Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...
Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...
Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites.
Using P1 nuclease enhanced 32P postlabeling, we investigated DNA adduct formation in HL-60 promyelocytic leukemia cells treated with the benzene metabolites hydroquinone, catechol, and...
Transient conformation changes in chromatin during excision repair of ultraviolet damage to DNA.
DNA labeled for 15 minutes during UV induced repair synthesis is two-fold more sensitive to micrococcal nuclease than the bulk nuclear DNA. As the length of the labeling period increases from 15...
The influence of chromatin structure on the distribution of DNA repair synthesis was studied by enzymatic digestion of "repair labeled" nuclei of mouse mammary cells: "repair labeled" nuclei were...
Bodell, W J, Singer, B, Thomas, G H, Cleaver, J E
The potent carcinogen, ethylnitrosourea, has been shown to ethylate oxygens, in preference to nitrogens, in the DNA of cultured cells. We have now studied the removal of seven ethyl derivatives in...
Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.
The distribution of methyl methanesulfonate induced DNA repair was measured in mouse mammary cell chromatin by digestion of "repair labeled" nuclei with micrococcal nuclease. The results indicate...
We have measured DNA repair in mouse satellite and main band DNA as resolved by Ag+-Cs2SO4 centrifugation in response to treatment with the alkylating agents, methyl methanesulfonate, and...
Bodell, W J, Pathak, D N, Lévay, G, Ye, Q, Pongracz, K
We have investigated the formation of DNA adducts in the bone marrow and white blood cells of male B6C3F1 mice treated with benzene using P1-enhanced 32P-postlabeling. No adducts were detected in the...
Investigation of benzene-DNA adducts and their detection in human bone marrow.
Bodell, W J, Levay, G, Pongracz, K
We have examined DNA adduct formation in HL-60 cells and human bone marrow treated with either hydroquinone or p-benzoquinone and have found that these treatments produce the same DNA adduct in both...
Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.
Bodell, W J, Aida, T, Berger, M S, Rosenblum, M L
Chloroethylnitrosoureas (CENUs) are alkylating and crosslinking agents used for the treatment of human cancer; they are both mutagenic and carcinogenic. We compared the levels of induction of sister...
Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...
Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...
Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites.
Using P1 nuclease enhanced 32P postlabeling, we investigated DNA adduct formation in HL-60 promyelocytic leukemia cells treated with the benzene metabolites hydroquinone, catechol, and...
Transient conformation changes in chromatin during excision repair of ultraviolet damage to DNA.
DNA labeled for 15 minutes during UV induced repair synthesis is two-fold more sensitive to micrococcal nuclease than the bulk nuclear DNA. As the length of the labeling period increases from 15...
The influence of chromatin structure on the distribution of DNA repair synthesis was studied by enzymatic digestion of "repair labeled" nuclei of mouse mammary cells: "repair labeled" nuclei were...
Bodell, W J, Singer, B, Thomas, G H, Cleaver, J E
The potent carcinogen, ethylnitrosourea, has been shown to ethylate oxygens, in preference to nitrogens, in the DNA of cultured cells. We have now studied the removal of seven ethyl derivatives in...
Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.
The distribution of methyl methanesulfonate induced DNA repair was measured in mouse mammary cell chromatin by digestion of "repair labeled" nuclei with micrococcal nuclease. The results indicate...
We have measured DNA repair in mouse satellite and main band DNA as resolved by Ag+-Cs2SO4 centrifugation in response to treatment with the alkylating agents, methyl methanesulfonate, and...
Bodell, W J, Pathak, D N, Lévay, G, Ye, Q, Pongracz, K
We have investigated the formation of DNA adducts in the bone marrow and white blood cells of male B6C3F1 mice treated with benzene using P1-enhanced 32P-postlabeling. No adducts were detected in the...
Investigation of benzene-DNA adducts and their detection in human bone marrow.
Bodell, W J, Levay, G, Pongracz, K
We have examined DNA adduct formation in HL-60 cells and human bone marrow treated with either hydroquinone or p-benzoquinone and have found that these treatments produce the same DNA adduct in both...
Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.
Bodell, W J, Aida, T, Berger, M S, Rosenblum, M L
Chloroethylnitrosoureas (CENUs) are alkylating and crosslinking agents used for the treatment of human cancer; they are both mutagenic and carcinogenic. We compared the levels of induction of sister...
Bodell, W. J., Giannini, D. D., Hassenbusch, S., Levin, V. A.
The level of N7-(2-hydroxyethyl)guanine (N7-HOEtG), one of the DNA alkylation products formed by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) treatment, was measured in human brain tumor samples by...