Wei-Jian Zhang

A different view on human albumin--authors' reply (2003)

Zhang, Wei-jian, Frei, Balz

Albumin selectively inhibits TNF{alpha}-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells (2002)

Zhang, Wei-Jian, Frei, Balz

Objective: Leukocyte adhesion to, and transmigration across, the vascular endothelium are critical initiating steps in inflammation and atherosclerosis. We hypothesized that albumin, the major plasma...

Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

Sauter, Bernhard V., Martinet, Olivier, Zhang, Wei-Jian, Mandeli, John, Woo, Savio L. C.

Inhibition of angiogenesis has been shown to be an effective strategy in cancer therapy in mice. However, its widespread application has been hampered by difficulties in the large-scale production of...

Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

Sauter, Bernhard V., Martinet, Olivier, Zhang, Wei-Jian, Mandeli, John, Woo, Savio L. C.

Inhibition of angiogenesis has been shown to be an effective strategy in cancer therapy in mice. However, its widespread application has been hampered by difficulties in the large-scale production of...

α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway

Zhang, Wei-Jian, Wei, Hao, Hagen, Tory, Frei, Balz

The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the...

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

Hackam, David J., Rotstein, Ori D., Schreiber, Alan, Zhang, Wei-jian, Grinstein, Sergio

Phagocytosis of bacteria by macrophages and neutrophils is an essential component of host defense against infection. The mechanism whereby the interaction of opsonized particles with Fcγ receptors...

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

Hackam, David J., Rotstein, Ori D., Zhang, Wei-jian, Gruenheid, Samantha, Gros, Philippe, Grinstein, Sergio

The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural...

Radical resection and outcome for malignant tumors of the pancreatic body and tail

Han, Shao-Liang, Zhang, Wei-Jian, Zheng, Xiao-Feng, Shen, Xian, Zeng, Qi-Qiang, Ke, Qing-Hong

AIM: To analyze the factors influencing radical (R0) resection rate and surgical outcome for malignant tumor of the pancreatic body and tail.