W. M. Shannon

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). (1998)

Shannon, W. M., Holland, L. E., Arnett, G., Brando, L. V., Hollingshead, M. G.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance; e.g., vaccinia virus (VV) adenovirus (Ad), vesicular...

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). (1998)

Shannon, W. M., Holland, L. E., Arnett, G., Brando, L. V., Brazier, A. D.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical...

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). (1998)

Shannon, W. M., Arnett, G., Brazier, A. D., Dulmadge, E. A., Hollingshead, M. G.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical...

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). (1998)

Shannon, W. M., Arnett, G., Brazier, A. D., Dulmadge, E. A., Hollingshead, M. G.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical...

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). Volume 1. (1998)

Shannon, W. M., Arnett, G., Brazier, A. D., Hollingshead, M. G., Kirsi, J. J.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical...

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). Volume 2. (1998)

Shannon, W. M., Arnett, G., Brazier, A. D., Hollingshead, M. G., Kirsi, J. J.

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical...

Research in Drug Development against Viral Diseases of Military Importance (Large-Scale Antiviral Drug Screening). Volume 2, Appendices. (1998)

Stephen, E., Shannon, W. M., Arnett, G., Brazier, A. D., Kirsi, J. J.

The purpose of this program was to evaluate the efficacy of candidate antiviral compounds against a of viruses of military importance. This program involved (a) prescreen testing of natural products...

Research in Drug Development against Viral Diseases of Military Importance (Large-Scale Antiviral Drug Screening). Volume 1. (1998)

Shannon, W. M., Arnett, G., Brazier, A. D., Kirsi, J. J., Wilkoff, L. J.

The purpose of this program was to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involved (a) prescreen vitro, (b) primary...

3'-Azido-3'-deoxythymidine-induced reduction in the ability of uninfected CD4-expressing cells to participate in syncytium formation.

Buckheit, R W, Germany-Decker, J, Qualls-Goodwin, K, Bowdon, B J, Shannon, W M

A cocultivation assay system consisting of uninfected human T cells and cells chronically infected with human immunodeficiency virus type 1 has been used to investigate syncytium formation in...

Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses.

Shannon, W M, Arnett, G, Westbrook, L, Shealy, Y F, O'Dell, C A, Brockman, R W

Carbodine, the carbocyclic analog of cytidine, was found to possess significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 (Hong Kong) in vitro. The compound...

Lack of efficacy of 2-deoxy-D-glucose in the treatment of experimental herpes genitalis in guinea pigs.

Shannon, W M, Arnett, G, Drennen, D J

Topical treatment of herpes genitalis in female guinea pigs with 2-deoxy-D-glucose in either agarose gels or miconazole nitrate ointments failed to prevent the development of genital lesions or to...

Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice.

Shannon, W M, Westbrook, L, Arnett, G, Daluge, S, Lee, H, Vince, R

The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate...

Evaluation of prodrugs of 9-beta-D-arabinofuranosyladenine for therapeutic efficacy in the topical treatment of genital herpesvirus infections in guinea pigs.

Shannon, W M, Arnett, G, Baker, D C, Kumar, S D, Higuchi, W I

Prodrugs of the antiviral agent 9-beta-D-arabinofuranosyladenine (araA), which were more effective than the parent compound in penetrating vaginal membranes in vitro, were synthesized and examined...

Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism.

Parker, W B, Shaddix, S C, Bowdon, B J, Rose, L M, Vince, R, Shannon, W M, ...

Carbovir (CBV) [the (--)-enantiomer of the carbocyclic analog of 2',3'-dideoxy-2',3'-didehydroguanosine] is a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication in vitro. We...

Novel method for evaluating antiviral drugs against human cytomegalovirus in mice.

Allen, L B, Li, S X, Arnett, G, Toyer, B, Shannon, W M, Hollingshead, M G

A virus-host cell system in which human cytomegalovirus-infected human cells are entrapped in agarose plugs has been developed. This model provides an inexpensive method for the in vivo evaluation...

Erythro-9-(2-hydroxy-3-nonyl) Adenine alone and in combination with 9-beta-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice.

Shannon, W M, Arnett, G, Schabel, F M, North, T W, Cohen, S S

Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the...

3'-Azido-3'-deoxythymidine-induced reduction in the ability of uninfected CD4-expressing cells to participate in syncytium formation.

Buckheit, R W, Germany-Decker, J, Qualls-Goodwin, K, Bowdon, B J, Shannon, W M

A cocultivation assay system consisting of uninfected human T cells and cells chronically infected with human immunodeficiency virus type 1 has been used to investigate syncytium formation in...

Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses.

Shannon, W M, Arnett, G, Westbrook, L, Shealy, Y F, O'Dell, C A, Brockman, R W

Carbodine, the carbocyclic analog of cytidine, was found to possess significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 (Hong Kong) in vitro. The compound...

Lack of efficacy of 2-deoxy-D-glucose in the treatment of experimental herpes genitalis in guinea pigs.

Shannon, W M, Arnett, G, Drennen, D J

Topical treatment of herpes genitalis in female guinea pigs with 2-deoxy-D-glucose in either agarose gels or miconazole nitrate ointments failed to prevent the development of genital lesions or to...

Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice.

Shannon, W M, Westbrook, L, Arnett, G, Daluge, S, Lee, H, Vince, R

The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate...

Evaluation of prodrugs of 9-beta-D-arabinofuranosyladenine for therapeutic efficacy in the topical treatment of genital herpesvirus infections in guinea pigs.

Shannon, W M, Arnett, G, Baker, D C, Kumar, S D, Higuchi, W I

Prodrugs of the antiviral agent 9-beta-D-arabinofuranosyladenine (araA), which were more effective than the parent compound in penetrating vaginal membranes in vitro, were synthesized and examined...

Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism.

Parker, W B, Shaddix, S C, Bowdon, B J, Rose, L M, Vince, R, Shannon, W M, ...

Carbovir (CBV) [the (--)-enantiomer of the carbocyclic analog of 2',3'-dideoxy-2',3'-didehydroguanosine] is a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication in vitro. We...

Novel method for evaluating antiviral drugs against human cytomegalovirus in mice.

Allen, L B, Li, S X, Arnett, G, Toyer, B, Shannon, W M, Hollingshead, M G

A virus-host cell system in which human cytomegalovirus-infected human cells are entrapped in agarose plugs has been developed. This model provides an inexpensive method for the in vivo evaluation...

Erythro-9-(2-hydroxy-3-nonyl) Adenine alone and in combination with 9-beta-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice.

Shannon, W M, Arnett, G, Schabel, F M, North, T W, Cohen, S S

Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the...