Ganten, T.M., Koschny, R., Sykora, J., Schulze-Bergkamen, H., Buchler, P., Haas, T.L., ...
Purpose: Tumor necrosis factor-related apoptosis¿inducing ligand (TRAIL/Apo2L) exhibits potent antitumor activity on systemic administration in nonhuman primates without deleterious side effects for...
Apoptosis as the pathomechanism of liver failure caused by amanita mushrooms. (2002)
Koch, A. F., Kienhues, A., Krammer, P., Stremmel, W., Mueller, M.
Rudi, J, Kolb, C, Maiwald, Matthias, Kuck, D, Sieg, A, Galle, PR, ...
The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were...
Rudi, J, Kolb, C, Maiwald, Matthias, Kuck, D, Sieg, A, Galle, PR, ...
The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were...
Rudi, J, Kolb, C, Maiwald, Matthias, Kuck, D, Sieg, A, Galle, PR, ...
The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were...
Rudi, J, Kolb, C, Maiwald, Matthias, Kuck, D, Sieg, A, Galle, PR, ...
The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were...
Rudi, J, Kolb, C, Maiwald, Matthias, Kuck, D, Sieg, A, Galle, PR, ...
The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were...
Torres, A M, Lunazzi, G C, Stremmel, W, Tiribelli, C
The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic...
When [14C]oleate bound to bovine serum albumin was incubated at 37 degrees C for 7 min with isolated rat hepatocytes in the absence of glucose, the cumulative oleate uptake curve had two components:...
Stremmel, W, Strohmeyer, G, Berk, P D
Several studies suggest that a portion of hepatocellular nonesterified fatty acid uptake may be carrier mediated. To further investigate this process, initial rates (Vo) of [14C]oleate uptake into...
To investigate the hypothesis that iron absorption in man involves a carrier-mediated cellular uptake mechanism, influx velocity (Vo) of 59Fe3+ by isolated human microvillous membrane (MVM) vesicles...
Stremmel, W, Gerber, M A, Glezerov, V, Thung, S N, Kochwa, S, Berk, P D
Affinity chromatography over bilirubinagarose and sulfobromophthalein (BSP)-agarose was used to isolate two proteins, with high affinities for bilirubin and BSP, respectively, from Triton...
Stremmel, W, Strohmeyer, G, Borchard, F, Kochwa, S, Berk, P D
When [14C]oleate-bovine serum albumin complexes were incubated in vitro with rat liver plasma membranes (LPM), specific, saturable binding of oleate to the membranes was observed. Maximal...
Stremmel, W, Lotz, G, Strohmeyer, G, Berk, P D
The mechanisms by which FFA are absorbed by the gut are unclear. To examine these processes, binding of [14C]oleate to isolated rat jejunal microvillous membranes (MVM) was studied in vitro. When...
To clarify sulfobromophthalein (BSP) and bilirubin uptake mechanisms, isolated rat hepatocytes were incubated with [35S]BSP. The initial uptake velocity (V0), determined from the first, linear...
Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.
The mechanism by which fatty acids enter cardiomyocytes is unclear. Therefore, the influx kinetics of [3H]oleate into isolated rat heart myocytes were examined. Cells were incubated at 37 degrees C...
Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.
The previous identification of a membrane fatty acid binding protein (MFABP) in brush border plasma membranes of the jejunum suggested that mucosal cell uptake of fatty acids might represent a...
Müller, M, Strand, S, Hug, H, Heinemann, E M, Walczak, H, Hofmann, W J, ...
Chemotherapeutic drugs are cytotoxic by induction of apoptosis in drug-sensitive cells. We investigated the mechanism of bleomycin-induced cytotoxicity in hepatoma cells. At concentrations present in...
Rudi, J, Kuck, D, Strand, S, Von Herbay, A, Mariani, S M, Krammer, P H, ...
Helicobacter pylori infection is associated with chronic gastritis, peptic ulceration, and gastric carcinoma. The potential role of CD95-mediated apoptosis was investigated in a panel of gastric...
Riedel, H D, Remus, A J, Fitscher, B A, Stremmel, W
Reduction of ferric iron in the presence of HuTu 80 cells or duodenal microvillus membranes (MVMs) was investigated. With both systems, NADH-dependent reduction of Fe3+/NTA (nitrilotriacetic acid)...
Torres, A M, Lunazzi, G C, Stremmel, W, Tiribelli, C
The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic...
When [14C]oleate bound to bovine serum albumin was incubated at 37 degrees C for 7 min with isolated rat hepatocytes in the absence of glucose, the cumulative oleate uptake curve had two components:...
Stremmel, W, Strohmeyer, G, Berk, P D
Several studies suggest that a portion of hepatocellular nonesterified fatty acid uptake may be carrier mediated. To further investigate this process, initial rates (Vo) of [14C]oleate uptake into...
To investigate the hypothesis that iron absorption in man involves a carrier-mediated cellular uptake mechanism, influx velocity (Vo) of 59Fe3+ by isolated human microvillous membrane (MVM) vesicles...
Stremmel, W, Gerber, M A, Glezerov, V, Thung, S N, Kochwa, S, Berk, P D
Affinity chromatography over bilirubinagarose and sulfobromophthalein (BSP)-agarose was used to isolate two proteins, with high affinities for bilirubin and BSP, respectively, from Triton...
Stremmel, W, Strohmeyer, G, Borchard, F, Kochwa, S, Berk, P D
When [14C]oleate-bovine serum albumin complexes were incubated in vitro with rat liver plasma membranes (LPM), specific, saturable binding of oleate to the membranes was observed. Maximal...
Stremmel, W, Lotz, G, Strohmeyer, G, Berk, P D
The mechanisms by which FFA are absorbed by the gut are unclear. To examine these processes, binding of [14C]oleate to isolated rat jejunal microvillous membranes (MVM) was studied in vitro. When...
To clarify sulfobromophthalein (BSP) and bilirubin uptake mechanisms, isolated rat hepatocytes were incubated with [35S]BSP. The initial uptake velocity (V0), determined from the first, linear...
Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.
The mechanism by which fatty acids enter cardiomyocytes is unclear. Therefore, the influx kinetics of [3H]oleate into isolated rat heart myocytes were examined. Cells were incubated at 37 degrees C...
Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.
The previous identification of a membrane fatty acid binding protein (MFABP) in brush border plasma membranes of the jejunum suggested that mucosal cell uptake of fatty acids might represent a...
Müller, M, Strand, S, Hug, H, Heinemann, E M, Walczak, H, Hofmann, W J, ...
Chemotherapeutic drugs are cytotoxic by induction of apoptosis in drug-sensitive cells. We investigated the mechanism of bleomycin-induced cytotoxicity in hepatoma cells. At concentrations present in...
Rudi, J, Kuck, D, Strand, S, Von Herbay, A, Mariani, S M, Krammer, P H, ...
Helicobacter pylori infection is associated with chronic gastritis, peptic ulceration, and gastric carcinoma. The potential role of CD95-mediated apoptosis was investigated in a panel of gastric...
Riedel, H D, Remus, A J, Fitscher, B A, Stremmel, W
Reduction of ferric iron in the presence of HuTu 80 cells or duodenal microvillus membranes (MVMs) was investigated. With both systems, NADH-dependent reduction of Fe3+/NTA (nitrilotriacetic acid)...
Boehme, M W, Deng, Y, Raeth, U, Bierhaus, A, Ziegler, R, Stremmel, W, ...
Inflammatory cytokines decrease the expression of thrombomodulin (TM) on the endothelial cell surface by suppression of TM transcription and translation or internalization with subsequent...
Thiele, K, Bierhaus, A, Autschbach, F, Hofmann, M, Stremmel, W, Thiele, H, ...
BACKGROUND/AIMS/PATIENTS—Glucocorticoid treatment is known to reduce nuclear factor-kappa B (NF-κB)p65 binding activity and activation in lamina propria cells of patients with Crohn's disease....
Hepatic iron overload in aceruloplasminaemia
Hellman, N, Schaefer, M, Gehrke, S, Stegen, P, Hoffman, W, Gitlin, J, ...
We report the case of a 52 year old male with diabetes mellitus and long standing evidence of hepatic iron excess. Initially considered to have haemochromatosis, this patient was reevaluated when...
Engler, S, Elsing, C, Flechtenmacher, C, Theilmann, L, Stremmel, W, Stiehl, A
Background: We present nine patients with progressive sclerosing cholangitis after septic shock.
Kulaksiz, H, Gehrke, S G, Janetzko, A, Rost, D, Bruckner, T, Kallinowski, B, ...
Background and aims: The hepatic peptide hormone hepcidin, which has recently been isolated from human plasma and urine, is thought to be a central regulator of iron homeostasis. We investigated the...
Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection
Encke, J, Findeklee, J, Geib, J, Pfaff, E, Stremmel, W
Antigen uptake and presentation capacities enable DC to prime and activate T cells. Recently, several studies demonstrated a diminished DC function in hepatitis C virus (HCV) infected patients...
Kallinowski, B, Haseroth, K, Marinos, G, Hanck, C, Stremmel, W, Theilmann, L, ...
There is evidence that TNF-α contributes to the pathogenesis of chronic viral hepatitis. The cellular effects of this cytokine are regulated by two specific receptors, and membranous shedding of...
Boehme, M W J, Raeth, U, Galle, P R, Stremmel, W, Scherbaum, W A
To date no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury and vasculitis. The objective of this...
Boehme, M W J, Raeth, U, Scherbaum, W A, Galle, P R, Stremmel, W
Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin,...
Veltkamp, C, Sartor, R B, Giese, T, Autschbach, F, Kaden, I, Veltkamp, R, ...
Background and aims: Erroneous thymic selection of developing T lymphocytes may be responsible for the expansion of self reactive T cells or may contribute to the absence of regulatory T cells...
Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
Stremmel, W, Merle, U, Zahn, A, Autschbach, F, Hinz, U, Ehehalt, R
Background and aims: We examined the hypothesis of an anti-inflammatory effect of phosphatidylcholine in ulcerative colitis.