Mark A. Perlmutter, John W. Gillespie, Yvonne Gathright, Sergio González, Alfredo Velasco, ...
Frozen tissue specimens are the gold standard for molecular analysis. However, snap freezing presents several challenges regarding collection and storage of tissue, and preservation of histological...
BRIEF COMMUNICATIONS Serum Proteomic Patterns for Detection of Prostate Cancer (2008)
David K, Cloud P. Paweletz, Paul S. Hackett, Ben A, Alfredo Velassco, ...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal...
Baba, Masaya, Furihata, Mutsuo, Hong, Seung-Beom, Tessarollo, Lino, Haines, Diana C., Southon, Eileen, ...
Background Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. BHD encodes...
Mai, Phuong L, Korde, Larissa, Kramer, Joan, Peters, June, Mueller, Christine M, Pfeiffer, Susan, ...
Abstract Background Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder. Familial testicular cancer in the presence of other findings...
Mai, Phuong L, Korde, Larissa, Kramer, Joan, Peters, June, Mueller, Christine M, Pfeiffer, Susan, ...
Abstract Background Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder. Familial testicular cancer in the presence of other findings...
Gene Promoter Methylation in Prostate TumorAssociated Stromal Cells (2006)
Hanson, Jeffrey A., Gillespie, John W., Grover, Amelia, Tangrea, Michael A., Chuaqui, Rodrigo F., Emmert-Buck, Michael R., ...
Background: Gene expression can be silenced through the methylation of specific sites in the promoter region. This mechanism of gene silencing has an important role in the carcinogenesis of prostate...
Vocke, Cathy D., Yang, Youfeng, Pavlovich, Christian P., Schmidt, Laura S., Nickerson, Michael L., Torres-Cabala, Carlos A., ...
The Birt-Hogg-Dubé (BHD) syndrome is an inherited genodermatosis characterized by a predisposition to hamartomatous skin lesions, pulmonary cysts, and renal carcinoma. Seventy-seven renal tumors...
Zeeberg, Barry R, Riss, Joseph, Kane, David W, Bussey, Kimberly J, Uchio, Edward, Linehan, W Marston, ...
Abstract Background When processing microarray data sets, we recently noticed that some gene names were being changed inadvertently to non-gene names. Results A little detective work traced the...
Serum Proteomic Patterns for Detection of Prostate Cancer (2002)
Petricoin, Emanuel F., Ornstein, David K., Paweletz, Cloud P., Ardekani, Ali, Hackett, Paul S., Hitt, Ben A., ...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal...
Radiofrequency Ablation: a Novel Approach for Treatment of Metastatic Pheochromocytoma (2001)
Pacak, Karel, Fojo, Tito, Goldstein, David S., Eisenhofer, Graeme, Walther, McClellan M., Linehan, W. Marston, ...
Sartor, Oliver, Cooper, Michael, Weinberger, Maribeth, Headlee, Donna, Thibault, Alain, Tompkins, Anne, ...
Backgroound The best treatment for patients with “hormone-refractory” metastatic prostate cancer is unclear, particularly in patients for whom suramin and hydrocortisone have failed. Purpose We...
Rosenberg, Steven A., Lotze, Michael T., Yang, James C., Topalian, Suzanne L., Chang, Alfred E., Schwartzentruber, Douglas J., ...
Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in selected patients with advanced...
Metastatic Models and Molecular Genetics of Prostate Cancer (1992)
Linehan, W. Marston, Long, John P., Steeg, Patricia S., Gnarra, James R.
Unexplained Excess Risk of Bladder Cancer in Men (1990)
Hartge, Patricia, Harvey, Elizabeth B., Linehan, W. Marston, Silverman, Debra T., Sullivan, Jerry W., Hoover, Robert N., ...
In nearly all populations studied, the risk of bladder cancer is two to four times as great in men as in Women.We estimated what the gender-specific incidence rates would be in the absence of...
Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, ...
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS...
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, ...
Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the...
Koochekpour, Shahriar, Jeffers, Michael, Wang, Paul H., Gong, Changning, Taylor, Gregory A., Roessler, Lisa M., ...
Loss of function in the von Hippel-Lindau (VHL) tumor suppressor gene occurs in familial and most sporadic renal cell carcinomas (RCCs). VHL has been linked to the regulation of cell cycle cessation...
Vasselli, James R., Shih, Joanna H., Iyengar, Shuba R., Maranchie, Jodi, Riss, Joseph, Worrell, Robert, ...
To identify potential molecular determinants of tumor biology and possible clinical outcomes, global gene-expression patterns were analyzed in the primary tumors of patients with metastatic renal...
Zeeberg, Barry R, Riss, Joseph, Kane, David W, Bussey, Kimberly J, Uchio, Edward, Linehan, W Marston, ...
Schmidt, Laura S., Warren, Michelle B., Nickerson, Michael L., Weirich, Gregor, Matrosova, Vera, Toro, Jorge R., ...
Birt-Hogg-Dubé syndrome (BHD), an inherited autosomal genodermatosis characterized by benign tumors of the hair follicle, has been associated with renal neoplasia, lung cysts, and spontaneous...
Provocative Agents and the Diagnosis of Medullary Carcinoma of the Thyroid Gland
Wells, Samuel A., Baylin, Stephen B., Linehan, W. Marston, Farrell, Ruth E., Cox, Edwin B., Cooper, Cary W.
Twenty-six patients with known or suspected medullary thyroid carcinoma (MTC) and 21 normal control subjects were tested intravenously on four separate days with calcium gluconate (CG), 2 mg...
Medullary Thyroid Carcinoma: Relationship of Method of Diagnosis to Pathologic Staging
Wells, Samuel A., Baylin, Stephen B., Gann, Donald S., Farrell, Ruth E., Dilley, William G., Preissig, Sandra H., ...
Medullary thyroid carcinoma (MTC) develops in virtually all patients affected with multiple endocrine neoplasia type II (MEN II), a disease inherited as an autosomal dominant trait. The thyroid tumor...
Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, ...
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS...
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, ...
Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the...
Koochekpour, Shahriar, Jeffers, Michael, Wang, Paul H., Gong, Changning, Taylor, Gregory A., Roessler, Lisa M., ...
Loss of function in the von Hippel-Lindau (VHL) tumor suppressor gene occurs in familial and most sporadic renal cell carcinomas (RCCs). VHL has been linked to the regulation of cell cycle cessation...
Vasselli, James R., Shih, Joanna H., Iyengar, Shuba R., Maranchie, Jodi, Riss, Joseph, Worrell, Robert, ...
To identify potential molecular determinants of tumor biology and possible clinical outcomes, global gene-expression patterns were analyzed in the primary tumors of patients with metastatic renal...
Zeeberg, Barry R, Riss, Joseph, Kane, David W, Bussey, Kimberly J, Uchio, Edward, Linehan, W Marston, ...
Toro, Jorge R., Nickerson, Michael L., Wei, Ming-Hui, Warren, Michelle B., Glenn, Gladys M., Turner, Maria L., ...
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant disorder characterized by smooth-muscle tumors of the skin and uterus and/or renal cancer. Although the identification...
Schmidt, Laura S., Nickerson, Michael L., Warren, Michelle B., Glenn, Gladys M., Toro, Jorge R., Merino, Maria J., ...
Birt-Hogg-Dubé syndrome (BHD), a genodermatosis characterized by multiple hamartomas of the hair follicle (fibrofolliculoma), predisposes individuals to an increased risk of developing renal...
Schmidt, Laura S., Warren, Michelle B., Nickerson, Michael L., Weirich, Gregor, Matrosova, Vera, Toro, Jorge R., ...
Birt-Hogg-Dubé syndrome (BHD), an inherited autosomal genodermatosis characterized by benign tumors of the hair follicle, has been associated with renal neoplasia, lung cysts, and spontaneous...
Provocative Agents and the Diagnosis of Medullary Carcinoma of the Thyroid Gland
Wells, Samuel A., Baylin, Stephen B., Linehan, W. Marston, Farrell, Ruth E., Cox, Edwin B., Cooper, Cary W.
Twenty-six patients with known or suspected medullary thyroid carcinoma (MTC) and 21 normal control subjects were tested intravenously on four separate days with calcium gluconate (CG), 2 mg...
Medullary Thyroid Carcinoma: Relationship of Method of Diagnosis to Pathologic Staging
Wells, Samuel A., Baylin, Stephen B., Gann, Donald S., Farrell, Ruth E., Dilley, William G., Preissig, Sandra H., ...
Medullary thyroid carcinoma (MTC) develops in virtually all patients affected with multiple endocrine neoplasia type II (MEN II), a disease inherited as an autosomal dominant trait. The thyroid tumor...
Mai, Phuong L, Korde, Larissa, Kramer, Joan, Peters, June, Mueller, Christine M, Pfeiffer, Susan, ...
Baba, Masaya, Hong, Seung-Beom, Sharma, Nirmala, Warren, Michelle B., Nickerson, Michael L., Iwamatsu, Akihiro, ...
Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which...
Lubensky, Irina A., Pack, Svetlana, Ault, David, Vortmeyer, Alexander O., Libutti, Steven K., Choyke, Peter L., ...
Although pancreatic neuroendocrine tumors (NETs) in von Hippel-Lindau (VHL) disease have been reported, their pathological features have not been characterized. In addition, it is unknown whether...
Molecular Profiling of Clinical Tissue Specimens : Feasibility and Applications
Emmert-Buck, Michael R., Strausberg, Robert L., Krizman, David B., Bonaldo, M. Fatima, Bonner, Robert F., Bostwick, David G., ...
Lubensky, Irina A., Schmidt, Laura, Zhuang, Zhengping, Weirich, Gregor, Pack, Svetlana, Zambrano, Norman, ...
Germline mutations of c-met oncogene at 7q31 have been detected in patients with hereditary papillary renal cell carcinoma. In addition, c-met mutations were shown to play a role in 13% of patients...
Mohr, Victoria H., Vortmeyer, Alexander O., Zhuang, Zhengping, Libutti, Steven K., Walther, McClellan M., Choyke, Peter L., ...
Microcystic adenoma and cysts of the pancreas occur sporadically or as a part of von Hippel-Lindau (VHL) disease. The pathology of pancreatic cystic disease in VHL patients has not been well...
Evaluation of Non-Formalin Tissue Fixation for Molecular Profiling Studies
Gillespie, John W., Best, Carolyn J.M., Bichsel, Verena E., Cole, Kristina A., Greenhut, Susan F., Hewitt, Stephen M., ...
Using a general strategy for evaluating clinical tissue specimens, we found that 70% ethanol fixation and paraffin embedding is a useful method for molecular profiling studies. Human prostate and...
Perlmutter, Mark A., Best, Carolyn J.M., Gillespie, John W., Gathright, Yvonne, González, Sergio, Velasco, Alfredo, ...
Frozen tissue specimens are the gold standard for molecular analysis. However, snap freezing presents several challenges regarding collection and storage of tissue, and preservation of histological...
Molecular Profiling of Clinical Tissue Specimens: Feasibility and Applications
Emmert-Buck, Michael R., Strausberg, Robert L., Krizman, David B., Bonaldo, M. Fatima, Bonner, Robert F., Bostwick, David G., ...
Toro, Jorge R., Pautler, Stephen E., Stewart, Laveta, Glenn, Gladys M., Weinreich, Michael, Toure, Ousmane, ...
Rationale: Birt-Hogg-Dubé syndrome (BHDS) is an autosomal, dominantly inherited genodermatosis that predisposes to fibrofolliculomas, kidney neoplasms, lung cysts, and spontaneous pneumothorax.
Shen, H.-C. Jennifer, Adem, Asha, Ylaya, Kris, Wilson, Arianne, He, Mei, Lorang, Dominique, ...
The von Hippel-Lindau (VHL) syndrome is a pleomorphic familial disease characterized by the development of highly vascularized tumors, such as hemangioblastomas of the central nervous system,...
Eisenhofer, Graeme, Huynh, Thanh-Truc, Elkahloun, Abdel, Morris, John C., Bratslavsky, Gennady, Linehan, W. Marston, ...
Pheochromocytomas in patients with von Hippel-Lindau (VHL) syndrome and multiple endocrine neoplasia type 2 (MEN 2) differ in the types and amounts of catecholamines produced and the resulting signs...
Hasumi, Yukiko, Baba, Masaya, Ajima, Rieko, Hasumi, Hisashi, Valera, Vladimir A., Klein, Mara E., ...
Germline mutations in the BHD/FLCN tumor suppressor gene predispose patients to develop renal tumors in the hamartoma syndrome, Birt-Hogg-Dubé (BHD). BHD encodes folliculin, a protein with unknown...