W. M. Crist

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

Nakamura, T, Alder, H, Gu, Y, Prasad, R, Canaani, O, Kamada, N, ...

Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1 gene, homolog of Drosophila trithorax and located at chromosome band...

The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, ...

We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor...

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

Synold, T W, Relling, M V, Boyett, J M, Rivera, G K, Sandlund, J T, Mahmoud, H, ...

High-dose methotrexate (HDMTX) is a component of most treatment protocols for childhood acute lymphoblastic leukemia (ALL), yet recent studies of receptor-mediated transport and saturable...

Clonal analysis of childhood acute lymphoblastic leukemia with "cytogenetically independent" cell populations.

Pui, C H, Raskind, W H, Kitchingman, G R, Raimondi, S C, Behm, F G, Murphy, S B, ...

Acute lymphoblastic leukemia (ALL) is generally regarded as a clonal disease in which a single abnormal progenitor cell gives rise to neoplastic progeny. Five of 463 cases of childhood ALL with...

Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome.

Kumagai, M, Manabe, A, Pui, C H, Behm, F G, Raimondi, S C, Hancock, M L, ...

We developed a stroma cell culture system that suppresses apoptosis of malignant cells from cases of B-lineage acute lymphoblastic leukemia. By multiparameter flow cytometric measurements of cell...

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

Nakamura, T, Alder, H, Gu, Y, Prasad, R, Canaani, O, Kamada, N, ...

Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1 gene, homolog of Drosophila trithorax and located at chromosome band...

The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, ...

We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor...

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

Synold, T W, Relling, M V, Boyett, J M, Rivera, G K, Sandlund, J T, Mahmoud, H, ...

High-dose methotrexate (HDMTX) is a component of most treatment protocols for childhood acute lymphoblastic leukemia (ALL), yet recent studies of receptor-mediated transport and saturable...

Clonal analysis of childhood acute lymphoblastic leukemia with "cytogenetically independent" cell populations.

Pui, C H, Raskind, W H, Kitchingman, G R, Raimondi, S C, Behm, F G, Murphy, S B, ...

Acute lymphoblastic leukemia (ALL) is generally regarded as a clonal disease in which a single abnormal progenitor cell gives rise to neoplastic progeny. Five of 463 cases of childhood ALL with...

Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome.

Kumagai, M, Manabe, A, Pui, C H, Behm, F G, Raimondi, S C, Hancock, M L, ...

We developed a stroma cell culture system that suppresses apoptosis of malignant cells from cases of B-lineage acute lymphoblastic leukemia. By multiparameter flow cytometric measurements of cell...

Disposition of antineoplastic agents in the very young child.

McLeod, H. L., Relling, M. V., Crom, W. R., Silverstein, K., Groom, S., Rodman, J. H., ...

Maturation of physiologic process which govern the disposition of pharmacologic agents can yield significant changes in absorption, distribution, metabolism, and elimination of drugs in neonates,...