Heil, M., Grimm, S., Martin, S., Zolk, O., Schaper, W., Zimmermann, R.
P490
Insights into pathways of arteriogenesis (2007)
The compensatory growth of blood vessels after major arterial occlusions has been termed arteriogenesis. Although having some characteristics in common with angiogenesis, marked differences between...
Knoll, R., Postel, R., Wang, J., Kratzner, R., Hennecke, G., Vacaru, A. M., ...
BACKGROUND: Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly...
Mees, B., Wagner, S., Ninci, E., Tribulova, S., Martin, S., Van Haperen, R., ...
OBJECTIVE: Arteriogenesis is the major mechanism of vascular growth, which is able to compensate for blood flow deficiency after arterial occlusion. Endothelial nitric oxide synthase (eNOS) activity...
Angiopoietin-2 impairs revascularization after limb ischemia (2007)
Reiss, Y., Droste, J., Heil, M., Tribulova, S., Schmidt, M. H., Schaper, W., ...
Angiopoietins play important roles in the formation of neovessels and complex vascular networks. Angiopoietin (Ang)-1 and Ang-2 belong to a family of growth factors that display opposing effects on...
Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway (2007)
Vogel, C., Bauer, A., Wiesnet, M., Preissner, K. T., Schaper, W., Marti, H. H., ...
Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to...
Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)
After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...
Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)
Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...
OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...
MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)
Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.
Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...
MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)
Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.
Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...
Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)
Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...
OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...
Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)
After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis (2006)
He, Y., Luo, Y., Tang, S., Rajantie, I., Salven, P., Heil, M., ...
Bmx/Etk non-receptor tyrosine protein kinase has been implicated in endothelial cell migration and tube formation in vitro. However, the role of Bmx in vivo is not known. Bmx is highly induced in the...
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis (2006)
Yu, J., Carmeliet, P., Schaper, W., Sinusas, A. J., Sessa, W. C., Alitalo, K., ...
Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)
After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...
The range of adaptation by collateral vessels after femoral artery occlusion (2006)
Eitenmuller, I., Volger, O., Kluge, A., Troidl, K., Barancik, M., Cai, W. J., ...
Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximately 35% of adenosine-recruitable maximal conductance (C(max)) probably because initially...
Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)
Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...
OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...
The range of adaptation by collateral vessels after femoral artery occlusion (2006)
Eitenmueller, I., Volger, O., Kluge, A., Troidl, K., Barancik, M., Cai, W.J., ...
Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximate to 35% of adenosine-recruitable maximal conductance (C-max) probably because initially...
MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)
Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.
Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...
Fischer, S., Wiesnet, M., Renz, D., Schaper, W.
In vivo, pathological conditions such as ischemia and ischemia/reperfusion are known to damage the blood-brain barrier (BBB) leading to the development of vasogenic brain edema. Using an in vitro...
Dipyridamole, an underestimated vascular protective drug (2005)
Dipyridamole, developed almost half a century ago, acts by inhibiting nucleoside transport, which increases adenosine levels leading to inhibition of platelet aggregation and vasodilatation mainly in...
Arteriogenic growth factors, chemokines and proteases as a prerequisite for arteriogenesis (2005)
Frequently, patients with ischemic vascular diseases have developed collateral blood vessels bypassing areas of arterial obstructions. This may support maintenance of organ function and prevent...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Preconditioning of arteriogenesis (2005)
OBJECTIVE: Last decade, the shear stress caused by increased blood flow in collateral circulation after occlusion of main artery was recognized as a trigger of vascular remodeling and collateral...
Preconditioning of arteriogenesis (2005)
OBJECTIVE: Last decade, the shear stress caused by increased blood flow in collateral circulation after occlusion of main artery was recognized as a trigger of vascular remodeling and collateral...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Arteriogenic growth factors, chemokines and proteases as a prerequisite for arteriogenesis (2005)
Frequently, patients with ischemic vascular diseases have developed collateral blood vessels bypassing areas of arterial obstructions. This may support maintenance of organ function and prevent...
Dipyridamole, an underestimated vascular protective drug (2005)
Dipyridamole, developed almost half a century ago, acts by inhibiting nucleoside transport, which increases adenosine levels leading to inhibition of platelet aggregation and vasodilatation mainly in...
Fischer, S., Wiesnet, M., Renz, D., Schaper, W.
In vivo, pathological conditions such as ischemia and ischemia/reperfusion are known to damage the blood-brain barrier (BBB) leading to the development of vasogenic brain edema. Using an in vitro...
Bone marrow-derived cells do not incorporate into the adult growing vasculature (2004)
Ziegelhoeffer, T., Fernandez, B., Kostin, S., Heil, M., Voswinckel, R., Helisch, A., ...
Bone marrow-Derived cells have been proposed to form new vessels or at least incorporate into growing vessels in adult organisms under certain physiological and pathological conditions. We...
Role of hypoxia/ischemia/VEGF-A, and strain difference (2004)
Deindl, E., Helisch, A., Scholz, D., Heil, M., Wagner, S., Schaper, W.
In-vitro-Effekte von Anästhetika auf die Blut-Hirn-Schranke (2004)
Fischer, S., Renz, D., Kleinstück, J., Schaper, W., Karliczek, G.F.
Growth of collateral blood vessels (arteriogenesis) is potentially able to preserve structure and function of limbs and organs after occlusion of a major artery. The success of the remodeling process...
Pathophysiology of collateral development (2004)
The formation of collateral arteries in patients suffering from occlusive atherosclerotic vascular diseases has been frequently reported. The growth of these collateral arteries has been termed...
Pipp, F., Boehm, S., Cai, W. J., Adili, F., Ziegler, B., Karanovic, G., ...
Physical forces and their translation into molecular mechanisms (2004)
Schaper, W., Pipp, F., Scholz, D., Boehm, S., Deindl, E., Barancik, M., ...
Van Royen, N., Voskuil, M., Hoefer, I., Jost, M., De Graaf, S., Hedwig, F., ...
BACKGROUND: Arteriogenesis refers to the development of collateral conductance arteries and is orchestrated by circulating monocytes, which invade growing collateral arteries and act as suppliers of...
Expression profiling of growing arteries/Hunting for new genes (2004)
Zimmermann, R., Boengler, K., Kampmann, A., Fernandez, B., Volger, O., Horrevoets, A.J.G., ...
Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1 (2003)
Voskuil, M., Royen, N. Van, Hoefer, I.E., Seidler, R., Guth, B.D., Bode, Ch., ...
Identification of differentially expressed genes like cofilin2 in growing collateral arteries (2003)
Boengler, K., Pipp, F., Broich, K., Fernandez, B., Schaper, W., Deindl, E.
Arteriogenesis, the growth of pre-existing collateral arteries, can be induced in rabbits by occlusion of the femoral artery. In order to analyze the differential gene expression in arteriogenesis,...
Boengler, K., Pipp, F., Fernandez, B., Richter, A., Schaper, W., Deindl, E.
Arteriogenesis, the growth of pre-existing collateral arteries, can be induced in rabbit by occlusion of the femoral artery. In order to identify and characterize genes differentially expressed...
Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp) (2003)
Boengler, K., Pipp, F., Fernandez, B., Ziegelhoeffer, T., Schaper, W., Deindl, E.
OBJECTIVE: Collateral artery growth (arteriogenesis) can be induced in rabbit and mice by occlusion of the femoral artery. We aimed to identify genes that are differentially expressed during...
Influence of inflammatory cytokines on arteriogenesis (2003)
Buschmann, I., Heil, M., Jost, M., Schaper, W.
Blood vessel growth after birth is limited to two major processes. Angiogenesis is the growth of new capillaries by sprouting or intussusception. The major stimulus for angiogenesis is ischemia. In...
Remodeling of the adventitia during coronary arteriogenesis (2003)
Cai, W. J., Koltai, S., Kocsis, E., Scholz, D., Kostin, S., Luo, X., ...
We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic occlusion of the left circumflex coronary...