Gene expression profile analysis of epilepsy-associated gangliogliomas (2008)
Aronica, E., Boer, J. De, Becker, A., Redeker, S., Spliet, W.G., Rijen, P.C. Van, ...
Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. The histological composition of GG, with the presence of dysplastic...
Development of tolerance to levetiracetam in rats with chronic epilepsy. (2008)
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Lopes Da Silva, F.H., Wadman, W.J., Gorter, J.A.
Purpose: Pharmacoresistance is a major problem in the treatment of epilepsy. We showed previously that pharmacoresistance, at least partially, is due to an up-regulation of the multidrug transporter...
Development of tolerance to levetiracetam in rats with chronic epilepsy (2008)
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Lopes Da Silva, F.H., Wadman, W.J., Gorter, J.A.
Purpose: Pharmacoresistance is a major problem in the treatment of epilepsy.We showed previously that pharmacoresistance, at least partially, is due to an up-regulation of the multidrug transporter...
Noam, Y.Y., Wadman, W.J., Hooft, J.A. Van
Natively expressed serotonin 5-HT(3) receptors typically possess a negative-slope conductance region in their I-V curve, due to a voltage-dependent block by external Ca(2+) ions. However, in almost...
Computer simulations of neuron-glia interactions mediated by ion flux (2008)
Somjen, G.G., Kager, J., Wadman, W.J.
Extracellular potassium concentration, [K(+)](o), and intracellular calcium, [Ca(2+)](i), rise during neuron excitation, seizures and spreading depression. Astrocytes probably restrain the rise of...
Complement activation in experimental and human temporal lobe epilepsy. (2007)
Aronica, E., Boer, K. De, Vliet, E.A. Van, Redeker, S., Baayen, J.C., Spliet, W.G.M., ...
We investigated the involvement of the complement cascade during epileptogenesis in a rat model of temporal lobe epilepsy (TLE), and in the chronic epileptic phase in both experimental as well as...
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Voskuyl, R.A., Redeker, S., Aronica, E., ...
Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to...
Raedt, R, Boon, P., Perssson, A., Alborn, A.M., Boterberg, T., Dycke, A. Van, ...
Purpose: Adult hippocampal neurogenesis is enhanced in several models for temporal lobe epilepsy (TLE). In this study, we used low-dose whole brain radiation to suppress hippocampal neurogenesis and...
Cappaert, N., Wadman, W.J., Witter, M.P.
The subiculum and the entorhinal cortex (EC) are important structures in processing and transmitting information between the neocortex and the hippocampus. The subiculum potentially receives...
Sun, G., Werkman, T.R., Battefeld, A., Clare, J.J>, Wadman, W.J.
PURPOSE: The transient and the persistent Na(+) current play a distinct role in neuronal excitability. Several antiepileptic drugs (AEDs) modulate the transient Na(+) current and block the persistent...
Wyckhuys, T, Smedt, T. De, Claeys, P., Raedt, R, Waterschoot, L., Vonck, K, ...
This experimental animal study evaluates the effect of high frequency deep brain stimulation (HFS DBS) on seizures in the Alternate Day Rapid Kindling model for temporal lobe epilepsy (TLE). The...
Deep brain stimulation in patients with refractory temporal lobe epilepsy. (2007)
Boon, P., Vonck, K, Herdt, V De, Dycke, A. Van, Goethals, M., Goossens, L., ...
This pilot study prospectively evaluated the efficacy of long-term deep brain stimulation (DBS) in medial temporal lobe (MTL) structures in patients with MTL epilepsy. METHODS: Twelve consecutive...
Gorter, J.A., Vliet, E.A. Van, Rauwerda, H., Breit, T, Stad, R., Schaik, R. Van, ...
We investigated expression of genes involved in the proteolytic process during epileptogenesis in a rat model of temporal lobe epilepsy (TLE). In a previous microarray study we found prominent...
Gorter, J.A., Vliet, E.A. Van, Rauwerda, H., Breit, T.M., Stad, R., Schaik, R. Van, ...
We investigated expression of genes involved in the proteolytic process during epileptogenesis in a rat model of temporal lobe epilepsy (TLE). In a previous microarray study we found prominent...
Wyckhuys, T, Smedt, T. De, Claeys, P., Raedt, R, Waterschoot, L., Vonck, K, ...
This experimental animal study evaluates the effect of high frequency deep brain stimulation (HFS DBS) on seizures in the Alternate Day Rapid Kindling model for temporal lobe epilepsy (TLE). The...
Deep brain stimulation in patients with refractory temporal lobe epilepsy. (2007)
Boon, P., Vonck, K, Herdt, V De, Dycke, A. Van, Goethals, M., Goossens, L., ...
This pilot study prospectively evaluated the efficacy of long-term deep brain stimulation (DBS) in medial temporal lobe (MTL) structures in patients with MTL epilepsy. METHODS: Twelve consecutive...
Complement activation in experimental and human temporal lobe epilepsy. (2007)
Aronica, E., Boer, K. De, Vliet, E.A. Van, Redeker, S., Baayen, J.C., Spliet, W.G.M., ...
We investigated the involvement of the complement cascade during epileptogenesis in a rat model of temporal lobe epilepsy (TLE), and in the chronic epileptic phase in both experimental as well as...
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Voskuyl, R.A., Redeker, S., Aronica, E., ...
Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to...
Raedt, R, Boon, P., Perssson, A., Alborn, A.M., Boterberg, T., Dycke, A. Van, ...
Purpose: Adult hippocampal neurogenesis is enhanced in several models for temporal lobe epilepsy (TLE). In this study, we used low-dose whole brain radiation to suppress hippocampal neurogenesis and...
Cappaert, N., Wadman, W.J., Witter, M.P.
The subiculum and the entorhinal cortex (EC) are important structures in processing and transmitting information between the neocortex and the hippocampus. The subiculum potentially receives...
Sun, G., Werkman, T.R., Battefeld, A., Clare, J.J., Wadman, W.J.
PURPOSE: The transient and the persistent Na(+) current play a distinct role in neuronal excitability. Several antiepileptic drugs (AEDs) modulate the transient Na(+) current and block the persistent...
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Redeker, S., Aronica, E., Wadman, W.J., ...
Purpose: Overexpression of multidrug transporters such as P-glycoprotein (P-gp) may play a significant role in pharmacoresistance, by preventing antiepileptic drugs (AEDs) from reaching their targets...
Gorter, J.A., Vliet, E.A. Van, Aronica, E., Breit, T., Rauwerda, H., ...
To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy, we investigated gene expression during epileptogenesis in the rat. RNA was obtained from three different...
Gorter, J.A., Vliet, E.A. Van, Aronica, E.M.A., Breit, T.M., Rauwerda, J., Lopes Da Silva, F.H., ...
To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy, we investigated gene expression during epileptogenesis in the rat. RNA was obtained from three different...
Dual role of calbindin-D in vesicular catecholamine release from mouse chromaffin cells. (2006)
Westerink, R.H.S., Rook, M.B., Beekwilder, J.P., Wadman, W.J.
Calbindin-D(28K) is suggested to play a postsynaptic role in neurotransmission and in the regulation of the intracellular Ca(2+) concentration. However, it is still unclear whether calbindin-D(28K)...
Vliet, E.A. Van, Schaik, R. Van, Edelbroek, P.M., Redeker, A.M.J., Aronica, E.M.A., Wadman, W.J., ...
Morphology of the olfactory system in the predatory mite Phytoseiulus persimilis (2006)
Wijk, M. Van, Wadman, W.J., Sabelis, M.W.
The predatory mite Phytoseiulus persimilis locates its prey, the two-spotted spider mite, by means of herbivore-induced plant volatiles. The olfactory response to this quantitatively and...
Gross morphology of the central nervous system of a phytoseiid mite (2006)
Wijk, M. Van, Wadman, W.J., Sabelis, M.W.
Abstract The general morphology of the central nervous system is analysed in intact females of the predatory mite, Phytoseiulus persimilis (Acari: Phytoseiidae), using a nucleic acid label (YOYO-1)...
Sun, G., Werkman, T.R., Wadman, W.J.
AIM: To study whether the functional properties of sodium channels, and subsequently the channel modulation by carbamazepine (CBZ) in hippocampal CA1 neurons can be changed after epileptic seizures....
Seizure-like afterdischarges simulated in a model neuron. (2006)
Kager, J., Wadman, W.J., Somjen, G.G.
To explore non-synaptic mechanisms in paroxysmal discharges, we used a computer model of a simplified hippocampal pyramidal cell, surrounded by interstitial space and a "glial-endothelial" buffer...
Welie, I. Van, Remme, M.W.H., Hooft, J.A. Van, Wadman, W.J.
Pyramidal neurons in the subiculum typically display either bursting or regular-spiking behaviour. Although this classification into two neuronal classes is well described, it is unknown how these...
Dedeurwaardere, S, Vonck, K, Herdt, V De, Waterschoot, L., Smedt, T, Raedt, R, ...
Epilepsy is a neurological disorder consisting of recurrent seizures, resulting from excessive, uncontrolled electrical activity in the brain. Epilepsy treatment is successful in the majority of the...
Olijslagers, J.E., Werkman, T.R., McCreary, A.C., Kruse, C.G., Wadman, W.J.
Schizophrenia has been associated with a dysfunction of brain dopamine (DA). This, so called, DA hypothesis has been refined as new insights into the pathophysiology of schizophrenia have emerged....
Olijslagers, J.E., Perlstein, B., Werkman, T.R., Mc.Creary, A.C., Siarey, R., Kruse, C.G., ...
The role of the 5-HT(2A) receptor in modulating amphetamine-induced inhibition of dopamine neuronal firing in A9 and A10 was investigated in rat midbrain slices. The antipsychotic drugs olanzapine...
Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2+ ions (2005)
Welie, I. Van, Wadman, W.J., Hooft, J.A. Van
Ba2+ is commonly used to discriminate two classes of ion currents. The classical inward-rectifying K+ current, I(Kir), is blocked by low millimolar concentrations of Ba2+, whereas the...
Dedeurwaerdere, S, Vonck, K, Hese Van, P, Wadman, W.J., Boon, P
PURPOSE: The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for...
Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam (2005)
De Smedt, T, Vonck, K, Raedt, R, Dedeurwaerdere, S, Claeys, P., Legros, B., ...
PURPOSE: This study assesses the use of the serial day Rapid Kindling with Recurrent Hippocampal Seizures (RKRHS) model in drug testing by investigating the anti-epileptic effect of levetiracetam...
Control of a local neural network by feedforward and feedback inhibition (2004)
The signal transfer of a neuronal network is shaped by the local interactions between the excitatory principal cells and the inhibitory interneurons. We investigated with a simple lumped model how...
Ketelaars, S.O.M., Gorter, J.A., Aronica, E., Wadman, W.J.
PURPOSE: The plasma membrane Ca2+ -adenosine triphosphatase (ATPase) (PMCA) and (potassium-dependent) sodium-calcium exchange [NC(K)X] represent two main calcium-extrusion mechanisms that are...
Olijslagers, J.E., Werkman, T.R., McCreary, AC, Siarey, R., Kruse, C.G., Wadman, W.J.
5-HT (20 microM) enhanced dopamine (DA) D2-like receptor mediated reduction of the firing rate of DA neurons in the substantia nigra pars compacta (A9) and ventral tegmental area (A10) in a rat...
Welie, I. Van, Hooft, J.A. Van, Wadman, W.J.
The hyperpolarization-activated cation current (Ih) plays an important role in determining membrane potential and firing characteristics of neurons and therefore is a potential target for regulation...