Wei Xiong

Publication List Details

Period

0000 - 2009

Number

121

Co-Authors

H.: Moving object extraction with a hand-held camera (2009)

Guofeng Zhang, Jiaya Jia, Wei Xiong, Tien-tsin Wong, Pheng-ann Heng, Hujun Bao

This paper presents a new method to detect and accurately extract the moving object from a video sequence taken by a hand-held camera. In order to extract the high quality moving foreground, previous...

Deciphering the Liquidity and Credit Crunch 2007-08 (2009)

Markus K. Brunnermeier, José Scheinkman, Til Schuermann, Hyun Shin, James Vickery, Glen Weyl, ...

This paper summarizes and explains the main events of the liquidity and credit crunch in 2007-08. Starting with the trends leading up to the crisis, I explain how these events unfolded and how four...

Dynamic Modeling of Workforce Requirements for Mass Prophylaxis Under Highly Uncertain Conditions: Cornell Dynamic POD Simulator (2009)

Castorena, Michelle, Hawkins, Caitlin, Hupert, Nathaniel, King, Kathleen, Muckstadt, John, Wu, Cindie, ...

The public health response to a bioterrorist attack or other large-scale health emergency may include mass prophylaxis using multiple Points of Dispensing (PODs) to deliver countermeasures rapidly to...

Moving Object Extraction with a Hand-held Camera (2009)

Guofeng Zhang, Jiaya Jia, Wei Xiong, Tien-tsin Wong, Pheng-ann Heng, Hujun Bao

This paper presents a new method to detect and accurately extract the moving object from a video sequence taken by a hand-held camera. In order to extract the high quality moving foreground, previous...

Identification of the proteomic changes in Synechocystis sp. PCC 6803 following prolonged UV-B irradiation (2009)

Gao, Yang, Xiong, Wei, Li, Xiao-bo, Gao, Chun-Fang, Zhang, Yi-liang, Li, Han, ...

The diversified physiological responses in cyanobacteria under ultraviolet-B (UV-B) radiation have been broadly researched. The changes in the metabolic control mechanisms hidden behind these...

Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis (2009)

Zhang, Wenling, Zeng, Zhaoyang, Zhou, Yanhong, Xiong, Wei, Fan, Songqing, Xiao, Lan, ...

Previous studies have revealed that Epstein–Barr virus (EBV) was closely associated with nasopharyngeal carcinoma (NPC). This study aimed to characterize the global pathways affected in the...

4,4′-Bipyridinium 1,4-phenylenediacetate (2009)

Maomao Jia, Xianlin Liu, Jing Miao, Wei Xiong, Zilu Chen

The title compound, C10H10N22+·C10H8O42−, has inversion centres located at the geometric centres of the 1,4-phenylenediacetate anion and 4,4′-bipyridinium cation. The anions and...

N-(1H-1,2,4-Triazol-5-yl)pyridine-2-carboxamide (2009)

Jing Miao, Maomao Jia, Xianlin Liu, Wei Xiong, Zilu Chen

In the structure of the title compound, C8H7N5O, the pyridine ring and the imidazole ring are nearly coplanar, making a dihedral angle of 2.97 (15)°. An intramolecular N—H...O...

Knowledge-Guided Semantic Indexing of Breast Cancer Histopathology Images (2008)

Adina Eunice Tutac, Daniel Racoceanu, Thomas Putti, Wei Xiong, Wee-kheng Leow, Vladimir Cretu

Narrowing the semantic gap represents one of the most outstanding challenges in medical image analysis and indexing. This paper introduces a medical knowledge – guided paradigm for semantic...

Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype (2008)

Zhou, Changhua, Nitschke, Ashley M, Xiong, Wei, Zhang, Qiang, Tang, Yan, Bloch, Michael, ...

Abstract Introduction Despite intensive study of the mechanisms of chemotherapeutic drug resistance in human breast cancer, few reports have systematically investigated the mechanisms that underlie...

Queueing Analysis of a Server Node in Transaction Processing Middleware Systems (2008)

Wei Xiong, Tayfur Altiok

Quantitative performance modeling of complex information systems is of immense importance for designing enterprise e-business infrastructures and applications. In this paper, we present a traffic...

©2007 Association of Schools of Public Health SYNOPSIS (2008)

Ms A, Nathaniel Hupert, Mph B, Wei Xiong, ...

Community-based mass prophylaxis is a core public health operational competency, but staffing needs may overwhelm the local trained health workforce. Just-in-time (JIT) training of emergency staff...

query topic dependent image features (2008)

Wei Xiong, Bo Qiu, Qi Tian, Henning Müller, Changsheng Xu

novel content-based medical image retrieval method based on

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells (2008)

Hao, Huang, Nancai, Yu, Lei, Fu, Xiong, Wei, Wen, Su, Guofu, Huang, ...

Abstract The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed...

Can modeling of HIV treatment processes improve outcomes? Capitalizing on an operations research approach to the global pandemic (2008)

Xiong, Wei, Hupert, Nathaniel, Hollingsworth, Eric B, O'Brien, Megan E, Fast, Jessica, Rodriguez, William R

Abstract Background Mathematical modeling has been applied to a range of policy-level decisions on resource allocation for HIV care and treatment. We describe the application of classic operations...

A semi-automated method for liver tumor segmentation based on 2D region growing with (2008)

Wong, Damon, Liu, Jiang, Yin, Fengshou, Tian, Qi, Zhou, Jiayin, Xiong, Wei, ...

Liver tumour segmentation from computed tomography (CT) scans is a challenging task. A semi-automatic method based on 2D region growing with knowledge-based constraints is proposed to segment lesions...

A semi-automated method for liver tumor segmentation based on 2D region growing with (2008)

Wong, Damon, Liu, Jiang, Yin, Fengshou, Tian, Qi, Xiong, Wei, Zhou, Jiayin, ...

Liver tumour segmentation from computed tomography (CT) scans is a challenging task. A semi-automatic method based on 2D region growing with knowledge-based constraints is proposed to segment lesions...

Semi-automatic Segmentation of Liver Tumors from CT Scans Using Bayesian Rule-based 3D Region Growing (2008)

Qi, Yingyi, Xiong, Wei, Leow, Wee Keng, Tian, Qi, Zhou, Jiayin, Liu, Jiang, ...

Automatic segmentation of liver tumorous regions often fails due to high noise and large variance of tumors. In this work, a semi-automatic algorithm is proposed to segment liver tumors from computed...

Semi-automatic Segmentation of 3D Liver Tumors from CT Scans Using Voxel Classification and Propagational Learning (2008)

Zhou, Jiayin, Xiong, Wei, Tian, Qi, Qi, Yingyi, Liu, Jiang, Leow, Wee Keng, ...

A semi-automatic scheme was developed for the segmentation of 3D liver tumors from computed tomography (CT) images. First a support vector machine (SVM) classifier was trained to extract tumor region...

A semi-automated method for liver tumor segmentation based on 2D region growing with (2008)

Wong, Damon, Liu, Jiang, Yin, Fengshou, Tian, Qi, Zhou, Jiayin, Xiong, Wei, ...

Liver tumour segmentation from computed tomography (CT) scans is a challenging task. A semi-automatic method based on 2D region growing with knowledge-based constraints is proposed to segment lesions...

Analysis of stress sensitivity and its influence on oil production from tight reservoirs (2008)

Lei, Qun, Xiong, Wei, Yuan, Cui, Wu, Yu-Shu

This paper presents a study of the relationship between permeability and effective stress in tight petroleum reservoir formations. Specifically, a quantitative method is developed to describe the...

Combining Multilevel Visual Features for Medical Image Retrieval in ImageCLEFmed 2005 (2008)

Wei Xiong, Bo Qiu, Qi Tian, Changsheng Xu, S. H. Ong, Kelvin Foong

In this paper we report our work on the fully automatic medical image retrieval task in ImageCLEFmed 2005. First, we manually identify visually similar sample images by visual perception for each...

An Analytical Approach for Performance Analysis of J2EE Application servers (2008)

Wei Xiong, Tayfur Altiok

With the advent of new technologies, there is an increasing demand for computer systems with stringent time constraints. The goal of our research is to compute client response times in J2EE...

A CAPACITY PLANNING TOOL FOR THE TUXEDO MIDDLEWARE USED IN TRANSACTION PROCESSING SYSTEMS (2008)

B. A. Peters, J. S. Smith, D. J. Medeiros, M. W. Rohrer, Tayfur Altiok, Wei Xiong

In this paper, we present a brief overview of Tuxedo middleware system (BEA Systems) and introduce an objectoriented computer simulation template developed for the purpose of capacity planning and...

Brownian Motion of A Particle Immersed in a Viscous, Incompressible, Thermally Fluctuating Solvent (2008)

Xiong, Wei

My current work concerns the hydrodynamics of particles immersed in a thermally fluctuating, viscous, incompressible solvent. The governing equations stipulate conservation of momentum in the fluid,...

Brownian Motion of A Particle Immersed in a Viscous, Incompressible, Thermally Fluctuating Solvent (2008)

Xiong, Wei

My current work concerns the hydrodynamics of particles immersed in a thermally fluctuating, viscous, incompressible solvent. The governing equations stipulate conservation of momentum in the fluid,...

Knowledge-Guided Semantic Indexing of Breast Cancer Histopathology Images (2008)

Tutac, Adina, Racoceanu, Daniel, Putti, Thomas, Xiong, Wei, Leow, Wee-Kheng, Cretu, Vladimir

Narrowing the semantic gap represents one of the most outstanding challenges in medical image analysis and indexing. This paper introduces a medical knowledge – guided paradigm for semantic...

Knowledge-Guided Semantic Indexing of Breast Cancer Histopathology Images (2008)

Tutac, Adina, Racoceanu, Daniel, Putti, Thomas, Xiong, Wei, Leow, Wee-Kheng, Cretu, Vladimir

Narrowing the semantic gap represents one of the most outstanding challenges in medical image analysis and indexing. This paper introduces a medical knowledge – guided paradigm for semantic indexing...

(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylato-κ2O4,O5)(4-oxido-2-oxo-1,2-dihydropyrimidine-5-carboxylato-κ2O4,O5)bis(1,10-phenanthroline-κ2N,N′)yttrium(III) dihydrate (2008)

Wei Xiong, Huihui Xing, Yan Su, Zilu Chen

In the title compound, [Y(C5H2N2O4)(C5H3N2O4)(C12H8N2)2]·2H2O, the YIII ion lies on a twofold rotation axis and exhibits a distorted square-antiprismatic coordination geometry. It is chelated by...

(4-Oxido-2-oxo-1,2-dihydropyrimidine-5-carboxylato-κ2O4,O5)(4-oxido-2-oxo-1,2-dihydropyrimidin-3-ium-5-carboxylato-κ2O4,O5)bis(1,10-phenanthroline-κ2N,N′)gadolinium(III) dihydrate (2008)

Wei Xiong, Huihui Xing, Yan Su, Zilu Chen

The title compound, [Gd(C5H2N2O4)(C5H3N2O4)(C12H8N2)2]·2H2O, was obtained from a solvothermal reaction of 2,4-dihydroxypyrimidine-5-carboxylic acid (H3iso), GdCl3·6H2O and...

Molecular mechanism of long-term depression and its role in experience-dependent ocular dominance plasticity of primary visual cortex (2008)

Xiong, Wei

Primary visual cortex is a classic model to study experience-dependent brain plasticity. In early life, if one eye is deprived of normal vision, there can be a dramatic change in the ocular dominance...

NOTHING SWEET NOTHING: A COLLECTION OF SHORT FICTION (2007)

Xiong, Wei

This collection is a representation of my work in the graduate fiction workshop at Miami University from fall 2005 to spring 2007

NOTHING SWEET NOTHING: A COLLECTION OF SHORT FICTION (2007)

Xiong, Wei

This collection is a representation of my work in the graduate fiction workshop at Miami University from fall 2005 to spring 2007

SynDB: a Synapse protein DataBase based on synapse ontology (2007)

Zhang, Wuxue, Zhang, Yong, Zheng, Hui, Zhang, Chen, Xiong, Wei, Olyarchuk, John G., ...

A synapse is the junction across which a nerve impulse passes from an axon terminal to a neuron, muscle cell or gland cell. The functions and building molecules of the synapse are essential to almost...

Manipulation of the quantum state by Majorana transition in spinor Bose-Einstein condensates (2006)

Xia, Lin, Xu, Xu, Yang, Fan, Xiong, Wei, Li, Juntao, Ma, Qianli, ...

Manipulation of the quantum state by the Majorana transition in spinor BEC system has been realized by altering the rotation frequency of the magnetic field's direction. This kind of manipulation...

A general framework for evaluating executive stock options (2006)

Ronnie Sircar, Wei Xiong

Motivated by recent recommendations by both European and American accounting standards boards that executive stock options be expensed in firms ’ statements, we provide an analytical and flexible...

Close Functional Coupling Between Ca2+ Release-Activated Ca2+ Channels and Reactive Oxygen Species Production in Murine Macrophages (2006)

Sheng-Wei Jin, Li Zhang, Qin-Quan Lian, Shang-Long Yao, Ping Wu, Xiao-Yan Zhou, ...

Aim. To investigate the role of Ca2+ release-activated Ca2+ (CRAC) channels in the ROS production in macrophages. Methods. The intracellular [Ca2+]i was analyzed by confocal laser microscopy. The...

Multipre : A novel framework with multiple parallel retrieval engines for contentbased image retrieval (2005)

Wei Xiong, Bo Qiu, Qi Tian, Changsheng Xu, S. H. Ong

We propose a novel framework for content-based image retrieval with multiple parallel retrieval engines (MultiPRE) to achieve higher retrieval performance. Visual features, including both low-level...

Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells (2005)

Ma, Jian, Zhou, Jie, Fan, Songqing, Wang, Lili, Li, Xiaoling, Yan, Qun, ...

The epidermal growth factor (EGF)-like domain is involved in receptor–ligand interactions, extracellular matrix formation, cell adhesion and chemotaxis. Nasopharyngeal carcinoma associated gene 6...

Speculative Trading and Stock Prices: An Analysis of Chinese A-B Share Premia (2004)

Mei, Jianping, Scheinkman, Jose A., Xiong, Wei

China’s stock markets, with stringent short-sales constraints, dominance of inexperienced individual investors, a small asset float and heavy share turnover (500% per year despite a high...

Speculative Trading and Stock Prices: An Analysis of Chinese A-B Share Premia (2004)

Mei, Jianping, Scheinkman, Jose A., Xiong, Wei

China’s stock markets, with stringent short-sales constraints, dominance of inexperienced individual investors, a small asset float and heavy share turnover (500% per year despite a high...

Speculative Trading and Stock Prices: An Analysis of Chinese A-B Share (2004)

Jianping Mei, Jose A. Scheinkman, Wei Xiong

China's stock markets, with stringent short-sales constraints, dominance of inexperienced individual investors, a small asset float and heavy share turnover (500% per year despite a high...

Evaluating Incentive Options (2004)

Ronnie Sircar, Wei Xiong

We provide an analytical and flexible framework to evaluate executive stock options. Our model takes into account the vesting period, American style, resetting and reloading provisions that are...

Role of a novel EGF-like domain containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells (2004)

Ma, Jian, Zhou, Jie, Fan, Songqing, Wang, Lili, Li, Xiaoling, Yan, Qun, ...

The EGF-like domain is involved in receptor-ligand interactions, extracellular matrix formation, cell adhesion and chemotaxis. NGX6 is a novel EGF-like domain containing gene located at the high...

Pingyao : the living ancient city / (2003)

Xiong, Wei.

Thesis (M. Arch.)--Texas Tech University, 2003.

short-sale constraints, and bubbles (2003)

José Scheinkman, Wei Xiong

Motivated by the behavior of internet stock prices in 1998-2000, we present a continuous time equilibrium model of bubbles where overconfidence generates agreements to disagree among agents about...

Information Leakage and Market Efficiency (2003)

Markus Brunnermeier, Margaret Bray, Smita Brunnermeier, Thomas De, Clemens Grafe, Dominik Hotz, ...

This paper analyzes the effects of information leakage on trading behavior and market efficiency. It shows that a trader who receives a leaked signal prior to a public announcement can exploit this...

Prospect Theory and Liquidation Decisions (2003)

Albert S. Kyle, Hui Ou-yang, Wei Xiong

this paper is to investigate formally the e#ect of prospect theory on the liquidation decisions of economic agents. Specifically, we analyze an agent with a project (or an indivisible asset). The...

Regulation of CCAAT/enhancer-binding protein-{beta} isoform synthesis by alternative translational initiation at multiple AUG start sites (2001)

Xiong, Wei, Hsieh, Ching-Chyuan, Kurtz, Andrew J., Rabek, Jeffrey P., Papaconstantinou, John

The mRNA of the intronless, single-copy CCAAT/enhancer-binding protein-&bgr; (C/EBP&bgr;) gene encodes several isoforms that have truncated transcription activation domains. This occurs by...

Content-based video similarity computation and indexing /--by Wei Xiong. (1998)

Xiong, Wei.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 1998.

Automatic and Dynamic Video Manipulation (1998)

Qing Li, Wei Xiong

Video data management is fast becoming one of the most important topics in multimedia databases. In this chapter, we describe the development of an experimental video information management system,...

Efficient scene change detection and camera motion annotation for video classification (1997)

Xiong, Wei, Lee, John Chung-Mong

With the fast growth of video sources, efficient video classification and management is becoming more and more important. Video partitioning and video features extraction are two of the key issues in...

Automatic video data structuring through shot partitioning and key frame selection (1996)

Xiong, Wei, Lee, John Chung-Mong, Ma, Rui-Hua

In this paper, we propose automatic solutions to the problems: (i) video partitioning, (ii) key frame selection, (iii) key frame pruning. For the first problem, an algorithm called "Net Comparision"...

An experimental video database management system based on advanced object-oriented techniques (1996)

Liusheng Huang, Qing Li, Wei Xiong

Video data management is fast becoming one of the most important topics in multimedia databases. Most of the recent work on video databases has so far focused on video classification, feature...

VIMS: Towards an Adaptive and Versatile Video Manipulation Server (1996)

John Chung-Mong, Lee Qing Li, Wei Xiong

Recently, there has been much research on video manipulation in the area of video-on-demand and video databases. Most of the recent work has so far focused on video classification, feature...

Net comparison: an adaptive and effective method for scene change detection (1995)

Xiong, Wei, Lee, John Chung-Mong

As video information proliferates, managing video sources becomes increasingly important. Automatic video partitioning is a prerequisite for organizing and indexing video sources. Several methods...

Net Comparison: An Adaptive and Effective Method for Scene Change Detection (1995)

Wei Xiong, Ding-gang Shen

As video information proliferates, managing video sources becomes increasingly important. Automatic video partitioning is a prerequisite for organizing and indexing video sources. Several methods...

Net Comparison: A Fast and Effective Method for Classifying Image Sequences (1995)

Wei Xiong, Man-ching Ip

As video information proliferates, managing video sources becomes increasingly important. Automatic video partitioning is a prerequisite for organizing and indexing video sources. Several methods...

Video Segment Indexing Through Classification and Interactive View-based Query (1995)

Wei Xiong, Ding-Gang Shen, Ruihua Ma

. As video information proliferates, managing video sources becomes increasingly important. Indices must be constructed to allow any future retrieval. We distinguish two categories of indexing: (i)...

VIMS: A Video Information Management System (1992)

Qing Li, Wei Xiong, Hongjiong Zhang

. Video data management is fast becoming one of the most important topics in multimedia databases. In this paper, we describe the development of an experimental video information management system,...

Speculative Trading and Stock Prices: Evidence from Chinese A-B Share Premia

Jianping Mei, Jose Scheinkman, Wei Xiong

The market dynamics of technology stocks in the late nineties has stimulated a growing body of theories that analyze the joint effects of short-sales constraints and heterogeneous beliefs on stock...

Asset Float and Speculative Bubbles

Harrison Hong, Jose Scheinkman, Wei Xiong

We model the relationship between asset float (tradeable shares) and speculative bubbles. Investors trade a stock with limited float because of insider lock-ups. They have heterogeneous beliefs due...

Investor Attention: Overconfidence and Category Learning

Lin Peng, Wei Xiong

Motivated by psychological evidence that attention is a scarce cognitive resource, we model investors' attention allocation in learning and study the effects of this on asset-price dynamics. We show...

Pay for Short-Term Performance: Executive Compensation in Speculative Markets

Patrick Bolton, Jose Scheinkman, Wei Xiong

We argue that the root cause behind the recent corporate scandals associated with CEO pay is the technology bubble of the latter half of the 1990s. Far from rejecting the optimal incentive...

Overconfidence and Speculative Bubbles

Jose A. Scheinkman, Wei Xiong

Motivated by the behavior of asset prices, trading volume, and price volatility during episodes of asset price bubbles, we present a continuous-time equilibrium model in which overconfidence...

Effects of Age on the Posttranscriptional Regulation of CCAAT/Enhancer Binding Protein α and CCAAT/Enhancer Binding Protein β Isoform Synthesis in Control and LPS-Treated Livers

Hsieh, Ching-Chyuan, Xiong, Wei, Xie, Qizhi, Rabek, Jeffrey P., Scott, Sheen G., An, Mi Ra, ...

The CCAAT/enhancer binding protein α (C/EBPα) and CCAAT/enhancer binding protein β (C/EBPβ) mRNAs are templates for the differential translation of several isoforms. Immunoblotting detects...

Regulation of CCAAT/enhancer-binding protein-β isoform synthesis by alternative translational initiation at multiple AUG start sites

Xiong, Wei, Hsieh, Ching-Chyuan, Kurtz, Andrew J., Rabek, Jeffrey P., Papaconstantinou, John

The mRNA of the intronless, single-copy CCAAT/enhancer-binding protein-β (C/EBPβ) gene encodes several isoforms that have truncated transcription activation domains. This occurs by the alternative...

Human Neutralizing Fab Molecules against Severe Acute Respiratory Syndrome Coronavirus Generated by Phage Display

Kang, Xiaoping, Yang, Bao-an, Hu, Yuyang, Zhao, Hui, Xiong, Wei, Yang, Yinhui, ...

Human recombinant Fab fragments specific for the spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV) were screened from a human Fab library, which was generated from RNAs from...

Effects of Age on the Posttranscriptional Regulation of CCAAT/Enhancer Binding Protein α and CCAAT/Enhancer Binding Protein β Isoform Synthesis in Control and LPS-Treated Livers

Hsieh, Ching-Chyuan, Xiong, Wei, Xie, Qizhi, Rabek, Jeffrey P., Scott, Sheen G., An, Mi Ra, ...

The CCAAT/enhancer binding protein α (C/EBPα) and CCAAT/enhancer binding protein β (C/EBPβ) mRNAs are templates for the differential translation of several isoforms. Immunoblotting detects...

Regulation of CCAAT/enhancer-binding protein-β isoform synthesis by alternative translational initiation at multiple AUG start sites

Xiong, Wei, Hsieh, Ching-Chyuan, Kurtz, Andrew J., Rabek, Jeffrey P., Papaconstantinou, John

The mRNA of the intronless, single-copy CCAAT/enhancer-binding protein-β (C/EBPβ) gene encodes several isoforms that have truncated transcription activation domains. This occurs by the alternative...

Human Neutralizing Fab Molecules against Severe Acute Respiratory Syndrome Coronavirus Generated by Phage Display

Kang, Xiaoping, Yang, Bao-an, Hu, Yuyang, Zhao, Hui, Xiong, Wei, Yang, Yinhui, ...

Human recombinant Fab fragments specific for the spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV) were screened from a human Fab library, which was generated from RNAs from...

Close Functional Coupling Between Ca2+ Release-Activated Ca2+ Channels and Reactive Oxygen Species Production in Murine Macrophages

Jin, Sheng-Wei, Zhang, Li, Lian, Qin-Quan, Yao, Shang-Long, Wu, Ping, Zhou, Xiao-Yan, ...

Aim. To investigate the role of Ca2+ release-activated Ca2+ (CRAC) channels in the ROS production in macrophages. Methods. The intracellular [Ca2+]i was analyzed by confocal laser microscopy. The...

SynDB: a Synapse protein DataBase based on synapse ontology

Zhang, Wuxue, Zhang, Yong, Zheng, Hui, Zhang, Chen, Xiong, Wei, Olyarchuk, John G., ...

A synapse is the junction across which a nerve impulse passes from an axon terminal to a neuron, muscle cell or gland cell. The functions and building molecules of the synapse are essential to almost...

A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation

Xiong, Wei, Farukhi, Yousaf Z, Tian, Yanli, DiSilvestre, Deborah, Li, Ronald A, Tomaselli, Gordon F

The molecular mechanisms underlying slow inactivation in sodium channels are elusive. Our results suggest that EEDD, a highly conserved ring of charge in the external vestibule of mammalian...

Molecular Motions of the Outer Ring of Charge of the Sodium Channel: Do They Couple to Slow Inactivation?

Xiong, Wei, Li, Ronald A., Tian, Yanli, Tomaselli, Gordon F.

In contrast to fast inactivation, the molecular basis of sodium (Na) channel slow inactivation is poorly understood. It has been suggested that structural rearrangements in the outer pore mediate...

Asset Float and Speculative Bubbles

HARRISON HONG, JOSÉ SCHEINKMAN, WEI XIONG

We model the relationship between asset float (tradeable shares) and speculative bubbles. Investors with heterogeneous beliefs and short-sales constraints trade a stock with limited float because of...

Executive Compensation and Short-Termist Behaviour in Speculative Markets

PATRICK BOLTON, JOSÉ SCHEINKMAN, WEI XIONG

We present a multiperiod agency model of stock-based executive compensation in a speculative stock market, where investors have heterogeneous beliefs and stock prices may deviate from underlying...

Evaluating Incentive Options

Wei Xiong, Ronnie Sircar

We provide an analytical and flexible framework to evaluate incentive options. Our model not only considers vesting periods and trading and hedging restrictions on the holders, but also specifically...

The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells

Colla, Simona, Zhan, Fenghuang, Xiong, Wei, Wu, Xiaosong, Xu, Hongwei, Stephens, Owen, ...

Multiple myeloma (MM) plasma cells, but not those from healthy donors and patients with monoclonal gammopathy of undetermined significance or other plasma cell dyscrasias involving the bone marrow,...

R2 and Price Inefficiency

Hou, Kewei, Peng, Lin, Xiong, Wei

Motivated by the recent debate on return R2 as an information-efficiency measure, this paper proposes and examines a new hypothesis that R2 is related to investors’ biases in processing...

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells

Hao, Huang, Nancai, Yu, Lei, Fu, Xiong, Wei, Wen, Su, Guofu, Huang, ...

The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed to...

Advisors and asset prices: A model of the origins of bubbles

Hong, Harrison, Scheinkman, José, Xiong, Wei

We develop a model of asset price bubbles based on the communication process between advisors and investors. Advisors are well-intentioned and want to maximize the welfare of their advisees (like a...

Executive Compensation and Short-termist Behavior in Speculative Markets

Patrick Bolton, Jose Scheinkman, Wei Xiong

We present a multiperiod agency model of stock based executive compensation in a speculative stock market, where investors are overconfident and stock prices may deviate from underlying fundamentals...

What Drives the Disposition Effect? An Analysis of a Long-Standing Preference-Based Explanation

Nicholas Barberis, Wei Xiong

One of the most striking portfolio puzzles is the %u201Cdisposition effect%u201D: the tendency of individuals to sell stocks in their portfolios that have risen in value since purchase, rather than...

Heterogeneous Expectations and Bond Markets

Wei Xiong, Hongjun Yan

This paper presents a dynamic equilibrium model of bond markets, in which two groups of agents hold heterogeneous expectations about future economic conditions. Our model shows that heterogeneous...

Advisors and Asset Prices: A Model of the Origins of Bubbles

Harrison Hong, Jose A. Scheinkman, Wei Xiong

We develop a model of asset price bubbles based on the communication process between advisors and investors. Advisors are well-intentioned and want to maximize the welfare of their advisees (like a...

A Genomic Islet Mediates Flagellar Phase Variation in Escherichia coli Strains Carrying the Flagellin-Specifying Locus flk▿ †

Feng, Lu, Liu, Bin, Liu, Yanqun, Ratiner, Yuli A., Hu, Bo, Li, Dan, ...

The occurrence of unilateral flagellar phase variation was previously demonstrated in Escherichia coli strains carrying the non-fliC flagellin-specifying locus flk. In this study, we investigated the...

Realization Utility

Nicholas C. Barberis, Wei Xiong

We study the possibility that, aside from standard sources of utility, investors also derive utility from realizing gains and losses on assets that they own. We propose a tractable model of this...

DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release

Chen, Xiao-Wei, Feng, Ya-Qin, Hao, Chan-Juan, Guo, Xiao-Li, He, Xin, Zhou, Zhi-Yong, ...

Schizophrenia is one of the most debilitating neuropsychiatric disorders, affecting 0.5–1.0% of the population worldwide. Its pathology, attributed to defects in synaptic transmission, remains...

Multi-market Delegated Asset Management

Zhiguo He, Wei Xiong

This paper studies optimal contracting in delegated asset management when a fund manager can exert unobservable effort and take unobservable investment positions in multiple markets. A key insight is...

Investor Attention and Time-varying Comovements

Lin Peng, Wei Xiong, Tim Bollerslev

"This paper analyses the effect of an increase in market-wide uncertainty on information flow and asset price comovements. We use the daily realised volatility of the 30-year treasury bond futures to...

What Drives the Disposition Effect? An Analysis of a Long-Standing Preference-Based Explanation

NICHOLAS BARBERIS, WEI XIONG

We investigate whether prospect theory preferences can predict a disposition effect. We consider two implementations of prospect theory: in one case, preferences are defined over "annual" gains and...

Operational Evaluation of High-Throughput Community-Based Mass Prophylaxis Using Just-in-Time Training

Spitzer, James D., Hupert, Nathaniel, Duckart, Jonathan, Xiong, Wei

Community-based mass prophylaxis is a core public health operational competency, but staffing needs may overwhelm the local trained health workforce. Just-in-time (JIT) training of emergency staff...

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

Schwander, Martin, Xiong, Wei, Tokita, Joshua, Lelli, Andrea, Elledge, Heather M., Kazmierczak, Piotr, ...

Deafness is the most common form of sensory impairment in humans and is frequently caused by single gene mutations. Interestingly, different mutations in a gene can cause syndromic and nonsyndromic...

An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma

Xiong, Wei, Wu, Xiaosong, Starnes, Sarah, Johnson, Sarah K., Haessler, Jeff, Wang, Siqing, ...

TP53 is a tumor suppressor gene that functions as transcriptional regulator influencing cellular responses to DNA damage. Here we explored the clinical and transcriptional effects of TP53 expression...

The Chinese Warrants Bubble

Wei Xiong, Jialin Yu

In 2005-08, over a dozen put warrants traded in China went so deep out of the money that they were certain to expire worthless. Nonetheless, each warrant was traded nearly three times each day at...

Dynamic Debt Runs

Zhiguo He, Wei Xiong

We develop a dynamic model of debt runs on a firm, which invests in an illiquid asset by rolling over staggered short-term debt contracts. We derive a unique threshold equilibrium, in which creditors...