W. Schaper

Mechanisms of arteriogenesis (2008)

Cai, W., Schaper, W.

Patients with occlusive atherosclerotic vascular diseases have frequently developed collateral blood vessels that bypass areas of arterial obstructions. The growth of these collateral arteries has...

Prevention of tissue death by killer cells? The role of the immune system in arteriogenesis (2007)

Adenoviral Transfer of the Cardiac Ankyrin Repeat Protein /AnkyrinRepeat Domain 1 (CARP/ANKRD1) Gene Enhances Arteriogenesis in an Ischemic Hindlimb Mode (2007)

Heil, M., Grimm, S., Martin, S., Zolk, O., Schaper, W., Zimmermann, R.

P490

Insights into pathways of arteriogenesis (2007)

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells (2007)

The compensatory growth of blood vessels after major arterial occlusions has been termed arteriogenesis. Although having some characteristics in common with angiogenesis, marked differences between...

Knoll, R., Postel, R., Wang, J., Kratzner, R., Hennecke, G., Vacaru, A. M., ...

BACKGROUND: Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly...

Endothelial nitric oxide synthase activity is essential for vasodilation during blood flow recovery but not for arteriogenesis (2007)

Mees, B., Wagner, S., Ninci, E., Tribulova, S., Martin, S., Van Haperen, R., ...

OBJECTIVE: Arteriogenesis is the major mechanism of vascular growth, which is able to compensate for blood flow deficiency after arterial occlusion. Endothelial nitric oxide synthase (eNOS) activity...

Angiopoietin-2 impairs revascularization after limb ischemia (2007)

Reiss, Y., Droste, J., Heil, M., Tribulova, S., Schmidt, M. H., Schaper, W., ...

Angiopoietins play important roles in the formation of neovessels and complex vascular networks. Angiopoietin (Ang)-1 and Ang-2 belong to a family of growth factors that display opposing effects on...

Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway (2007)

Vogel, C., Bauer, A., Wiesnet, M., Preissner, K. T., Schaper, W., Marti, H. H., ...

Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to...

Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)

Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)

After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...

Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...

OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...

MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)

Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.

Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...

MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)

Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.

Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...

Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)

Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...

OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...

Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)

Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis (2006)

After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...

He, Y., Luo, Y., Tang, S., Rajantie, I., Salven, P., Heil, M., ...

Bmx/Etk non-receptor tyrosine protein kinase has been implicated in endothelial cell migration and tube formation in vitro. However, the role of Bmx in vivo is not known. Bmx is highly induced in the...

Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis (2006)

Yu, J., Carmeliet, P., Schaper, W., Sinusas, A. J., Sessa, W. C., Alitalo, K., ...

Enhanced arteriogenesis in mice overexpressing erythropoietin (2006)

The range of adaptation by collateral vessels after femoral artery occlusion (2006)

After permanent occlusion of the femoral artery, the survival of ischemic limb tissue depends on collateral artery growth (arteriogenesis). In previous work, we have shown that shear stress triggers...

Eitenmuller, I., Volger, O., Kluge, A., Troidl, K., Barancik, M., Cai, W. J., ...

Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximately 35% of adenosine-recruitable maximal conductance (C(max)) probably because initially...

Impact of mouse strain differences in innate hindlimb collateral vasculature (2006)

Helisch, A., Wagner, S., Khan, N., Drinane, M., Wolfram, S., Heil, M., ...

OBJECTIVE: To assess the importance of genetic background for collateral artery development. METHODS AND RESULTS: C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral artery ligation by laser...

The range of adaptation by collateral vessels after femoral artery occlusion (2006)

Eitenmueller, I., Volger, O., Kluge, A., Troidl, K., Barancik, M., Cai, W.J., ...

Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximate to 35% of adenosine-recruitable maximal conductance (C-max) probably because initially...

MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (2006)

Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.

Smooth muscle cells (SMCs) form the backbone of arteries and their proliferation hallmarks collateral vessel growth, a process termed arteriogenesis, as well as pathogenic responses such as...

MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells (erratum) (2006)

Vogel, S., Kubin, T., Deindl, E., Schaper, W., Zimmermann, R.

START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease (2005)

Royen, N. Van, Schirmer, S.H., Atasever, B., Behrens, C.Y.H., Ubbink, D.Th., Buschmann, E.E., ...

START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular disease (2005)

Royen, N. Van, Schirmer, S.H., Atasever, B., Behrens, C.Y.H., Ubbink, D.T., Buschmann, E.E., ...

H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway (2005)

Fischer, S., Wiesnet, M., Renz, D., Schaper, W.

In vivo, pathological conditions such as ischemia and ischemia/reperfusion are known to damage the blood-brain barrier (BBB) leading to the development of vasogenic brain edema. Using an in vitro...

Dipyridamole, an underestimated vascular protective drug (2005)

Arteriogenic growth factors, chemokines and proteases as a prerequisite for arteriogenesis (2005)

Dipyridamole, developed almost half a century ago, acts by inhibiting nucleoside transport, which increases adenosine levels leading to inhibition of platelet aggregation and vasodilatation mainly in...

Cellular mechanisms of arteriogenesis (2005)

Frequently, patients with ischemic vascular diseases have developed collateral blood vessels bypassing areas of arterial obstructions. This may support maintenance of organ function and prevent...

Transforming growth factor-beta1 downregulates beating frequency and remodeling of cultured rat adult cardiomyocytes (2005)

Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...

We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...

Preconditioning of arteriogenesis (2005)

Preconditioning of arteriogenesis (2005)

OBJECTIVE: Last decade, the shear stress caused by increased blood flow in collateral circulation after occlusion of main artery was recognized as a trigger of vascular remodeling and collateral...

Transforming growth factor-beta1 downregulates beating frequency and remodeling of cultured rat adult cardiomyocytes (2005)

OBJECTIVE: Last decade, the shear stress caused by increased blood flow in collateral circulation after occlusion of main artery was recognized as a trigger of vascular remodeling and collateral...

Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...

We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...

Cellular mechanisms of arteriogenesis (2005)

Arteriogenic growth factors, chemokines and proteases as a prerequisite for arteriogenesis (2005)

Dipyridamole, an underestimated vascular protective drug (2005)

Frequently, patients with ischemic vascular diseases have developed collateral blood vessels bypassing areas of arterial obstructions. This may support maintenance of organ function and prevent...

H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway (2005)

Dipyridamole, developed almost half a century ago, acts by inhibiting nucleoside transport, which increases adenosine levels leading to inhibition of platelet aggregation and vasodilatation mainly in...

Fischer, S., Wiesnet, M., Renz, D., Schaper, W.

In vivo, pathological conditions such as ischemia and ischemia/reperfusion are known to damage the blood-brain barrier (BBB) leading to the development of vasogenic brain edema. Using an in vitro...

CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization (2004)

Royen, N. Van, Voskuil, M., Hoefer, I., Jost, M., Graaf, S. De, Hedwig, F., ...

Arteriogenesis and atheriosclerosis: strange bedfellows (2004)

Royen, N. Van, Schaper, W.

CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization (2004)

Royen, N. Van, Voskuil, M., Hoefer, I., Jost, M., Graaf, S. De, Hedwig, F., ...

Bone marrow-derived cells do not incorporate into the adult growing vasculature (2004)

Ziegelhoeffer, T., Fernandez, B., Kostin, S., Heil, M., Voswinckel, R., Helisch, A., ...

Bone marrow-Derived cells have been proposed to form new vessels or at least incorporate into growing vessels in adult organisms under certain physiological and pathological conditions. We...

A different outlook on the role of bone marrow stem cells in vascular growth Bone marrow delivers logistics not parts (2004)

A different outlook on the role of bone marrow stem cells in vascular growth Bone marrow delivers logistics not parts (2004)

A different outlook on the role of bone marrow stem cells in vascular growth Bone marrow delivers logistics not parts (2004)

A different outlook on the role of bone marrow stem cells in vascular growth Bone marrow delivers logistics not parts (2004)

Expression of endothelial nitric oxide synthase in the vascular wall during arteriogenesis (2004)

Cai, W. J., Kocsis, E., Luo, X., Schaper, W., Schaper, J.

Role of hypoxia/ischemia/VEGF-A, and strain difference (2004)

Deindl, E., Helisch, A., Scholz, D., Heil, M., Wagner, S., Schaper, W.

In-vitro-Effekte von Anästhetika auf die Blut-Hirn-Schranke (2004)

Fischer, S., Renz, D., Kleinstück, J., Schaper, W., Karliczek, G.F.

Simultaneous Activation of Several Second Messengers in Hypoxia-Induced Hyperpermeability of Brain Derived endothelial Cells (2004)

Fischer, S., Wiesnet, M., Marti, H.H., Renz, D., Schaper, W.

Influence of mechanical, cellular and molecular factors on collateral artery growth (Arteriogenesis) (2004)

Pathophysiology of collateral development (2004)

Growth of collateral blood vessels (arteriogenesis) is potentially able to preserve structure and function of limbs and organs after occlusion of a major artery. The success of the remodeling process...

Influence of mechanical, cellular, and molecular factors on collateral artery growth (Arteriogenesis) (2004)

The formation of collateral arteries in patients suffering from occlusive atherosclerotic vascular diseases has been frequently reported. The growth of these collateral arteries has been termed...

Arterial Regeneration by collateral artery growth (arteriogenesis) (2004)

Heil, M., Wagner, S., Schaper, W.

Elevated fluid shear stress enhances post-occlusive collateral artery growth and gene expression in the pig hind limb (2004)

Pipp, F., Boehm, S., Cai, W. J., Adili, F., Ziegler, B., Karanovic, G., ...

Introduction (2004)

Physical forces and their translation into molecular mechanisms (2004)

Schaper, W., Pipp, F., Scholz, D., Boehm, S., Deindl, E., Barancik, M., ...

Arteriogenesis (2004)

Schaper, W., Schaper, J.

Preconditioning of arterogenesis (2004)

CD44 Regulates Arteriogenesis in Mice and Is Differentially Expressed in Patients With Poor and Good Collateralization (2004)

Van Royen, N., Voskuil, M., Hoefer, I., Jost, M., De Graaf, S., Hedwig, F., ...

BACKGROUND: Arteriogenesis refers to the development of collateral conductance arteries and is orchestrated by circulating monocytes, which invade growing collateral arteries and act as suppliers of...

Magnetic resonance angiography of collateral vessels in a murine femoral artery ligation model. (2004)

Wagner, S., Helisch, A., Ziegelhoeffer, T., Bachmann, G., Schaper, W.

Expression profiling of growing arteries/Hunting for new genes (2004)

Zimmermann, R., Boengler, K., Kampmann, A., Fernandez, B., Volger, O., Horrevoets, A.J.G., ...

A different outlook on the role of bone marrow stem cells in vascular growth Bone marrow delivers logistics not parts (2004)

Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis (2003)

Ziegelhöffer, T, Kanse, S M, Fernandez, B, Neubauer, E, ...

To define the role of the plasminogen activators (PAs) urokinase PA (uPA) and tissue PA (tPA) as well as the uPA receptor (uPAR) in arteriogenesis, we investigated their impact in a rabbit and mouse...

Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1 (2003)

Voskuil, M., Royen, N. Van, Hoefer, I.E., Seidler, R., Guth, B.D., Bode, Ch., ...

Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits (2003)

Royen, N. Van, Hoefer, I., Buschmann, I., Kostin, S., Voskuil, M., Bode, Ch., ...

Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression (2003)

Royen, N. Van, Hoefer, I., Bottinger, M., Hua, J., Grundmann, S., Voskuil, M., ...

Invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease (2003)

Buschmann, I.R., Voskuil, M., Royen, N. Van, Hoefer, I.E., Scheffler, K., Grundmann, S., ...

Design of the start-trial: stimulation of arteriogenesis using subcutaneous application of gmcsf as a new treatment for peripheral vascular disease. a randomized, double-blind, placebo-controlled trial (2003)

Royen, N. Van, Atasever, B., Voskuil, M., Katzer, E., Ubbink, D.Th., Schirmer, S.H., ...

Identification of differentially expressed genes like cofilin2 in growing collateral arteries (2003)

Boengler, K., Pipp, F., Broich, K., Fernandez, B., Schaper, W., Deindl, E.

Arteriogenesis, the growth of pre-existing collateral arteries, can be induced in rabbits by occlusion of the femoral artery. In order to analyze the differential gene expression in arteriogenesis,...

The ankyrin repeat containing SOCS box protein 5: a novel protein associated with arteriogenesis (2003)

Boengler, K., Pipp, F., Fernandez, B., Richter, A., Schaper, W., Deindl, E.

Arteriogenesis, the growth of pre-existing collateral arteries, can be induced in rabbit by occlusion of the femoral artery. In order to identify and characterize genes differentially expressed...

Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp) (2003)

Boengler, K., Pipp, F., Fernandez, B., Ziegelhoeffer, T., Schaper, W., Deindl, E.

OBJECTIVE: Collateral artery growth (arteriogenesis) can be induced in rabbit and mice by occlusion of the femoral artery. We aimed to identify genes that are differentially expressed during...

Rapid identification of differentially expressed genes by combination of SSH and MOS (2003)

Boengler, K., Pipp, F., Schaper, W., Deindl, E.

Influence of inflammatory cytokines on arteriogenesis (2003)

Buschmann, I., Heil, M., Jost, M., Schaper, W.

Blood vessel growth after birth is limited to two major processes. Angiogenesis is the growth of new capillaries by sprouting or intussusception. The major stimulus for angiogenesis is ischemia. In...

Invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease (2003)

Buschmann, I., Voskuil, M., Van Royen, N., Hoefer, I.E., Scheffler, K., Grundmann, S., ...

Presence of CX37 and lack of desmin in smooth muscle cells are early markers for arteriogenesis (2003)

Cai, W.J., Kocsis, E., Scholz, D., Luo, X., Schaper, W., Schaper, J.

Remodeling of the adventitia during coronary arteriogenesis (2003)

Cai, W. J., Koltai, S., Kocsis, E., Scholz, D., Kostin, S., Luo, X., ...

We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic occlusion of the left circumflex coronary...

Dissection of monocyte and endothelial activities by using VEGF-receptor specific ligands (2003)

Clauss, M., Pipp, F., Issbrucker, K., Weich, H., Heil, M., Schaper, W.

Involvement of the fibroblast growth factor system in adaptive and chemokine-induced arteriogenesis (2003)

Deindl, E., Hoefer, I. E., Fernandez, B., Barancik, M., Heil, M., Strniskova, M., ...

Fibroblast growth factors (FGFs) have been applied in a variety of therapeutic and experimental studies to improve collateral blood flow. However, the pathophysiological role and the temporospatial...

Effect of intermittent high altitude hypoxia on gene expression in rat heart and lung (2003)

Deindl, E., Kolar, F., Neubauer, E., Vogel, S., Schaper, W., Ostadal, B.

Hypoxia has been identified as an important stimulus for gene expression during embryogenesis and in various pathological situations. Its influence under physiological conditions, however, has only...

Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis (2003)

Deindl, E., Ziegelhoffer, T., Kanse, S. M., Fernandez, B., Neubauer, E., Carmeliet, P., ...

To define the role of the plasminogen activators (PAs) urokinase PA (uPA) and tissue PA (tPA) as well as the uPA receptor (uPAR) in arteriogenesis, we investigated their impact in a rabbit and mouse...

Osteoglycin expression and localization in rabbit tissues and atherosclerotic plaques. (2003)

Fernandez, B., Kampmann, A., Pipp, F., Zimmermann, R., Schaper, W.

Identification of a cis-element regulating transcriptional activity in response to fluid shear stress in bovine aortic endothelial cells (2003)

Fisslthaler, B., Boengler, K., Fleming, I., Schaper, W., Busse, R., Deindl, E.

Fluid shear stress exerts numerous effects on gene expression in endothelial cells. To investigate the regulatory mechanisms involved, we designed oligonucleotides composed of a 20-bp core containing...

An engineered heparin-binding form of VEGF-E (hbVEGF-E). Biological effects in vitro and mobilizatiion of precursor cells (2003)

Heil, M., Mitnacht-Krauss, R., Issbrucker, K., Dehio, C., Schaper, W., ...

Vascular endothelial growth factor (VEGF-A) is the founding member of a family of angiogenic proteins with various binding abilities to three cognate VEGF receptors. Previously, a gene encoding from...

Arteriogenesis: the development and growth of collateral arteries (2003)

Helisch, A., Schaper, W.

In patients with atherosclerotic vascular diseases, collateral vessels bypassing major arterial obstructions have frequently been observed. This may explain why some patients remain without symptoms...

Porcine aortic endothelial cells show little effects on smooth muscle cells but are potent stimulators of cardiomyocyte growth (2003)

Kubin, T., Vogel, S., Wetzel, J., Hein, S., Pipp, F., Herold, J., ...

Smooth muscle cells (SMC) and endothelial cells (EC) play a pivotal role in arteriogenesis and atherosclerosis. We evaluated the role of EC on the growth of SMC and neonatal cardiomyocytes (NEO) by...

Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice mimics ischemic preconditioning through SAPK/JNK1/2 activation (2003)

Martire, A., Fernandez, B., Buehler, A., Strohm, C., Schaper, J., Zimmermann, R., ...

OBJECTIVE AND METHODS: Although a beneficial association between innate immunity and ischemic preconditioning has recently been proposed, the mechanisms responsible for this link are poorly...

Biopanning of single-chain antibodies expressing phages reveals distinct expression patterns of angiogenic and arteriogenic vessels (2003)

Mazur, A., Deylig, A., Schaper, W., Meinertz, T., Ito, W. D.

"Therapeutic angiogenesis" requires targeted delivery of growth factors for maximal benefit and limitation of potential hazards such as enhancement of tumor or plaque angiogenesis. Physiological...

VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism (2003)

Pipp, F., Heil, M., Issbrucker, K., Ziegelhoeffer, T., Martin, S., ...

Two signaling receptors for vascular endothelial growth factor (VEGF) in the vasculature are known with not yet well-understood roles in collateral vessel growth (arteriogenesis). In this study, we...

Time- and cell type-specific induction of platelet-derived growth factor receptor-§ during cerebral ischemia (2003)

Renner, O., Tsimpas, A., Kostin, S., Valable, S., Petit, E., Schaper, W., ...

On arteriogenesis - a reply (2003)

Factors regulation arteriogenesis (2003)

Schaper, W., Scholz, D.

Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression (2003)

Scheinowitz, M., Kessler-Icekson, G., Freimann, S., Zimmermann, R., Schaper, W., Golomb, E., ...

OBJECTIVES. We investigated the effect of short- and long-term swimming exercise, with or without insulin-like growth factor (IGF)-I administration, on the expression of myocardial IGFs and...

Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) -/- mice (2003)

Scholz, D., Elsaesser, H., Sauer, A., Friedrich, C., Luttun, A., Carmeliet, P., ...

We studied the influence of placenta growth factor (PlGF) on arteriogenesis and tested the role of bone marrow (BM)-derived cells on PlGF-depleted vascular growth. METHODS: Right femoral artery was...

Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PIGF)-/-mice (2003)

Scholz, D., Elsässer, H., Sauer, A., Friedrich, C., Luttun, A., Carmeliet, P., ...

Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression (2003)

Van Royen, N., Hoefer, I., Bottinger, M., Hua, J., Grundmann, S., Voskuil, M., ...

Monocyte chemoattractant protein-1 (MCP-1) stimulates the formation of a collateral circulation on arterial occlusion. The present study served to determine whether these proarteriogenic properties...

Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits (2003)

Van Royen, N., Hoefer, I.E., Buschmann, I., Kostin, S., Voskuil, M., Bode, C., ...

Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial (2003)

Van Royen, N., Piek, J. J., Legemate, D. A., Schaper, W., Oskam, J., Atasever, B., ...

Peripheral arterial disease (PAD) affects a large percentage of the elderly population. Standard invasive treatment, apart from risk factor modulation, consists of bypass surgery or percutaneous...

Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1 (2003)

Voskuil, M., Van Royen, N., Hoefer, I.E., Seidler, R., Guth, B.D., Bode, C., ...

Bone marrow derived progenitor cells do not contribute to pulmonary angiogenesis and vascular remodeling in compensatory lung growth. (2003)

Voswinckel, R., Ziegelhoeffer, T., Heil, M., Kostin, S., Breier, G., Mehling, T., ...

Circulating vascular progenitor cells do not contribute to compensatory lung growth. (2003)

Voswinckel, R., Ziegelhoeffer, T., Heil, M., Kostin, S., Breier, G., Mehling, T., ...

Inhibition of collateral artery growth by mibefradil: possible role of volume-regulated chloride channels (2003)

Ziegelhoeffer, T., Scholz, D., Friedrich, C., Helisch, A., Wagner, S., Fernandez, B., ...

Endothelial cell swelling is one of the earliest hallmarks of arteriogenesis, the growth and maturation of collaterals. Mibefradil was found to block endothelial Cl(-) channels that control the...

Angiogenese und ihre therapeutischen Optionen in der Kardiologie (2003)

Schaper, W., Scholz, D.

Peripheral arterial disease diagnosis and treatment (2003)

Schmitz-Rixen, T., Schaper, W.

A MLP-Telethonin-Titin complex is an essential component of the mechanical stretch machinery, and is defective in a subset of himan dilated cardiomyopathy (2003)

Knoell, R., Hoshijima, M., Hoffman, H., Person, V., Lorenzen-Schmidt, I., ...

Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits (2003)

Van Royen, N, Hoefer, I, Buschmann, I, Kostin, S, Voskuil, M, Bode, Ch, ...

Objective: The objective of our study was to quantify the arteriogenic potency of Monocyte Chemoattractant Protein-1 (MCP-1) under hyperlipidemic conditions. Additionally, we aimed to determine the...

Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation (2002)

Royen, N. Van, Hoefer, I., Buschmann, I., Heil, M., Kostin, S., Deindl, E., ...

Delay of infarct development in FGF-1 transgenic mice (2002)

Bühler, A., Martire, A., Strohm, C., Wolfram, S., Fernandez, B., Palmen, M., ...

Angiogenesis-independent cardioprotection in FGF-1 transgenic mice (2002)

Buehler, A., Martire, A., Strohm, C., Wolfram, S., Fernandez, B., Palmen, M., ...

Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1 (2002)

Fischer, S., Wobben, M., Marti, H.H., Renz, D., Schaper, W.

Differential expression of GAPDH and beta3-actin in growing collateral arteries (2002)

Deindl, E., Boengler, K., Van Royen, N., Schaper, W.

Blood monocyte concentration is critical for enhancement o collateral artery growth (2002)

Heil, M., Ziegelhoeffer, T., Pipp, F., Kostin, S., Martin, S., Clauss, M., ...

Blood monocyte concentration is critical for enhancement of collateral artery growth (2002)

Heil, M., Ziegelhoeffer, T., Pipp, F., Kostin, S., Martin, S., Clauss, M., ...

0.1152/ajpheart. 01098.2001.-Arteriogenesis has been associated with the presence of monocytes/macrophages within the collateral vessel wall. We tested the hypothesis that arteriogenesis is...

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy (2002)

Knöll, R., Hoshijima, M., Hoffman, H.M., Person, V., Lorenzen-Schmidt, I., ...

Historische Aspekte zur Gesellschaft von den Anfängen bis zur Gegenwart (2002)

Development of the collateral circulation. History of an idea. (2002)

Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice (2002)

Scholz, D., Ziegelhöffer, T., Helisch, A., Wagner, S., Friedrich, C., Podzuweit, T., ...

Arteriogenesis: nature´s way to maintain structure and metabolism in the presence of occluded arteries (2002)

Schaper, W., Heil, M., Pipp, F.

History of the German Cardiac Society (DGHKF) (2002)

Transcription inhibitor actinomycin-D abolishes the cardioprotective effect of ischemic preconditioning (2002)

Strohm, C., Barancik, M., Strniskova, M., Ullmann, C., Zimmermann, R., ...

Arteriogenesis, a new concept of vascular adaptation in occlusive disease (2002)

Exogenous application of tranforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation (2002)

Van Royen, N., Hoefer, I., Buschmann, I., Heil, M., Kostin, S., Deindl, E., ...

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001)

Vincenti, V, De Mol, M, ...

Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF...

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001)

Vincenti, V, De Mol, M, ...

Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PIGF), remains unknown. Both VEGF and PIGF...

Angiogenese en arteriogenese; de lange weg van concept naar klinische toepassing (2001)

Voskuil, M., Royen, N. Van, Hoefer, I., Buschmann, I., Schaper, W., Piek, J.J.

Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease (2001)

Royen, N. Van, Piek, J.J., Buschmann, I., Hoefer, I.E., Voskuil, M., Schaper, W.

Time course of arteriogenesis following femoral artery occlusion in the rabbit (2001)

Hoefer, I.E., Royen, N. Van, Buschmann, I., Piek, J.J., Schaper, W.

Arteriogenesis: Mechanisms and modulation of collateral artery development (2001)

Royen, N. Van, Piek, J.J., Schaper, W., Bode, Ch., Buschmann, I.

Reliability aspects of high temperature power MOSFETs (2000)

Wondrak, W, Schaper, W, Dieval, B, Hartnagel, HL, MANCA, Jean, CROES, Kristof, ...

Gate oxide reliability and thermal shock resistance of power MOSFETs for high temperature applications, have been investigated, by accelerated tests and several analytical and electrical techniques....

Reliability aspects of high temperature power MOSFETs (2000)

Wondrak, W, Schaper, W, Dieval, B, Hartnagel, HL, MANCA, Jean, CROES, Kristof, ...

Gate oxide reliability and thermal shock resistance of power MOSFETs for high temperature applications, have been investigated, by accelerated tests and several analytical and electrical techniques....

Collateral circulation of the heart (1999)

Schaper, W., Piek, J.J., Munoz-Chapuli, R., Wolf, C., Ito, W.

Hermetic glass sealing of ALN packages for high temperature applications (1999)

Krüger, R., Roosen, A., Schaper, W.

Arteriogenesis, the good and bad of it (1999)

Schaper, W., Buschmann, I.

The impact factor (1997)

DE JONG, J. W., SCHAPER, W.

The international rank order of clinical cardiology (1996)

De Jong, J. W., Schaper, W.

A cardiological ranking list was prepared based on papers published in 1981–1992. The nations studied comprised the G-7 countries, Belgium, Denmark, Finland, the Netherlands, Norway, Sweden and...

Control of coronary angiogenesis (1995)

Generation and localisation of monoclonal antibodies against fibroblast growth factors in ischaemic collateralised porcine myocardium (1993)

We investigated the development of coronary collaterals in canine and porcine models using either progressive experimental coronary occlusion or microembolism of small vessels. Muscular arteries...

Bernotat-Danielowski, Sabine, Sharma, Hari S, Schott, Robert J, Schaper, W

Objective: The collateral circulation plays a critical role in the prognosis of ischaemic heart disease, with a clear correlation between neovascularisation, infarction, and tissue recovery. The aim...

PHASE TRANSFORMATIONS OF SUPERSATURED SPUTTERED Nb Co FILMS (1990)

Biegel, W., Schaper, W., Hoffmann, J., Freyhardt, H., Busch, R., ...

Supersaturated NbCo thin films were prepared in the concentration range 4 -15 at.% Co by triode co-sputtering. Based on thermodynamic calculations (CALPHAD) for the Nb-Co system, we expect during...

PHASE TRANSFORMATIONS OF SUPERSATURED SPUTTERED Nb Co FILMS (1990)

Biegel, W., Schaper, W., Hoffmann, J., Freyhardt, H., Busch, R., ...

Supersaturated NbCo thin films were prepared in the concentration range 4 -15 at.% Co by triode co-sputtering. Based on thermodynamic calculations (CALPHAD) for the Nb-Co system, we expect during...

PHASE TRANSFORMATIONS OF SUPERSATURED SPUTTERED Nb Co FILMS (1990)

Biegel, W., Schaper, W., Hoffmann, J., Freyhardt, H., Busch, R., ...

Supersaturated NbCo thin films were prepared in the concentration range 4 -15 at.% Co by triode co-sputtering. Based on thermodynamic calculations (CALPHAD) for the Nb-Co system, we expect during...

Heart rate reduction, a new and old therapeutic principle? (1987)

Ultrastructural Characteristics of Regional Ischaemia and Infarction in the Canine Heart (1985)

Schaper, J., Alpers, P., Gottwik, M., Schaper, W.

Abstract selection for the ECC -- '84 in Dusseldorf (1984)

Schaper, W., Gottwik, M. G., Winkler, B., Stämmler, G.

Ultrastructural correlates of reduced cardiac function in human heart disease (1983)

Schaper, J., Schaper, W.

The ultrastructural correlates of a decrease in cardiac function resulting in heart failure are unknown. For this reason, transmural needle biopsies were taken during cardiac surgery from patients...

Natural defense mechanisms during ischemia (1983)

Reduced volume fraction of myofibrils in myocardium of patients with decompensated pressure overload (1981)

Mechanisms are described that are known to prolong survival of ischemic myocardium. Some of these mechanisms are species-specific: collateral blood flow does not contribute to survival in rats,...

Schaper, J, Kittstein, D, Walter, P, Schaper, W

Changes in myocardial oxygen consumption 45 minutes after experimental coronary occlusion do not alter infarct size (1980)

MÜLLER, K D, KLEIN, H, SCHAPER, W

The influence of myocardial oxygen consumption (MVO2) at the moment of coronary occlusion on the size of the ensuing infarct was investigated in two groups of anaesthetised dogs. In one group (n = 9)...

Coronary collaterals in the canine heart: development and functional significance (1979)

Schwarz, F, Schaper, W

Effect of coronary stenosis on myocardial-function, ultrastructure and aortocoronary bypass graft hemodynamics (1978)

Thiedemann, Ku, Schaper, W, Schlepper, M

Role of cardiac contractility in hypertrophy from chronic volume loading (1977)

Winkler, B, Schaper, W

In an experimental model of chronic cardiac volume overloading, ie chronic A-V block, evaluations of cardiac function were performed during the phase of the development of hypertrophy (one and two...

Minimum requirements for the measurement of regional myocardial flow using tracer microspheres (1977)

Winkler, B, Wüsten, B, Schaper, W

Cardiac function in the chronically volume-overloaded canine heart (1977)

Schaper, W

In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1...

Role of cardiac contractility in hypertrophy from chronic volume loading (1977)

WÜSTEN, B., FLAMENG, W., WINKLER, B., SCHAPER, W.

In an experimental model of chronic cardiac volume overloading, ie chronic A-V block, evaluations of cardiac function were performed during the phase of the development of hypertrophy (one and two...

Vascular and cardiac contractile reserve in the dog heart with chronic multiple coronary occlusions (1976)

Mack, B, Türschmann, W, Schaper, W

Nineteen mongrel dogs survived chronic occlusion of the left circumflex and of the right coronary artery without infarction due to the timely development of a collateral circulation. Only 38 per cent...

Influence of tachycardia on regional myocardial flow in chronic experimental coronary occlusion (1976)

Coronary dilatation reserve in experimental cardiac-hypertrophy (1976)

The influences of tachycardia on regional myocardial flow was studied in normal dogs and in dogs with chronic coronary artery occlusions. Coronary vasodilation was induced by coronary occlusion and...

Wusten, B, Turschmann, W, Schaper, W

Effects of prindolol on isoproterenol-induced subendocardial ischaemia in dogs with multiple chronic coronary artery occlusion (1975)

Influence of perfusion pressure and heart rate on local myocardial flow in the collateralized heart with chronic coronary occlusion (1975)

Multiple chronic coronary artery occlusions were produced in dogs by implantation of ameroid rings on the circumflex branches of the left and right coronary artery. Sixty-five per cent of the animals...

Wüsten, B, Winkler, B, Pasyk, S, Schaper, W

We studied the influence of controlled changes in perfusion pressure and heart rate on the regional distribution of myocardial flow in normal dogs and in dogs with multiple chronic coronary artery...

Nutritional flow in the collateralized heart (1975)

[Coronary dilation reserve in experimental cardiac hypertrophy] (1975)

Türschmann, W, Schaper, W

Effects of prindolol on isoproterenol-induced subendocardial ischaemia in dogs with multiple chronic coronary artery occlusion (1975)

FLAMENG, W., WÜSTEN, B., SCHAPER, W.

AUTHORS' SYNOPSISMultiple chronic coronary artery occlusions were produced in dogs by implantation of ameroid rings on the circumflex branches of the left and right coronary artery. Sixty-five per...

Behaviour of the coronary collateral circulation after release acute left circumflex coronary artery occlusion in the present of the massive myocardial infarction (1974)

[Subendocardial ischemia in frequency-induced stress and decreased perfusion pressure] (1974)

Wüsten, B, Pasyk, S, Schaper, W

On the distribution of myocardial flow. Part II: Effects of arterial stenosis and vasodilation (1974)