W. M. Wiersinga

Hypothalamic thyroid hormone feedback in health and disease (2006)

Fliers, E., Alkemade, J.M., Wiersinga, W.M., Swaab, D.F.

The role of the human hypothalamus in the neuroendocrine response to illness has only recently begun to be explored. Extensive changes in the hypothalamus-pituitary-thyroid (HPT) axis occur within...

Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression (2006)

Brouwer, J.P., Appelhof, B.C., Koper, J.W., Fliers, E., Huyser, J, ...

Objective: We investigated whether treatment response is predicted by hypothalamus-pituitary-adrenal (HPA) axis parameters, or by genetic polymorphisms in the glucocorticoid receptor (GR), that...

Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake (2006)

Boelen, A., Kwakkel, J., Wiersinga, W.M., Fliers, E.

During illness, changes in thyroid hormone metabolism occur, known as nonthyroidal illness and characterised by decreased serum triiodothyronine (T-3) and thyroxine (T-4) without an increase in TSH....

Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression) (2006)

Appelhof, B.C., Huyser, J, Verweij, M., Brouwer, J.P., Dyck, R. Van, Fliers, E., ...

Background: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be...

Medullary thyroid carcinomain children (2006)

Heij, H.A., Aronson, D.C., Bos, C. Van Den, Wiersinga, W.M., Vulsma, T.

Author's response: medical or surgical decompression of optic neuropathy in Graves' ophthalmopathy: the choice remains unclear (2006)

Wiersinga, W.M.

Contributions of cytokines to nonthyroidal illness (2006)

Boelen, A., Wiersinga, W.M., Koehrle, J.

Thyroid cancer and the endocrinologist [ch 10] (2006)

Wiersinga, W.M.

A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance? (2006)

Strieder, T.G.A., Drexhage, H.A., Lam-Tse, W.K., Prummel, M.F., Tijssen, J.G.P., Wiersinga, W.M.

Clinical assessment of patients with Graves' orbitopathy: the European Group on Graves' Orbitopathy recommendations to generalists, specialists and clinical researchers (2006)

Wiersinga, W.M., Perros, P., Kahaly, G.J., Mourits, M.P., Baldeschi, L., Boboridis, K., ...

Establishment of reference values for endocrine tests--part V: acromegaly (2006)

Endert, E., Rooden, M. Van, Fliers, E., Prummel, M.F., Wiersinga, W.M.

Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA (2006)

Kwakkel, J., Wiersinga, W.M., Boelen, A.

Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice (2006)

Boelen, A., Kwakkel, J., Vos, X.G., Wiersinga, W.M., Fliers, E.

Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart (2006)

Stoykov, I.M., Zandieh-Doulabi, B., Moorman, A.F.M., Christoffels, V.M., Wiersinga, W.M., Bakker, O.

Amiodarone inhibits thyroidal iodide transport in vitro by a cyclic adenosine 5'-monophosphate- and iodine-independent mechanism (2006)

Tedelind, S., Larsson, F., Johanson, C., Beeren, H.C. Van, Wiersinga, W.M., Nyström, E., ...

Early versus late orbital decompression in Graves' orbitopathy: a retrospective study in 125 patients (2006)

Baldeschi, L., Lindeboom, R., Prummel, M.F., Wiersinga, W.M.

The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals (2006)

Toorians, A.W.F., Endert, E., Wiersinga, W.M., Gooren, L.J.G., Fliers, E.

Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression (2006)

Brouwer, J.P., Appelhof, B.C., Peeters, R.P., Hoogendijk, W.J.G., Huyser, J, Schene, A.H., ...

Smoking and autoimmune thyroid disease: the plot thickens (2006)

Krassas, G.E., Wiersinga, W.M.

European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium (2006)

Pacini, F., Schlumberger, M., Dralle, H., Elisei, R., Smit, J.W.A., Wiersinga, W.M.

Hypothalamic thyroid hormone feedback in health and disease [ch 11] (2006)

Fliers, E., Alkemade, J.M., Wiersinga, W.M., Swaab, D.F.

Management of amiodarone-induced thyrotoxicosis in Latin America: an electronic survey (2006)

Diehl, L.A., Romaldini, J.H., Graf, H., Bartalena, L., Martino, E., Albino, C.C., ...

PGC-1alpha regulates the isoform mRNA ratio of the alternatively spliced thyroid hormone receptor alpha transcript (2006)

Thijssen-Timmer, D.C., Kwakkel, J., Emter, R., Kralli, A., Wiersinga, W.M., ...

A questionnaire survey on the management of Graves' orbitopathy in Europe (2006)

Perros, P., Baldeschi, L., Boboridis, K., Dickinson, A.J., Hullo, A., Kahaly, G.J., ...

Is there a need to redefine the upper normal limit of TSH? (2006)

Brabant, G., Beck-Peccoz, P., Jarzab, B., Laurberg, P., Orgiazzi, J., Szabolcs, I., ...

Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary (2006)

Alkemade, J.M., Friesema, E.C., Kuiper, G.G., Wiersinga, W.M., Swaab, D.F., Visser, T.J., ...

Hypothyroidism and myxedema coma [ch 105] (2006)

Wiersinga, W.M.

Onzekerheden over het nut van behandeling van subklinische schildklierfunctiestoornissen (2006)

Wiersinga, W.M.

A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease (2006)

Taylor, J.C., Gough, S.C., Hunt, P.J., Brix, T.H., Chatterjee, K., Connell, J.M., ...

Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism (2005)

Wekking, E.M., Appelhof, B.C., Fliers, E., Schene, A.H., Huyser, J, Tijssen, J.G.P., ...

Evaluation of endocrine tests. B: screening for hypercortisolism (2005)

Holleman, F., Endert, E., Prummel, M.F., Vessem-Timmermans, M. Van, Wiersinga, W.M., Fliers, E.

Surgical or medical decompression as a first-line treatment of optic neuropathy in Graves' ophthalmopathy? A randomized controlled trial (2005)

Baldeschi, L., Saeed, P., Mourits, M.P., Prummel, M.F., Wiersinga, W.M.

The removal of the deep lateral wall in orbital decompression: Its contribution to exophthalmos reduction and influence on consecutive diplopia (2005)

Baldeschi, L., MacAndie, K., Hintschich, C.R., Prummel, M.F., Wiersinga, W.M.

Disseminated medullary thyroid carcinoma despite early thyroid surgery in the multiple endocrine neoplasia-2A syndrome (2005)

Santen, H.M. Van, Aronson, D.C., Wiersinga, W.M., ...

Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus (2005)

Alkemade, J.M., Friesema, E.C., Unmehopa, U.A., Fabriek, B.O., Kuiper, G.C., Leonard, J.L., ...

Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus (2005)

Alkemade, J.M., Ummehopa, U.A., Wiersinga, W.M., Swaab, D.F., Fliers, E.

Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary (2005)

Alkemade, J.M., Vuijst, C.L., Ummehopa, U.A., Bakker, O., Vennström, B., Wiersinga, W.M., ...

The philosophy of Graves' ophthalmopathy (2005)

Wiersinga, W.M.

Establishment of reference values for endocrine tests. Part IV: adrenal insufficiency (2005)

Endert, E., Ouwehand, A., Fliers, E., Prummel, M.F., Wiersinga, W.M.

Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism (2005)

Wekking, E.M., Appelhof, B.C., Fliers, E., Schene, A.H., Huyser, J, Tijssen, J.G.P., ...

Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation (2005)

Boelen, A., Kwakkel, J., Alkemade, J.M., Renckens, R., Kaptein, E., Kuiper, G., ...

Thyroid eye disease: current concepts and the EUGOGO perspective (2005)

Krassas, G.E., Wiersinga, W.M.

Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3 '-triiodothyronine therapy (2005)

Appelhof, B.C., Peeters, R.P., Wiersinga, W.M., Visser, Th.J., Wekking, E.M., Huyser, J, ...

The removal of the deep lateral wall in orbital decompression: Its contribution to exophthalmos reduction and influence on consecutive diplopia (2005)

Baldeschi, L., MacAndie, K., Hintschich, C.R., Prummel, M.F., Wiersinga, W.M.

Association of the TSHR gene with Graves' disease: the first disease specific locus (2005)

Dechairo, B.M., Zabaneh, D., Collins, J., Brand, O., Dawson, G.J., Green, A.P., ...

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial (2005)

Appelhof, B.C., Fliers, E., Wekking, E.M., Schene, A.H., Huyser, J, Tijssen, J.G.P., ...

The effect of iodine-containing contrast media on the thyroid (2005)

Wiersinga, W.M.

TSH: is there a need to redefine the Normal range? [ch. 2] (2005)

Wiersinga, W.M.

Childhood Graves' ophthalmopathy: results of a European questionnaire study (2005)

Krassas, G.E., Segni, M., Wiersinga, W.M.

Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus (2005)

Alkemade, J.M., Friesema, E.C., Unmehopa, U.A., Fabriek, B.O., Kuiper, G.C., Leonard, J.L., ...

Surgical or medical decompression as a first-line treatment of optic neuropathy in Graves' ophthalmopathy? A randomized controlled trial (2005)

Baldeschi, L., Saeed, P., Mourits, M.P., Prummel, M.F., Wiersinga, W.M.

Disseminated medullary thyroid carcinoma despite early thyroid surgery in the multiple endocrine neoplasia-2A syndrome (2005)

Santen, H.M. Van, Aronson, D.C., Wiersinga, W.M., ...

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial (2005)

Appelhof, B.C., Fliers, E., Wekking, E.M., Schene, A.H., Huyser, J, Tijssen, J.G.P., ...

Monitoring activity of Graves' Ophthalmology [ch. 21] (2005)

Wiersinga, W.M.

Relationship between thyroid disorders and orbitopathy, including management factors [ch. 20] (2005)

Wiersinga, W.M.

Stress is not associated with thyroid peroxidase autoantibodies in euthyroid women (2005)

Strieder, T.G.A., Prummel, M.F., Tijssen, J.G.P., Brosschot, J.F., Wiersinga, W.M.

Thyroid and adrenal axis in major depression: a controlled study in outpatients (2005)

Brouwer, J.P., Appelhof, B.C., Hoogendijk, W.J.G., Huyser, J, Endert, E., Zuketto, C., ...

Autoimmune endocrine disorders [in Best practice & research Clinical endocrinology & metabolism; editor in chief Holly J.M.P.] (2005)

Wiersinga, W.M.

Thyroid peroxidase autoantibodies in euthyroid subjects (2005)

Prummel, M.F., Wiersinga, W.M.

Nonthyroidal illness [ch. 11D] (2005)

Wiersinga, W.M.

Thyroid hormone receptor expression in the human hypothalamus and anterior pituitary (2005)

Alkemade, J.M., Vuijst, C.L., Ummehopa, U.A., Bakker, O., Vennström, B., Wiersinga, W.M., ...

Functional thyrotropin receptor expression in the pituitary folliculo-stellate cell line TtT/GF (2005)

Brokken, L.J.S., Bakker, O., Wiersinga, W.M., Prummel, M.F.

Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus (2005)

Alkemade, J.M., Ummehopa, U.A., Wiersinga, W.M., Swaab, D.F., Fliers, E.

Serum IL-18 levels are not increased in patients with untreated Graves' ophthalmopathy (2004)

Prummel, M.F., Wiersinga, W.M.

Triiodothyronine addition to paroxetine in the treatment of major depressive disorder (2004)

Appelhof, B.C., Brouwer, J.P., Dyck, R. Van, Fliers, E., Hoogendijk, W.J.G., Huyser, J, ...

A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves' ophthalmopathy (2004)

Prummel, M.F., Terwee, C.B., Gerding, M.N., Baldeschi, L., Mourits, M.P., Blank, L., ...

Yersina Enterocolitica infections and autoimmune thyroid diseases (2004)

Prummel, M.F., Wiersinga, W.M.

Orbital irradiation for Graves' ophthalmopathy: Is it safe? A long-term follow-up study (2004)

Tan, H., Saeed, P., Schlingemann, R.O., Verbraak, F.D., ...

Thyroid associated ophthalmopathy: pediatric and endocrine aspects (2004)

Wiersinga, W.M.

Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line (2004)

Brokken, L.J.S., Leendertse, M., Bakker, O., Wiersinga, W.M., Prummel, M.F.

Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice (2004)

Schlumberger, M., Pacini, F., Wiersinga, W.M., Toft, A., Smit, J.W.A., Franco, F.S., ...

Ultra short-loop feedback control of thyrotropin secretion (2004)

Prummel, M.F., Brokken, L.J.S., Wiersinga, W.M.

Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis. (2004)

Boelen, A., Kwakkel, J., Mentrup, B., Baur, A., Koehrle, J., ...

Diagnosis and management of amiodarone-induced thyrotoxicosis in Europe: results of an international survey among members of the European Thyroid Association (2004)

Bartalena, L., Wiersinga, W.M., Tanda, M.L., Bogazzi, F., Plantanida, E., Lai, A., ...

Hypothyroïdie, hyperthyroïdie (2004)

Wiersinga, W.M.

Hashimoto's disease (2004)

Wiersinga, W.M.

Amiodarone and thyroid (2004)

Wiersinga, W.M.

Thyroid gland, anatomy and physiology (2004)

Wiersinga, W.M.

Diurnal variation in rat liver thyroid hormone receptor (TR)-alpha messenger ribonucleic acid (mRNA) is dependent on the biological clock in the suprachiasmatic nucleus, whereas diurnal variation of TR beta 1 mRNA is modified by food intake (2004)

Zandieh Doulabi, B., Kalsbeek, A., Fliers, E., Bakker, O., Wiersinga, W.M.

Effects of Graves' ophthalmopathy on quality of life (2004)

Wiersinga, W.M., Prummel, M.F., Terwee, C.B.

Orbital irradiation for Graves' ophthalmopathy: Is it safe? A long-term follow-up study (2004)

Tan, H., Saeed, P., Schlingemann, R.O., Verbraak, F.D., ...

Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective (2004)

Schlumberger, M., Berg, G., Cohen, O., Duntas, L., Jamar, F., Jarzab, B., ...

Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy (2004)

Roestenberg, P., Nieuwenhoven, F.A. Van, Wieten, L., Boer, P., Diekman, T., Tiller, A.M., ...

The environment and autoimmune thyroid diseases (2004)

Prummel, M.F., Strieder, T.G.A., Wiersinga, W.M.

A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves' ophthalmopathy (2004)

Prummel, M.F., Terwee, C.B., Gerding, M.N., Baldeschi, L., Mourits, M.P., Blank, L., ...

Subklinische hyperthyreoïdie; start van klinische trial naar het nut van behandeling met radioactief jood [brief] (2004)

Hoogendoorn, E.H., Wiersinga, W.M., Prummel, M.F., Heijer, M. Den, Corstens, F.H.

Thyroid autoimmunity and miscarriage (2004)

Prummel, M.F., Wiersinga, W.M.

Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice (2004)

Boelen, A., Kwakkel, J., Thijssen-Timmer, D.C., Alkemade, J.M., Fliers, E., Wiersinga, W.M.

Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness (2004)

Boelen, A., Kwakkel, J., Platvoet, M.C., Baur, A., Köhrle, J., Wiersinga, W.M.

Graves' ophthalmology: state of the art and perspectives (2004)

Bartalena, L., Wiersinga, W.M., Pinchera, A.

Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus (PVN) of patients with major depression (2003)

Alkemade, A., Unmehopa, U.A., Brouwer, J.P., Hoogendijk, W.J.G., Wiersinga, W.M., Swaab, D.F., ...

Zonal expression of the thyroid hormone receptor a isoforms in rodent liver (2003)

Zandieh Doulabi, B., Dop, E., Schneiders, M.S., Schiphorst, M.P.T., Mansen, A., Vennstrom, B., ...

Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease (2003)

Strieder, T.G.A., Prummel, M.F., Tijssen, J.G.P., Endert, E., Wiersinga, W.M.

The future endocrine patient. Reflections on the future of clinical endocrinology (2003)

Lamberts, S.W.J., Romijn, J.A., Wiersinga, W.M.

Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression [letter] (2003)

Alkemade, A., Ummehopa, U.A., Brouwer, J.P., Hoogendijk, W.J.G., Wiersinga, W.M., Swaab, D.F., ...

Thyrotropin receptor autoantibodies are associated with continued thyrotropin suppression in treated euthyroid Graves' disease patients (2003)

Brokken, L.J.S., Wiersinga, W.M., Prummel, M.F.

Chronic infection with Yersinia enterocolitica in patients with clinical or latent hyperthyroidism [ch. 92] (2003)

Wenzel, B.E., Strieder, T.G.A., Gaspar, E., Wiersinga, W.M.

Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA (2003)

Timmer, D.C., Bakker, O., Wiersinga, W.M.

Een geval van fraude bij farmaceutisch onderzoek in de neurologie (2003)

Hoeksema, H.L., Troost, J., Grobbee, D.E., Wiersinga, W.M., Klasen, E.C.

On assessing responsiveness of health-related quality of life instruments: guidelines for instrument evaluation (2003)

Terwee, C.B., Dekker, F.W., Wiersinga, W.M., Prummel, M.F., Bossuyt, P.M.M.

Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience (2003)

Prummel, M.F., Bakker, A., Wiersinga, W.M., Baldeschi, L., Mourits, M.P., Kendall-Taylor, P., ...

Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease (2003)

Strieder, T.G.A., Wenzel, B.E., Prummel, M.F., Tijssen, J.G.P., Wiersinga, W.M.

Subklinische schildklierfunctiestoornissen (2003)

Corssmit, E.P.M., Wiersinga, W.M.

Screenen van zwangeren op hypothyreoidie: vooralsnog alleen in hoogrisicogroepen (2003)

Fliers, E., Wiersinga, W.M.

De interpretatie van de bepaling van thyreoidstimulerend hormoon (TSH) (2003)

Wiersinga, W.M.

Subklinische hyperthyreoidie: niet per se een schildklieraandoening (2003)

Corssmit, E.P.M., Wiersinga, W.M.

Evaluation of endocrine tests. A: the TRH test in patients with hyperprolactinaemia (2003)

Moli, R. Le, Endert, E., Fliers, E., Prummel, M.F., Wiersinga, W.M.

Establishment of reference values for endocrine tests. III: primary aldosteronism (2003)

Baas, S.J., Endert, E., Fliers, E., Prummel, M.F., Wiersinga, W.M.

Orbital radiotherapy for Graves' ophthalmopathy: Useful or useless? Safe or dangerous? (2003)

Bartelena, L., Marcocci, C., Gorman, C.A., Wiersinga, W.M., Pinchera, A.

Facial disfigurement: is it in the eye of the beholder? A study in patients with Graves' ophthalmopathy (2003)

Terwee, C.B., Dekker, F.W., Bonsel, G.J., Heisterkamp, S.H., Prummel, M.F., Baldeschi, L., ...

Thyroiditis (2003)

Wiersinga, W.M.

TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients (2003)

Bakker, O., Baldeschi, L., Wiersinga, W.M., Prummel, M.F.

Dronerarone acts as a selective inhibitor of 3,5,3 '-triiodothyronine binding to thyroid hormone receptor-alpha(1): In vitro and in vivo evidence (2003)

Beeren, H.C. Van, Jong, W.M.C., Kaptein, E., Visser, T.J., Bakker, O., Wiersinga, W.M.

Myxedema coma (2003)

Fliers, E., Wiersinga, W.M.

Zonal expression of the thyroid hormone alpha isoforms in rodent liver (2003)

Zandieh Doulabi, B., Dop, E., Schneiders, M.S., Schiphorst, M.P., Vennstrom, B., Dijkstra, C.D., ...

Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression [research letter] (2003)

Alkemade, J.M., Ummehopa, U.A., Brouwer, J.P., Hoogendijk, W.J.G., Wiersinga, W.M., Swaab, D.F., ...

Facial disfigurement: is it in the eye of the beholder? A study in patients with Graves' ophthalmopathy (2003)

Terwee, C.B., Dekker, F.W., Bonsel, G.J., Heisterkamp, S.H., Prummel, M.F., Baldeschi, L., ...

Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience (2003)

Prummel, M.F., Bakker, A., Wiersinga, W.M., Baldeschi, L., Mourits, M.P., Kendall-Taylor, P., ...

TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients (2003)

Bakker, O., Baldeschi, L., Wiersinga, W.M., Prummel, M.F.

The future endocrine patient. Reflections on the future of clinical endocrinology (2003)

Lamberts, S.W., Romijn, J.A., Wiersinga, W.M.

In recent years the future position of clinical endocrinology has been extensively discussed by Western European endocrine societies. Clinical endocrinology seems to suffer from being too...

Determining median urinary iodine concentration that indicates adequates iodine intake at population level (2002)

Delange, F., Benoist, B. De, Burgi, H., AMC-werkgroeplid, :, Wiersinga, W.M.

Iodine-induced thyroid disease [ch. 17] (2002)

Wiersinga, W.M., Braverman, L.E.

Etiology of Graves ophthalmology [http://www.hotthyroidology.com] (2002)

Wiersinga, W.M.

Management of non-toxic multinodular goitre [chapter 3.5.2] (2002)

Wiersinga, W.M.

The thyroid [section 3] (2002)

Wiersinga, W.M.

Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitus type 1 (2002)

Gallas, P.R.J., Stolk, R.P., Bakker, K., Endert, E., Wiersinga, W.M.

The role of octreotide in the management of Graves' ophthalmopathy (2002)

Wiersinga, W.M.

Epidemiology and prevention of Graves' ophthalmopathy (2002)

Wiersinga, W.M., Bartalena, L.

Hart en inwendige ziekte [hoofdstuk 36] (2002)

Wiersinga, W.M.

Management of thyrotoxicosis without hyperthyroidism (2002)

Wiersinga, W.M.

Graves' ophthalmology and dermopathy [chapter 3.3.8] (2002)

Prummel, M.F., Wiersinga, W.M.

Graves'ophthalmology: a rational approach to treatment (2002)

Wiersinga, W.M., Prummel, M.F.

Autoimmune thyroid diseases [ch. 18] (2002)

Prummel, M.F., Wiersinga, W.M.

Smoking and disease severity are independent determinants of serum adhesion molecule levels in Graves' ophthalmopathy (2002)

Gerding, M.N., Prummel, M.F., Wiersinga, W.M.

TR beta 1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation (2002)

Zandieh Doulabi, B., Beeren, H.C. Van, Labruyere, W.T., Lamers, W.H., Fliers, E., ...

Perspective - Part III - Retrobulbar irradiation in Graves orbitopathy: The Dutch experience (2002)

Wiersinga, W.M.

Sneltraject voor Graves' oftalmopathie (2002)

Wiersinga, W.M.

Long-term effects of Graves' ophthalmopathy on health-related quality of life (2002)

Terwee, C.B., Tan, H.S., Dekker, F., Prummel, M.F., Wiersinga, W.M.

TR beta 1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation (2002)

Zandieh Doulabi, B., Beeren, H.C. Van, Labruyere, W.T., Lamers, W.H., Fliers, E., ...

Decreased neuropeptide Y (NPY) expression in the infundibular nucleus of patients with nonthyroidal illness (2001)

Fliers, E., Unmehopa, U., Manniesing, S., Wiersinga, W.M., Swaab, D.F.

Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum (2001)

Kuijpens, J.L., Vader, H.L., Drexhage, H.A., Wiersinga, W.M., Son, M.J. Van, Pop, V.J.M.

Graves'ophthalmopathy through the eyes of the patient: A state of the art on health-related quality of life assessment (2001)

Terwee, C.B., Dekker, F.W., Prummel, M.F., Wiersinga, W.M.

Relation between lean body mass and thyroid volume in competition rowers before and during intensive fysical training (2001)

Wesche, M.F.T., Wiersinga, W.M.

Endocriene ziekten [hfdstk. 16] (2001)

Wiersinga, W.M.

Thyroid hormone replacement therapy (2001)

Wiersinga, W.M.

The hypothalamic-pituitary-thyroid axis in critical illness (2001)

Fliers, E., Alkemade, A., Wiersinga, W.M.

Management of nontoxic goiter [ DOI 10.1036/1096-7133.edl2858] (2001)

Wiersinga, W.M.

Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum (2001)

Kuijpens, J.L., Vader, H.L., Drexhage, H.A., Wiersinga, W.M., Son, M.J. Van, Pop, V.J.

Thyroid cancer in children and adolescents: Consequences in later life (2001)

Wiersinga, W.M.

Suppression of serum TSH by Graves' Ig: Evidence for a functional pituitary TSH receptor (2001)

Brokken, L.J.S., Scheenhart, J.W.C., Wiersinga, W.M., Prummel, M.F.

Functional anatomy, physiology and pathophysiology (2001)

Wiersinga, W.M.

Geen jodiumdeficientie of endemisch struma onder 6-18-jarige schoolkinderen in de regio's Doetinchem en Amsterdam (2001)

Wiersinga, W.M., Podoba, J., Srbecky, M., Vessem, M. Van, Beeren, H.C. Van

Genetic and environmental contributions to pathogenesis (ch. 7) (2001)

Wiersinga, W.M.

A survey of iodine intake and thyroid volume in Dutch schoolchildren: reference values in an iodine-sufficient area and the effect of puberty (2001)

Wiersinga, W.M., Podoba, J., Srbecky, M., Vessem, M. Van, Beeren, H.C. Van

Van gen naar ziekte; receptor voor thyreoidstimulerend hormoon, hyper- en hypothyreoidie (2001)

Wiersinga, W.M.

Editorial: Pathogenesis of Graves' ophthalmopathy - current understanding (2001)

Wiersinga, W.M., Prummel, M.F.

The biological relevance of thyroid hormone receptors in immortalized human umbilical vein endothelial cells (2001)

Diekman, M.J.M., Zandieh Doulabi, B., Fliers, E., Bakker, O., Wiersinga, W.M.

Zwangerschap(swens) bij hyper- en hypothyreoidie (2001)

Corssmit, E.P.M., Wiersinga, W.M., Boer, K., Prummel, M.F.

Tijdige herkenning en behandeling van zwangeren met hyperthyreoidie: het belang voor het kind (2001)

Wiersinga, W.M., Corssmit, E.P.M., Boer, K., Prummel, M.F.

Diagnose und Therapie der subklinischen Hypothyreose (2001)

Wiersinga, W.M.

The usefullness of quantitative orbital magnetic resonance imaging in Graves'ophthalmopathy (2001)

Prummel, M.F., Gerding, M.N., Zonneveld, F.W., Wiersinga, W.M.

Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism (2001)

Diekman, M.J.M., Blom, H.J., Tijssen, J.G.P., Wiersinga, W.M.

Hypothyroidism and myxedema coma [ch.105] (2001)

Wiersinga, W.M.

Decreased neuropeptide Y (NPY) expression in the infundibular nucleus of patients with nonthyroidal illness (2001)

Fliers, E., Unmehopa, U.A., Manniesing, S., Vuijst, C.L., Wiersinga, W.M., Swaab, D.F.

Het lage T3- syndroom bij ernstige ziekte (2001)

Wiersinga, W.M.

Resistance to thyroid hormone (2001)

Bakker, O., Wiersinga, W.M.

Interpretation and validity of changes in scores on the Graves' ophthalmopathy quality of life questionaire (GO-QOL) after different treatments (2001)

Terwee, C.B., Dekker, F.W., Mourits, M.P., Gerding, M.N., Baldeschi, L., Kalmann, R., ...

Endocrine factors related to changes in total peripheral vascular resistance after treatment of thyrotoxic and hypothyroid patients (2001)

Diekman, M.J.M., Harms, M.P.M., Endert, E., Wieling, W., Wiersinga, W.M.

A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter (2001)

Wesche, M.F.T., Lips, P., Smits, N.J., Wiersinga, W.M.

Decreased neuropeptide Y (NPY) expression in the infundibular nucleus of patients with nonthyroidal illness (2001)

Fliers, E., Unmehopa, U.A., Manniesing, S., Vuijst, C.L., Wiersinga, W.M., Swaab, D.F.

Endocrine factors related to changes in total peripheral vascular resistance after treatment of thyrotoxic and hypothyroid patients (2001)

Diekman, M.J.M., Harms, M.P.M., Endert, E., Wieling, W., Wiersinga, W.M.

What is a goiter ? (2000)

Wiersinga, W.M.

Fraud in a pharmaceutical trial: letter (2000)

Hoeksema, H.L., Troost, J., Grobbee, D.E., Wiersinga, W.M., Klasen, E.C.

Oxidised LDL in thyroid disease (2000)

Wiersinga, W.M., Diekman, M.J.M.

Management of the nontoxic multinodular goitre: a European questionnaire study (2000)

Bonnema, S.J., Bennedbaek, F.N., Wiersinga, W.M., Hegedus, L.

Neurologic development of the newborn and young child in relation to maternal thyroid function (2000)

Smit, B.J., Kok, J.H., Vulsma, T., Briet, J.M., Boer, K., Wiersinga, W.M.

Recent developments in Graves' ophthalmopathy (2000)

Prummel, M.F., Wiersinga, W.M., Mourits, M.P., Heufelder, A.E.

Introduction to Graves' ophthalmopathy (2000)

Prummel, M.F., Koornneef, L., Mourits, M.P., Heufelder, A.E., Wiersinga, W.M.

Assessment of disease severity (2000)

Garrity, J.A., Terwee, C.B., Feldon, S.E., Wiersinga, W.M.

Assessment of disease activity of Graves' ophthalmopathy (2000)

Prummel, M.F., Wiersinga, W.M., Mourits, M.P.

Recommendations for the assessment of therapeutic outcome of Graves' ophthalmopathy in clinical trials (2000)

Pinchera, A., Wiersinga, W.M.

Thyroid management in Graves' ophthalmopathy (2000)

Prummel, M.F., Wiersinga, W.M., Marcocci, C., Weetman, A.P.

Immunosuppressive management of Graves' ophthalmopathy (2000)

Marcocci, C., Pinchera, A., Prummel, M.F., Wiersinga, W.M.

Future research in Graves' ophthalmopathy (2000)

Drexhage, H.A., Weetman, A.P., Heufelder, A.E., Feldon, S.E., Koornneef, L., Mourits, M.P., ...

Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy (2000)

Gerding, M.N., Broenink, M., Bakker, O., Wiersinga, W.M., Prummel, M.F.

Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis (2000)

Verberne, H.J., Fliers, E., Prummel, M.F., Stam, J., Brandjes, D.P.M., Wiersinga, W.M.

Nonthyroidal illness (2000)

Wiersinga, W.M.

Both Th1- and Th2-derived cytokines in serum are elevated in Graves' ophthalmopathy (2000)

Gerding, M.N., Prummel, M.F., Wiersinga, W.M.

The rise of a submerged goiter (2000)

Diekman, M.J.M., Tinnemans, J.G.M., Wiersinga, W.M.

Expression of the thyroid-stimulating hormone receptor in the folliculo-stellate cells of the human anterior pituitary (2000)

Prummel, M.F., Brokken, L.J.S., Meduri, G., Mishrahi, M., Bakker, O., Wiersinga, W.M.

Somatostatin receptor scintigraphy in thyroidal diseases (2000)

Krenning, E.P., Herder, W.W. De, Wiersinga, W.M., Kwekkeboom, D.J.

Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor (2000)

Beeren, H.C. Van, Bakker, O., Wiersinga, W.M.

The thyroid and environment (2000)

Peter, F., Wiersinga, W.M., Hostalek, U.

Environmental factors in healthy woman at risk for autoimmune thyroid disease (2000)

Wiersinga, W.M., Prummel, M.F., Strieder, T.G.A.

Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes (2000)

Diekman, M.J.M., Anghelescu, N., Endert, E., Bakker, O., Wiersinga, W.M.

An evidence-based approach to the treatment of Graves' ophthalmopathy (2000)

Wiersinga, W.M., Prummel, M.F.

Lymklierchirurgie bij schildkliercarcinoom [letter] (2000)

Goslings, B.M., Links, T.P., Smit, J.W.A., Wiersinga, W.M.

Assessment of disease activity in Graves'ophthalmology by orbital ultrasonography and clinical parameters (2000)

Gerding, M.N., Prummel, M.F., Wiersinga, W.M.

Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis (2000)

Verberne, H.J., Fliers, E., Prummel, M.F., Stam, J., Brandjes, D.P.M., Wiersinga, W.M.

Neurologic development of the newborn and young child in relation to maternal thyroid function (2000)

Smit, B.J., Kok, J.H., Vulsma, T., Briët, J.M., Boer, K., Wiersinga, W.M.

Adult hypothyroidism [chapter 9] (1999)

Wiersinga, W.M., DeGroot, L.J.

Octreotide-scintigraphy is a disease-activity parameter in Grave's ophthalmology (1999)

Gerding, M.N., Royen, E.A. Van, Koornneef, L., Krenning, E.P., Wiersinga, W.M., ...

Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy (1999)

Pop, V.J., Kuijpens, J.L., Baar, A.L. Van, Verkerk, G., Son, M.M., ...

Interaction between nuclear hormone receptors and coactivators analyzed using a nonradioactive "Pull-down" assay (1999)

Bakker, O., Beeren, H.C. Van, Emrich, T., Wiersinga, W.M.

De bijnier (1999)

Wiersinga, W.M.

Establishment of reference values for endocrine tests II: hyperprolactinemia (1999)

Moli, R. Le, Endert, E., Fliers, E., Mulder, T., Prummel, M.F., Romijn, J.A., ...

Environmental factors in autoimmune thyroid disease (1999)

Wiersinga, W.M.

Test-retest reliability of the GO-QOL: a disease-specific quality of life questionnaire for patients with Graves' ophthalmopathy (1999)

Terwee, C.B., Gerding, M.N., Dekker, F.W., Prummel, M.F., Wiersinga, W.M.

Schildklierhormonen (1999)

Wiersinga, W.M.

Treatment of endocrine ophthalmopathy (1999)

Wiersinga, W.M.

Effects of mutations in the ?1-thyroid hormone receptor on the inhibition of T3 binding by desethylamiodarone (1999)

Beeren, H.C. Van, Bakker, O., Chatterjee, V.K.K., Wiersinga, W.M.

Determinants of longterm outcome of radioiodine therapy of sporadic non-toxic goitre (1999)

Moli, R. Le, Wesche, M.F.T., Wiersinga, W.M.

Physiological and pathophysiological aspects of thyrotropin-releasing hormone (TRH) gene expression in the human hypothalamus (1998)

Fliers, E., Wiersinga, W.M., Swaab, D.F.

Cell-mediated immunity and postpartum thyroid dysfunction: A possibility for the prediction of disease (1998)

Kuijpens, J.L., Haan-Meulman, M. De, Vader, H.L., Pop, V.J.M., Wiersinga, W.M., Drexhage, H.A.

Prediction of postpartum thyroid dysfunction: Can it be improved? (1998)

Kuijpens, J.L., Pop, V.J.M., Vader, H.L., Drexhage, H.A., Wiersinga, W.M.

Radioactief jodium en het ontstaan van oogverschijnselen bij de ziekte van Graves' (1998)

Wiersinga, W.M.

Preventing Graves' ophthalmopathy (1998)

Wiersinga, W.M.

Expression of the alfa1, alfa2, and beta1 T3-receptor mRNAs in the fasted rat measured using competitive PCR (1998)

Bakker, O., Razaki, H., Jong, J. De, Ris-Stalpers, C., Wiersinga, W.M.

A thyrotropin-secreting pituitary adenoma as a cause of thysrotoxic periodic paralysis (1998)

Alings, A.M.W., Fliers, E., Herder, W.W. De, Hofland, L.J., Sluiter, H.E., Links, T.P., ...

Subklinische schildklierfunctiestoornissen (1998)

Wiersinga, W.M., Krenning, E.P.

Thyroid size and thyroid function during pregnancy (1998)

Berghout, A., Wiersinga, W.M.

Physiological and pathophysiological aspects of thyrotropin-releasing hormone gene expression in the human hypothalamus (1998)

Fliers, E., Wiersinga, W.M., Swaab, D.F.

The decrease of liver LDL receptor mRNA during fasting is related to the decrease in serum T3 (1998)

Bakker, O., Wiersinga, W.M.

Ultrasonographic versus scintigraphic measurement of thyroid volume in patients referred for 131-I therapy (1998)

Wesche, M.F.T., Smits, N.J., Wiersinga, W.M.

Therapy of compressive goiter in the elderly (1998)

Wiersinga, W.M.

Establishment of reference values for endocrine tests. I: Cushing's syndrome (1998)

Endert, E., Fliers, E., Prummel, M.F., Romijn, J.A., Wiersinga, W.M.

Towards a rational use of endocrine function tests in the diagnosis of endocrine diseases (1998)

Bossuyt, P.M.M., Wiersinga, W.M.

Prediction of post partum thyroid dysfunction: can it be improved ? (1998)

Kuijpens, J.L., Pop, V.J., Vader, H.L., Drexhage, H.A., Wiersinga, W.M.

Amiodarone decreases gene expression of low-density lipoprotein receptor at both the mRNA and the protein level (1998)

Hudig, F., Bakker, O., Wiersinga, W.M.

Cell-mediated immunity and postpartum thyroid dysfunction: a possibility for the prediction of disease? (1998)

Kuijpens, J.L., Haan-Meulman, M. De, Vader, H.L., Pop, V.J.M., Wiersinga, W.M., Drexhage, H.A.

Development of a disease specific quality of life questionaire for patients with Graves'ophthalmopathy: the GO-QOL (1998)

Terwee, C.B., Gerding, M.N., Dekker, F.W., Prummel, M.F., Wiersinga, W.M.

Current management of thyroid-associated ophthalmology in Europe. Results of an international survey (1998)

Weetman, A.P., Wiersinga, W.M.

Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene (1998)

Bakker, O., Hudig, F., Meijssen, S., Wiersinga, W.M.

Immunomodulatory treatment of Graves' ophthalmopathy (1998)

Prummel, M.F., Wiersinga, W.M.

Thyroid size and thyroid function during pregnancy: an analysis (1998)

Berghout, A., Wiersinga, W.M.

Increased oxidizability of low-density lipoproteins in hypothyroidism (1998)

Diekman, M.J.M., Demacker, P.N.M., Kastelein, J.J.P., Stalenhoef, A.F.H., Wiersinga, W.M.

Lean body mass as a determinant of thyroid size (1998)

Wesche, M.F.T., Wiersinga, W.M., Smits, N.J.

Octreotide scintigrapghy in thyroidal and orbital Graves' disease (1998)

Wiersinga, W.M., Gerding, M.N., Prummel, M.F., Krenning, E.P.

Cushing's syndrome complicated by multiple opportunistic infections (1998)

Bakker, R.C., Gallas, P.R.J., Romijn, J.A., Wiersinga, W.M.

Development of a disease specific quality of life questionaire for patients with Graves'ophthalmopathy: the GO-QOL (1998)

Terwee, C.B., Gerding, M.N., Dekker, F.W., Prummel, M.F., Wiersinga, W.M.

A thyrotropin-secreting pituitary adenoma as a cause of thysrotoxic periodic paralysis (1998)

Alings, A.M.W., Fliers, E., Herder, W.W. De, Hofland, L.J., Sluiter, H.E., Links, T.P., ...

The use of colour slides in the assessment of changes in soft-tissue involvement in Graves' ophthalmopathy (1998)

Gerding, M.N., Prummel, M.F., Kalmann, R., Koornneef, L., Wiersinga, W.M.

Ultrasonographic versus scintigraphic measurement of thyroid volume in patients referred for 131-I therapy (1998)

Wesche, M.F.T., Smits, N.J., Wiersinga, W.M.

Lean body mass as a determinant of thyroid size (1998)

Wesche, M.F.T., Wiersinga, W.M., Smits, N.J.

Laboratoriumdiagnostiek van hyperthyreo?die en hypothyreo?die (1998)

Wiersinga, W.M., Krenning, E.P.

Zwangerschap en schildklierziekten (1998)

Krenning, E.P., Wiersinga, W.M.

Schildkliermodus (1998)

Krenning, E.P., Wiersinga, W.M.

Graves' oftalmopathie (1998)

Wiersinga, W.M., Krenning, E.P.

Thyriotoxicosis (1998)

Wiersinga, W.M., Krenning, E.P.

Schildklierziekten (1998)

Wiersinga, W.M., Krenning, E.P.

Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women (1998)

Diekman, M.J.M., Romijn, J.A., Endert, E., Sauerwein, H.P., Wiersinga, W.M.

Physiological and pathophysiological aspects of thyrotropin-releasing hormone gene expression in the human hypothalamus (1998)

Fliers, E., Wiersinga, W.M., Swaab, D.F.

Increased oxidizability of low-density lipoproteins in hypothyroidism (1998)

Diekman, M.J.M., Demacker, P.N.M., Kastelein, J.J.P., Stalenhoef, A.F.H., Wiersinga, W.M.

Expression of the alfa1, alfa2, and beta1 T3-receptor mRNAs in the fasted rat measured using competitive PCR (1998)

Bakker, O., Razaki, H., Jong, J. De, Ris-Stalpers, C., Wiersinga, W.M.

Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women (1998)

Diekman, M.J.M., Romijn, J.A., Endert, E., Sauerwein, H.P., Wiersinga, W.M.

Towards a rational use of endocrine function tests in the diagnosis of endocrine diseases (1998)

Bossuyt, P.M.M., Wiersinga, W.M.

Decreased hypothalamic thyrotropin-releasing hormone (TRH) gene expression in patients with nonthyroidal illness (1997)

Fliers, E., Guldenaar, S.E.F., Wiersinga, W.M., Swaab, D.F.

Amiodarone and the thyroid (1997)

Wiersinga, W.M.

Subclinical thyroidology (1997)

Wiersinga, W.M.

Graves' ophthalmopathy (1997)

Wiersinga, W.M.

Towards an animal model of amiodarone-induced thyroid dysfunction (1997)

Wiersinga, W.M.

Anti-heat shock protein (hsp)72 antibodies are present in patients with Graves' disease (GD) and in smoking control subjects (1997)

Prummel, M.F., Pareren, Y.K. Van, Bakker, O., Wiersinga, W.M.

Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy (1997)

Mourits, M.P., Prummel, M.F., Wiersinga, W.M., Koornneef, L.

Tri-iodothyronine prevents the amiodarone-induced decrease in the expression of the liver low-density lipoprotein receptor gene (1997)

Hudig, F., Bakker, O., Wiersinga, W.M.

Thyroid volume and urinary iodine in European achoolchildren: standardization of values for assessment of iodine deficiency (1997)

Delange, F., Benker, G., Caron, PH., Eber, O., Ott, W., Peter, F., ...

Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice (1997)

Boelen, A., Platvoet, M.C., Wiersinga, W.M.

Quality of life in patients with Graves' ophthalmopathy is markedly decreased: measurement by the medical outcomes study instrument (1997)

Gerding, M.N., Terwee, C.B., Dekker, F.W., Koornneef, L., Prummel, M.F., Wiersinga, W.M.

Quality of life in patients with Graves' ophthalmopathy is markedly decreased: measurement by the medical outcomes study instrument (1997)

Gerding, M.N., Terwee, C.B., Dekker, F.W., Koornneef, L., Prummel, M.F., Wiersinga, W.M.

Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy (1997)

Mourits, M.P., Prummel, M.F., Wiersinga, W.M., Koornneef, L.

Quality of life in patients with Graves' ophthalmopathy is markedly decreased: measurement by the medical outcomes study instrument (1997)

Gerding, M.N., Terwee, C.B., Dekker, F.W., Koornneef, L., Prummel, M.F., Wiersinga, W.M.

Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness (1997)

Fliers, E., Guldenaar, S.E.F., Wiersinga, W.M., Swaab, D.F.

Thyrotropin-releasing hormone gene expression in the human hypothalamus (1996)

Guldenaar, S.E.F., Veldkamp, B., Bakker, O., Wiersinga, W.M., Swaab, D.F., Fliers, E.

Distribution of thyrotropin-releasing hormone(TRH)-containing cells and fibers in the human hypothalamus (1994)

Fliers, E., Wiersinga, W.M., Visser, T.J., Swaab, D.F.

Antithyroid action of carbocisteine.

Wiersinga, W M

Two cases of amiodarone-induced thyrotoxicosis successfully treated with a short course of antithyroid drugs while amiodarone was continued.

Trip, M D, Düren, D R, Wiersinga, W M

Two patients with amiodarone-induced thyrotoxicosis were treated successfully with potassium perchlorate and carbimazole while treatment with amiodarone was continued. These antithyroid drugs were...

BOOK REVIEWS

Wiersinga, W M, Rose, Geoffrey E, Reeves, Barnaby

Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach.

Mourits, M P, Koornneef, L, Wiersinga, W M, Prummel, M F, Berghout, A

Patients with serious inflammatory Graves' ophthalmopathy should be treated with anti-inflammatory drugs or radiotherapy to prevent complications like fibrosis, while those with non-inflammatory...

Extraocular muscle surgery for Graves' ophthalmopathy: does prior treatment influence surgical outcome?

Mourits, M. P., Koorneef, L., Prummel, M. F., Wiersinga, W. M., ...

We analysed the results of extraocular muscle surgery in 38 patients with stable Graves' ophthalmopathy. Fixed sutures were used in all patients. A useful field of binocular single vision was...

Circulating monocyte migration inhibitory factor in serum of Graves' ophthalmopathy patients: a parameter for disease activity?

Broersma, L, Mourits, M P, Koornneef, L, Wiersinga, W M, Prummel, M P, ...

A factor which inhibits the random migration of monocytes in vitro was found in the serum of nearly half of Graves' ophthalmopathy patients. This factor was found in serum of only 4% of the healthy...

Soluble IL-2 receptor levels in patients with Graves' ophthalmopathy.

Prummel, M F, Wiersinga, W M, Mourits, M P, Koornneef, L

In various autoimmune diseases circulating levels of soluble IL-2 receptor (sIL-2R) seem to be related to disease activity. Because reliable parameters of disease activity in Graves' ophthalmopathy...

Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease

STRIEDER, T G A, WENZEL, B E, PRUMMEL, M F, TIJSSEN, J G P, WIERSINGA, W M

Infections have been implicated in the pathogenesis of a number of autoimmune diseases, and Yersinia enterocolitica (YE) might play a role in the development of autoimmune thyroid disease (AITD)....

Both Th1- and Th2-derived cytokines in serum are elevated in Graves' ophthalmopathy

Gerding, M N, Van Der Meer, JW C, Prummel, M F, Wiersinga, W M

Increased serum cytokine levels have been reported in patients with autoimmune thyroid disease, but less is known about their levels in patients with Graves' ophthalmopathy (GO). It is not known...

Smoking and disease severity are independent determinants of serum adhesion molecule levels in Graves’ ophthalmopathy

GERDING, M N, PRUMMEL, M F, WIERSINGA, W M

Adhesion molecules play a key role in autoimmune disorders, and serum concentrations of soluble adhesion molecules are increased in Graves’ ophthalmopathy (GO). Whether this is due to the strong...

Anti-heat shock protein (hsp)72 antibodies are present in patients with Graves' disease (GD) and in smoking control subjects

PRUMMEL, M F, VAN PAREREN, Y, BARKER, O, WIERSINGA, W M

Hsp72 is expressed in thyroidal tissue and on retroocular fibroblasts from patients with GD. In this study we investigated whether GD patients have hsp72 antibodies, and if they correlate with...

Amiodarone and thyroid hormone metabolism.

Wiersinga, W. M., Trip, M. D.