Willeke, P., Gaubitz, M., Schotte, H., Becker, H., Mickholz, E., Domschke, W., ...
Objectives. To analyse the prevalence of α-fodrin antibodies in patients with primary (pSS) and secondary Sjögren's syndrome (sSS) and the relation to clinical, serological and immunological...
Willeke, P., Gaubitz, M., Schotte, H., Becker, H., Mickholz, E., Domschke, W., ...
Objectives. To analyse the prevalence of α-fodrin antibodies in patients with primary (pSS) and secondary Sjögren's syndrome (sSS) and the relation to clinical, serological and immunological...
Willeke, P., Gaubitz, M., Schotte, H., Becker, H., Mickholz, E., Domschke, W., ...
Objectives. To analyse the prevalence of α-fodrin antibodies in patients with primary (pSS) and secondary Sjögren's syndrome (sSS) and the relation to clinical, serological and immunological...
Schotte, H., Schlüter, B., Willeke, P., Mickholz, E., Schorat, M. A., Domschke, W., ...
Objectives. To determine the influence of etanercept treatment on the number of peripheral blood mononuclear cells (PBMC) secreting immunoregulatory key cytokines and the correlation of these cell...
Schotte, H., Gaubitz, M., Willeke, P., Tidow, N., Assmann, G., Domschke, W., ...
Objectives. Overproduction of interleukin-10 (IL-10) is a pivotal feature in the pathophysiology of systemic lupus erythematosus (SLE). In vitro IL-10 secretion has previously been related to...
Schotte, H., Schlüter, B., Willeke, P., Mickholz, E., Schorat, M. A., Domschke, W., ...
Objectives. To determine the influence of etanercept treatment on the number of peripheral blood mononuclear cells (PBMC) secreting immunoregulatory key cytokines and the correlation of these cell...
Schotte, H., Gaubitz, M., Willeke, P., Tidow, N., Assmann, G., Domschke, W., ...
Objectives. Overproduction of interleukin-10 (IL-10) is a pivotal feature in the pathophysiology of systemic lupus erythematosus (SLE). In vitro IL-10 secretion has previously been related to...
Schotte, H., Schlüter, B., Willeke, P., Mickholz, E., Schorat, M. A., Domschke, W., ...
Objectives. To determine the influence of etanercept treatment on the number of peripheral blood mononuclear cells (PBMC) secreting immunoregulatory key cytokines and the correlation of these cell...
Schotte, H., Gaubitz, M., Willeke, P., Tidow, N., Assmann, G., Domschke, W., ...
Objectives. Overproduction of interleukin-10 (IL-10) is a pivotal feature in the pathophysiology of systemic lupus erythematosus (SLE). In vitro IL-10 secretion has previously been related to...
Gastric electrical stimulation in intractable symptomatic gastroparesis (2003)
Abrahamsson, Hasse, Huizinga, Jan D, Konturek, J W, Galmiche, Jean Paul, ...
BACKGROUND: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessed...
Gaubitz, M., Jackisch, C., Domschke, W., Heindel, W., Pfleiderer, B.
Objective. To determine the impact of implant integrity on clinical symptoms and antibody status in women with silicone breast implants (SBIs). Methods. Ninety consecutive women were...
Schotte, H., Schlüter, B., Rust, S., Assmann, G., Domschke, W., Gaubitz, M.
Background. A biallelic polymorphism (−174 G/C) within the interleukin‐6 (IL‐6) promoter reportedly has functional importance through the modulation of...
Menzel, J., Poremba, C., Böcker, W., Domschke, W.
Background: It has been proposed that adenomas of the papilla of Vater are precursors of adenocarcinomas. Duodenoscopy with ERCP and forceps biopsies have substantially improved the morphologic...
Systemic granulomatous disease after intravesical BCG instillation
Mooren, F C, Lerch, M M, Ullerich, H, Bürger, H, Domschke, W
Letter: Anaphylactoid skin reaction after intradermal secretin.
Baenkler, H W, Domschke, W, Domschke, S, Demling, L, Wunsch, E, Jaeger, E
Systemic granulomatous disease after intravesical BCG instillation
Mooren, F C, Lerch, M M, Ullerich, H, Bürger, H, Domschke, W
Letter: Anaphylactoid skin reaction after intradermal secretin.
Baenkler, H W, Domschke, W, Domschke, S, Demling, L, Wunsch, E, Jaeger, E
Lügering, N, Kucharzik, T, Lügering, A, Winde, G, Sorg, C, Domschke, W, ...
Expression of the two myeloic related proteins MRP8 and MRP14 is restricted to distinct stages of monocytic differentiation. Heterodimeric MRP8/14 complexes (27E10 antigen) have been shown to...
Willeke, P, Schotte, H, Schluter, B, Erren, M, Becker, H, Dyong, A, ...
Methods: PBMC spontaneously secreting tumour necrosis factor α (TNFα), interleukin 1ß (IL1ß), and interleukin 6 (IL6) were assessed by enzyme linked immunospot (ELISPOT) analysis in a cohort of...
Konturek, J W, Hengst, K, Kulesza, E, Gabryelewicz, A, Konturek, S J, Domschke, W
BACKGROUND: Nitric oxide (NO) is an unstable vasodilator formed by NO synthetase (NOS) from L-arginine (L-Arg) in various cells but its role in the control of pancreatic secretion in humans has not...
Cholecystokinin in the control of gastric acid secretion in man.
Konturek, J W, Stoll, R, Konturek, S J, Domschke, W
This study was designed to determine the role of cholecystokinin in the control gastric acid secretion in men using loxiglumide, a specific cholecystokinin receptor blocker. Three groups of healthy...
Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects.
Lux, G, Hagel, J, Bäcker, P, Bäcker, G, Vogl, R, Ruppin, H, ...
In a prospective randomised study, the effect of acupuncture on sham feeding stimulated gastric acid secretion was investigated. In eight healthy volunteers (five men, three women, mean (SEM) age...
Konturek, J W, Dembinski, A, Stoll, R, Domschke, W, Konturek, S J
The gastropathy associated with the ingestion of non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin is a common side effect of this class of drugs, but the precise mechanisms by which...
Blum, A L, Bethge, H, Bode, J C, Domschke, W, Feurle, G, Hackenberg, K, ...
A randomised controlled multicentre trial was performed in 160 patients with gastric ulcer, proved by endoscopy and biopsy, to compare ulcer healing with sucralfate and ranitidine (double blind...
Lux, G, Hagel, J, Baecker, P, Baecker, B, Vogl, R, Ruppin, H, ...
Konturek, J W, Gillessen, A, Konturek, S J, Domschke, W
Helicobacter pylori infection may be associated with duodenal ulcer (DU) and accompanied by enhanced gastrin release but the mechanism of this H pylori related hypergastrinaemia in DU patients is...
Green, W E, Ruppin, H, Wingate, D L, Domschke, W, Wünsch, D E, Demling, L, ...
Synthetic 13-norleucine-motilin (13-nle-motilin), structural and biological analogue of the naturally-occurring duodenal polypeptide, motilin, is known to stimulate antral and duodenal motor activity...
Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.
HACKI, W H, Bloom, S R, Mitznegg, P, Domschke, W, Domschke, S, Belohlavek, D, ...
The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Secretin was...
Effect of secretin on plasma motilin in man.
Mitznegg, P, Bloom, S R, Domschke, W, Haecki, W H, Domschke, S, Belohlavek, D, ...
Graded doses of 0-1, 0-3, 0-9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded...
Domschke, W, Domschke, S, Hagel, J, Demling, L, Croft, D N
Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of...
Vasoactive intestinal peptide in man: pharmacokinetics, metabolic and circulatory effects.
Domschke, S, Domschke, W, Bloom, S R, Mitznegg, P, Mitchell, S J, Lux, G, ...
Graded doses of 0.6, 1.3, and 3.3 pmol/kg/min of vasoactive intestinal peptide (VIP) were intravenously infused over 30 minute periods in four healthy volunteers and plasma VIP levels were measured...
Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine.
Bryant, M G, Bloom, S R, Polak, J M, Hobbs, S, Domschke, W, Domschke, S, ...
Using sensitive and specific radioimmunoassays, concentrations of hormonal peptides have been measured in small biopsies taken from the human stomach, duodenum, and proximal jejunum. Comparison is...
Tissue reactions under piezoelectric shockwave application for the fragmentation of biliary calculi.
Ell, C, Kerzel, W, Heyder, N, Rödl, W, Langer, H, Mischke, U, ...
The tissue reactions that occurred during piezoelectric shockwaves for the fragmentation of biliary calculi were investigated in 10 surgically removed stone containing human gall bladders and in...
Human intestinal M cells exhibit enterocyte-like intermediate filaments
Kucharzik, T, Lugering, N, Schmid, K, Schmidt, M, Stoll, R, Domschke, W
a Department of Medicine B, b Department of Pathology, c Centre for Molecular Biology of Inflammation, University of Münster, Münster, Germany
Domagk, D, Poremba, C, Dietl, K-H, Senninger, N, Heinecke, A, Domschke, W, ...
Background: In bile duct strictures, examination of wall layers by intraductal ultrasonography (IDUS) performed during endoscopic retrograde cholangiopancreatography (ERCP) may be diagnostically...
Foell, D, Kucharzik, T, Kraft, M, Vogl, T, Sorg, C, Domschke, W, ...
Background: Intestinal inflammation in Crohn’s disease (CD) and ulcerative colitis (UC) is characterised by an influx of neutrophils into the intestinal mucosa. S100A12 is a calcium binding protein...
Gastric ulcer healing in the rat: kinetics and localisation of de novo procollagen synthesis
Shahin, M, Gillessen, A, Pohle, T, Weber, C, Schuppan, D, Herbst, H, ...
a Department of Medicine B, University of Münster, Germany, b Department of Gastroenterology, Free University of Berlin, Germany, c Institute of Pathology, University of Hamburg, Germany
Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD).
Kucharzik, T, Stoll, R, Lügering, N, Domschke, W
IBD is characterized by increased serum concentrations of different cytokines. IL-10 inhibits the production of proinflammatory cytokines such as IL-1, tumour necrosis factor-alpha (TNF-a),...
Serum 27E10 antigen: a new potential marker for staging HIV disease.
Lügering, N, Stoll, R, Kucharzik, T, Burmeister, G, Sorg, C, Domschke, W
MRP8 and MRP14 are myeloic related proteins expressed by most circulating and emigrated neutrophils and monocytes. Their composite molecule MRP8/14 (27E10 antigen) was shown to exhibit striking...
LÜGERING, A, FLOER, M, LÜGERING, N, CICHON, C, SCHMIDT, M A, DOMSCHKE, W, ...
M cells represent an important gateway for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. The goal of this...
Kucharzik, T, LÜgering, N, Pauels, H-G, Domschke, W, Stoll, R
Several studies have demonstrated that intestinal epithelial cells play a major role in the initiation and perpetuation of intestinal inflammation by secreting proinflammatory cytokines and...
LÜGERING, N, KUCHARZIK, T, GOCKEL, H, SORG, C, STOLL, R, DOMSCHKE, W
Cytokines produced from intestinal epithelial cells may function as signals to neighbouring immune cells. In the present study we analysed the effects of colonic epithelial cell lines (HT-29, Caco-2,...
Bisping, G, Lügering, N, Lütke-Brintrup, S, Schürmann, G, Domschke, W, ...
Intestinal epithelial cells seem to play a key role during IBD. The network of cellular interactions between epithelial cells and lamina propria mononuclear cells is still incompletely understood. In...
Maaser, C, Schoeppner, S, Kucharzik, T, Kraft, M, Schoenherr, E, Domschke, W, ...
Epithelial cells are positioned in close proximity to endothelial cells. A non-contact coculture system was used to investigate whether colonic epithelial cells activated with various cytokines are...
Kraft, M, Riedel, S, Maaser, C, Kucharzik, T, Steinbuechel, A, Domschke, W, ...
Helicobacter pylori colonizes the gastric epithelial surface and induces epithelial cells to increase production of the neutrophil attractant IL-8. Little is known about the role of the gastric...
KUCHARZIK, T, LÜGERING, N, WEIGELT, H, ADOLF, M, DOMSCHKE, W, STOLL, R
Activated monocytes with increased expression of proinflammatory cytokines play a major role in inflammatory bowel disease (IBD). Immunoregulatory cytokines such as IL-4 and IL-10 can effectively...
LÜGERING, N, KUCHARZIK, T, FISAHN, M, DOMSCHKE, W, STOLL, R
Little is known about the mechanisms triggering and controlling both the development and perpetuation of extraintestinal complications in CD. The aim of the present study was to test the hypothesis...
Colon carcinoma cell lines stimulate monocytes and lamina propria mononuclear cells to produce IL-10
KUCHARZIK, T, LÜGERING, N, WINDE, G, DOMSCHKE, W, STOLL, R
Cytokines released from tumour cells may have function as signals to neighbouring immune and inflammatory cells. Several studies have shown that the immunoregulatory cytokines IL-10 and transforming...
Schotte, H, Schluter, B, Drynda, S, Willeke, P, Tidow, N, Assmann, G, ...
Objectives: To analyse the association of interleukin 10 (IL10) promoter polymorphisms, which have been shown to be related to IL10 secretion capacity, with the response to long term treatment with...
Weiss, F, Simon, P, Witt, H, Mayerle, J, Hlouschek, V, Zimmer, K, ...
Lügering, N, Kucharzik, T, Maaser, C, Kraft, M, Domschke, W
Interleukin‐15 (IL‐15) is a novel cytokine with actions similar to IL‐2 because of common receptor components. Although IL‐15 is expressed in colonic epithelial cells and may regulate...
Schnekenburger, J, Mayerle, J, Krüger, B, Buchwalow, I, Weiss, F U, Albrecht, E, ...
Background: We have previously shown that cell contacts between pancreatic acinar cells dissociate early in pancreatitis and that this is a prerequisite for the development of pancreatic oedema. Here...