Su, H, Huang, Y, Takagawa, J, Barcena, A, Arakawa-Hoyt, J, Ye, J, ...
Adeno-associated viral vectors (AAV) are attractive tool for gene therapy for coronary artery disease. However, gene expression in myocardium mediated by AAV serotype 2 (AAV2) does not peak until 4-6...
DEVELOPMENT OF A CURRENT INJECTION PROBE (CIP) FOR HIGH POWER LEVEL FILTER ANALYSIS. (2005)
The report describes the successful development of a radio frequency current injection probe capable of injecting amperes of rf current over the frequency range 100 hertz to 1 megahertz into power...
Su, Hua, Joho, S, Huang, Y, Barcena, A, Arakawa-Hoyt, J, Grossman, W, ...
It has been shown that the adeno-associated virus (AAV) vector can deliver the VEGF gene efficiently into the ischemic mouse myocardium. However, the AAV genomes can be found in extracardiac organs...
Research Progress and Forecast Report for MSNW FEL Oscillator Program. (2002)
Slater,J., Quimby,D. C., Grossman,W.
The purpose of this program is to provide assessment data for determining the potential of tapered-wiggler free-electron laser (FEL) oscillators. It is expected that the tapered-wiggler concept will...
Tapered-Wiggler Free-Electron Laser Oscillator Program. (2002)
Slater,J., Grossman,W., Quimby,D., Vetter,A., Wilcoxon,J.
The purpose of this program is to provide data and analysis for assessing the potential of tapered-wiggler free-electron laser (FEL) oscillators as high-efficiency sources of coherent radiation. It...
Shen, You-Tang, Wiedmann, R.T., Greenland, B.D., Lynch, J.J., Grossman, W.
Objective: The goal of this study was to determine if the hemodynamic effects of the combined administration of an angiotensin converting enzyme (ACE) inhibitor and angiotensin II type 1 (AT1)...
Diastolic function and heart failure: an overview (1990)
Diastolic dysfunction is being recognized increasingly as a primary cause of congestive heart failure. It may result from physiological abnormalities of myocardial relaxation, or anatomical...
Amende, I, Bentivegna, L A, Zeind, A J, Wenzlaff, P, Grossman, W, Morgan, J P
Ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([Ca2+]i). The present study was...
Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts.
Harada, K, Grossman, W, Friedman, M, Edelman, E R, Prasad, P V, Keighley, C S, ...
The effect of basic fibroblast growth factor (bFGF) administration on regional myocardial function and blood flow in chronically ischemic hearts was studied in 26 pigs instrumented with proximal...
Chronic exercise training protects aged cardiac muscle against hypoxia.
Wei, J Y, Li, Y, Lincoln, T, Grossman, W, Mendelowitz, D
To test the hypothesis that chronic exercise may improve tolerance to hypoxia in aged hearts, we compared cardiac function of exercised rats to that of their age-matched, nonexercised controls. Right...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...
Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...
Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations.
Brodie, B R, Grossman, W, Mann, T, McLaurin, L P
The effect of sodium nitroprusside on the relationship between left ventricular pressure and volume during diastole was studied in 11 patients with congestive heart failure. Nitroprusside was infused...
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W, Jones, D, McLaurin, L P
It is generally recognized that chronic left ventricular (LV) pressure overload results primarily in wall thickening and concentric hypertrophy, while chronic LV volume overload is characterized by...
Effect of age on myocardial adaptation to volume overload in the rat.
Isoyama, S, Grossman, W, Wei, J Y
To test the hypothesis that the capacity for left ventricular (LV) adaptation to volume overload might diminish with age, we examined the hemodynamics and degree of myocardial hypertrophy in response...
Feldman, M D, Alderman, J D, Aroesty, J M, Royal, H D, Ferguson, J J, Owen, R M, ...
Previous reports have shown that increases in heart rate may result in enhanced left ventricular (LV) systolic and diastolic performance. To assess whether this phenomenon occurs in the presence of...
Takahashi, T, Schunkert, H, Isoyama, S, Wei, J Y, Nadal-Ginard, B, Grossman, W, ...
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of gene expression) changes. Our previous studies have shown that advancing age in the rat...
Amende, I, Bentivegna, L A, Zeind, A J, Wenzlaff, P, Grossman, W, Morgan, J P
Ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([Ca2+]i). The present study was...
Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts.
Harada, K, Grossman, W, Friedman, M, Edelman, E R, Prasad, P V, Keighley, C S, ...
The effect of basic fibroblast growth factor (bFGF) administration on regional myocardial function and blood flow in chronically ischemic hearts was studied in 26 pigs instrumented with proximal...
Chronic exercise training protects aged cardiac muscle against hypoxia.
Wei, J Y, Li, Y, Lincoln, T, Grossman, W, Mendelowitz, D
To test the hypothesis that chronic exercise may improve tolerance to hypoxia in aged hearts, we compared cardiac function of exercised rats to that of their age-matched, nonexercised controls. Right...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Takahashi, T, Allen, P D, Lacro, R V, Marks, A R, Dennis, A R, Schoen, F J, ...
Cytoplasmic free calcium ions (Ca2+) play a central role in excitation-contraction coupling of cardiac muscle. Abnormal Ca2+ handling has been implicated in systolic and diastolic dysfunction in...
Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations.
Brodie, B R, Grossman, W, Mann, T, McLaurin, L P
The effect of sodium nitroprusside on the relationship between left ventricular pressure and volume during diastole was studied in 11 patients with congestive heart failure. Nitroprusside was infused...
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W, Jones, D, McLaurin, L P
It is generally recognized that chronic left ventricular (LV) pressure overload results primarily in wall thickening and concentric hypertrophy, while chronic LV volume overload is characterized by...
Effect of age on myocardial adaptation to volume overload in the rat.
Isoyama, S, Grossman, W, Wei, J Y
To test the hypothesis that the capacity for left ventricular (LV) adaptation to volume overload might diminish with age, we examined the hemodynamics and degree of myocardial hypertrophy in response...
Feldman, M D, Alderman, J D, Aroesty, J M, Royal, H D, Ferguson, J J, Owen, R M, ...
Previous reports have shown that increases in heart rate may result in enhanced left ventricular (LV) systolic and diastolic performance. To assess whether this phenomenon occurs in the presence of...
Takahashi, T, Schunkert, H, Isoyama, S, Wei, J Y, Nadal-Ginard, B, Grossman, W, ...
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of gene expression) changes. Our previous studies have shown that advancing age in the rat...
Changes in the inotropic state of the left ventricle during isometric exercise.
Grossman, W, McLaurin, L P, Saltz, S B, Paraskos, J A, Dalen, J E, Dexter, L
An echocardiographic study of the interventricular septum in constrictive pericarditis.
Gibson, T C, Grossman, W, McLaurin, L P, Moos, S, Craige, E
Ten patients with constrictive pericarditis were studied echocardiographically with specific reference to inter-ventricular septal dynamics. Abnormal movement of the interventricular septum was...
Noninvasive study of effect of isometric exercise on left ventricular performance in normal man.
Stefadouros, M A, Grossman, W, El-Shahawy, M, Stefadouros, F, Witham, A C
Kihara, Y., Gwathmey, J. K., Grossman, W., Morgan, J. P.
1. We used the bioluminescent protein aequorin, which emits light when it combines with Ca2+, to test the hypothesis that the inotropic and lusitropic actions of DPI 201-106 are due to changes in...