WB Lott

Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B-12 and the HCV core protein (2004)

Li, DS, Lott, WB, Martyn, J, Haqshenas, G, Gowans, EJ

To investigate the role of the hepatitis C virus internal ribosome entry site (HCV IRES) domain IV in translation initiation and regulation, two chimeric IRES elements were constructed to contain the...

Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site (2002)

Takyar, SS, Gowans, EJ, Lott, WB

The effect of cyanocobalamin (CNCbl, vitamin 1312) on hepatitis C virus internal ribosome entry site (HCV IRES)-dependent initiation of translation was studied by ribosomal toeprinting and sucrose...

Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription (2001)

Hooker, CW, Lott, WB, Harrich, D

Early HIV-1 reverse transcription can be separated into initiation and elongation phases. Here we show, using PCR analysis of negative-strand strong-stop DNA [(-)ssDNA] synthesis in intact virus,...