Weiqun Liu

CCAAT/Enhancer Binding Protein alpha uses distinct domains to prolong pituitary cells in the Growth 1 and DNA Synthesis phases of the cell cycle (2002)

Liu, Weiqun, Enwright, John F, Hyun, William, Day, Richard N, Schaufele, Fred

Abstract Background A number of transcription factors coordinate differentiation by simultaneously regulating gene expression and cell proliferation. CCAAT/enhancer binding protein alpha (C/EBPα) is...

BACE knockout mice are healthy despite lacking the primary {beta}-secretase activity in brain: implications for Alzheimer's disease therapeutics (2001)

Roberds, Steven L., Anderson, John, Basi, Guriqbal, Bienkowski, Michael J., Branstetter, Daniel G., Chen, Karen S., ...

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, &bgr;-amyloid...

CCAAT/Enhancer Binding Protein alpha uses distinct domains to prolong pituitary cells in the Growth 1 and DNA Synthesis phases of the cell cycle

Liu, Weiqun, Enwright, John F, Hyun, William, Day, Richard N, Schaufele, Fred

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, ...

The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful...

Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein.

Liu, Haiying, Zhang, Wenqing, Reed, Robyn B, Liu, Weiqun, Grabowski, Paula J

The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of...

CCAAT/Enhancer Binding Protein alpha uses distinct domains to prolong pituitary cells in the Growth 1 and DNA Synthesis phases of the cell cycle

Liu, Weiqun, Enwright, John F, Hyun, William, Day, Richard N, Schaufele, Fred

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, ...

The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful...

Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein.

Liu, Haiying, Zhang, Wenqing, Reed, Robyn B, Liu, Weiqun, Grabowski, Paula J

The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of...

Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection▿

Bahjat, Keith S., Liu, Weiqun, Lemmens, Edward E., Schoenberger, Stephen P., Portnoy, Daniel A., Dubensky, Thomas W., ...

Interaction with host immunoreceptors during microbial infection directly impacts the magnitude of the ensuing innate immune response. How these signals affect the quality of the adaptive T-cell...

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains▿

Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., ...

Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort...

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

Skoberne, Mojca, Yewdall, Alice, Bahjat, Keith S., Godefroy, Emmanuelle, Lauer, Peter, Lemmens, Edward, ...

Vaccine strategies that utilize human DCs to enhance antitumor immunity have yet to realize their full potential. Approaches that optimally target a spectrum of antigens to DCs are urgently needed....

Killed but Metabolically Active Bacillus anthracis Vaccines Induce Broad and Protective Immunity against Anthrax▿

Skoble, Justin, Beaber, John W., Gao, Yi, Lovchik, Julie A., Sower, Laurie E., Liu, Weiqun, ...

Bacillus anthracis is the causative agent of anthrax. We have developed a novel whole-bacterial-cell anthrax vaccine utilizing B. anthracis that is killed but metabolically active (KBMA). Vaccine...