Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats
Jones, R B, Dickinson, K, Anthony, D M, Marita, A R, Kaul, C L, Buckett, W R
The effect of BTS 67 582, a novel antidiabetic agent, has been evaluated on plasma glucose and plasma insulin in normal and streptozotocin-induced diabetic rats.BTS 67 582 (3 to 300 mg kg−1,...
Heal, D J, Cheetham, S C, Prow, M R, Martin, K F, Buckett, W R
Effects on 5-HT function of sibutramine and its active metabolites, BTS 54 354 and BTS 54 505, were compared with fluoxetine, (+)-fenfluramine and (+)-amphetamine.In vitro sibutramine weakly...
1. The aminosteroid Org. NA13 (3alpha-dimethylamino-5alpha-androstan-2beta-ol-17-one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea-pigs. 2. Experimental...
The xanthene-spiropiperidines: a new group of centrally-active drugs [proceedings]
Buckett, W R, Crossland, N J, Galt, R H, Matusiak, Z, Pearce, R J, Shaw, J S, ...
Heal, D. J., Prow, M. R., Buckett, W. R.
1. A novel method for measurement of 3-methoxy-4-hydroxyphenylglycol (MHPG) in mouse brain by use of high performance liquid chromatography (h.p.l.c.) with electrochemical detection is described....
Heal, D. J., Bristow, L. M., Hurst, E. M., Elliott, J. M., Buckett, W. R.
1. Clonidine induces hypoactivity in rodents. Male rats were found to be markedly more susceptible to the sedative effects of this alpha 2-adrenoceptor agonist than females. Thus to obtain identical...
Heal, D. J., Prow, M. R., Buckett, W. R.
1. Experiments were conducted to determine the respective roles which noradrenergic and 5-hydroxytryptaminergic neurones play in the down-regulation of postsynaptic alpha 2-adrenoceptors by...