Guikai Wu, Xianzhi Jiang, Wen-hwa Lee, Phang-lang Chen
Immortalized cells maintain telomere length through either a telomerase-dependent process or a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). Homologous...
Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice (2003)
Sharp, Z.Dave, Lee, Wen-Hwa, Nikitin, Alexander Yu, Flesken-Nikitin, Andrea, Ikeno, Yuji, Reddick, Robert, ...
The efficacy of dietary restriction in retarding tumor growth is well established in rodents. However, gene and cell lineage specificity of dietary restriction effects is far less defined. Mice with...
Training Program in the Molecular Basis of Breast Cancer Research (2001)
The objective of the program is to establish at the University of Texas Health Science Center at San Antonio an in-depth training program in the Molecular Genetics of Breast Cancer. The goal of the...
Training Program in the Molecular Basis of Breast Cancer Research. (1998)
The objective of this program is to establish at the University of Texas Health Science Center in San Antonio an in-depth training program in the Molecular Genetics of Breast Cancer. The most...
Training Program in the Molecular Basis of Breast Cancer Research. (1998)
The objective of the program is to establish at the University of Texas Health Science Center at San Antonio an in-depth training program in the Molecular Genetics of Breast Cancer. One goal of the...
Training Program in the Molecular Basis of Breast Cancer Research. (1998)
The objective of the program is to train highly qualified doctoral students in the genetic, cellular, and molecular basis of Breast Cancer. The training in Breast Cancer research that students obtain...
Training Program in the Molecular Basis of Breast Cancer Research (1998)
The objective of the program was to train highly qualified doctoral students in the genetic, cellular, and molecular basis of Breast Cancer. The training in Breast Cancer research which students...
Training Program in the Molecular Basis of Breast Cancer Research (1998)
The objective of the program is to train highly qualified doctoral students in the genetic, cellular, and molecular basis of Breast Cancer. The training program, conducted within the Molecular...
Involvement of BRCA2 BRC Repeats in RAD51 Mediated DNA Repair (1998)
Gao, Qing, Ting, Nicholas, Lee, Wen-Hwa
Mutations in the BRCA2 gene have been found in many familial breast cancers. Cells deficient for functional BRCA2 show various cellular abnormalities including increased sensitivity to genotoxic...
Phosphorylation of hRad17 by ATR is Required for Cell Cycle Checkpoint Activation (1998)
ATR is protein kinase required for both DNA damage-induced cell cycle checkpoint responses and the DNA replication checkpoint, which prevents mitosis before completion of DNA synthesis. Although ATM...
Training Program in the Molecular Basis of Breast Cancer Research (1998)
The objective of the program is to train highly qualified doctoral students in the genetic, cellular, and molecular basis of Breast Cancer. The training program, conducted within the Molecular...
Allele Loss at the Retinoblastoma Locus in Human Ovarian Cancer (1991)
Li, Shi-bo, Schwartz, Peter E., Lee, Wen-Hwa, Yang-Feng, Teresa L.
To gain a broad spectrum on allelic loss of specific loci in ovarian tumors, we initially examined DNA from 23 pairs of ovarian tumors and matched peripheral blood lymphocyte samples from the same...
Thesis (Ph. D. in Molecular Biology)--University of California, Berkeley, Dec. 1981.
Typescript.
Chen, Yumay, Chen, Phang-Lang, Chen, Chi-Fen, Sharp, Z. Dave, Lee, Wen-Hwa
Trip230 is a novel coactivator of the thyroid hormone receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein. In an examination of its subcellular distribution, Trip230...
Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Xiao, Jun, Sharp, Z. Dave, Lee, Wen-Hwa
The BRCA2 gene was identified based on its involvement in familial breast cancer. The analysis of its sequence predicts that the gene encodes a protein with 3,418 amino acids but provides very few...
Nikitin, Alexander Yu., Juárez-Pérez, María I., Li, Song, Huang, Leaf, Lee, Wen-Hwa
Alterations in pathways mediated by retinoblastoma susceptibility gene (RB) product are among the most common in human cancer. Mice with a single copy of the Rb gene are shown to develop a syndrome...
A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
Chang, Kai-Hsuan, Chen, Yumay, Chen, Tung-Ti, Chou, Wen-Hai, Chen, Phang-Lang, Ma, Yen-Ying, ...
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at the molecular level, we have systematically...
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
Zheng, Lei, Annab, Lois A., Afshari, Cynthia A., Lee, Wen-Hwa, Boyer, Thomas G.
Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive properties of BRCA1...
Zheng, Lei, Chen, Yumay, Lee, Wen-Hwa
hsHec1p, a Homo sapiens coiled-coil-enriched protein, plays an important role in M-phase progression in mammalian cells. A Saccharomyces cerevisiae protein, identical to Tid3p/Ndc80p and here...
Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p
Zheng, Lei, Chen, Yumay, Riley, Daniel J., Chen, Phang-Lang, Lee, Wen-Hwa
Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence...
Lee, Wen-Hwa, Bister, Klaus, Moscovici, Carlo, Duesberg, Peter H.
Several clones of Fujinami sarcoma virus (FSV) isolated from a laboratory stock or from mutagenized virus were temperature sensitive (ts) in transformation of cells in culture. When shifted from the...
Lee, Wen-Hwa, Nunn, Michael, Duesberg, Peter H.
The src genes of different Rous sarcoma virus (RSV) strains have been reported to be highly conserved by some investigators using RNA-cDNA hybridization, whereas others using oligonucleotide,...
Induction of gene expression in response to DNA damage is important for repairing damaged DNA for cell survival. Previously, we identified a novel zinc finger protein, ZBRK1, which contains a KRAB...
Fujinami sarcoma virus: An avian RNA tumor virus with a unique transforming gene
Lee, Wen-Hwa, Bister, Klaus, Pawson, Anthony, Robins, Terry, Moscovici, Carlo, Duesberg, Peter H.
The oncogenic properties and RNA of the Fujinami avian sarcoma virus (FSV) and the protein it encodes were investigated and compared to those of other avian tumor viruses with sarcomagenic properties...
Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, ...
CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as...
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Furuta, Saori, Jiang, Xianzhi, Gu, Bingnan, Cheng, Eric, Chen, Phang-Lang, Lee, Wen-Hwa
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the...
CtIP Activates Its Own and Cyclin D1 Promoters via the E2F/RB Pathway during G1/S Progression
Cell cycle progression from G1 to S phase is mainly controlled by E2F transcription factors and RB family proteins. Previously we showed that the presence of CtIP is essential for G1/S transition in...
Chen, Yumay, Chen, Phang-Lang, Chen, Chi-Fen, Sharp, Z. Dave, Lee, Wen-Hwa
Trip230 is a novel coactivator of the thyroid hormone receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein. In an examination of its subcellular distribution, Trip230...
Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Xiao, Jun, Sharp, Z. Dave, Lee, Wen-Hwa
The BRCA2 gene was identified based on its involvement in familial breast cancer. The analysis of its sequence predicts that the gene encodes a protein with 3,418 amino acids but provides very few...
Nikitin, Alexander Yu., Juárez-Pérez, María I., Li, Song, Huang, Leaf, Lee, Wen-Hwa
Alterations in pathways mediated by retinoblastoma susceptibility gene (RB) product are among the most common in human cancer. Mice with a single copy of the Rb gene are shown to develop a syndrome...
A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
Chang, Kai-Hsuan, Chen, Yumay, Chen, Tung-Ti, Chou, Wen-Hai, Chen, Phang-Lang, Ma, Yen-Ying, ...
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at the molecular level, we have systematically...
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
Zheng, Lei, Annab, Lois A., Afshari, Cynthia A., Lee, Wen-Hwa, Boyer, Thomas G.
Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive properties of BRCA1...
Zheng, Lei, Chen, Yumay, Lee, Wen-Hwa
hsHec1p, a Homo sapiens coiled-coil-enriched protein, plays an important role in M-phase progression in mammalian cells. A Saccharomyces cerevisiae protein, identical to Tid3p/Ndc80p and here...
Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p
Zheng, Lei, Chen, Yumay, Riley, Daniel J., Chen, Phang-Lang, Lee, Wen-Hwa
Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence...
Lee, Wen-Hwa, Bister, Klaus, Moscovici, Carlo, Duesberg, Peter H.
Several clones of Fujinami sarcoma virus (FSV) isolated from a laboratory stock or from mutagenized virus were temperature sensitive (ts) in transformation of cells in culture. When shifted from the...
Lee, Wen-Hwa, Nunn, Michael, Duesberg, Peter H.
The src genes of different Rous sarcoma virus (RSV) strains have been reported to be highly conserved by some investigators using RNA-cDNA hybridization, whereas others using oligonucleotide,...
Induction of gene expression in response to DNA damage is important for repairing damaged DNA for cell survival. Previously, we identified a novel zinc finger protein, ZBRK1, which contains a KRAB...
Fujinami sarcoma virus: An avian RNA tumor virus with a unique transforming gene
Lee, Wen-Hwa, Bister, Klaus, Pawson, Anthony, Robins, Terry, Moscovici, Carlo, Duesberg, Peter H.
The oncogenic properties and RNA of the Fujinami avian sarcoma virus (FSV) and the protein it encodes were investigated and compared to those of other avian tumor viruses with sarcomagenic properties...
Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, ...
CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as...
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Furuta, Saori, Jiang, Xianzhi, Gu, Bingnan, Cheng, Eric, Chen, Phang-Lang, Lee, Wen-Hwa
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the...
CtIP Activates Its Own and Cyclin D1 Promoters via the E2F/RB Pathway during G1/S Progression
Cell cycle progression from G1 to S phase is mainly controlled by E2F transcription factors and RB family proteins. Previously we showed that the presence of CtIP is essential for G1/S transition in...
Lin, Xiaoqin, Liu, Chang-Ching, Gao, Qing, Zhang, Xiaohai, Wu, GuiKai, Lee, Wen-Hwa
Faithful mitotic partitioning of the Golgi apparatus and the centrosome is critical for proper cell division. Although these two cytoplasmic organelles are probably coordinated during cell division,...
Wu, Guikai, Lin, Yi-Tzu, Wei, Randy, Chen, Yumay, Shan, Zhiyin, Lee, Wen-Hwa
Spindle integrity is critical for efficient mitotic progression and accurate chromosome segregation. Deregulation of spindles often leads to structural and functional aberrations, ultimately...
Role of SUV3 Helicase in Maintaining Mitochondrial Homeostasis in Human Cells*
Khidr, Lily, Wu, Guikai, Davila, Antonio, Procaccio, Vincent, Wallace, Douglas, Lee, Wen-Hwa
In yeast mitochondria, RNA degradation takes place through the coordinated activities of ySuv3 helicase and yDss1 exoribonuclease (mtEXO), whereas in bacteria, RNA is degraded via RNaseE, RhlB,...