Wandy L. Beatty

Identification of Mycobacterial Surface Proteins Released into Subcellular Compartments of Infected Macrophages

Beatty, Wandy L., Russell, David G.

Considerable effort has focused on the identification of proteins secreted from Mycobacterium spp. that contribute to the development of protective immunity. Little is known, however, about the...

Chlamydia pneumoniae Expresses Genes Required for DNA Replication but Not Cytokinesis during Persistent Infection of HEp-2 Cells

Byrne, Gerald I., Ouellette, Scot P., Wang, Zhao, Rao, J. P., Lu, Lin, Beatty, Wandy L., ...

Chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. The intracellular growth rate of C. pneumoniae slows...

Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2–M2AP adhesive protein complex

Huynh, My-Hang, Rabenau, Karen E., Harper, Jill M., Beatty, Wandy L., Sibley, L.David, Carruthers, Vern B.

Vertebrate cells are highly susceptible to infection by obligate intracellular parasites such as Toxoplasma gondii, yet the mechanism by which these microbes breach the confines of their target cell...

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Identification of Mycobacterial Surface Proteins Released into Subcellular Compartments of Infected Macrophages

Beatty, Wandy L., Russell, David G.

Considerable effort has focused on the identification of proteins secreted from Mycobacterium spp. that contribute to the development of protective immunity. Little is known, however, about the...

Chlamydia pneumoniae Expresses Genes Required for DNA Replication but Not Cytokinesis during Persistent Infection of HEp-2 Cells

Byrne, Gerald I., Ouellette, Scot P., Wang, Zhao, Rao, J. P., Lu, Lin, Beatty, Wandy L., ...

Chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. The intracellular growth rate of C. pneumoniae slows...

Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2–M2AP adhesive protein complex

Huynh, My-Hang, Rabenau, Karen E., Harper, Jill M., Beatty, Wandy L., Sibley, L.David, Carruthers, Vern B.

Vertebrate cells are highly susceptible to infection by obligate intracellular parasites such as Toxoplasma gondii, yet the mechanism by which these microbes breach the confines of their target cell...

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis

Belland, Robert J., Zhong, Guangming, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, Sharma, Jyotika, ...

Chlamydia trachomatis is one of the most common bacterial pathogens and is the etiological agent of debilitating sexually transmitted and ocular diseases in humans. The organism is an obligate...

Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation

Belland, Robert J., Nelson, David E., Virok, Dezso, Crane, Deborah D., Hogan, Daniel, Sturdevant, Daniel, ...

Chlamydia trachomatis is an obligatory intracellular prokaryotic parasite that causes a spectrum of clinically important chronic inflammatory diseases of humans. Persistent infection may play a role...

Artemisinin Induces Calcium-Dependent Protein Secretion in the Protozoan Parasite Toxoplasma gondii▿ †

Nagamune, Kisaburo, Beatty, Wandy L., Sibley, L. David

Intracellular calcium controls several crucial cellular events in apicomplexan parasites, including protein secretion, motility, and invasion into and egress from host cells. The plant compound...

Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells

Beatty, Wandy L., Méresse, Stéphane, Gounon, Pierre, Davoust, Jean, Mounier, Joëlle, Sansonetti, Philippe J., ...

Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium...

Microneme Rhomboid Protease TgROM1 Is Required for Efficient Intracellular Growth of Toxoplasma gondii▿ †

Brossier, Fabien, Starnes, G. Lucas, Beatty, Wandy L., Sibley, L. David

Rhomboids are serine proteases that cleave their substrates within the transmembrane domain. Toxoplasma gondii contains six rhomboids that are expressed in different life cycle stages and localized...

Late Endocytic Multivesicular Bodies Intersect the Chlamydial Inclusion in the Absence of CD63▿

Beatty, Wandy L.

Chlamydiae are obligate intracellular bacterial pathogens that replicate solely within a membrane-bound vacuole termed an inclusion. Within the confines of the inclusion, the replicating bacteria...