Lymperopoulos, Anastasios, Rengo, Giuseppe, Zincarelli, Carmela, Kim, Jihee, Soltys, Stephen, Koch, Walter J
Aldosterone produces a multitude of effects in vivo, including promotion of postmyocardial infarction adverse cardiac remodeling and heart failure progression. It is produced and secreted by the...
Burns C. Blaxall, Ph. D, Rainer Spang, Ph. D, Howard A. Rockman, Walter J. Koch, ...
Copyright (c) 2003 by the American Physiological Society. Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We...
Leosco, Dario, Rengo, Giuseppe, Iaccarino, Guido, Golino, Luca, Marchese, Massimo, Fortunato, Francesca, ...
Aims We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We...
Giangrande, Paloma H., Zhang, JianXin, Tanner, Alice, Eckhart, Andrea D., Rempel, Rachel E., Andrechek, Eran R., ...
Intimal hyperplasia (IH) and restenosis limit the long-term utility of bypass surgery and angioplasty due to pathological proliferation and migration of vascular smooth muscle cells (VSMCs) into the...
Whalen, Erin J., Foster, Matthew W., Matsumoto, Akio, Ozawa, Kentaro, Violin, Jonathan D., Que, Loretta G., ...
β-adrenergic receptors (β-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein...
Giangrande, Paloma H., Zhang, JianXin, Tanner, Alice, Eckhart, Andrea D., Rempel, Rachel E., Andrechek, Eran R., ...
Intimal hyperplasia (IH) and restenosis limit the long-term utility of bypass surgery and angioplasty due to pathological proliferation and migration of vascular smooth muscle cells (VSMCs) into the...
Whalen, Erin J., Foster, Matthew W., Matsumoto, Akio, Ozawa, Kentaro, Violin, Jonathan D., Que, Loretta G., ...
β-adrenergic receptors (β-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein...
Leosco, Dario, Rengo, Giuseppe, Iaccarino, Guido, Golino, Luca, Marchese, Massimo, Fortunato, Francesca, ...
Aims We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular remodelling of the post-myocardial infarction failing heart. We also...
Harris, David M., Eckhart, Andrea D., Koch, Walter J.
No abstract available.
Hata, Jonathan A., Williams, Matthew L., Schroder, Jacob N., Lima, Brian, Keys, Janelle R., Blaxall, Burns C., ...
Background In human heart failure, increased expression of G protein–coupled receptor kinases (GRKs) causes the loss of β-adrenergic receptor (βAR) signaling and function. Mechanical unloading...
Hata, Jonathan A., Williams, Matthew L., Schroder, Jacob N., Lima, Brian, Keys, Janelle R., Blaxall, Burns C., ...
Background In human heart failure, increased expression of G protein–coupled receptor kinases (GRKs) causes the loss of β-adrenergic receptor (βAR) signaling and function. Mechanical unloading...
Tevaearai, Hendrik T., Walton, G. Brant, Keys, Janelle R., Koch, Walter J., Eckhart, Andrea D.
Acute myocardial ischemia is a critical adverse effect potentially occurring during cardiac procedures. A peptide inhibitor of the -adrenergic receptor kinase (ARK1), ARKct, has been successful in...
Tevaearai, Hendrik T., Walton, G. Brant, Keys, Janelle R., Koch, Walter J., Eckhart, Andrea D.
Acute myocardial ischemia is a critical adverse effect potentially occurring during cardiac procedures. A peptide inhibitor of the -adrenergic receptor kinase (ARK1), ARKct, has been successful in...
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure (2005)
Iaccarino, Guido, Barbato, Emanuele, Cipolletta, Ersilia, De Amicis, Vincenzo, Margulies, Kenneth B., Leosco, Dario, ...
Aims The G protein-coupled receptor kinase-2 (GRK2 or β-ARK1) regulates β-adrenergic receptors (β-ARs) in the heart, and its cardiac expression is elevated in human heart failure (HF). We sought...
Most,Patrick, Remppis,Andrew, Pleger,Sven T., Loffler,Eva, Ehlermann,Philipp, Bernotat,Juliane, ...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile...
Most, Patrick, Remppis, Andrew, Pleger, Sven T., Loffler, Eva, Ehlermann, Philipp, Bernotat, Juliane, ...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile...
Keys, Janelle R., Greene, Emily A., Cooper, Chris J., Naga Prasad, Sathyamangla V., Rockman, Howard A., Koch, Walter J.
The G protein-coupled receptor (GPCR) kinase, {beta}-adrenergic receptor ({beta}AR) kinase ({beta}ARK1) is elevated in heart failure, however its role is not fully understood. {beta}ARK1 contains...
Keys, Janelle R., Greene, Emily A., Cooper, Chris J., Naga Prasad, Sathyamangla V., Rockman, Howard A., Koch, Walter J.
The G protein-coupled receptor (GPCR) kinase, {beta}-adrenergic receptor ({beta}AR) kinase ({beta}ARK1) is elevated in heart failure, however its role is not fully understood. {beta}ARK1 contains...
Cross, Heather R, Murphy, Elizabeth, Koch, Walter J, Steenbergen, Charles
Objective: Cardiac overexpression of β2-adrenergic receptors (β2ARs) in male mice (MTG4) results in increased contractility and increased ischemic injury. Considering recent clinical data...
Beta-Adrenergic gene therapy for cardiovascular disease (2000)
Eckhart, Andrea D, Koch, Walter J
Abstract Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex...
Heubach, Jürgen F, Trebeß, Ina, Wettwer, Erich, Himmel, Herbert M, Michel, Martin C, Kaumann, Alberto J, ...
Objectives: The reported increase in basal activity of hearts from transgenic mice (TG4) overexpressing the human β2-adrenoceptor (β2-AR) was explained by spontaneously active β2-ARs that...
Includes abstract.
Iaccarino, Guido, Smithwick, L. Ashley, Lefkowitz, Robert J., Koch, Walter J.
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedures. To date, the roles of heterotrimeric G proteins in the triggering of pathological vascular...
Rockman, Howard A., Chien, Kenneth R., Choi, Dong-Ju, Iaccarino, Guido, Hunter, John J., Ross, John, ...
Heart failure is accompanied by severely impaired β-adrenergic receptor (βAR) function, which includes loss of βAR density and functional uncoupling of remaining receptors. An important mechanism...
Akhter, Shahab A., Skaer, Christine A., Kypson, Alan P., McDonald, Patricia H., Peppel, Karsten C., Glower, Donald D., ...
Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing...
White, David C., Hata, Jonathan A., Shah, Ashish S., Glower, Donald D., Lefkowitz, Robert J., Koch, Walter J.
When the heart fails, there is often a constellation of biochemical alterations of the β-adrenergic receptor (βAR) signaling system, leading to the loss of cardiac inotropic reserve. βAR...
Dorn, Gerald W., Tepe, Nicole M., Lorenz, John N., Koch, Walter J., Liggett, Stephen B.
Transgenic overexpression of Gαq in the heart triggers events leading to a phenotype of eccentric hypertrophy, depressed ventricular function, marked expression of hypertrophy-associated genes, and...
Zhu, Wei-Zhong, Zheng, Ming, Koch, Walter J., Lefkowitz, Robert J., Kobilka, Brian K., Xiao, Rui-Ping
The goal of this study was to determine whether β1-adrenergic receptor (AR) and β2-AR differ in regulating cardiomyocyte survival and apoptosis and, if so, to explore underlying mechanisms. One...
Harding, Victoria B., Jones, Larry R., Lefkowitz, Robert J., Koch, Walter J., Rockman, Howard A.
Chronic human heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased levels of βAR kinase 1 (βARK1), which seems critical to the...
Beta-Adrenergic gene therapy for cardiovascular disease
Eckhart, Andrea D, Koch, Walter J
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular...
S100A1: A regulator of myocardial contractility
Most, Patrick, Bernotat, Juliane, Ehlermann, Philipp, Pleger, Sven T., Reppel, Michael, Börries, Melanie, ...
S100A1, a Ca2+ binding protein of the EF-hand type, is preferentially expressed in myocardial tissue and has been found to colocalize with the sarcoplasmic reticulum (SR) and the contractile...
Predisposition to Arrhythmia and Autonomic Dysfunction in Nhlh1-Deficient Mice
Cogliati, Tiziana, Good, Deborah J., Haigney, Mark, Delgado-Romero, Petra, Eckhaus, Michael A., Koch, Walter J., ...
Nhlh1 is a basic helix-loop-helix transcription factor whose expression is restricted to the nervous system and which may play a role in neuronal differentiation. To directly study Nhlh1 function, we...
A novel protective effect of erythropoietin in the infarcted heart
Parsa, Cyrus J., Matsumoto, Akio, Kim, Jihee, Riel, Ryan U., Pascal, Laura S., Walton, G. Brant, ...
Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also increase thrombotic events and mortality rates in patients with ischemic heart disease. We reasoned that...
Freeman, Kalev, Lerman, Imanuel, Kranias, Evangelia G., Bohlmeyer, Teresa, Bristow, Michael R., Lefkowitz, Robert J., ...
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative...
Foerster, Katharina, Groner, Ferdi, Matthes, Jan, Koch, Walter J., Birnbaumer, Lutz, Herzig, Stefan
Two subtypes of β-adrenoceptors, β1 and β2, mediate cardiac catecholamine effects. These two types differ qualitatively, e.g., regarding G protein coupling and calcium channel stimulation....
Maurice, John P., Hata, Jonathan A., Shah, Ashish S., White, David C., McDonald, Patricia H., Dolber, Paul C., ...
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy...
Tao, Ling, Gao, Erhe, Bryan, Nathan S., Qu, Yan, Liu, Hui-Rong, Hu, Aihua, ...
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) and nitric oxide have been shown to exert antiapoptotic effects in vitro. Recent evidence suggests...
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
Most, Patrick, Pleger, Sven T., Völkers, Mirko, Heidt, Beatrix, Boerries, Melanie, Weichenhan, Dieter, ...
Cardiac-restricted overexpression of the Ca2+-binding protein S100A1 has been shown to lead to increased myocardial contractile performance in vitro and in vivo. Since decreased cardiac expression of...
Iaccarino, Guido, Smithwick, L. Ashley, Lefkowitz, Robert J., Koch, Walter J.
Restenosis continues to be a major problem limiting the effectiveness of revascularization procedures. To date, the roles of heterotrimeric G proteins in the triggering of pathological vascular...
Rockman, Howard A., Chien, Kenneth R., Choi, Dong-Ju, Iaccarino, Guido, Hunter, John J., Ross, John, ...
Heart failure is accompanied by severely impaired β-adrenergic receptor (βAR) function, which includes loss of βAR density and functional uncoupling of remaining receptors. An important mechanism...
Akhter, Shahab A., Skaer, Christine A., Kypson, Alan P., McDonald, Patricia H., Peppel, Karsten C., Glower, Donald D., ...
Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing...
White, David C., Hata, Jonathan A., Shah, Ashish S., Glower, Donald D., Lefkowitz, Robert J., Koch, Walter J.
When the heart fails, there is often a constellation of biochemical alterations of the β-adrenergic receptor (βAR) signaling system, leading to the loss of cardiac inotropic reserve. βAR...
Dorn, Gerald W., Tepe, Nicole M., Lorenz, John N., Koch, Walter J., Liggett, Stephen B.
Transgenic overexpression of Gαq in the heart triggers events leading to a phenotype of eccentric hypertrophy, depressed ventricular function, marked expression of hypertrophy-associated genes, and...
Zhu, Wei-Zhong, Zheng, Ming, Koch, Walter J., Lefkowitz, Robert J., Kobilka, Brian K., Xiao, Rui-Ping
The goal of this study was to determine whether β1-adrenergic receptor (AR) and β2-AR differ in regulating cardiomyocyte survival and apoptosis and, if so, to explore underlying mechanisms. One...
Harding, Victoria B., Jones, Larry R., Lefkowitz, Robert J., Koch, Walter J., Rockman, Howard A.
Chronic human heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased levels of βAR kinase 1 (βARK1), which seems critical to the...
Beta-Adrenergic gene therapy for cardiovascular disease
Eckhart, Andrea D, Koch, Walter J
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular...
S100A1: A regulator of myocardial contractility
Most, Patrick, Bernotat, Juliane, Ehlermann, Philipp, Pleger, Sven T., Reppel, Michael, Börries, Melanie, ...
S100A1, a Ca2+ binding protein of the EF-hand type, is preferentially expressed in myocardial tissue and has been found to colocalize with the sarcoplasmic reticulum (SR) and the contractile...
Predisposition to Arrhythmia and Autonomic Dysfunction in Nhlh1-Deficient Mice
Cogliati, Tiziana, Good, Deborah J., Haigney, Mark, Delgado-Romero, Petra, Eckhaus, Michael A., Koch, Walter J., ...
Nhlh1 is a basic helix-loop-helix transcription factor whose expression is restricted to the nervous system and which may play a role in neuronal differentiation. To directly study Nhlh1 function, we...
A novel protective effect of erythropoietin in the infarcted heart
Parsa, Cyrus J., Matsumoto, Akio, Kim, Jihee, Riel, Ryan U., Pascal, Laura S., Walton, G. Brant, ...
Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also increase thrombotic events and mortality rates in patients with ischemic heart disease. We reasoned that...
Freeman, Kalev, Lerman, Imanuel, Kranias, Evangelia G., Bohlmeyer, Teresa, Bristow, Michael R., Lefkowitz, Robert J., ...
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative...
Foerster, Katharina, Groner, Ferdi, Matthes, Jan, Koch, Walter J., Birnbaumer, Lutz, Herzig, Stefan
Two subtypes of β-adrenoceptors, β1 and β2, mediate cardiac catecholamine effects. These two types differ qualitatively, e.g., regarding G protein coupling and calcium channel stimulation....
Maurice, John P., Hata, Jonathan A., Shah, Ashish S., White, David C., McDonald, Patricia H., Dolber, Paul C., ...
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy...
Tao, Ling, Gao, Erhe, Bryan, Nathan S., Qu, Yan, Liu, Hui-Rong, Hu, Aihua, ...
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) and nitric oxide have been shown to exert antiapoptotic effects in vitro. Recent evidence suggests...
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
Most, Patrick, Pleger, Sven T., Völkers, Mirko, Heidt, Beatrix, Boerries, Melanie, Weichenhan, Dieter, ...
Cardiac-restricted overexpression of the Ca2+-binding protein S100A1 has been shown to lead to increased myocardial contractile performance in vitro and in vivo. Since decreased cardiac expression of...
Beta blocker specificity: a building block toward personalized medicine
DeGeorge, Brent R., Koch, Walter J.
Drugs known as beta blockers, which antagonize the β-adrenergic receptor (β-AR), are an important component of the treatment regimen for chronic heart failure (HF). However, a significant body of...
Boerries, Melanie, Most, Patrick, Gledhill, Jonathan R., Walker, John E., Katus, Hugo A., Koch, Walter J., ...
S100A1, a Ca2+-sensing protein of the EF-hand family that is expressed predominantly in cardiac muscle, plays a pivotal role in cardiac contractility in vitro and in vivo. It has recently been...
Gong, Haibin, Adamson, Dawn L, Ranu, Hardeep K, Koch, Walter J, Heubach, Jürgen F, Ravens, Ursula, ...
The atria and ventricles of transgenic mice (TGβ2) with cardiac overexpression of the human β2-adrenoceptor (β2AR) were initially reported to show maximum contractility in the absence of β-AR...
Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia
Giangrande, Paloma H., Zhang, JianXin, Tanner, Alice, Eckhart, Andrea D., Rempel, Rachel E., Andrechek, Eran R., ...
Intimal hyperplasia (IH) and restenosis limit the long-term utility of bypass surgery and angioplasty due to pathological proliferation and migration of vascular smooth muscle cells (VSMCs) into the...
Martini, Jeffrey S., Raake, Philip, Vinge, Leif E., DeGeorge, Brent, Chuprun, J. Kurt, Harris, David M., ...
G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs important for myocardial regulation, and...
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts
Augustus, Ayanna S., Buchanan, Jonathan, Addya, Sankar, Rengo, Giuseppe, Pestell, Richard G., Fortina, Paolo, ...
Caveolin-3 (Cav3), the primary protein component of caveolae in muscle cells, regulates numerous signaling pathways including insulin receptor signaling and facilitates free fatty acid (FA) uptake by...
Cohn, Heather Irina, Harris, David M., Pesant, Stephanie, Pfeiffer, Michael, Zhou, Rui-Hai, Koch, Walter J., ...
G protein-coupled receptor kinase 2 (GRK2) is a serine/theorinine kinase that phosphorylates and desensitizes agonist-bound G protein-coupled receptors. GRK2 is increased in expression and activity...
Lymperopoulos, Anastasios, Rengo, Giuseppe, Zincarelli, Carmela, Kim, Jihee, Soltys, Stephen, Koch, Walter J.
Aldosterone produces a multitude of effects in vivo, including promotion of postmyocardial infarction adverse cardiac remodeling and heart failure progression. It is produced and secreted by the...