RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability (2008)
Xu, Dongyi, Guo, Rong, Sobeck, Alexandra, Bachrati, Csanad Z., Yang, Jay, Enomoto, Takemi, ...
BLM, the helicase mutated in Bloom syndrome, associates with topoisomerase 3α, RMI1 (RecQ-mediated genome instability), and RPA, to form a complex essential for the maintenance of genome stability....
Xue, Yutong, Li, Yongjiang, Guo, Rong, Ling, Chen, Wang, Weidong
In response to DNA damage, the Fanconi anemia (FA) core complex functions as a signaling machine for monoubiquitination of FANCD2 and FANCI. It remains unclear whether this complex can also...
High-level Synthesis of Multi-process Behavioral Descriptions ∗ (2007)
This paper presents a new high-level synthesis methodology to generate optimized implementations for multi-process behavioral descriptions. The concurrent communicating processes specification...
Endocytosis of DSL ligands and activation of the Notch signaling pathway in Drosophila (2006)
The DSL-Notch signaling pathway is a conserved signaling mechanism for cell-cell communication that dictates a wide range of developmental and physiological processes in organisms ranging from...
Endocytosis of DSL ligands and activation of the Notch signaling pathway in Drosophila (2006)
Department: Genetics and Development.
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
It has been observed that even highly optimized software programs perform “redundant ” computations during their execution, due to the nature (statistics) of the values assumed by input or...
Yin, Jinhu, Tae Kwon, Yong, Varshavsky, Alexander, Wang, Weidong
The Rothmund-Thomson syndrome (growth retardation, skin and bone defects, predisposition to cancer) and the RAPADILINO syndrome are caused by mutations in the RECQL4 gene. The 133-kD RECQL4 is a...
Yin, Jinhu, Kwon, Yong Tae, Varshavsky, Alexander, Wang, Weidong
The Rothmund–Thomson syndrome (growth retardation, skin and bone defects, predisposition to cancer) and the RAPADILINO syndrome are caused by mutations in the RECQL4 gene. The 133 kDa RECQL4...
Yin, Jinhu, Tae Kwon, Yong, Varshavsky, Alexander, Wang, Weidong
The Rothmund-Thomson syndrome (growth retardation, skin and bone defects, predisposition to cancer) and the RAPADILINO syndrome are caused by mutations in the RECQL4 gene. The 133-kD RECQL4 is a...
Gong, Hong, Wang, Weidong, Kwon, Tae-Hwan, Jonassen, Thomas, Frøkiaer, Jørgen, Nielsen, Søren
Background. The aims of this study were to investigate the changes in the expression levels of renal aquaporins (AQPs) in response to haemorrhagic shock (HS) in rats and whether a change in the...
Input space adaptive embedded software synthesis (2002)
Weidong Wang, Ganesh Lakshminarayana
This paper presents a novel technique, called input space adaptive software synthesis, for the energy and performance optimization of embedded software. The proposed technique is based on the fact...
Identification of a polymorphic, neuron-specific chromatin remodeling complex (2002)
Olave, Ivan, Wang, Weidong, Xue, Yutong, Kuo, Ann, Crabtree, Gerald R.
Thesis (M.S.)--Mississippi State University. School of Architecture.
Thesis (M.A.)--Wesleyan University, 2001.
The first debate on the rule of law /--by Weidong Wang. (2000)
Th. : Faculty of the law school : University of Chicago : Illinois : 1999.
Typescript.
Typescript.
Thesis (doctoral)--University of Chicago, 1999.
The first part of the thesis describes a method for using RELAP5 models to corroborate the scaling methodology that has been used for design of the Purdue University Multidimensional Test Apparatus...
A fuzzy set based method for image classification / (1997)
Thesis (M.A.)--San Diego State University, 1997.
Typescript.
A family of chromatin remodeling factors related to Williams syndrome transcription factor
Bochar, Daniel A., Savard, Julie, Wang, Weidong, Lafleur, David W., Moore, Paul, Côté, Jacques, ...
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report...
Wang, Weidong, Chi, Tianhuai, Xue, Yutong, Zhou, Sharleen, Kuo, Ann, Crabtree, Gerald R.
The SWI/SNF complex in yeast and Drosophila is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. The mechanism by which...
Xue, Yutong, Canman, Julie C., Lee, Cheol Soon, Nie, Zuqin, Yang, Dafeng, Moreno, G. Tony, ...
The SWI/SNF family of chromatin-remodeling complexes facilitates gene expression by helping transcription factors gain access to their targets in chromatin. SWI/SNF and Rsc are distinctive members of...
A Specificity and Targeting Subunit of a Human SWI/SNF Family-Related Chromatin-Remodeling Complex
Nie, Zuqin, Xue, Yutong, Yang, Dafeng, Zhou, Sharleen, Deroo, Bonnie J., Archer, Trevor K., ...
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain access to targets in chromatin. This family includes BAF (also called...
Nie, Zuqin, Yan, Zhijiang, Chen, Everett H., Sechi, Salvatore, Ling, Chen, Zhou, Sharleen, ...
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their...
A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome
Meetei, Amom Ruhikanta, Sechi, Salvatore, Wallisch, Michael, Yang, Dafeng, Young, Mary K., Joenje, Hans, ...
Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of cancer. To investigate the mechanism of this disease, we isolated from...
Hsiao, Pei-Wen, Fryer, Christy J., Trotter, Kevin W., Wang, Weidong, Archer, Trevor K.
Nuclear hormone receptors are ligand-dependent transcriptional regulators that modulate chromatin structure. However, the precise molecular mechanisms by which receptors recruit chromatin-remodeling...
Identification of a polymorphic, neuron-specific chromatin remodeling complex
Olave, Ivan, Wang, Weidong, Xue, Yutong, Kuo, Ann, Crabtree, Gerald R.
A variety of chromatin remodeling complexes are thought to assist sequence-specific transcription factors. The complexes described to date are expressed ubiquitously, suggesting that they have...
Xue, Yutong, Gibbons, Richard, Yan, Zhijiang, Yang, Dafeng, McDowell, Tarra L., Sechi, Salvatore, ...
ATRX syndrome is characterized by X-linked mental retardation associated with α-thalassemia. The gene mutated in this disease, ATRX, encodes a plant homeodomain-like finger and a SWI2/SNF2-like...
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
Yin, Jinhu, Sobeck, Alexandra, Xu, Chang, Meetei, Amom Ruhikanta, Hoatlin, Maureen, Li, Lei, ...
Bloom's syndrome (BS) is a rare human genetic disorder characterized by dwarfism, immunodeficiency, genomic instability and cancer predisposition. We have previously purified three complexes...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Sobeck, Alexandra, Stone, Stacie, Costanzo, Vincenzo, De Graaf, Bendert, Reuter, Tanja, De Winter, Johan, ...
Fanconi anemia (FA) is a multigene cancer susceptibility disorder characterized by cellular hypersensitivity to DNA interstrand cross-linking agents such as mitomycin C (MMC). FA proteins are...
Li, Jiwen, Lin, Qiushi, Wang, Weidong, Wade, Paul, Wong, Jiemin
Specific recruitment of corepressor complexes containing histone deacetylases (HDAC) by transcription factors is believed to play an essential role in transcriptional repression. Recent studies...
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Wu, Leonard, Bachrati, Csanad Z., Ou, Jiongwen, Xu, Chang, Yin, Jinhu, Chang, Michael, ...
BLM encodes a member of the highly conserved RecQ DNA helicase family, which is essential for the maintenance of genome stability. Homozygous inactivation of BLM gives rise to the cancer...
A family of chromatin remodeling factors related to Williams syndrome transcription factor
Bochar, Daniel A., Savard, Julie, Wang, Weidong, Lafleur, David W., Moore, Paul, Côté, Jacques, ...
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report...
Wang, Weidong, Chi, Tianhuai, Xue, Yutong, Zhou, Sharleen, Kuo, Ann, Crabtree, Gerald R.
The SWI/SNF complex in yeast and Drosophila is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. The mechanism by which...
Xue, Yutong, Canman, Julie C., Lee, Cheol Soon, Nie, Zuqin, Yang, Dafeng, Moreno, G. Tony, ...
The SWI/SNF family of chromatin-remodeling complexes facilitates gene expression by helping transcription factors gain access to their targets in chromatin. SWI/SNF and Rsc are distinctive members of...
A Specificity and Targeting Subunit of a Human SWI/SNF Family-Related Chromatin-Remodeling Complex
Nie, Zuqin, Xue, Yutong, Yang, Dafeng, Zhou, Sharleen, Deroo, Bonnie J., Archer, Trevor K., ...
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain access to targets in chromatin. This family includes BAF (also called...
Nie, Zuqin, Yan, Zhijiang, Chen, Everett H., Sechi, Salvatore, Ling, Chen, Zhou, Sharleen, ...
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their...
Li, Jiwen, Lin, Qiushi, Wang, Weidong, Wade, Paul, Wong, Jiemin
Specific recruitment of corepressor complexes containing histone deacetylases (HDAC) by transcription factors is believed to play an essential role in transcriptional repression. Recent studies...
A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome
Meetei, Amom Ruhikanta, Sechi, Salvatore, Wallisch, Michael, Yang, Dafeng, Young, Mary K., Joenje, Hans, ...
Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of cancer. To investigate the mechanism of this disease, we isolated from...
Hsiao, Pei-Wen, Fryer, Christy J., Trotter, Kevin W., Wang, Weidong, Archer, Trevor K.
Nuclear hormone receptors are ligand-dependent transcriptional regulators that modulate chromatin structure. However, the precise molecular mechanisms by which receptors recruit chromatin-remodeling...
Identification of a polymorphic, neuron-specific chromatin remodeling complex
Olave, Ivan, Wang, Weidong, Xue, Yutong, Kuo, Ann, Crabtree, Gerald R.
A variety of chromatin remodeling complexes are thought to assist sequence-specific transcription factors. The complexes described to date are expressed ubiquitously, suggesting that they have...
Xue, Yutong, Gibbons, Richard, Yan, Zhijiang, Yang, Dafeng, McDowell, Tarra L., Sechi, Salvatore, ...
ATRX syndrome is characterized by X-linked mental retardation associated with α-thalassemia. The gene mutated in this disease, ATRX, encodes a plant homeodomain-like finger and a SWI2/SNF2-like...
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
Yin, Jinhu, Sobeck, Alexandra, Xu, Chang, Meetei, Amom Ruhikanta, Hoatlin, Maureen, Li, Lei, ...
Bloom's syndrome (BS) is a rare human genetic disorder characterized by dwarfism, immunodeficiency, genomic instability and cancer predisposition. We have previously purified three complexes...
Yan, Zhijiang, Cui, Kairong, Murray, Darryl M., Ling, Chen, Xue, Yutong, Gerstein, Amy, ...
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can...
Sobeck, Alexandra, Stone, Stacie, Costanzo, Vincenzo, De Graaf, Bendert, Reuter, Tanja, De Winter, Johan, ...
Fanconi anemia (FA) is a multigene cancer susceptibility disorder characterized by cellular hypersensitivity to DNA interstrand cross-linking agents such as mitomycin C (MMC). FA proteins are...
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Wu, Leonard, Bachrati, Csanad Z., Ou, Jiongwen, Xu, Chang, Yin, Jinhu, Chang, Michael, ...
BLM encodes a member of the highly conserved RecQ DNA helicase family, which is essential for the maintenance of genome stability. Homozygous inactivation of BLM gives rise to the cancer...
Evidence for subcomplexes in the Fanconi anemia pathway
Medhurst, Annette L., Laghmani, El Houari, Steltenpool, Jurgen, Ferrer, Miriam, Fontaine, Chantal, De Groot, Jan, ...
Fanconi anemia (FA) is a genomic instability disorder, clinically characterized by congenital abnormalities, progressive bone marrow failure, and predisposition to malignancy. Cells derived from...
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
Ling, Chen, Ishiai, Masamichi, Ali, Abdullah Mahmood, Medhurst, Annette L, Neveling, Kornelia, Kalb, Reinhard, ...
The Fanconi anemia (FA) core complex plays a central role in the DNA damage response network involving breast cancer susceptibility gene products, BRCA1 and BRCA2. The complex consists of eight FA...
Molecular Mechanisms of Antidiuretic Effect of Oxytocin
Li, Chunling, Wang, Weidong, Summer, Sandra N., Westfall, Timothy D., Brooks, David P., Falk, Sandor, ...
Oxytocin is known to have an antidiuretic effect, but the mechanisms underlying this effect are not completely understood. We infused oxytocin by osmotic minipump into vasopressin-deficient...
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability
Xu, Dongyi, Guo, Rong, Sobeck, Alexandra, Bachrati, Csanad Z., Yang, Jay, Enomoto, Takemi, ...
BLM, the helicase mutated in Bloom syndrome, associates with topoisomerase 3α, RMI1 (RecQ-mediated genome instability), and RPA, to form a complex essential for the maintenance of genome stability....
Identification of small-molecule inducers of pancreatic β-cell expansion
Wang, Weidong, Walker, John R., Wang, Xia, Tremblay, Matthew S., Lee, Jae Wook, Wu, Xu, ...
To identify small molecules that can induce β-cell replication, a large chemical library was screened for proliferation of growth-arrested, reversibly immortalized mouse β cells by using an...
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Tao, Jifang, Hu, Keping, Chang, Qiang, Wu, Hao, Sherman, Nicholas E., Martinowich, Keri, ...
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain...
Li, Chunling, Wang, Weidong, Summer, Sandra N., Falk, Sandor, Schrier, Robert W.
Excessive glucocorticoid hormone, as occurs with Cushing syndrome, is known to be associated with altered body water homeostasis, but the molecular mechanisms are unknown. In this study, rats treated...
hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response*
Li, Yongjiang, Bolderson, Emma, Kumar, Rakesh, Muniandy, Parameswary A., Xue, Yutong, Richard, Derek J., ...
hSSB1 (human single strand DNA-binding protein 1) has been shown to participate in homologous recombination (HR)-dependent repair of DNA double strand breaks (DSBs) and ataxia telangiectasia-mutated...