W. Joost Wiersinga

Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis) (2007)

W. Joost Wiersinga, Catharina W. Wieland, Mark C. Dessing, Narisara Chantratita, Allen C. Cheng, Direk Limmathurotsakul, ...

BackgroundToll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most...

Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

Wiersinga, W. Joost, Wieland, Catharina W, Dessing, Mark C, Chantratita, Narisara, Cheng, Allen C, Limmathurotsakul, Direk, ...

Willem Wiersinga and colleagues find up-regulation of multiple Toll-like receptors (TLRs) in peripheral blood cells of patients with melioidosis. However, only TLR2 had an effect on the immune...

High-Throughput mRNA Profiling Characterizes the Expression of Inflammatory Molecules in Sepsis Caused by Burkholderia pseudomallei▿

Wiersinga, W. Joost, Dessing, Mark C., Kager, Piet A., Cheng, Allen C., Limmathurotsakul, Direk, Day, Nicholas P., ...

Sepsis is characterized by an uncontrolled inflammatory response to invading microorganisms. We describe the inflammatory mRNA profiles in whole-blood leukocytes, monocytes, and granulocytes using a...

Endogenous Interleukin-18 Improves the Early Antimicrobial Host Response in Severe Melioidosis▿

Wiersinga, W. Joost, Wieland, Catharina W., De Boer, Anita, Florquin, Sandrine, Dondorp, Arjen, ...

Melioidosis is caused by the soil saprophyte Burkholderia pseudomallei and is endemic in Southeast Asia. The pathogenesis of melioidosis is still largely unknown, although gamma interferon (IFN-γ)...

MyD88 Dependent Signaling Contributes to Protective Host Defense against Burkholderia pseudomallei

Wiersinga, W. Joost, Wieland, Catharina W., Van Der Poll, Tom