Rutten, W.L.C., Ruardij, T.G., Roelofsen, B.H.
A 'cultured probe' is a hybrid type of neural information transducer or prosthesis, for stimulation and/or recording of neural activity in the brain or the spinal cord (ventral motor region or dorsal...
Cross-interval histogram analysis of neuronal activity on multi-electrode arrays (2003)
Castellone, P., Rutten, W.L.C., Marani, E.
Cross-neuron-interval histogram (CNIH) analysis has been performed in order to study correlated activity and connectivity between pairs of neurons in a spontaneously active developing cultured...
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts...
This paper describes the adhesion and growth of dissociated cortical neurons on chemically patterned surfaces over a time period of 30 days. The presence of neurons was demonstrated by measurement of...
Adsorbed layers of polyediylenoxide-polypropylenoxide (PEO-PPO) blockcopolymers were tested as neurophobic background coatings in neuronal patterning studies over a time period of 30 days....
Staveren Van, G.W., Buitenweg, J.R., Heida, T., Rutten, W.L.C.
Dissociated embryonal or postnatal rat cortical cells were cultured onto multi electrode arrays (MEA's) with 61 electrode sites. They developed into networks and became spontaneously active after...
Heida, T., Wagenaar, J.B.M., Rutten, W.L.C., Marani, E.
High electric field strengths may induce high cell membrane potentials. At a certain breakdown level the membrane potential becomes constant due to the transition from an insulating state into a high...
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
Amplitudes and shapes of extracellular recordings from single neurons cultured on a substrate embedded microelectrode depend not only on the volume conducting properties of the neuron-electrode...
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
Extracellular stimulation of single cultured neurons which are completely sealing a microelectrode is usually performed using anodic or biphasic currents of at least 200 nA. However, recently...
Activity patterns of cultured neural networks on micro electrode arrays (2001)
A hybrid neuro-electronic interface is a cell-cultured micro electrode array, acting as a neural information transducer for stimulation and/or recording of neural activity in the brain or the spinal...
Survival of adhering cortical neurons on polyethylenimine micropatterns (2001)
Ruardij, T.G., Goedbloed, M.H., Rutten, W.L.C.
The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with...
Nano-ampere stimulation window for cultured neurons on micro-electrode arrays (2001)
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
From experiments, it appears to be possible to stimulate a neuron by depolarisation of the lower membrane patch, the sealing part of the membrane, using a nano-ampere current through the...
Heida, T., Rutten, W.L.C., Marani, E.
Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite...
Neuroelectronic interfacing with cultured multielectrode arrays toward a cultured probe (2001)
Rutten, W.L.C., Mouveroux, J.M.P., Buitenweg, J.R., Heida, T., Ruardij, T.G., Marani, E., ...
Efficient and selective electrical stimulation and recording of neural activity in peripheral, spinal, or central pathways requires multielectrode arrays at micrometer scale. ¿Cultured probe¿...
Dielectrophoretic trapping of dissociated fetal cortical rat neurons (2001)
Heida, T., Rutten, W.L.C., Marani, E.
Recording and stimulating neuronal activity at multiple sites can be realized with planar microelectrode arrays. Efficient use of such arrays requires each site to be covered by at least one neuron....
Trapping cortical rat neurons (2000)
Heida, T., Rutten, W.L.C., Marani, E.
Cortical rat neurons were trapped by dielectrophoresis (DEP). Experimental data were compared with theoretically deduced relationships. The neuron was represented by a single-shell model. A planar...
Geometry based dynamic modeling of the neuron-electrode interface (2000)
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
A dynamic model of the neuron-electrode interface is presented which is based on the interface geometry and the electrical properties of the neuronal membrane. The model is used to compute the...
Ruardij, T.G., Goedbloed, M.H., Rutten, W.L.C.
In this study adhesion and patterning of cortical neurons on modified glass surfaces was investigated. Patterns of cortical neurons were prepared with a combination of polyethylenimine (PEI) and...
Ruardij, T.G., Goedbloed, M.H., Rutten, W.L.C.
This study aims on the preparation of isolated islands of cortical neurons on modified glass surfaces. Isolated islands of cortical neurons were obtained with a combination of neuron-adhesive...
Finite element modeling of the neuron-electrode interface (2000)
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
The electrical contact between an embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. The contact is improved when the electrode is covered, or...
Ruardij, T.G., Goedbloed, M.H., Rutten, W.L.C.
Adhesion and patterning of cortical neurons was investigated on isolated islands of neuron-adhesive polyethylenimine (PEI) surrounded by a neuron-repellent fluorocarbon (FC) layer. In addition, the...
Endoneural selective stimulating using wire-microelectrode arrays (1999)
Smit, J.P.A., Rutten, W.L.C., Boom, H.B.K.
In acute experiments eight 5- to 24-wire-microelectrode arrays were inserted into the common peroneal nerve of the rat, to investigate whether the electrodes could selectively stimulate motor units...
Finite element modeling of the neuron-electrode interface: stimulus transfer and geometry (1999)
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
The relation between stimulus transfer and the geometry of the neuron-electrode interface can not be determined properly using electrical equivalent circuits, since current that flows from the...
A gate-array/multi-electrode device: circuit performance and interfacing (1999)
Rutten, W.L.C., Droog, A., Rouw, M., Smit, J.P.A.
The Twente 128-fold 3-dimensional multi-micro electrode device for endoneural stimulation is controlled by a 4×4 mm CMOS gate array chip. The chip contains the electronic circuitry, i.e. eight...
Efficiency of endoneural stimulation with 5- to 24-fold multielectrodes (1998)
Optimal selective stimulation of nerve with endoneurally (intrafascicularly) inserted multi-microelectrodes means that each electrode activates, with its own threshold stimulation current, as few...
Buitenweg, J.R., Rutten, W.L.C., Marani, E.
The quality of the electrical contact between a cultured neuron and a substrate embedded microelectrode is of importance for effective transfer of an extracellular applied stimulus current to the...
Characterization of the behaviour of dissociated neurons exposed to dielectrophoretic forces (1998)
Heida, T., Rutten, W.L.C., Marani, E.
The behaviour of cortical rat neurons exposed to dielectrophoretic forces is investigated by varying the amplitude and frequency of the applied field. The number of neurons trapped in the center of a...
Meier, J.H., Rutten, W.L.C., Boom, H.B.K.
A model is presented that calculates the single-fiber extracellular field and action potential (ap) of an active myelinated nerve fiber placed centrally or eccentrically inside a nerve with a...
Frieswijk, T.A., Dijkstra, E.A., Rutten, W.L.C.
A control algorithm for regulation of the force produced by the rat EDL muscle is presented, using a 128-electrodes intraneural stimulation device. The algorithm is based on force regulation in...
Smit, J.P.A., Rutten, W.L.C., Boom, H.B.K.
In acute experiments on six Wistar rats, a wire-microelectrode array was inserted into the common peroneal nerve. A 5-channel array and a 24-channel array were available. Each electrode in the array...
Multi-microelectrode devices for intrafascicular use in peripheral nerve (1996)
This minisymposium paper gives an overview of experimental, modeling, design and microfabrication steps which lead towards the University of Twente three-dimensional 128-fold silicon microelectrode...
Bielen, J.A., Schmidt, A.W., Weiel, R., Rutten, W.L.C.
The fabrication of the basic structure of needle electrode arrays by means of the LIGA method is investigated. To be able to contact all needle electrodes individually, the arrays were fabricated on...
For neuroprosthetic use of afferent activity, model results and experimental recordings of action potentials (ap's) made with tungsten micro electrodes in rat peroneal/sural nerve are presented and...
Frieswijk, T.A., Bielen, J.A., Rutten, W.L.C.
The application of a solder bump technique for contacting a multi electrode sensor/actuator system is presented. Techniques adapted from the literature could successfully be scaled down to 55×55 ¿m...
Intraneural stimulation using 2D wire-microelectrode arrays: I. Experimental results (1995)
A two-dimensional 24-channel wire-microelectrode array was inserted into the peroneal nerve of the rat during acute experiments. The electrodes in the array are on a regular grid of 6 by 4...
A two-dimensional wire-microelectrode array was inserted into the peroneal nerve of the rat through an incision. For each of the electrodes in the array the corresponding twitch-force recruitment...
Rutten, W.L.C., Frieswijk, T.A., Smit, J.P.A., Rozijn, T.H., Meier, J.H.
In order to design the shape and dimensions of new 3D multi-microelectrode information transducers properly, i. e. adapted to the scale of information delivery to and from peripheral nerve fibres, a...
Frieswijk, T.A., Rutten, W.L.C.
A three-dimensional array of microelectrodes for use in intraneural stimulation and recording is presented. The 128 electrodes are at the tips of silicon needles, which are electrically insulated...
A technique for electrically inserting electrode arrays into peripheral nerves (1994)
The authors developed a system based on high-frequency cutting methods to facilitate the insertion of multi-dimensional electrode arrays into peripheral nerves. The system incorporates a feedback...
Single fibre action potentials in skeletal muscle related to recording distances (1994)
Veen Van, B.K., Mast, E., Busschers, R., Verloop, A.J., Wallinga, W., Rutten, W.L.C., ...
Single muscle fibre action potentials (SFAPs) are considered to be functions of a bioelectrical source and electrical conductivity parameters of the medium. In most model studies SFAPs are computed...
Multipolar intrafascicular stimulation (1992)
The suppressing effect of two intrafascicular anodes on the neural recruitment elicited by one intrafascicular cathode has been studied. Recruitment curves are calculated with a nerve stimulation...
Smit, J.P.A., Rutten, W.L.C., Frieswijk, F.A., Rozijn, T.H., Busschers, R.
Force recruitment curves have been determined using stimulation with an intraneural wire electrode. The recruitment curves vary with the position of the electrode in the fiber bundle. The results...
The effect of fiber-electrode distance on single fiber action potentials (1992)
Veen Van, B.K., Wallinga, W., Mast, E., Busschers, R., Rutten, W.L.C., Boom, H.B.K.
Hermens, H.J., Baten, C.T.M., Rutten, W.L.C., Boom, H.B.K.
Three components determine the power spectrum of the surface EMG signal: the auto- and cross-power spectra of the firing processes and the power spectra of the motor unit action potential (MUAP). To...
Simulation of multipolar fiber selective neural stimulation using intrafascicular electrodes (1992)
Meier, J.H., Rutten, W.L.C., Zoutman, A.E., Boom, H.B.K., Bergveld, P.
A realistic, quantitative model for the excitation of myelinated nerve fibers by intrafascicular electrodes is presented. It predicts the stimulatory regions of any configuration of any number of...
Artificial control of muscle by endoneural multi electrode stimulation and sensing (1991)
Rutten, W.L.C., Bouwman, R.L.M.
Artificial electrical stimulation of motor nerves for muscle control can be made selective by using intrafascicular micro electrode arrays which contact many individual or small groups of nerve...
Sensitivity and selectivity of intraneural stimulation using a silicon electrode array (1991)
Rutten, W.L.C., Wier Van, H., Put, J.H.M.
A multielectrode array in silicon technology, as well as experimental paradigms and model calculations for sensitivity and selectivity measures, have been developed. The array consists of twelve...
Finite element simulations of magnetomyograms of rat skeletal muscle. (1990)
Rutten, W.L.C., Wildeman, A., Rozijn, T.H.
The following topics are dealt with: biosensors; cardiology; processing of bioelectric signals; biomedical application of automatic control; lasers and electrooptics; computers in medicine; expert...
In vivo magnetomyograms of skeletal muscle (1989)
Rutten, W.L.C., Wildeman, A., Veen Van, B.K., Wallinga, W.
Magnetomyography (MMG) is a new noninvasive technique inspired by the magnetoneurographic method of J.P. Wikswo (IEEE Trans. Biomed. Eng., Vol.BME-30, p.215-21, 1983). MMG is used to detect action...
Fibre selective neural stimulation using intrafascicular electrodes (1989)
Meier, J.H., Rutten, W.L.C., Put, J.H.M.
Using a nerve stimulation model, areas of excitation can be calculated for different configurations of intrafascicular electrodes. Theory predicts that fibre selectivity and recruitment order depend...
Rutten, W.L.C., Wier Van, H.J, Put, J.H.M., Meier, J.H.
The ideal neural stimulatory information transducer must be able to activate individual neural fibers within a fascicular bundle, for example in a sensory or motor nerve. In a local approach using...