TRANSMAMMARY TRANSMISSION OF STRONGYLOIDES STERCORALIS IN DOGS (2002)
W. L. Shoop, B. F. Michael, C. H. Eary, H. W. Haines
Vertical transmission of larvae is a major pathway in the life cycle of several species of Strongyloides, but evidence for it occurring in humans or dogs with Strongyloides stercoralis is absent. In...
T. Felcetto, J. Ondeyka, S. L. Colletti, P. T. Meinke, W. L. Shoop
A medicinal chemistry program on the nodulisporic acid chemical class, guided by an artificial membrane flea-feeding assay, has recently identified permissive and nonpermissive regions of the...
SYSTEMIC EFFICACY OF NODULISPORAMIDES AGAINST FLEAS ON DOGS (2001)
W. L. Shoop, M. Zakson-Aiken, L. M. Gregory, B. F. Michael, J. Pivnichny, P. T. Meinke, ...
Nodulisporic acid A (NSA) has been shown previously to be safe in dogs and to deliver >90% flea control for 4 days following a single oral administration. Three newly prepared nodulisporamide...
SYSTEMIC EFFICACY OF NODULISPORIC ACID AGAINST FLEAS ON DOGS (2001)
W. L. Shoop, L. M. Gregory, M. Zakson-Aiken, B. F. Michael, H. W. Haines, J. G. Ondeyka, ...
Nodulisporic acid A (NSA) is a novel natural product from a new structural class that was shown previously to have insecticidal activity against blowfly larvae. To determine if there was useful...
M. Zakson-Aiken, L. M. Gregory, W. L. Shoop
Larvae of the cat flea,Ctenocephalides felis(Bouché), are the target of numerous growth regulators. This study explores the development of an assay that tests the susceptibility of cat flea larvae...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...