Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...
Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...
Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy (2004)
Murphy, R.T., Mogensen, J., Shaw, A., Kubo, T., McKenna, W., Hughes, S.
Idiopathic dilated cardiomyopathy is a common cause of heart failure. Half of cases are believed to be hereditary, and mutations in cardiac sarcomeric contractile protein genes have been reported...
Cardiological assessment of first-degree relatives in sudden arrhythmic death syndrome (2003)
Wood, D.A., Wright, M., Syrris, P., Sheppard, M.N., Casey, A., Davies, M.J., ...
4·1% of sudden cardiac deaths in the 16–64 age-group are unexplained. In this group, cardiac pathological findings are normal and toxicological tests are negative; termed sudden arrythmic death...
Mutation of the myosin converter domain alters cross-bridge elasticity (2002)
Köhler, J., Winkler, G., Schulte, I., Scholz, T., McKenna, W., Brenner, B., ...
Elastic distortion of a structural element of the actomyosin complex is fundamental to the ability of myosin to generate motile forces. An elastic element allows strain to develop within the...
Cazeau, S., Leclercq, C., Lavergne, T., Walker, S., Varma, C., Linde, C., ...
Background: One third of patients with chronic heart failure have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic dysfunction...
Kappenberger, L.J., Linde, C., Jeanrenaud, X., Daubert, C., McKenna, W., Meisel, E., ...
Background The therapeutic options for hypertrophic obstructive cardiomyopathy (HOCM) classically include medical treatment with beta-blockers and calcium antag-onists or myectomy–myotomy as a...
Gadler, F., Linde, C., Daubert, C., McKenna, W., Meisel, E., Aliot, E., ...
Aims Atrioventricular synchronous pacing exerts beneficial effects, including reduction of left ventricular outflow tract gradients, in patients with hypertrophic obstructive cardiomyopathy. The...
An In Situ Infrared Study of the Oxidation of SO(2) on Platinum Electrodes. (1998)
Koreniewski, C., McKenna, W., Pons, S.
The oxidation of sulfur dioxide on metal electrodes is of interest for its application in a variety of industrial processes, particularly in operations involving degradation of automobile emissions,...
Blackwood, D., Korzeniewski, C., McKenna, W., Li, J., Pons, S
Infrared spectroscopy, and in particular the method of subtractively normalized interfacial Fourier transform infrared spectroscopy (SNIFTIRS), has been used extensively to examine interactions of...
Pacing in hypertrophic obstructive cardiomyopathy: A randomized crossover study (1997)
Kappenberger, L., Linde, C., Daubert, C., McKenna, W., Meisel, E., Sadoul, N., ...
Background Uncontrolled studies have shown that short atrioventricular delay dual chamber pacing reduces outflow tract obstruction in hypertrophic obstructive cardiomyopathy. Although the exact...
'A few simple words' of interior monologue in Ulysses: reconfiguring the evidence (1996)
A study of interior monologue in James Joyce's Ulysses that discriminates between the language of Stephen Dedalus, Molly Bloom, and Leopold Bloom by the use of literary and computational methods...
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
Thierfelder, L, MacRae, C, Watkins, H, Tomfohrde, J, Williams, M, McKenna, W, ...
We report that a gene responsible for familial hypertrophic cardiomyopathy (FHC) in a kindred with a mild degree of cardiac hypertrophy maps to chromosome 15q2. The gene encoding cardiac actin,...
Cohen, M S, Chai, Y, Britigan, B E, McKenna, W, Adams, J, Svendsen, T, ...
The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which...
Dyer, D W, West, E P, McKenna, W, Thompson, S A, Sparling, P F
We isolated an iron-uptake mutant of Neisseria meningitidis M986-NCV-1 that was severely limited in the ability to use several sources of iron in the form of Fe3+. This mutant, FAM11, grew poorly or...
Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.
Solomon, S D, Jarcho, J A, McKenna, W, Geisterfer-Lowrance, A, Germain, R, Salerni, R, ...
We demonstrate that familial hypertrophic cardiomyopathy (FHC), an autosomal dominant disorder of heart muscle, is a genetically heterogeneous disease. The locus responsible for FHC in members of one...
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Watkins, H, Thierfelder, L, Hwang, D S, McKenna, W, Seidman, J G, Seidman, C E
Hypertrophic cardiomyopathy occurs as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the beta cardiac myosin heavy chain...
Watkins, H, Thierfelder, L, Anan, R, Jarcho, J, Matsumori, A, McKenna, W, ...
The origins of the beta cardiac myosin heavy-chain (MHC) gene missense mutations that cause familial hypertrophic cardiomyopathy (FHC) in 14 families have been evaluated. Of eight different...
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
Thierfelder, L, MacRae, C, Watkins, H, Tomfohrde, J, Williams, M, McKenna, W, ...
We report that a gene responsible for familial hypertrophic cardiomyopathy (FHC) in a kindred with a mild degree of cardiac hypertrophy maps to chromosome 15q2. The gene encoding cardiac actin,...
Cohen, M S, Chai, Y, Britigan, B E, McKenna, W, Adams, J, Svendsen, T, ...
The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which...
Dyer, D W, West, E P, McKenna, W, Thompson, S A, Sparling, P F
We isolated an iron-uptake mutant of Neisseria meningitidis M986-NCV-1 that was severely limited in the ability to use several sources of iron in the form of Fe3+. This mutant, FAM11, grew poorly or...
Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.
Solomon, S D, Jarcho, J A, McKenna, W, Geisterfer-Lowrance, A, Germain, R, Salerni, R, ...
We demonstrate that familial hypertrophic cardiomyopathy (FHC), an autosomal dominant disorder of heart muscle, is a genetically heterogeneous disease. The locus responsible for FHC in members of one...
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Watkins, H, Thierfelder, L, Hwang, D S, McKenna, W, Seidman, J G, Seidman, C E
Hypertrophic cardiomyopathy occurs as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the beta cardiac myosin heavy chain...
Watkins, H, Thierfelder, L, Anan, R, Jarcho, J, Matsumori, A, McKenna, W, ...
The origins of the beta cardiac myosin heavy-chain (MHC) gene missense mutations that cause familial hypertrophic cardiomyopathy (FHC) in 14 families have been evaluated. Of eight different...
Amiodarone and thyroid autoimmunity in the United Kingdom.
Weetman, A. P., Bhandal, S. K., Burrin, J. M., Robinson, K., McKenna, W.
Syncope in hypertrophic cardiomyopathy.
McKenna, W, Harris, L, Deanfield, J
A patient with hypertrophic cardiomyopathy, syncope, and frequent ventricular tachycardia was monitored during a syncopal episode. An unrecordable blood pressure and the loss of a left ventricular...
Gaer, J A, Gordon, L, Wharton, J, Polak, J M, Taylor, K M, McKenna, W, ...
A novel method of cardiac denervation by cryoablation has been developed experimentally. The technique uses liquid nitrogen delivered under pressure to ablate the principal sources of cardiac...
Echocardiographic measurement of the normal adult right ventricle.
Foale, R, Nihoyannopoulos, P, McKenna, W, Kleinebenne, A, Nadazdin, A, Rowland, E, ...
In studies of the right ventricle the complexities of chamber shape may be overcome by use of multiple tomographic imaging planes. An established protocol for the echocardiographic description of the...
Cardiac autoimmunity in HIV related heart muscle disease
Currie, P, Goldman, J, Caforio, A, Jacob, A, Baig, M, Brettle, R, ...
Objective—To assess the frequency of circulating cardiac specific autoantibodies in HIV positive patients with and without echocardiographic evidence of left ventricular...
Cardiopulmonary responses to exercise in patients with hypertrophic cardiomyopathy
Jones, S, Elliott, P, Sharma, S, McKenna, W, Whipp, B
Objective—To examine the submaximal and maximal indices of the exercise response of patients with hypertrophic cardiomyopathy. Design and setting—Prospective examination of cardiopulmonary...
Diagnostic utility of metabolic exercise testing in a patient with cardiovascular disease
Elliott, P, Hanna, M, Ward, S, Chinnery, P, Turnbull, D, Wood, N, ...
Disproportionate exercise limitation in patients with cardiovascular disease is a common problem faced by clinical cardiologists and other physicians. Symptoms may be attributed to psychological...
Elliott, P, Brecker, S, McKenna, W
Percutaneous alcohol ablation of the interventricular septum via the first septal perforator branch of the left anterior descending artery can successfully treat dynamic left ventricular outflow...
Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease
Varnava, A, Elliott, P, Sharma, S, McKenna, W, Davies, M
OBJECTIVE—To make a quantitative assessment of the relation between disarray, fibrosis, and small vessel disease in hypertrophic cardiomyopathy. DESIGN—Detailed macroscopic and histological...
Absence of viral nucleic acids in early and late dilated cardiomyopathy
Mahon, N, Zal, B, Arno, G, Risley, P, Pinto-Basto, J, McKenna, W, ...
OBJECTIVE—To investigate whether viral infection acts as a trigger factor for the development of dilated cardiomyopathy in genetically predisposed individuals with a family history of...
Varnava, A, Baboonian, C, Davison, F, De Cruz, L, Elliott, P, Davies, M, ...
AIM—To screen for a mutation of the cardiac troponin T gene in two families where there had been sudden deaths without an increase in left ventricular mass but with myocardial disarray suggesting...
Mahon, N, Sharma, S, Elliott, P, Baig, M, Norman, M, Barbeyto, S, ...
BACKGROUND—Left ventricular enlargement with normal systolic function is common in asymptomatic relatives of patients with familial dilated cardiomyopathy, many of whom progress to overt dilated...
Health related quality of life and psychological wellbeing in patients with dilated cardiomyopathy
Steptoe, A, Mohabir, A, Mahon, N, McKenna, W
OBJECTIVE—To assess the health related quality of life and psychological wellbeing of patients with dilated cardiomyopathy, and relate these to clinical variables and psychological...
Echocardiographic pitfalls in the diagnosis of hypertrophic cardiomyopathy
Prasad, K., Atherton, J., Smith, G., McKenna, W., Frenneaux, M., Nihoyannopoulos, P.
Effect of multisite pacing on ventricular coordination
Varma, C, O'Callaghan, P, Mahon, N G, Hnatkova, K, McKenna, W, Camm, A J, ...
Objective: To determine the effect of multisite pacing on left ventricular function.
Exercise induced neurally mediated syncope in an elite rower: a treatment dilemma
Whyte, G, Stephens, N, Budgett, R, Sharma, S, Shave, R, McKenna, W
Spontaneous atrial fibrillation in a freestyle skier
Whyte, G, Stephens, N, Sharma, S, Shave, R, Budgett, R, McKenna, W