Lee, W R, Syu, W J, Du, B, Matsuda, M, Tan, S, Wolf, A, ...
More than 20 consensus N-linked glycosylation sites occur in the gp120 coding sequence of most isolates of human immunodeficiency virus type 1. Based on the N-linked glycosylation pattern of a...
Chen, S S, Lee, C N, Lee, W R, McIntosh, K, Lee, T H
The N-terminal region of the envelope (env) transmembrane protein of human immunodeficiency virus type 1 (HIV-1) has a leucine zipper-like motif. This highly conserved zipper motif, which consists of...
Lee, W R, Yu, X F, Syu, W J, Essex, M, Lee, T H
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical...
Syu, W J, Lee, W R, Du, B, Yu, Q C, Essex, M, Lee, T H
All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein....
Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.
Chenevert, S W, Fossett, N G, Chang, S H, Tsigelny, I, Baker, M E, Lee, W R
We have determined the nucleotide sequences of eight ethyl methanesulphonate-induced mutants in Drosophila alcohol dehydrogenase (ADH), of which six were previously characterized by Hollocher and...
Lee, W R, Syu, W J, Du, B, Matsuda, M, Tan, S, Wolf, A, ...
More than 20 consensus N-linked glycosylation sites occur in the gp120 coding sequence of most isolates of human immunodeficiency virus type 1. Based on the N-linked glycosylation pattern of a...
Chen, S S, Lee, C N, Lee, W R, McIntosh, K, Lee, T H
The N-terminal region of the envelope (env) transmembrane protein of human immunodeficiency virus type 1 (HIV-1) has a leucine zipper-like motif. This highly conserved zipper motif, which consists of...
Lee, W R, Yu, X F, Syu, W J, Essex, M, Lee, T H
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical...
Syu, W J, Lee, W R, Du, B, Yu, Q C, Essex, M, Lee, T H
All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein....
Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.
Chenevert, S W, Fossett, N G, Chang, S H, Tsigelny, I, Baker, M E, Lee, W R
We have determined the nucleotide sequences of eight ethyl methanesulphonate-induced mutants in Drosophila alcohol dehydrogenase (ADH), of which six were previously characterized by Hollocher and...
Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium.
Ko, M K, Lee, W R, McKechnie, N M, Hall-Parker, B
Light microscopy (including fluorescence microscopy) and electron microscopy were applied to a study of the photoreceptor-retinal pigment epithelium (RPE) complex in a human eye which had been...
Bilateral Kimura's disease of the eyelids.
Kennedy, S. M., Pitts, J. F., Lee, W. R., Gibbons, D. C.
A case of Kimura's disease affecting the eyelids bilaterally is reported in a 5-year-old boy of Afro-Caribbean extraction who has been followed for 12 years with repeat biopsies. He initially...
Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome.
Lee, W R, Marshall, G E, Kirkness, C M
A corneal disc, obtained from a 52-year-old woman suffering from an early stage of the iridocorneal endothelial syndrome (ICE), was investigated by various morphological techniques to analyse the...
Immunogold study of non-collagenous matrix components in normal and exfoliative iris.
Vogiatzis, A, Marshall, G E, Konstas, A G, Lee, W R
The present investigation was undertaken to determine if some of the components of exfoliation material in iris tissue were unique to exfoliation or were part of normal iris architecture. Eleven...
Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome.
Aitken, D A, Beirouty, Z A, Lee, W R
BACKGROUND--This study describes the adhesion systems in the corneal epithelium in the recurrent erosion syndrome and the mechanisms by which binucleate and multinucleate cells are formed within the...
Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula.
Marshall, G E, Konstas, A G, Reid, G G, Edwards, J G, Lee, W R
Tissue obtained from the macula in 10 human eyes (53-77 years) was used for an investigation into the extracellular matrices of the retinal pigment epithelium (RPE), Bruch's membrane, and the...
Multidrug resistance in ocular melanoma.
McNamara, M, Clynes, M, Dunne, B, NicAmhlaoibh, R, Lee, W R, Barnes, C, ...
AIMS/BACKGROUND: Metastatic disease in patients with ocular melanoma is resistant to chemotherapy. One of the main mechanisms of modulating multidrug resistance is the expression of the multidrug...
Recurrence of astrocytoma of optic nerve after 48 years.
Mullaney, J., Walsh, J., Lee, W. R., Adams, J. H.
A tumour presumed to be a juvenile glioma of the optic nerve was removed by a Kronlein procedure from a 4-year old boy in 1925. In 1973 a severe proptosis made it necessary to remove the atrophic eye...
Experimental ocular toxocariasis: a mouse model.
Ghafoor, S. Y., Smith, H. V., Lee, W. R., Quinn, R., Girdwood, R. W.
Male mice, strain C57 black, were infected with Toxocara canis by a single intragastric dose of 1500 infective eggs. The eyes were studied at sequential time periods after infection (6 to 63 days) by...
Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease.
Damato, B E, Allan, D, Murray, S B, Lee, W R
Histological examination of 99 human lacrimal glands showed a relationship between atrophy of the secretory acini and secretory duct obstruction, ascending periductal fibrosis, and obliteration of...
Retinal pathology in the Kearns-Sayre syndrome.
McKechnie, N M, King, M, Lee, W R
Examination of the retinal tissues obtained at necropsy from a 14-year-old boy with Kearns-Sayre syndrome showed marked photoreceptor and pigment epithelial cell loss in the retinal periphery and...
In vitro studies with a pulsed neodymium/YAG laser.
Venkatesh, S, Guthrie, S, Foulds, W S, Lee, W R, Cruickshank, F R, Bailey, R T
The relationships between the destructive effects of Q-switched Nd/YAG laser pulses and a number of experimental parameters were studied for various target materials including in particular excised,...
Thermal lens measurements in the cornea.
Venkatesh, S, Guthrie, S, Cruickshank, F R, Bailey, R T, Foulds, W S, Lee, W R
Q-switched pulses from a neodymium/YAG (yttrium-aluminium-garnet) laser were passed through corneal discs taken from the enucleated eyes of three baboons and four rabbits. The time course of heat...
Assessment of immunological techniques in the diagnosis and prognosis of ocular malignant melanoma.
Cochran, A. J., Foulds, W. S., Damato, B. E., Trope, G. E., Morrison, L., Lee, W. R.
Tests of cell mediated immunity (one and two stage leucocyte migration inhibition assays) and humoural immunity (membrane immunofluorescence and serum effects on leucocyte migration) were done with...
Ultrastructural pathology of melanomalytic glaucoma.
A patient presented with a heavily pigmented ciliary body tumour accompanied by diffuse pigmentation of the iris and chamber angle and secondary open angle glaucoma. The case was diagnosed clinically...
An in-vitro morphological study of Q-switched neodymium/YAG laser trabeculotomy.
Venkatesh, S, Lee, W R, Guthrie, S, Cruickshank, F R, Foulds, W S, Quigley, R J, ...
Laser trabeculotomies produced by directing a pulsed neodymium/YAG laser beam at specimens of human anterior chamber angle obtained post mortem or after enucleation were studied by light microscopy...
Experimental suprachoroidal plombage with a urethane based hydrophilic polymer.
Foulds, W. S., Aitken, D., Lee, W. R.
Small portions of dehydrated hydrophilic polymer (HPU 90, Smith and Nephew) have been inserted into the suprachoroidal space in rabbits to investigate the possible use of suprachoroidal plombage in...
Cochran, A J, Holland, G N, Saxton, R E, Damato, B E, Foulds, W R, Herschman, H R, ...
S-100 protein is a 21,000 dalton acidic calcium-binding protein present in ocular melanomas and some normal ocular tissues. Ocular fluids and extracts of ocular tumours were examined by a sensitive...
Ultrastructural distribution of collagen types I-VI in aging human retinal vessels.
Marshall, G E, Konstas, A G, Lee, W R
Retinal vessels from freshly enucleated human eyes were classified into three stages of the hyalinisation process. The distribution of collagen types I-VI within the vessel walls was studied...
Immunogold localisation of laminin in normal and exfoliative iris.
Konstas, A. G., Marshall, G. E., Lee, W. R.
Immunoelectron microscopic studies of exfoliative iris tissue (seven specimens) revealed the presence of laminin in the fibrillar component of exfoliation material. The immunogold label was uniformly...
Multifocal posterior uveitis: clinical and pathological findings.
A pathological study was performed on the necropsy eyes of a 59-year old-woman who had suffered for nine years from multifocal posterior uveitis. The disease had been controlled by steroid therapy...
Dacryolith formation around an eyelash retained in the lacrimal sac.
A dacryolith was discovered in the lacrimal sac during a dacryocystorhinostomy for chronic dacryocystitis in which there was mucocele formation. Morphological examination confirmed the presence of an...
Ocular injuries from liquid golf ball cores.
Lucas, D R, Dunham, A C, Lee, W R, Weir, W, Wilkinson, F C
Tissue removed from nine new cases from 18 hours to 20 weeks after injury by a golf ball contained crystalline and other foreign material to which there was a mild inflammatory reaction followed by...
Effects of pilocarpine on the morphology of the human outflow apparatus.
Grierson, I, Lee, W R, Abraham, S
The morphology of the outflow apparatus in human eyes which had been treated topically with either 2 or 4% pilocarpine on 4 occasions at 6-hourly intervals before enucleation was compared with an...
Morphological changes in the human conjunctival epithelium. I. In the normal elderly population.
Abdel-Khalek, L. M., Williamson, J., Lee, W. R.
Forty-nine biopsies of bulbar conjunctiva from patients with no apparent conjunctival disease were studied by light and transmission electron microscopy. No significant morphological changes were...
Morphological changes in the human conjunctival epithelium. II. In keratoconjunctivitis sicca.
Abdel-Khalek, L. M., Williamson, J., Lee, W. R.
A clinicopathological correlation was performed on 24 patients suffering from keratoconjunctivitis sicca (KCS). Examination of conjunctival biopsies by light and transmission electron microscopy...
Grierson, I, Lee, W R, Moseley, H, Abraham, S
The scanning electron microscope was used to study the endothelium lining the trabecular wall of Schelemm's canal in 10 human eyes enucleated in treatment of choroidal melanomas. The eyes of 5...
Histological and morphometric analysis of the effects of argon laser epilation
Hanumanthu, S, Webb, L A, Lee, W R, Williamson, J
Aim: To analyse the location and extent of tissue damage induced after argon laser epilation.
Coupland, S E, Hellmich, M, Auw-Haedrich, C, Lee, W R, Anagnostopoulos, I, Stein, H
Aim: To determine (a) the expression of plasma cell related antigens in extranodal marginal zone B cell lymphomas (EMZL) of the ocular adnexa; and (b) the prognostic value of plasmacellular...