Wayne C. H. Wang

Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element

Shashikant, Cooduvalli S., Kim, Chang B., Borbély, Marc A., Wang, Wayne C. H., Ruddle, Frank H.

Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we...

Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes

Anand, Sanjay, Wang, Wayne C. H., Powell, Dennis R., Bolanowski, Stacey A., Zhang, Jian, Ledje, Christina, ...

There is considerable interest in understanding how cis-regulatory modifications drive morphological changes across species. Because developmental regulatory genes, including Hox genes, are...

Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element

Shashikant, Cooduvalli S., Kim, Chang B., Borbély, Marc A., Wang, Wayne C. H., Ruddle, Frank H.

Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we...

Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes

Anand, Sanjay, Wang, Wayne C. H., Powell, Dennis R., Bolanowski, Stacey A., Zhang, Jian, Ledje, Christina, ...

There is considerable interest in understanding how cis-regulatory modifications drive morphological changes across species. Because developmental regulatory genes, including Hox genes, are...

Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation

McGraw, Dennis W., Elwing, Jean M., Fogel, Kevin M., Wang, Wayne C.H., Glinka, Clare B., Mihlbachler, Kathryn A., ...

Receptor-mediated airway smooth muscle (ASM) contraction via Gαq, and relaxation via Gαs, underlie the bronchospastic features of asthma and its treatment. Asthma models show increased ASM Gαi...