroxydione sodium succinate
Lerman, L. H., Paton, W. D. M.
The actions of hydroxydione sodium succinate (“Viadril”) have been studied in chloralose or decerebrate cats, or cats otherwise untreated. It is virtually devoid of action at the neuromuscular,...
Morphine depresses the twitch and tetanus of stimulated guinea-pig ileum by reducing acetylcholine released from cholinergic nerve endings. Acetylcholine output per shock falls to roughly the same...
Paton, W. D. M., Pertwee, R. G.
1. Cannabis extract prolonged sleeping time in mice in a thermally neutral environment (30-32° C) in which hypothermia does not occur. The prolongation was dose related, just detectable at 50 mg/kg,...
1. Noradrenaline and adrenaline reduce the output of acetylcholine by the guinea-pig ileum longitudinal strip by up to 80%, both in resting conditions and after stimulation. The effect is graded with...
The ganglion blocking action of procainamide
Paton, W. D. M., Thompson, J. W.
In cats and rabbits procainamide (20 to 50 mg, intravenously) produced a fall of blood pressure of 20 to 50 mm Hg which reached a maximal effect within 1 min and lasted for about 5 min. Procainamide...
Halliday, D.J.X., Little, Hilary J., Paton, W.D.M.
1 The actions of a range of general anaesthetic agents on the rates of release of acetylcholine from the guinea-pig ileum were tested, by means of a superfusion system designed to maintain the...
Little, Hilary J., Paton, W.D.M.
1 The effects of high pressures of helium and of nitrogen on acetylcholine release were tested using the guinea-pig ileum as a model preparation. A superfusion system was designed in which this...
Decompression Sickness during Construction of the Dartford Tunnel
Golding, F. Campbell, Griffiths, P., Hempleman, H. V., Paton, W. D. M., Walder, D. N.
A clinical, radiological and statistical survey has been made of decompression sickness during the construction of the Dartford Tunnel. Over a period of two years, 1,200 men were employed on...
The Pharmacological Activity of Extracts of Cotton Dust
Davenport, Anne, Paton, W. D. M.
Aqueous extracts prepared from dust collected in the card-rooms of several cotton mills have been prepared and found to contain activity which contracts the smooth muscle of guinea-pig ileum,...