Scientific Commons: W. Machleidt

The granule exocytosis cytotoxicity pathway is the major molecular mechanism for cytotoxic T lymphocyte (CTL) and natural killer (NK) cytotoxicity, but the question of how these cytotoxic lymphocytes...

Lonomycin-activated calpain triggers apoptosis - A probable role for Bcl-2 family members (2002)

Gil-Parrado,S., Fernandez-Montalvan,A., Assfalg-Machleidt,I., Popp,O., Bestvater,F., Holloschi,A., ...

Ubiquitous calpains (mu- and m-calpain) have been repeatedly implicated in apoptosis, but the underlying mechanism(s) remain(s) to be elucidated. We examined ionomycin-induced cell death in LCLC 103H...

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C- terminal heptapeptide segment of penetratin (2002)

Schaschke,N., Deluca,D., Assfalg-Machleidt,I., Höhneke,C., Sommerhoff,C. P., Machleidt,W.

Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors...

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C- terminal heptapeptide segment of penetratin (2002)

Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Höhneke, C., Sommerhoff, C. P., Machleidt, W.

Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors...

Surface cathepsin B protects cytotoxic lymphocytes from self- destruction after degranulation (2002)

Balaji, K. N., Schaschke, N., Machleidt, W., Catalfamo, M., Henkart, P. A.

The granule exocytosis cytotoxicity pathway is the major molecular mechanism for cytotoxic T lymphocyte (CTL) and natural killer (NK) cytotoxicity, but the question of how these cytotoxic lymphocytes...

Lonomycin-activated calpain triggers apoptosis - A probable role for Bcl-2 family members (2002)

Gil-Parrado, S., Fernandez-Montalvan, A., Assfalg-Machleidt, I., Popp, O., Bestvater, F., Holloschi, A., ...

Ubiquitous calpains (mu- and m-calpain) have been repeatedly implicated in apoptosis, but the underlying mechanism(s) remain(s) to be elucidated. We examined ionomycin-induced cell death in LCLC 103H...

Partial sequence of a chloroform-methanol soluble polypeptide from Neurospora mitochondrial membranes (1976)

Machleidt, W., Michel, Rainer, Neupert, Walter, Wachter, Elmar

Isolation and characterization of a mitochondrially synthesized polypeptide from Neurospora crassa cni-1 mutant (1975)

Michel, Rainer, Liebl, A., Machleidt, W., Otto, J., Neupert, Walter

N,N'-dicyclohexylcarbodiimide binds specifically to a single glutamyl residue of the proteolipid subunit of the mitochondrial adenosinetriphosphatases from Neurospora crassa and Saccharomyces cerevisiae.

Sebald, W, Machleidt, W, Wachter, E

The N,N'-dicyclohexylcarbodiimide-binding proteolipid subunit of the mitochondrial adenosinetriphosphatases (ATP phosphohydrolase, EC 3.6.1.3) of Neurospora crassa and Saccharomyces cerevisiae were...

Subunit 1 of cytochrome oxidase from Neurospora crassa: nucleotide sequence of the coding gene and partial amino acid sequence of the protein.

Burger, G, Scriven, C, Machleidt, W, Werner, S

A partial protein sequence (223 residues) of cytochrome oxidase subunit 1 from Neurospora crassa has been established. The nucleotide sequence of a cloned mitochondrial DNA segment, including the...

Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin.

Barrett, A J, Fritz, H, Grubb, A, Isemura, S, Järvinen, M, Katunuma, N, ...

Amino acid sequence of a cystatin from venom of the African puff adder (Bitis arietans).

Ritonja, A, Evans, H J, Machleidt, W, Barrett, A J

The amino acid sequence of a cystatin from the venom of the African puff adder (Bitis arietans) is reported. It shows the protein to be more closely related to the Type 2 cystatins than the others,...

Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.

Randak, C, Auerswald, E A, Assfalg-Machleidt, I, Reenstra, W W, Machleidt, W

In the presence of ATP, genistein, like the ATP analogue adenosine 5'-[beta,gamma-imido]triphosphate (pp[NH]pA), increases cystic fibrosis transmembrane conductance regulator (CFTR) chloride currents...