Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...
Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...
Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...
Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...
Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...
Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...
Greystoke, A., Blagden, S., Thomas, A. L., Scott, E., Attard, G., Molife, R., ...
Background: TZT-1027 is a tubulin-binding drug and synthetic derivative of dolastatin-10 with cytotoxic and antivascular activity in vitro and in vivo. Studies have demonstrated anti-tumour activity...
Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., ...
Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the anti-idiotypic network, to stimulate immune...
Greystoke, A., Blagden, S., Thomas, A. L., Scott, E., Attard, G., Molife, R., ...
Background: TZT-1027 is a tubulin-binding drug and synthetic derivative of dolastatin-10 with cytotoxic and antivascular activity in vitro and in vivo. Studies have demonstrated anti-tumour activity...
Lapointe, R., Létourneau, R., Steward, W., Hawkins, R. E., Batist, G., Vincent, M., ...
Background: Troxacitabine (Troxatyl™) is a novel L-enantiomer nucleoside analog with activity in pancreatic cancer xenograft models. Patients and methods: Troxacitabine 1.5 mg/m2 was administered...
NCIC-CTG phase II study of gemcitabine in patients with malignant glioma (IND.94) (2000)
Gertler, S. Z., MacDonald, D., Goodyear, M., Forsyth, P., Stewart, D. J., Belanger, K., ...
Purpose: We conducted a phase II multicentre study of gemcitabine in patients with anaplastic astrocytoma and glioblastoma multiforme at first relapse. Patients and methods: Patients with anaplastic...
Ten Bokkel Huinink, W. W., Prove, A. M., Piccart, M., Steward, W., Tursz, T., Wanders, J., ...
Background Docetaxel, a semisynthetic analog of paclitaxel, made for the needles of the European yew, Taxus baccata, is a potentially important chemotherapeutic agent for the treatment of cancer....
Steward, W, Blackledge, G, Verweij, J
In multicentre studies, non-compliance with the protocol may limit the chances of reaching a correct conclusion. A procedure to examine the administration of chemotherapy in multicentre EORTC...
High-dose DTIC in advanced soft-tissue sarcomas in the adult (1991)
SYLVESTER, Richard, Buesa, J.M., Mouridsen, H.T., Van Oosterom, A.T., Verweij, J., Wagener, T., ...
High-dose DTIC in advanced soft-tissue sarcomas in the adult (1991)
Buesa, J.M., Mouridsen, H.T., Van Oosterom, A.T., Verweij, J., Wagener, T., Steward, W., ...
Forty-four of 50 adult patients with advanced soft-tissue sarcoma who had received previous chemotherapy were evaluable for response after treatment with DTIC. The therapeutic schedule consisted of...
Buesa, J. M., Mouridsen, H. T., Van Oosterom, A. T., Verweij, J., Wagener, T., Steward, W., ...
Forty-four of 50 adult patients with advanced soft-tissue sarcoma who had received previous chemotherapy were evaluable for response after treatment with DTIC. The therapeutic schedule consisted of...
Santoro, A, Rouesse, J, Mouridsen, H, Steward, W, ...
Despite the low incidence of sarcomas, the Soft Tissue and Bone Sarcoma Group has established itself as one of the more active cooperative groups of the European Organization for Research and...
Chemotherapy for upper gastrointestinal tumours
Thomas, A, O'Byrne, K, Steward, W
The aim of this review is to identify current chemotherapy treatment for tumours of the oesophagus, stomach, pancreas, and liver. The role of both neoadjuvant, adjuvant, and palliative chemotherapy...
Familiar drugs may prevent cancer
Sharma, R, Gescher, A, O'Byrne, K, Steward, W
Despite positive results in large scale chemoprevention trials, many physicians are unaware of the potential cancer preventive properties of drugs in common usage. The antioestrogen tamoxifen and the...
rhGM-CSF ameliorates neutropenia in patients with malignant glioma treated with BCNU.
Rampling, R., Steward, W., Paul, J., Macham, M. A., Harvey, E., Eckley, D.
Nitrosoureas are the drugs most effective in the treatment of patients with intracerebral malignant glioma. Their limiting toxicity is delayed myelosuppression. A prospective, randomised crossover...
Volunteers or victims: patients' views of randomised cancer clinical trials.
Slevin, M., Mossman, J., Bowling, A., Leonard, R., Steward, W., Harper, P., ...
Randomised clinical trials are essential for the objective evaluation of different treatment strategies in cancer. However, in the field of oncology, very few of the eligible patients are entered...
Nielsen, O. S., Dombernowsky, P., Mouridsen, H., Crowther, D., Verweij, J., Buesa, J., ...
The activity and toxicity of single-agent standard-dose doxorubicin were compared with that of two schedules of high-dose epirubicin. A total of 334 chemonaive patients with histologically confirmed...