Genomic imbalances in precancerous tissues signal oral cancer risk (2009)
Garnis, Cathie, Chari, Raj, Buys, Timon PH, Zhang, Lewei, Ng, Raymond T, Rosin, Miriam P, ...
Abstract Oral cancer develops through a series of histopathological stages: through mild (low grade), moderate, and severe (high grade) dysplasia to carcinoma in situ and then invasive disease. Early...
Chari, Raj, Coe, Bradley P, Wedseltoft, Craig, Benetti, Marie, Wilson, Ian M, Vucic, Emily A, ...
Abstract Background High throughput microarray technologies have afforded the investigation of genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software packages to...
MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data (2008)
Chi, Bryan, DeLeeuw, Ronald J, Coe, Bradley P, Ng, Raymond T, MacAulay, Calum, Lam, Wan L
Abstract Background Recent advances in global genomic profiling methodologies have enabled multi-dimensional characterization of biological systems. Complete analysis of these genomic profiles...
Shadeo, Ashleen, Chari, Raj, Lonergan, Kim M, Pusic, Andrea, Miller, Dianne, Ehlen, Tom, ...
Abstract Background The highest rates of cervical cancer are found in developing countries. Frontline monitoring has reduced these rates in developed countries and present day screening programs...
Fadlelmola, Faisal M, Zhou, Minglong, De Leeuw, Ronald J, Dosanjh, Nirpjit S, Harmer, Karynn, Huntsman, David, ...
Abstract Background Hodgkin lymphoma (HL) and Anaplastic Large Cell Lymphoma (ALCL), are forms of malignant lymphoma defined by unique morphologic, immunophenotypic, genotypic, and clinical...
Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma (2008)
Raj Chari, Andy Lam, Raymond T. Ng, John Yee, John English, ...
Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the...
Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma (2008)
Raj Chari, Andy Lam, Raymond T. Ng, John Yee, John English, ...
Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the...
Mastracci, Teresa L, Boulos, Fouad I, Andrulis, Irene L, Lam, Wan L
Abstract Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal...
Effect of active smoking on the human bronchial epithelium transcriptome (2007)
Chari, Raj, Lonergan, Kim M, Ng, Raymond T, MacAulay, Calum, Lam, Wan L, Lam, Stephen
Abstract Background Lung cancer is the most common cause of cancer-related deaths. Tobacco smoke exposure is the strongest aetiological factor associated with lung cancer. In this study, using serial...
Modeling recurrent DNA copy number alterations in array CGH data (2007)
Shah, Sohrab P., Lam, Wan L., Ng, Raymond T., Murphy, Kevin P.
Motivation: Recurrent DNA copy number alterations (CNA) measured with array comparative genomic hybridization (aCGH) reveal important molecular features of human genetics and disease. Studying aCGH...
Comprehensive serial analysis of gene expression of the cervical transcriptome (2007)
Shadeo, Ashleen, Chari, Raj, Vatcher, Greg, Campbell, Jennifer, Lonergan, Kim M, Matisic, Jasenka, ...
Abstract Background More than half of the approximately 500,000 women diagnosed with cervical cancer worldwide each year will die from this disease. Investigation of genes expressed in precancer...
Julie M. Kneller, Thomas Ehlen, Jasenka P. Matisic, Dianne Miller, Dirk Van Niekerk, Wan L. Lam, ...
Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing...
Public Databases and Software for the Pathway Analysis of Cancer Genomes (2007)
The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data...
Public Databases and Software for the Pathway Analysis of Cancer Genomes (2007)
The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data...
Bmc Genomics, Raj Chari, Kim M Lonergan, Raymond T Ng, Calum Macaulay, Wan L Lam, ...
Research article Effect of active smoking on the human bronchial epithelium transcriptome
SIGMA: A System for Integrative Genomic Microarray Analysis of Cancer Genomes (2006)
Chari, Raj, Lockwood, William W, Coe, Bradley P, Chu, Anna, Macey, Devon, Thomson, Andrew, ...
Abstract Background The prevalence of high resolution profiling of genomes has created a need for the integrative analysis of information generated from multiple methodologies and platforms. Although...
Aviel-Ronen, Sarit, Qi Zhu, Chang, Coe, Bradley P, Liu, Ni, Watson, Spencer K, Lam, Wan L, ...
Abstract Background Formalin-fixed paraffin-embedded (FFPE) tissues represent the largest source of archival biological material available for genomic studies of human cancer. Therefore, it is...
Comprehensive copy number profiles of breast cancer cell model genomes (2006)
Abstract Introduction Breast cancer is the most commonly diagnosed cancer in women worldwide and consequently has been extensively investigated in terms of histopathology, immunochemistry and...
Computational Methods for the Analysis of Array Comparative Genomic Hybridization (2006)
Raj Chari, William W. Lockwood, Wan L. Lam
Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of...
Integrating copy number polymorphisms into array CGH analysis using a robust HMM (2006)
Shah, Sohrab P., Xuan, Xiang, DeLeeuw, Ron J., Khojasteh, Mehrnoush, Lam, Wan L., Ng, Raymond, ...
Motivation: Array comparative genomic hybridization (aCGH) is a pervasive technique used to identify chromosomal aberrations in human diseases, including cancer. Aberrations are defined as regions of...
Bmc Genomics, Raj Chari, William W Lockwood, Bradley P Coe, Anna Chu, Devon Macey, ...
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
A stepwise framework for the normalization of array CGH data (2005)
Khojasteh, Mehrnoush, Lam, Wan L, Ward, Rabab K, MacAulay, Calum
Abstract Background In two-channel competitive genomic hybridization microarray experiments, the ratio of the two fluorescent signal intensities at each spot on the microarray is commonly used to...
Mehrnoush Khojasteh, Wan L Lam, Rabab K Ward, Calum Macaulay, Biomed Central, Calum Macaulay
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis (2005)
Garnis, Cathie, Campbell, Jennifer, Davies, Jonathan J., MacAulay, Calum, Lam, Stephen, Lam, Wan L.
Lung cancer is the leading cause of cancer death in North America. Despite advances in lung cancer treatment, the overall 5 year survival rate for those diagnosed with the disease is bleak presumably...
Genetic alteration and gene expression modulation during cancer progression (2004)
Garnis, Cathie, Buys, Timon PH, Lam, Wan L
Abstract Cancer progresses through a series of histopathological stages. Progression is thought to be driven by the accumulation of genetic alterations and consequently gene expression pattern...
Chi, Bryan, DeLeeuw, Ronald J, Coe, Bradley P, MacAulay, Calum, Lam, Wan L
Abstract Background Array comparative genomic hybridization (CGH) is a technique which detects copy number differences in DNA segments. Complete sequencing of the human genome and the development of...
Watson, Spencer K, DeLeeuw, Ronald J, Ishkanian, Adrian S, Malloff, Chad A, Lam, Wan L
Abstract Background The recent development of array based comparative genomic hybridization (CGH) technology provides improved resolution for detection of genomic DNA copy number alterations. In...
Ronald J. Deleeuw, Jonathan J. Davies, Andreas Rosenwald, Gwyn Bebb, Louis M. Staudt, ...
whole genome array CGH profiling of mantle cell lymphoma model genomes
Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes (2004)
Jonathan J. Davies, Andreas Rosenwald, Gwyn Bebb, Y D. Gascoyne, ...
mantle cell lymphoma model genomes
Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes (2004)
DeLeeuw, Ronald J., Davies, Jonathan J., Rosenwald, Andreas, Bebb, Gwyn, Gascoyne, Randy D., Dyer, Martin J.S., ...
Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma with median patient survival times of approximately 3 years. Although the characteristic t(11;14)(q13;q32) is found in virtually all...
Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis (2004)
Garnis, Cathie, Campbell, Jennifer, Davies, Jonathan J., MacAulay, Calum, Lam, Stephen, Lam, Wan L.
Lung cancer is the leading cause of cancer death in the North America. Despite advances in lung cancer treatment, the overall 5 year survival rate for those diagnosed with the disease is bleak...
Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes (2004)
De Leeuw, Ronald J., Davies, Jonathan J., Rosenwald, Andreas, Bebb, Gwyn, Gascoyne, Randy D., Dyer, Martin J.S., ...
Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin's lymphoma with median patient survival times of ∼3 years. Although the characteristic t(11;14)(q13;q32) is found in virtually all cases,...
Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes (2004)
DeLeeuw, Ronald J., Davies, Jonathan J., Rosenwald, Andreas, Bebb, Gwyn, Gascoyne, Randy D., Dyer, Martin J.S., ...
Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma with median patient survival times of approximately 3 years. Although the characteristic t(11;14)(q13;q32) is found in virtually all...
Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis (2004)
Garnis, Cathie, Campbell, Jennifer, Davies, Jonathan J., MacAulay, Calum, Lam, Stephen, Lam, Wan L.
Lung cancer is the leading cause of cancer death in the North America. Despite advances in lung cancer treatment, the overall 5 year survival rate for those diagnosed with the disease is bleak...
Lam, Wan L., Vielkind, Juergan R.
Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment, the mortality rate remains high. To improve survival, early...
Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment of prostate cancer, the mortality rate remains high. To improve...
The ribosomal RNA genes of Halobacterium cutirubrum / (1986)
Submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Master of Science, Department of Microbiology.
Genetic alteration and gene expression modulation during cancer progression
Garnis, Cathie, Buys, Timon PH, Lam, Wan L
Cancer progresses through a series of histopathological stages. Progression is thought to be driven by the accumulation of genetic alterations and consequently gene expression pattern changes. The...
A stepwise framework for the normalization of array CGH data
Khojasteh, Mehrnoush, Lam, Wan L, Ward, Rabab K, MacAulay, Calum
Genetic alteration and gene expression modulation during cancer progression
Garnis, Cathie, Buys, Timon PH, Lam, Wan L
Cancer progresses through a series of histopathological stages. Progression is thought to be driven by the accumulation of genetic alterations and consequently gene expression pattern changes. The...
A stepwise framework for the normalization of array CGH data
Khojasteh, Mehrnoush, Lam, Wan L, Ward, Rabab K, MacAulay, Calum
SIGMA: A System for Integrative Genomic Microarray Analysis of Cancer Genomes
Chari, Raj, Lockwood, William W, Coe, Bradley P, Chu, Anna, Macey, Devon, Thomson, Andrew, ...
Comprehensive serial analysis of gene expression of the cervical transcriptome
Shadeo, Ashleen, Chari, Raj, Vatcher, Greg, Campbell, Jennifer, Lonergan, Kim M, Matisic, Jasenka, ...
A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome
Wong, Kendy K., DeLeeuw, Ronald J., Dosanjh, Nirpjit S., Kimm, Lindsey R., Cheng, Ze, Horsman, Douglas E., ...
Segmental copy-number variations (CNVs) in the human genome are associated with developmental disorders and susceptibility to diseases. More importantly, CNVs may represent a major genetic component...
Effect of active smoking on the human bronchial epithelium transcriptome
Chari, Raj, Lonergan, Kim M, Ng, Raymond T, MacAulay, Calum, Lam, Wan L, Lam, Stephen
Mastracci, Teresa L, Boulos, Fouad I, Andrulis, Irene L, Lam, Wan L
Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct...
Fadlelmola, Faisal M, Zhou, Minglong, De Leeuw, Ronald J, Dosanjh, Nirpjit S, Harmer, Karynn, Huntsman, David, ...
MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data
Chi, Bryan, DeLeeuw, Ronald J, Coe, Bradley P, Ng, Raymond T, MacAulay, Calum, Lam, Wan L
Aviel-Ronen, Sarit, Coe, Bradley P., Lau, Suzanne K., Da Cunha Santos, Gilda, Zhu, Chang-Qi, Strumpf, Dan, ...
Bronchioloalveolar carcinoma (BAC), a subtype of lung adenocarcinoma (ADC) without stromal, vascular, or pleural invasion, is considered an in situ tumor with a 100% survival rate. However, the...
Computational Methods for the Analysis of Array Comparative Genomic Hybridization
Chari, Raj, Lockwood, William W., Lam, Wan L.
Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of...
Public Databases and Software for the Pathway Analysis of Cancer Genomes
Tsui, Ivy F.L., Chari, Raj, Buys, Timon P.H., Lam, Wan L.
The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data...
Genomic imbalances in precancerous tissues signal oral cancer risk
Garnis, Cathie, Chari, Raj, Buys, Timon PH, Zhang, Lewei, Ng, Raymond T, Rosin, Miriam P, ...
Oral cancer develops through a series of histopathological stages: through mild (low grade), moderate, and severe (high grade) dysplasia to carcinoma in situ and then invasive disease. Early...
Kneller, Julie M., Ehlen, Thomas, Matisic, Jasenka P., Miller, Dianne, Van Niekerk, Dirk, Lam, Wan L., ...
Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing...
Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, ...
Public Databases and Software for the Pathway Analysis of Cancer Genomes
Tsui, Ivy F.L., Chari, Raj, Buys, Timon P.H., Lam, Wan L.
The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data...