Warren G. Young

High-throughput Morphometric Analysis of Individual Neurons (2004)

Wu, Chi-Cheng, Reilly, John F., Young, Warren G., Morrison, John H., Bloom, Floyd E.

To facilitate high-throughput quantitative analysis of neuronal structure, this study optimized the diOlistic method of whole neuron labeling to examine multiple neurons in fixed brain, and optimized...

High-throughput Morphometric Analysis of Individual Neurons (2004)

Wu, Chi-Cheng, Reilly, John F., Young, Warren G., Morrison, John H., Bloom, Floyd E.

To facilitate high-throughput quantitative analysis of neuronal structure, this study optimized the diOlistic method of whole neuron labeling to examine multiple neurons in fixed brain, and optimized...

High-throughput Morphometric Analysis of Individual Neurons (2004)

Wu, Chi-Cheng, Reilly, John F., Young, Warren G., Morrison, John H., Bloom, Floyd E.

To facilitate high-throughput quantitative analysis of neuronal structure, this study optimized the diOlistic method of whole neuron labeling to examine multiple neurons in fixed brain, and optimized...

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis (2003)

Redwine, Jeffrey M., Kosofsky, Barry, Jacobs, Russell E., Games, Dora, Reilly, John F., Morrison, John H., ...

High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human...

Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model

Reilly, John F., Games, Dora, Rydel, Russell E., Freedman, Stephen, Schenk, Dale, Young, Warren G., ...

Various transgenic mouse models of Alzheimer's disease (AD) have been developed that overexpress mutant forms of amyloid precursor protein in an effort to elucidate more fully the potential role of...

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis

Redwine, Jeffrey M., Kosofsky, Barry, Jacobs, Russell E., Games, Dora, Reilly, John F., Morrison, John H., ...

High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human...

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses

Wu, Chi-Cheng, Chawla, Faisal, Games, Dora, Rydel, Russell E., Freedman, Stephen, Schenk, Dale, ...

Increasing evidence from mouse models of Alzheimer's disease shows that overexpression of a mutant form of the amyloid precursor protein (APP) and its product, β-amyloid peptide, initiate...

Adult mouse brain gene expression patterns bear an embryologic imprint

Zapala, Matthew A., Hovatta, Iiris, Ellison, Julie A., Wodicka, Lisa, Del Rio, Jo A., Tennant, Richard, ...

The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult...

New Prospects and Strategies for Drug Target Discovery in Neurodegenerative Disorders

Hilbush, Brian S., Morrison, John H., Young, Warren G., Sutcliffe, J. Gregor, Bloom, Floyd E.

Summary: The future of neurodegenerative therapeutics development depends upon effective disease modification strategies centered on carefully investigated targets. Pharmaceutical research endeavors...

Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model

Reilly, John F., Games, Dora, Rydel, Russell E., Freedman, Stephen, Schenk, Dale, Young, Warren G., ...

Various transgenic mouse models of Alzheimer's disease (AD) have been developed that overexpress mutant forms of amyloid precursor protein in an effort to elucidate more fully the potential role of...

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis

Redwine, Jeffrey M., Kosofsky, Barry, Jacobs, Russell E., Games, Dora, Reilly, John F., Morrison, John H., ...

High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human...

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses

Wu, Chi-Cheng, Chawla, Faisal, Games, Dora, Rydel, Russell E., Freedman, Stephen, Schenk, Dale, ...

Increasing evidence from mouse models of Alzheimer's disease shows that overexpression of a mutant form of the amyloid precursor protein (APP) and its product, β-amyloid peptide, initiate...

Adult mouse brain gene expression patterns bear an embryologic imprint

Zapala, Matthew A., Hovatta, Iiris, Ellison, Julie A., Wodicka, Lisa, Del Rio, Jo A., Tennant, Richard, ...

The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult...

New Prospects and Strategies for Drug Target Discovery in Neurodegenerative Disorders

Hilbush, Brian S., Morrison, John H., Young, Warren G., Sutcliffe, J. Gregor, Bloom, Floyd E.

Summary: The future of neurodegenerative therapeutics development depends upon effective disease modification strategies centered on carefully investigated targets. Pharmaceutical research endeavors...