Weisan Chen

RNAdb-a comprehensive mammalian noncoding RNA database (2005)

Ken C. Pang, Stuart Stephen, Pär G. Engström, Khairina Tajul-arifin, Weisan Chen, Claes Wahlestedt, ...

In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here,...

RNAdb--a comprehensive mammalian noncoding RNA database (2005)

Pang, Ken C., Stephen, Stuart, Engström, Pär G., Tajul-Arifin, Khairina, Chen, Weisan, Wahlestedt, Claes, ...

In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here,...

Antigen presentation of MHC class 1 molecules (1993)

Chen, Weisan.

Typescript (photocopy) Bibliography: leaves 104-118.

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

Princiotta, Michael F., Schubert, Ulrich, Chen, Weisan, Bennink, Jack R., Myung, Jayhyuk, Crews, Craig M., ...

The proteasome is the primary protease used by cells for degrading proteins and generating peptide ligands for class I molecules of the major histocompatibility complex. Based on the properties of...

CD8+ T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

Gnjatic, Sacha, Jäger, Elke, Chen, Weisan, Altorki, Nasser K., Matsuo, Mitsutoshi, Lee, Sang-Yull, ...

NY-ESO-1 is a germ cell antigen aberrantly expressed in different tumor types that elicits strong humoral and cellular immune responses in cancer patients. Monitoring spontaneous CD8+ T cell...

Mice Deficient in Perforin, CD4+ T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8+ T-Cell Responses to Influenza Virus

Chen, Weisan, Bennink, Jack R., Morton, Phillip A., Yewdell, Jonathan W.

CD8 T-cell (TCD8+) responses elicited by viral infection demonstrate the phenomenon of immunodominance: the numbers of TCD8+ responding to different viral peptides vary over a wide range in a...

The Early Expression of Glycoprotein B from Herpes Simplex Virus Can Be Detected by Antigen-Specific CD8+ T Cells

Mueller, Scott N., Jones, Claerwen M., Chen, Weisan, Kawaoka, Yoshihiro, Castrucci, Maria R., Heath, William R., ...

The immune response to cutaneous herpes simplex virus type 1 (HSV-1) infection begins with remarkable rapidity. Activation of specific cytotoxic T lymphocytes (CTL) begins within hours of infection,...

Heat-Aggregated Noninfectious Influenza Virus Induces a More Balanced CD8+-T-Lymphocyte Immunodominance Hierarchy Than Infectious Virus

Cho, Yunjung, Basta, Sameh, Chen, Weisan, Bennink, Jack R., Yewdell, Jonathan W.

CD8+-T-cell (TCD8+) responses to infectious viruses are characterized by an immunodominance hierarchy in which the majority of TCD8+ respond to one or a few immunodominant determinants, with a...

Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

Chen, Qiyuan, Jackson, Heather, Parente, Phillip, Luke, Tina, Rizkalla, Mark, Tai, Tsin Yee, ...

There is increasing evidence showing the involvement of CD4+ T cells in initiating and maintaining antitumor immune responses. NY-ESO-1 is expressed by various tumors but not normal tissues except...

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

Davis, Ian D., Chen, Weisan, Jackson, Heather, Parente, Phillip, Shackleton, Mark, Hopkins, Wendie, ...

NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a saponin-based adjuvant that induces antibody and T cell responses. We performed a placebo-controlled clinical...

RNAdb—a comprehensive mammalian noncoding RNA database

Pang, Ken C., Stephen, Stuart, Engström, Pär G., Tajul-Arifin, Khairina, Chen, Weisan, Wahlestedt, Claes, ...

In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here,...

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

La Gruta, Nicole L., Kedzierska, Katherine, Pang, Ken, Webby, Richard, Davenport, Miles, Chen, Weisan, ...

Immunodominance hierarchies are a substantial, but poorly understood, characteristic of CD8+ T cell-mediated immunity. Factors influencing the differential responses to the influenza A virus...

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

Princiotta, Michael F., Schubert, Ulrich, Chen, Weisan, Bennink, Jack R., Myung, Jayhyuk, Crews, Craig M., ...

The proteasome is the primary protease used by cells for degrading proteins and generating peptide ligands for class I molecules of the major histocompatibility complex. Based on the properties of...

CD8+ T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

Gnjatic, Sacha, Jäger, Elke, Chen, Weisan, Altorki, Nasser K., Matsuo, Mitsutoshi, Lee, Sang-Yull, ...

NY-ESO-1 is a germ cell antigen aberrantly expressed in different tumor types that elicits strong humoral and cellular immune responses in cancer patients. Monitoring spontaneous CD8+ T cell...

Mice Deficient in Perforin, CD4+ T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8+ T-Cell Responses to Influenza Virus

Chen, Weisan, Bennink, Jack R., Morton, Phillip A., Yewdell, Jonathan W.

CD8 T-cell (TCD8+) responses elicited by viral infection demonstrate the phenomenon of immunodominance: the numbers of TCD8+ responding to different viral peptides vary over a wide range in a...

The Early Expression of Glycoprotein B from Herpes Simplex Virus Can Be Detected by Antigen-Specific CD8+ T Cells

Mueller, Scott N., Jones, Claerwen M., Chen, Weisan, Kawaoka, Yoshihiro, Castrucci, Maria R., Heath, William R., ...

The immune response to cutaneous herpes simplex virus type 1 (HSV-1) infection begins with remarkable rapidity. Activation of specific cytotoxic T lymphocytes (CTL) begins within hours of infection,...

Heat-Aggregated Noninfectious Influenza Virus Induces a More Balanced CD8+-T-Lymphocyte Immunodominance Hierarchy Than Infectious Virus

Cho, Yunjung, Basta, Sameh, Chen, Weisan, Bennink, Jack R., Yewdell, Jonathan W.

CD8+-T-cell (TCD8+) responses to infectious viruses are characterized by an immunodominance hierarchy in which the majority of TCD8+ respond to one or a few immunodominant determinants, with a...

Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

Chen, Qiyuan, Jackson, Heather, Parente, Phillip, Luke, Tina, Rizkalla, Mark, Tai, Tsin Yee, ...

There is increasing evidence showing the involvement of CD4+ T cells in initiating and maintaining antitumor immune responses. NY-ESO-1 is expressed by various tumors but not normal tissues except...

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

Davis, Ian D., Chen, Weisan, Jackson, Heather, Parente, Phillip, Shackleton, Mark, Hopkins, Wendie, ...

NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a saponin-based adjuvant that induces antibody and T cell responses. We performed a placebo-controlled clinical...

RNAdb—a comprehensive mammalian noncoding RNA database

Pang, Ken C., Stephen, Stuart, Engström, Pär G., Tajul-Arifin, Khairina, Chen, Weisan, Wahlestedt, Claes, ...

In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here,...

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

La Gruta, Nicole L., Kedzierska, Katherine, Pang, Ken, Webby, Richard, Davenport, Miles, Chen, Weisan, ...

Immunodominance hierarchies are a substantial, but poorly understood, characteristic of CD8+ T cell-mediated immunity. Factors influencing the differential responses to the influenza A virus...

Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of Major Histocompatibility Complex Class I–restricted Viral Determinants

Chen, Weisan, Yewdell, Jonathan W., Levine, Rodney L., Bennink, Jack R.

In studying the subdominant status of two cysteine-containing influenza virus nuclear protein (NP) determinants (NP39–47 and NP218–226) restricted by H-2Kd, we found that the antigenicity of...

Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

Chen, Weisan, Norbury, Christopher C., Cho, Yunjung, Yewdell, Jonathan W., Bennink, Jack R.

Vertebrates express three cytokine-inducible proteasome subunits that are incorporated in the place of their constitutively synthesized counterparts. There is increasing evidence that the set of...

Introduction of a Glycosylation Site into a Secreted Protein Provides Evidence for an Alternative Antigen Processing Pathway: Transport of Precursors of Major Histocompatability Complex Class I–Restricted Peptides from the Endoplasmic Reticulum to the Cytosol

Bačík, Igor, Snyder, Heidi Link, Antón, Luis C., Russ, Gustav, Chen, Weisan, Bennink, Jack R., ...

We found that the presentation of a H-2Kd-restricted determinant from influenza virus nucleoprotein (NP) to T cells is strictly dependent on expression of the transporter associated with antigen...