Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway (2009)
Orton, Richard J, Adriaens, Michiel E, Gormand, Amelie, Sturm, Oliver E, Kolch, Walter, Gilbert, David R
Abstract Background The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell...
Kwang-hyun Cho, Sung-young Shin, Hyun-woo Kim, Olaf Wolkenhauer, Brian Mcferran, Walter Kolch
modeling of the influence of RKIP
Dynamics of receptor and protein transducer homodimerisation (2008)
Vera, Julio, Millat, Thomas, Kolch, Walter, Wolkenhauer, Olaf
Abstract Background Signalling pathways are complex systems in which not only simple monomeric molecules interact, but also more complex structures that include constitutive or induced protein...
REVIEW ARTICLE Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway (2008)
Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a molecular-signalling network that governs the...
Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch, ...
The Mitogen Activated Protein Kinase (MAPK) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a molecular signalling network that governs the...
Rogers, Simon, Girolami, Mark, Kolch, Walter, Waters, Katrina M., Liu, Tao, Thrall, Brian, ...
Motivation: Modern transcriptomics and proteomics enable us to survey the expression of RNAs and proteins at large scales. While these data are usually generated and analyzed separately, there is an...
Petra Zürbig, Joshua Coon, Hartwig Bauer, Georg Behrens, Mohammed Dakna, Anna Dominiczak, ...
Owing to its availability, ease of collection and correlation with (patho-) physiology, urine is an attractive source for clinical proteomics. However, the lack of comparable datasets from large...
Gloeckner, Christian Johannes, Kinkl, Norbert, Schumacher, Annette, Braun, Ralf J., O'Neill, Eric, Meitinger, Thomas, ...
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal dominant late-onset Parkinson disease (PD). The LRRK2 protein consists of multiple...
D.: When kinases meet mathematics: the systems biology of MAPK signalling (2005)
Muffy Calder, David Gilbert, Walter Kolch, Walter Kolch
The MAPK/ERK pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and...
Gloeckner, Christian Johannes, Kinkl, Norbert, Schumacher, Annette, Braun, Ralf J., O'Neill, Eric, Meitinger, Thomas, ...
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal dominant late-onset Parkinson disease (PD). The LRRK2 protein consists of multiple...
Modelling and simulation of intracellular dynamics: Choosing an appropriate framework (2004)
Olaf Wolkenhauer, Mukhtar Ullah, Walter Kolch, Kwang-hyun Cho
Abstract--- Systems biology, that is, mathematical modelling and simulation of biochemical reaction networks in intracellular processes has gained renewed interest in recent years. For most...
Kwang-hyun Cho, Walter Kolch, Olaf Wolkenhauer
Mathematical modeling and dynamic simulation of signal transduction pathways is a central theme in systems biology and is increasingly attracting attention in the postgenomic era. The estimation of...
Mathematical modeling of the influence of RKIP on the ERK signaling pathway (2003)
Kwang-hyun Cho, Sung-young Shin, Hyun-woo Kim, Olaf Wolkenhauer, Brian Mcferran, Walter Kolch
Abstract. This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and...
The role of MAPK pathways in the action of chemotherapeutic drugs (2002)
Boldt, Simone, Weidle, Ulrich H., Kolch, Walter
In this study we have investigated the role of mitogen-induced and stress-activated MAP kinase pathways in the cellular response to taxol, etoposide and ceramide in three different human cancer cell...
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP (1999)
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...
Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., ...
We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with...
Yeung, Kam C., Rose, David W., Dhillon, Amardeep S., Yaros, Diane, Gustafsson, Marcus, Chatterjee, Devasis, ...
The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1. RKIP inhibits the phosphorylation of...
Baumann, Matthias, Mischak, Harald, Dammeier, Sascha, Kolch, Walter, Gires, Olivier, Pich, Dagmar, ...
BZLF1 is a member of the extended AP-1 family of transcription factors which binds to specific BZLF1 sequence motifs within early Epstein-Barr virus (EBV) promoters and to closely related AP-1...
Regulation of Raf-1 activation and signalling by dephosphorylation
Dhillon, Amardeep S., Meikle, Sharon, Yazici, Zihni, Eulitz, Manfred, Kolch, Walter
The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the...
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped...
Dhillon, Amardeep S., Meikle, Sharon, Peyssonnaux, Carole, Grindlay, Joan, Kaiser, Christian, Steen, Helge, ...
It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing...
Regulation and Role of Raf-1/B-Raf Heterodimerization†
Rushworth, Linda K., Hindley, Alison D., O'Neill, Eric, Kolch, Walter
The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental cellular processes including proliferation, survival, and differentiation. The...
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
Orton, Richard J., Sturm, Oliver E., Vyshemirsky, Vladislav, Calder, Muffy, Gilbert, David R., Kolch, Walter
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a molecular-signalling network that governs the...
Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., ...
We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with...
Yeung, Kam C., Rose, David W., Dhillon, Amardeep S., Yaros, Diane, Gustafsson, Marcus, Chatterjee, Devasis, ...
The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1. RKIP inhibits the phosphorylation of...
Baumann, Matthias, Mischak, Harald, Dammeier, Sascha, Kolch, Walter, Gires, Olivier, Pich, Dagmar, ...
BZLF1 is a member of the extended AP-1 family of transcription factors which binds to specific BZLF1 sequence motifs within early Epstein-Barr virus (EBV) promoters and to closely related AP-1...
Regulation of Raf-1 activation and signalling by dephosphorylation
Dhillon, Amardeep S., Meikle, Sharon, Yazici, Zihni, Eulitz, Manfred, Kolch, Walter
The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the...
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped...
Dhillon, Amardeep S., Meikle, Sharon, Peyssonnaux, Carole, Grindlay, Joan, Kaiser, Christian, Steen, Helge, ...
It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing...
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
Orton, Richard J., Sturm, Oliver E., Vyshemirsky, Vladislav, Calder, Muffy, Gilbert, David R., Kolch, Walter
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a molecular-signalling network that governs the...
Regulation and Role of Raf-1/B-Raf Heterodimerization†
Rushworth, Linda K., Hindley, Alison D., O'Neill, Eric, Kolch, Walter
The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental cellular processes including proliferation, survival, and differentiation. The...
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...