Megran, D W, Lefebvre, K, Willetts, V, Bowie, W R
In this randomized study, a single 800-mg oral dose of cefixime cured 96 of 97 men with uncomplicated gonococcal urethritis, compared with 44 cures of 46 men who received standard therapy with...
Bowie, W R, Willetts, V, Megran, D W
Men and women with suspected or proven genital infections caused by Chlamydia trachomatis were enrolled in a double-blind study to evaluate the efficacy and tolerability of fleroxacin. Patients...
Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin.
Bowie, W R, Willetts, V, Jewesson, P J
New fluoroquinolones have generally been well tolerated. In a double-blind evaluation of oral fleroxacin, using 400, 600, or 800 mg once daily for 7 days in an ambulatory setting for treatment of...
Bowie, W R, Shaw, C E, Chan, D G, Black, W A
In vitro Ro 15-8074 and Ro 19-5247 (T2525), two new oral cephalosporins, were active against 410 penicillin-susceptible and -resistant isolates of Neisseria gonorrhoeae. Two new macrolides, A-56268...
Bowie, W R, Shaw, C E, Chan, D G, Boyd, J, Black, W A
Management of sexually transmitted diseases is facilitated by having antimicrobial agents with activity against all of the major genital pathogens. Newer quinolones show promise of being active...
Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis.
Bowie, W R, Willetts, V, Sibau, L
Norfloxacin has some activity in vitro against Chlamydia trachomatis and Ureaplasma urealyticum, although not at levels attainable in serum. In this study, norfloxacin was administered (400 mg orally...
In vitro activity of clavulanic acid, amoxicillin, and ticarcillin against Chlamydia trachomatis.
In vitro, growth of Chlamydia trachomatis was not entirely eliminated by 960 micrograms of ticarcillin per ml, 64 micrograms of amoxicillin per ml, 32 micrograms of clavulanic acid per ml, a...
Newer penicillins and cephalosporins are being evaluated in many infections. One of these infections, acute pelvic inflammatory disease, can be caused by Chlamydia trachomatis. This study...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Comparison of an in vitro method and an in vivo method of Giardia excystation.
Isaac-Renton, J L, Shahriari, H, Bowie, W R
An in vitro method and an in vivo method of excystation were compared to determine the most useful method for the retrieval of Giardia duodenalis isolates. Cysts from 11 Giardia strains were used. In...
Immunogenic proteins of Trichomonas vaginalis as demonstrated by the immunoblot technique.
Garber, G E, Proctor, E M, Bowie, W R
Fifteen clinical isolates of Trichomonas vaginalis were evaluated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis with transfer to nitrocellulose and by immunoblots probed with human...
Complement activation and stimulation of chemotaxis by Chlamydia trachomatis.
Megran, D W, Stiver, H G, Bowie, W R
The stimulus for the migration of polymorphonuclear leukocytes (PMNs) in acute chlamydial infection was studied in vitro by examining the chemotaxigenic effect of L2 and DE Chlamydia trachomatis...
Isolation of a cell-detaching factor of Trichomonas vaginalis.
Garber, G E, Lemchuk-Favel, L T, Bowie, W R
The pathogenetic role of soluble products of Trichomonas vaginalis growth in culture is controversial. To evaluate this role, T. vaginalis was grown in broth and cell culture and the cell-free...
Cell culture compared with broth for detection of Trichomonas vaginalis.
Garber, G E, Sibau, L, Ma, R, Proctor, E M, Shaw, C E, Bowie, W R
Trichomonas vaginalis can be grown in cell culture. We studied the growth kinetics of T. vaginalis in McCoy cell culture compared with that in a conventional broth medium (Diamond TYI-S-33 medium...
Bacteriology of the urethra in normal men and men with nongonococcal urethritis.
Bowie, W R, Pollock, H M, Forsyth, P S, Floyd, J F, Alexander, E R, Wang, S P, ...
Sixty-nine Caucasian males without a previous history of urethritis and who developed nongonococcal urethritis (NGU) and 39 similar men without urethritis (NU) were cultured from the urethra for...
Lee, C K, Bowie, W R, Alexander, E R
The antimicrobial susceptibility of a low-laboratory-passage, slow-growing, genital Chlamydia trachomatis strain was studied by five different procedures with the use of McCoy cells pretreated with...
In Vitro Activity of Rosaramicin Against Chlamydia trachomatis
In vitro, rosaramicin was highly active against Chlamydia trachomatis when added to the culture system 1 or 48 h after inoculation with the chlamydia.
Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.
Bowie, W R, Wang, S P, Alexander, E R, Floyd, J, Forsyth, P S, Pollock, H M, ...
Chlamydia trachomatis, Ureaplasma urealyticum (T-mycoplasma), and Hemophilus vaginalis have previously been considered possible etiological agents in nongonococcal urethritis (NGU). In this study,...
Implications of the Canada youth and AIDS study for health care providers.
Bowie, W R, Warren, W K, Fisher, W A, MacDonald, N E, Doherty, J A, Wells, G A
McDougall, L, Mathias, R G, O'Connor, B A, Bowie, W R
OBJECTIVE: To determine the knowledge of primary care physicians about Chlamydia trachomatis genital infection and its management. DESIGN: Self-administered questionnaire comprising direct questions...
In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84.
Bowie, W R, Shaw, C E, Chan, D G, Jones, H D, Black, W A
Consecutive isolates of Neisseria gonorrhoeae obtained at a sexually transmitted disease clinic in Vancouver between June 1982 and June 1984 were tested for in-vitro susceptibility to eight...
Megran, D W, Lefebvre, K, Willetts, V, Bowie, W R
In this randomized study, a single 800-mg oral dose of cefixime cured 96 of 97 men with uncomplicated gonococcal urethritis, compared with 44 cures of 46 men who received standard therapy with...
Bowie, W R, Willetts, V, Megran, D W
Men and women with suspected or proven genital infections caused by Chlamydia trachomatis were enrolled in a double-blind study to evaluate the efficacy and tolerability of fleroxacin. Patients...
Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin.
Bowie, W R, Willetts, V, Jewesson, P J
New fluoroquinolones have generally been well tolerated. In a double-blind evaluation of oral fleroxacin, using 400, 600, or 800 mg once daily for 7 days in an ambulatory setting for treatment of...
Bowie, W R, Shaw, C E, Chan, D G, Black, W A
In vitro Ro 15-8074 and Ro 19-5247 (T2525), two new oral cephalosporins, were active against 410 penicillin-susceptible and -resistant isolates of Neisseria gonorrhoeae. Two new macrolides, A-56268...
Bowie, W R, Shaw, C E, Chan, D G, Boyd, J, Black, W A
Management of sexually transmitted diseases is facilitated by having antimicrobial agents with activity against all of the major genital pathogens. Newer quinolones show promise of being active...
Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis.
Bowie, W R, Willetts, V, Sibau, L
Norfloxacin has some activity in vitro against Chlamydia trachomatis and Ureaplasma urealyticum, although not at levels attainable in serum. In this study, norfloxacin was administered (400 mg orally...
In vitro activity of clavulanic acid, amoxicillin, and ticarcillin against Chlamydia trachomatis.
In vitro, growth of Chlamydia trachomatis was not entirely eliminated by 960 micrograms of ticarcillin per ml, 64 micrograms of amoxicillin per ml, 32 micrograms of clavulanic acid per ml, a...
Newer penicillins and cephalosporins are being evaluated in many infections. One of these infections, acute pelvic inflammatory disease, can be caused by Chlamydia trachomatis. This study...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Comparison of an in vitro method and an in vivo method of Giardia excystation.
Isaac-Renton, J L, Shahriari, H, Bowie, W R
An in vitro method and an in vivo method of excystation were compared to determine the most useful method for the retrieval of Giardia duodenalis isolates. Cysts from 11 Giardia strains were used. In...
Immunogenic proteins of Trichomonas vaginalis as demonstrated by the immunoblot technique.
Garber, G E, Proctor, E M, Bowie, W R
Fifteen clinical isolates of Trichomonas vaginalis were evaluated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis with transfer to nitrocellulose and by immunoblots probed with human...
Complement activation and stimulation of chemotaxis by Chlamydia trachomatis.
Megran, D W, Stiver, H G, Bowie, W R
The stimulus for the migration of polymorphonuclear leukocytes (PMNs) in acute chlamydial infection was studied in vitro by examining the chemotaxigenic effect of L2 and DE Chlamydia trachomatis...
Isolation of a cell-detaching factor of Trichomonas vaginalis.
Garber, G E, Lemchuk-Favel, L T, Bowie, W R
The pathogenetic role of soluble products of Trichomonas vaginalis growth in culture is controversial. To evaluate this role, T. vaginalis was grown in broth and cell culture and the cell-free...
Cell culture compared with broth for detection of Trichomonas vaginalis.
Garber, G E, Sibau, L, Ma, R, Proctor, E M, Shaw, C E, Bowie, W R
Trichomonas vaginalis can be grown in cell culture. We studied the growth kinetics of T. vaginalis in McCoy cell culture compared with that in a conventional broth medium (Diamond TYI-S-33 medium...
Bacteriology of the urethra in normal men and men with nongonococcal urethritis.
Bowie, W R, Pollock, H M, Forsyth, P S, Floyd, J F, Alexander, E R, Wang, S P, ...
Sixty-nine Caucasian males without a previous history of urethritis and who developed nongonococcal urethritis (NGU) and 39 similar men without urethritis (NU) were cultured from the urethra for...
Lee, C K, Bowie, W R, Alexander, E R
The antimicrobial susceptibility of a low-laboratory-passage, slow-growing, genital Chlamydia trachomatis strain was studied by five different procedures with the use of McCoy cells pretreated with...
In Vitro Activity of Rosaramicin Against Chlamydia trachomatis
In vitro, rosaramicin was highly active against Chlamydia trachomatis when added to the culture system 1 or 48 h after inoculation with the chlamydia.
Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.
Bowie, W R, Wang, S P, Alexander, E R, Floyd, J, Forsyth, P S, Pollock, H M, ...
Chlamydia trachomatis, Ureaplasma urealyticum (T-mycoplasma), and Hemophilus vaginalis have previously been considered possible etiological agents in nongonococcal urethritis (NGU). In this study,...
Implications of the Canada youth and AIDS study for health care providers.
Bowie, W R, Warren, W K, Fisher, W A, MacDonald, N E, Doherty, J A, Wells, G A
McDougall, L, Mathias, R G, O'Connor, B A, Bowie, W R
OBJECTIVE: To determine the knowledge of primary care physicians about Chlamydia trachomatis genital infection and its management. DESIGN: Self-administered questionnaire comprising direct questions...
In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84.
Bowie, W R, Shaw, C E, Chan, D G, Jones, H D, Black, W A
Consecutive isolates of Neisseria gonorrhoeae obtained at a sexually transmitted disease clinic in Vancouver between June 1982 and June 1984 were tested for in-vitro susceptibility to eight...
Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in two different populations of women.
Bowie, W. R., Borrie-Hume, C. J., Manzon, L. M., Fawcett, A., Percival-Smith, R. K., Jones, H. D.
Bowie, W R, Digiacomo, R F, Holmes, K K, Gale, J L
Inoculation of the urethra, conjunctiva, pharynx, and anal canal of six male crab-eating macaques (Macaca fascicularis) with urethral exudate from male patients with urethral gonorrhoea or with...
Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days.
Bowie, W R, Yu, J S, Fawcett, A, Jones, H D
In a previous study treatment with minocycline 100 mg orally every day for seven days was as effective for nongonococcal urethritis (NGU) as 200 mg for seven days or 100 or 200 mg for 21 days. In...