Evolution of a TRIM5-CypA splice isoform in old world monkeys (2008)
Newman, Ruchi M., Hall, Laura, Kirmaier, Andrea, Pozzi, Lu-Ann M., Pery, Erez, Farzan, Michael, ...
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif...
Lee, Arthur S., Gutiérrez-Arcelus, María, Perry, George H., Vallender, Eric J., Johnson, Welkin E., Miller, Gregory M., ...
Copy number variants (CNVs) are heritable gains and losses of genomic DNA in normal individuals. While copy number variation is widely studied in humans, our knowledge of CNVs in other mammalian...
Submitted to the Sackler School of Graduate Biomedical Sciences, Dept. of Molecular Biology and Microbiology.
Constructing primate phylogenies from ancient retrovirus sequences
Johnson, Welkin E., Coffin, John M.
The genomes of modern humans are riddled with thousands of endogenous retroviruses (HERVs), the proviral remnants of ancient viral infections of the primate lineage. Most HERVs are nonfunctional,...
Species Specificity of Macaque Rhadinovirus Glycoprotein B Sequences
Auerbach, Marcy R., Czajak, Susan C., Johnson, Welkin E., Desrosiers, Ronald C., Alexander, Louis
All members of the Herpesviridae family contain sequences for a highly conserved glycoprotein B (gB) gene. We investigated the phylogenetic relationships of gB sequences from eight independent...
Johnson, Welkin E., Sauvron, Jennifer M., Desrosiers, Ronald C.
The transmembrane subunit (TM) of human immunodeficiency virus type 1 (HIV-1) envelope protein contains four well-conserved sites for the attachment of N-linked carbohydrates. To study the...
Johnson, Welkin E., Morgan, Jennifer, Reitter, Julie, Puffer, Bridget A., Czajak, Susan, Doms, Robert W., ...
Coding sequences for the first two variable loops of the gp120 envelope glycoprotein were removed from simian immunodeficiency virus (SIV) strain 239 (SIVmac239). This deletion encompassed 100 amino...
Johnson, Welkin E., Lifson, Jeffrey D., Lang, Sabine M., Johnson, R. Paul, Desrosiers, Ronald C.
The properties of three variants of cloned simian immunodeficiency virus strain 239 (SIV239) were compared. One strain (M5) lacked five sites for N-linked carbohydrate attachment in variable regions...
Johnson, Welkin E., Sanford, Hannah, Schwall, Linda, Burton, Dennis R., Robinson, James E., ...
Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary...
Yuste, Eloisa, Sanford, Hannah B., Carmody, Jill, Bixby, Jacqueline, Little, Susan, Zwick, Michael B., ...
To date, only a small number of anti-human immunodeficiency virus type 1 (HIV-1) monoclonal antibodies (MAbs) with relatively broad neutralizing activity have been isolated from infected individuals....
Constructing primate phylogenies from ancient retrovirus sequences
Johnson, Welkin E., Coffin, John M.
The genomes of modern humans are riddled with thousands of endogenous retroviruses (HERVs), the proviral remnants of ancient viral infections of the primate lineage. Most HERVs are nonfunctional,...
Species Specificity of Macaque Rhadinovirus Glycoprotein B Sequences
Auerbach, Marcy R., Czajak, Susan C., Johnson, Welkin E., Desrosiers, Ronald C., Alexander, Louis
All members of the Herpesviridae family contain sequences for a highly conserved glycoprotein B (gB) gene. We investigated the phylogenetic relationships of gB sequences from eight independent...
Johnson, Welkin E., Sauvron, Jennifer M., Desrosiers, Ronald C.
The transmembrane subunit (TM) of human immunodeficiency virus type 1 (HIV-1) envelope protein contains four well-conserved sites for the attachment of N-linked carbohydrates. To study the...
Johnson, Welkin E., Morgan, Jennifer, Reitter, Julie, Puffer, Bridget A., Czajak, Susan, Doms, Robert W., ...
Coding sequences for the first two variable loops of the gp120 envelope glycoprotein were removed from simian immunodeficiency virus (SIV) strain 239 (SIVmac239). This deletion encompassed 100 amino...
Johnson, Welkin E., Lifson, Jeffrey D., Lang, Sabine M., Johnson, R. Paul, Desrosiers, Ronald C.
The properties of three variants of cloned simian immunodeficiency virus strain 239 (SIV239) were compared. One strain (M5) lacked five sites for N-linked carbohydrate attachment in variable regions...
Johnson, Welkin E., Sanford, Hannah, Schwall, Linda, Burton, Dennis R., Robinson, James E., ...
Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary...
Yuste, Eloisa, Sanford, Hannah B., Carmody, Jill, Bixby, Jacqueline, Little, Susan, Zwick, Michael B., ...
To date, only a small number of anti-human immunodeficiency virus type 1 (HIV-1) monoclonal antibodies (MAbs) with relatively broad neutralizing activity have been isolated from infected individuals....
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5α
Newman, Ruchi M., Hall, Laura, Connole, Michelle, Chen, Guo-Lin, Sato, Shuji, Yuste, Eloisa, ...
Retroviral restriction factor TRIM5α exhibits a high degree of sequence variation among primate species. It has been proposed that this diversity is the cumulative result of ancient,...
Dhillon, Amandeep K., Donners, Helen, Pantophlet, Ralph, Johnson, Welkin E., Decker, Julie M., Shaw, George M., ...
Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements...
McNatt, Matthew W., Zang, Trinity, Hatziioannou, Theodora, Bartlett, Mackenzie, Fofana, Ismael Ben, Johnson, Welkin E., ...
Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as...
Sato, Shuji, Yuste, Eloisa, Lauer, William A., Chang, Eun Hyuk, Morgan, Jennifer S., Bixby, Jacqueline G., ...
Here, we describe the evolution of antigenic escape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239. By 42 weeks postinfection, 50% neutralization...
Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2
Jia, Bin, Serra-Moreno, Ruth, Neidermyer, William, Rahmberg, Andrew, Mackey, John, Fofana, Ismael Ben, ...
Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host–cell factor that interferes with the detachment of virus particles from infected cells. HIV-1...