Activation of ERK/MAPK in the Lateral Amygdala of the Mouse is Required for Acquisition of a Fear-Potentiated Startle response (2009)
Di Benedetto, B.,
Kallnik, M.,
Vogt-Weisenhorn, D. M.,
Falls, W. A.,
Wurst, W.,
Hölter, S. M.
Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling (2009)
Kamprath, K.,
Plendl, W.,
Marsicano, G.,
Deussing, J. M.,
Wurst, W.,
Lutz, B.,
...
The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models (2009)
Fuchs, H.,
Gailus-Durner, V.,
Adler, T.,
Pimentel, J. A. A.,
Becker, L.,
Bolle, I.,
...
AMYGDALOID pERK1/2 IN CORTICOTROPIN-RELEASING HORMONE OVEREXPRESSING MICE UNDER BASAL AND ACUTE STRESS CONDITIONS (2009)
Silberstein, S.,
Vogl, A. M.,
Refojo, D.,
Senin, S. A.,
Wurst, W.,
Holsboer, F.,
...
A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice (2009)
Enard, W.,
Gehre, S.,
Hammerschmidt, K.,
Hölter, S. M.,
Blass, T.,
Somel, M.,
...
CENTRAL CORTICOTROPIN-RELEASING HORMONE OVEREXPRESSION ENHANCES REM SLEEP IN CONDITIONAL TRANSGENIC MICE (2009)
Kimura, M.,
Müller-Preuss, P.,
Lu, A.,
Wiesner, E.,
Flachskamm, C.,
Wurst, W.,
...
CRF1 and CRF2 Receptors are Required for Potentiated Startle to Contextual but not Discrete Cues (2009)
Risbrough, V. B.,
Geyer, M. A.,
Hauger, R. L.,
Coste, S.,
Stenzel-Poore, M.,
Wurst, W.,
...
Immunology, Signal Transduction, and Behavior in Hypothalamic-Pituitary-Adrenal Axis-related Genetic Mouse Models (2009)
Silberstein, S.,
Vogl, A. M.,
Bonfiglio, J. J.,
Wurst, W.,
Holsboer, F.,
Arzt, E.,
...
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain (2009)
Prakash, N.,
Puelles, E.,
Freude, K.,
Trumbach, D.,
Omodei, D.,
Di Salvio, M.,
...
Functional validation of P2RX7 as a susceptibility marker for depression using humanized mouse mutants (2009)
Walser, S. M.,
Henniger, M.,
Oldekamp, J.,
Holsboer, F.,
Wurst, W.,
Sillaber, I.,
...
"Sighted C3H" mice - a tool for analysing the influence of vision on mouse behavior? (2008)
Hölter, S. M.,
Dalke, C.,
Kallnik, M.,
Becker, L.,
Horsch, M.,
Schrewe, A.,
...
Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area - Possible novel signalling pathways (2008)
Tsolakidou, A.,
Trumbach, D.,
Panhuysen, M.,
Pütz, B.,
Deussing, J.,
Wurst, W.,
...
Genetic mouse models for behavioral analysis through transgenic RNAi technology (2008)
Delic, S.,
Streif, S.,
Deussing, J. M.,
Weber, P.,
Ueffing, M.,
Hölter, S. M.,
...
CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells (2008)
Kronsbein, H. C.,
Jastorff, A. M.,
Maccarrone, G.,
Stalla, G.,
Wurst, W.,
Holsboer, F.,
...
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon (2008)
Omodei, D.,
Acampora, D.,
Mancuso, P.,
Prakash, N.,
Di Giovannantonio, L. G.,
Wurst, W.,
...
Conditional overexpression of corticotropin-releasing hormone in mice, an animal model for understanding the development of corticotropin-releasing hormone-mediated brain pathology (2008)
Deussing, J. M.,
Lu, A.,
Steiner, M. A.,
Vogl, A. M.,
Holsboer, F.,
Wotjak, C. T.,
...
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death (2008)
Seiler, A.,
Schneider, M.,
Forster, H.,
Roth, S.,
Wirth, E. K.,
Culmsee, C.,
...
Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice (2008)
Tripathi, P. P.,
Di Giovannantonio, L. G.,
Viegi, A.,
Wurst, W.,
Simeone, A.,
Bozzi, Y.
Novel Caspase-Suicide Proteins for Tamoxifen-Inducible Apoptosis (2008)
Chu, Y. Y.,
Senghaas, N.,
Köster, R. W.,
Wurst, W.,
Kühn, R.
Taking advantage of a mutant estrogen receptor ligand binding domain (ER T), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ERT2 fusion proteins become...
TRANSGENIC OVEREXPRESSION OF CORTICOTROPIN RELEASING HORMONE PROVIDES PARTIAL PROTECTION AGAINST NEURODEGENERATION IN AN IN VIVO MODEL OF ACUTE EXCITOTOXIC STRESS (2008)
Hanstein, R.,
Lu, A.,
Wurst, W.,
Holsboer, F.,
Deussing, J. M.,
Clement, A. B.,
...
Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic-pituitaryadrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning,...
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior (2008)
Lu, A.,
Steiner, M. A.,
Whittle, N.,
Vogl, A. M.,
Walser, S. M.,
Ableitner, M.,
...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. Both, basic and clinical studies suggested that disrupting CRH...
Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain (2007)
Blak, A. A.,
Naserke, T.,
Saarimaki-Vire, J.,
Peltopuro, P.,
Giraldo-Velasquez, M.,
Vogt-Weisenhorn, D. M.,
...
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity (2007)
Deussing, J. M.,
Kuhne, C.,
Pütz, B.,
Panhuysen, M.,
Breu, J.,
Stenzel-Poore, M. P.,
...
Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1 (2007)
Görner, K.,
Holtorf, E.,
Waak, J.,
Pham, T. T.,
Vogt-Weisenhorn, D. M.,
Wurst, W.,
...
Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice (2007)
Kallnik, M.,
Elvert, R.,
Ehrhardt, N.,
Kissling, D.,
Mahabir, E.,
Welzl, G.,
...
Comparison of gene expression patterns in murine blood and brain after chronic paroxetine treatment (2007)
Kronsbein, H. C.,
Weber, P.,
Refojo, D.,
Wurst, W.,
Holsboer, F.,
Deussing, J. M.
Role of CRF-R1 and CRF-R2 receptors in unconditioned and conditioned fear-induced increases in startle (2007)
Risbrough, V. B.,
Coste, S.,
Stenzel-Poore, M.,
Wurst, W.,
Hauger, R.,
Geyer, M. A.
Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain (2007)
Saarimaki-Vire, J.,
Peltopuro, P.,
Lahti, L.,
Naserke, T.,
Blak, A. A.,
...
Ontogeny of steroid receptor coactivators in thehippocampus and their role in regulating postnatal HPA axis function (2007)
Schmidt, M. V.,
Oitzl, M.,
Steenbergen, P.,
Lachize, S.,
Wurst, W.,
Müller, M. B.,
...
The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour (2007)
Vauti, F.,
Goller, T.,
Beine, R.,
Becker, L.,
Klopstock, T.,
Hölter, S. M.,
...
Differential disinhibition of the neonatal hypothalamic-pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice (2006)
Schmidt, M. V.,
Deussing, J. M.,
Oitzl, M. S.,
Ohl, F.,
Levine, S.,
Wurst, W.,
...
Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice (2006)
Borgkvist, A.,
Puelles, E.,
Carta, M.,
Acampora, D.,
Ang, S. L.,
Wurst, W.,
...
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells (2006)
De-Zolt, S.,
Schnütgen, F.,
Seisenberger, C.,
Hansen, J.,
Hollatz, M.,
Floss, T.,
...
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse (2006)
Galy, B.,
Hölter, S. M.,
Klopstock, T.,
Ferring, D.,
Becker, L.,
Kaden, S.,
...
Molecular characterization, structure and developmental expression of Megane bHLH factor (2006)
Guimera, J.,
Vogt-Weisenhorn, D.,
Echevarria, D.,
Martinez, S.,
Wurst, W.
Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge (2006)
Nguyen, N. K.,
Keck, M. E.,
Hetzenauer, A.,
Thöringer, C. K.,
Wurst, W.,
Deussing, J. M.,
...
In vivo characterization of embryonic dopaminergic neurons derived from transgenic mice ectopically expressing Otx2 in the anterior hindbrain (2006)
Papazoglou, A.,
Hackl, C.,
Klein, A.,
Prakash, N.,
Wurst, W.,
Nikkhah, G.
Lysosomal storage disease upon disruption of the neuronal chloride transport protein CIC-6 (2006)
Poët, M.,
Kornak, U.,
Schweizer, M.,
Zdebik, A. A.,
Scheel, O.,
Hoelter, S.,
...
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo (2006)
Prakash, N.,
Brodski, C.,
Naserke, T.,
Puelles, E.,
Gogoi, R.,
Hall, A.,
...
Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice (2006)
Schmidt, M.V.,
Deussing, J.M.,
Oitzl, M.S.,
Ohl, F.,
Levine, S.,
Wurst, W.,
...
In the adult, corticotropin-releasing hormone (CRH) is the key mediator for the behavioural and neuroendocrine response to stress. It has also been hypothesized that, during postnatal development of...
Evolutionarily conserved role of nucleostemin: Controlling proliferation of stem/progenitor cells during early vertebrate development (2006)
Beekman, Chantal,
NICHANE, M,
De Clercq, Sarah,
Maetens, Marion,
FLOSS, T,
WURST, W,
...
Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse (2005)
Blak, A. A.,
Naserke, T.,
Vogt Weisenhorn, D. M.,
Prakash, N.,
Partanen, J.,
Wurst, W.
Gene expression profiling reveals corticotropin-releasing hormone (CRH) dependent signaling pathways (2005)
Deussing, J. M.,
Kühne, C.,
Panhuysen, M.,
Pütz, B.,
Breu, J.,
Paez-Pereda, M.,
...
Introducing the German Mouse Clinic: open access platform for standardized phenotyping (2005)
Gailus-Durner, V.,
Fuchs, H.,
Becker, L.,
Bolle, I.,
Brielmeier, M.,
Calzada-Wack, J.,
...
Molecular mechanisms controlling the development of dopaminergic and noradrenergic neurons (2005)
Hakim, V.,
Prakash, N.,
Naserke, T.,
Puelles, E.,
Liser, K.,
Goldhand, T.,
...
Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality (vol 42, pg 91, 2005) (2005)
Hitz, C.,
Vogt-Weisenhorn, D.,
Ruiz, P.,
Wurst, W.,
Floss, T.
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development (2005)
Jakupoglu, C.,
Przemeck, G. K. H.,
Schneider, M.,
Moreno, S. G.,
Mayr, N.,
Hatzopoulos, A. K.,
...
Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain - modelling central CRH system hyperactivity (2005)
Lu, A.,
Steiner, M.,
Engelholm, M.,
Engelholm, M.,
Wotjak, C. T.,
Holsboer, F.,
...
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas (2005)
Refojo, D.,
Echenique, C.,
Müller, M. B.,
Deussing, J. M.,
Wurst, W.,
...
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (vol 119, pg 589, 2003) (2005)
Schmidt, M. V.,
Oitzl, M. S.,
Müller, M. B.,
Ohl, F.,
Wurst, W.,
Holsboer, F.,
...
Conditional Crh1 receptor knockout mice show altered neuronal activation pattern to mild anxiogenic challenge (2005)
Singewald, N.,
Nguyen, N. K.,
Hetzenauer, A.,
Thöringer, C. K.,
Wurst, W.,
Deussing, J.,
...
Fgfr1-dependent boundary cells between developing mid- and hindbrain (2005)
Trokovic, R.,
Jukkola, T.,
Saarimaki, J.,
Peltopuro, P.,
Naserke, T.,
Vogt-Weisenhorn, D. M.,
...
The knockout mouse project (2004)
Austin, C. P.,
Battey, J. F.,
Bradley, A.,
Bucan, M.,
Capecchi, M.,
Collins, F. S.,
...
Multiple roles of ephrins during the formation of thalamocortical projections: Maps and more (2004)
Bolz, J.,
Uziel, D.,
Mühlfriedel, S.,
Gullmar, A.,
Peuckert, C.,
Zarbalis, K.,
...
Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus (2004)
Chen, Y. C.,
Bender, R. A.,
Brunson, K. L.,
Pomper, J. K.,
Grigoriadis, D. E.,
Wurst, W.,
...
Limbic Crhr1 mediates anxiety-related behaviour and is required for hormonal adaptation to stress (2004)
Müller, M. B.,
Zimmermann, S.,
Sillaber, I.,
Hagemeyer, T. P.,
Deussing, J. M.,
Droste, S.,
...
Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region (2004)
Panhuysen, M.,
Weisenhorn, D. M. V.,
Blanquet, V.,
Brodski, C.,
Heinzmann, U.,
Beisker, W.,
...
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain (2004)
Puelles, E.,
Annino, A.,
Tuorto, F.,
Usiello, A.,
Acampora, D.,
Czerny, T.,
...
The European dimension for the mouse genome mutagenesis program (2004)
Auwerx, J.,
Avner, P.,
Baldock, R.,
Ballabio, A.,
Balling, R.,
Barbacid, M.,
...
The European Mouse Mutagenesis Consortium is the European initiative contributing to the international effort on functional annotation of the mouse genome. Its objectives are to establish and...
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice (2003)
Corradi, A,
Croci, L,
Broccoli, V,
Zecchini, S,
Previtali, S,
Wurst, W,
...
Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion...
Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain hindbrain organizer (2003)
Brodski, C.,
Weisenhorn, D. M. V.,
Signore, M.,
Sillaber, I.,
Oesterheld, M.,
Broccoli, V.,
...
Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the mid-hindbrain organizer (2003)
Brodski, C.,
Weisenhorn, D. V.,
Signore, M.,
Naserke, T.,
Fischer, T.,
Sillaber, I.,
...
Addressing in vivo functions of urocortin III, a novel member of the CRH family of neuropeptides (2003)
Deussing, J.,
Breu, J.,
Binder, E. B.,
Ohl, F.,
Holsboer, F.,
Wurst, W.
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome (2003)
Hansen, J.,
Floss, T.,
Van Sloun, P.,
Fuchtbauer, E. M.,
Vauti, F.,
Arnold, H. H.,
...
Limbic Crhr1 mediates anxiety-related behaviour and is required for hormonal adaptation to stress (2003)
Müller, M. B.,
Zimmermann, S.,
Sillaber, I.,
Hagemeyer, T. P.,
Deussing, J.,
Droste, S.,
...
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain (2003)
Puelles, E.,
Acampora, D.,
Lacroix, E.,
Signore, M.,
Annino, A.,
Tuorto, F.,
...
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice (2003)
Schmidt, M.,
Oitzl, M. S.,
Müller, M. B.,
Ohl, F.,
Wurst, W.,
Holsboer, F.,
...
Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: A potential link to microglia and atrocytes that express CRH-R1 (2003)
Stevens, S. L.,
Shaw, T. E.,
Dykhuizen, E.,
Lessov, N. S.,
Hill, J. K.,
Wurst, W.,
...
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals (2003)
Trokovic, R.,
Trokovic, N.,
Hernesniemi, S.,
Pirvola, U.,
Weisenhorn, D. M. V.,
Rossant, J.,
...
Miswiring of limbic thalamocortical projections in the absence of ephrin-A5 (2002)
Uziel, D,
Mühlfriedel, S,
Zarbalis, K,
Wurst, W,
Levitt, P,
Bolz, J
Axon guidance cues of the ephrin ligand family have been hypothesized to regulate the formation of thalamocortical connections, but in vivo evidence for such a role has not been examined directly. To...
Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling (2002)
Landgrebe, J,
Welzl, G,
Metz, T,
Van Gaalen, MM,
Ropers, H,
Wurst, W,
...
Antidepressants arc widely used for the treatment of psychiatric disorders, including depression and anxiety. Although they are efficient drugs. there are several unsolved questions regarding their...
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors (2002)
Sillaber, I,
Rammes, G,
Zimmermann, S,
Mahal, B,
Zieglgänsberger, W,
Wurst, W,
...
There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the...
mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons (2002)
Pfaar, H,
Von Holst, A,
Weisenhorn, DMV,
Brodski, C,
Guimera, J,
Wurst, W
Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to...
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: An in vivo microdialysis study in mutant mice (2002)
Peñalva, RG,
Flachskamm, C,
Zimmermann, S,
Wurst, W,
Holsboer, F,
Reul, JMHM,
...
Corticotropin-releasing hormone plays an important role in the coordination of various responses to stress. Previous research has implicated both corticotropin-releasing hormone and the serotonergic...
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. (2001)
Preil, J.,
Müller, M. B.,
Gesing, A.,
Sillaber, I.,
Van Gaalen, M. M.,
...
Expression of CRHR 1 and CRHR 2 in mouse pituitary and adrenal gland: implications for HPA system regulation. (2001)
Müller, M. B.,
Preil, J.,
Renner, U.,
Zimmermann, S.,
Kresse, A. E.,
Stalla, G. K.,
...
Functional annotation of mouse genome sequences. (2001)
Nadeau, H.,
Balling, R.,
Barsh, G.,
Beier, D.,
Brown, S. D. M.,
Bucan, M.,
...
Targeted mutagenesis of Lis 1 disrupts cortical development and LIS 1 homodimerization. (2001)
Cahana, A.,
Escamez, T.,
Nowakowski, R. S.,
Hayes, N. L.,
Giacobini, M.,
Holst, A. Von,
...
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells. (2000)
Wiles, M. V.,
Vauti, F.,
Otte, J.,
Ruiz, P.,
Füchtbauer, A.,
...
An induction gene trap for identifying a homeoprotein-regulated locus. (2000)
Mainguy, G.,
Montesinos, M. L.,
Lesaffre, B.,
Zevnik, B.,
Karasawa, M.,
Kothary, R.,
...
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. (2000)
Müller, M. B.,
Landgraf, R.,
Preil, J.,
Sillaber, I.,
Kresse, A. E.,
Keck, M. E.,
...
Regulation of Epidermal Bullous Pemphigoid Antigen 1 (BPAG 1 e) synthesis by homeoprotein transcription factors. (1999)
Mainguy, G.,
Ernø, H.,
Montesinos, M. L.,
Lesaffre, B.,
Wurst, W.,
Volovitch, M.,
...
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. (1998)
Timpl, P.,
Spanagel, R.,
Sillaber, I.,
Kresse, A.,
Stalla, G. K.,
...
Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif. (1998)
Sam, M.,
Wurst, W.,
Klüppel, M.,
Jin, O.,
Heng, H.,
Bernstein, A.
Pharmacokinetics of pantoprazole in patients with end-stage renal failure (1998)
Kliem, V,
Bahlmann, J,
Hartmann, M,
Huber, R,
Luhmann, R,
Wurst, W
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Forrester, L M,
Nagy, A,
Sam, M,
Watt, A,
Stevenson, L,
Bernstein, A,
...
We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of receptor/ligand-mediated signaling pathways. Using this approach, we...
The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability
Conrad, M.,
Moreno, S. G.,
Sinowatz, F.,
Ursini, F.,
Kölle, S.,
Roveri, A.,
...
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is regarded as the major molecular target of selenodeficiency in rodents, accounting for most of the histopathological and...
A Large-Scale Gene-Trap Screen for Insertional Mutations in Developmentally Regulated Genes in Mice
Wurst, W.,
Rossant, J.,
Prideaux, V.,
Kownacka, M.,
Joyner, A.,
Hill, D. P.,
...
We have used a gene-trap vector and mouse embryonic stem (ES) cells to screen for insertional mutations in genes developmentally regulated at 8.5 days of embryogenesis (dpc). From 38,730 cell lines...
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Forrester, L M,
Nagy, A,
Sam, M,
Watt, A,
Stevenson, L,
Bernstein, A,
...
We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of receptor/ligand-mediated signaling pathways. Using this approach, we...
The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability
Conrad, M.,
Moreno, S. G.,
Sinowatz, F.,
Ursini, F.,
Kölle, S.,
Roveri, A.,
...
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is regarded as the major molecular target of selenodeficiency in rodents, accounting for most of the histopathological and...
A Large-Scale Gene-Trap Screen for Insertional Mutations in Developmentally Regulated Genes in Mice
Wurst, W.,
Rossant, J.,
Prideaux, V.,
Kownacka, M.,
Joyner, A.,
Hill, D. P.,
...
We have used a gene-trap vector and mouse embryonic stem (ES) cells to screen for insertional mutations in genes developmentally regulated at 8.5 days of embryogenesis (dpc). From 38,730 cell lines...
Lack of pharmacokinetic interaction of pantoprazole with diazepam in man
GUGLER, R.,
HARTMANN, M.,
RUDI, J.,
BROD, I.,
HUBER, R.,
STEINIJANS, V. W.,
...
Pantoprazole, a substituted benzimidazole, is a potent and well tolerated inhibitor of the gastric H+,K+-ATPase with a low potential to inhibit cytochrome P450. In this randomized, placebo-controlled...
Deletion of Glucose Transporter GLUT8 in Mice Increases Locomotor Activity
Schmidt, S.,
Gawlik, V.,
Hölter, S. M.,
Augustin, R.,
Scheepers, A.,
Behrens, M.,
...
Transport of glucose into neuronal cells is predominantly mediated by the glucose transporters GLUT1 and GLUT3. In addition, GLUT8 is expressed in some regions of the brain. By in situ hybridization...
Current status of acid pump antagonists (reversible PPIs).
Wurst, W.,
Hartmann, M.
The introduction of H2-receptor antagonists in the mid-1970s provided, for the first time, acceptable medical therapy for acid-related diseases. Their short duration of action and single receptor...
Optimizing the intragastric pH as a supportive therapy in upper GI bleeding.
Brunner, G.,
Luna, P.,
Hartmann, M.,
Wurst, W.
Acid inhibitory therapy has long been considered of no benefit for upper GI bleeding. The reason was that achlorhydria in the stomach could not be achieved with any single or combination of acid...