Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes
Lai, Jian-Ping, Ho, Wen-Zhe, Zhan, Guan-Xia, Yi, Yanjie, Collman, Ronald G., Douglas, Steven D.
Substance P (SP) is a potent modulator of neuroimmunoregulation. We recently reported that human immune cells express SP and its receptor. We have now investigated the possible role that SP and its...
Differential Expression of Neurokinin-1 Receptor by Human Mucosal and Peripheral Lymphoid Cells
Goode, Triona, O'Connell, Joe, Ho, Wen-Zhe, O'Sullivan, Gerald C., Collins, J. Kevin, Douglas, Steven D., ...
Substance P (SP) has been implicated in peripheral and mucosal neuroimmunoregulation. However, confusion remains regarding immunocyte expression of the receptor for SP, neurokinin-1 receptor (NK-1R),...
Fehder, William P., Ho, Wen-Zhe, Campbell, Donald E., Tourtellotte, Wallace W., Michaels, Lisa, Cutilli, Joann R., ...
We have developed a simple chromatographic procedure for the partial purification of substance P (SP) from acidified plasma and serum samples. We have evaluated a sensitive antigen competition enzyme...
Lai, Jian-Ping, Douglas, Steven D., Shaheen, Farida, Pleasure, David E., Ho, Wen-Zhe
We have applied a newly developed real-time reverse transcriptase (RT) PCR (RT-PCR) assay for quantification of substance P (SP) mRNA expression (the SP real-time RT-PCR assay) in human blood...
Lai, Jian-Ping, Yang, Ji-Hong, Douglas, Steven D., Wang, Xu, Riedel, Eric, Ho, Wen-Zhe
CCR5, a β-chemokine receptor, plays an important role in human immunodeficiency virus (HIV) infection of human immune cells, as it is a primary coreceptor for HIV entry into macrophages. We have...
Real-Time Reverse Transcription-PCR Quantitation of Substance P Receptor (NK-1R) mRNA
Lai, Jian-Ping, Douglas, Steven D., Wang, Yan-Jian, Ho, Wen-Zhe
The substance P (SP)-preferring receptor, neurokinin-1 receptor (NK-1R), has an important role in inflammation, immune regulation, and viral infection. We applied a newly developed real-time reverse...
Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes
Lai, Jian-Ping, Ho, Wen-Zhe, Zhan, Guan-Xia, Yi, Yanjie, Collman, Ronald G., Douglas, Steven D.
Substance P (SP) is a potent modulator of neuroimmunoregulation. We recently reported that human immune cells express SP and its receptor. We have now investigated the possible role that SP and its...
Differential Expression of Neurokinin-1 Receptor by Human Mucosal and Peripheral Lymphoid Cells
Goode, Triona, O'Connell, Joe, Ho, Wen-Zhe, O'Sullivan, Gerald C., Collins, J. Kevin, Douglas, Steven D., ...
Substance P (SP) has been implicated in peripheral and mucosal neuroimmunoregulation. However, confusion remains regarding immunocyte expression of the receptor for SP, neurokinin-1 receptor (NK-1R),...
Fehder, William P., Ho, Wen-Zhe, Campbell, Donald E., Tourtellotte, Wallace W., Michaels, Lisa, Cutilli, Joann R., ...
We have developed a simple chromatographic procedure for the partial purification of substance P (SP) from acidified plasma and serum samples. We have evaluated a sensitive antigen competition enzyme...
Lai, Jian-Ping, Douglas, Steven D., Shaheen, Farida, Pleasure, David E., Ho, Wen-Zhe
We have applied a newly developed real-time reverse transcriptase (RT) PCR (RT-PCR) assay for quantification of substance P (SP) mRNA expression (the SP real-time RT-PCR assay) in human blood...
Lai, Jian-Ping, Yang, Ji-Hong, Douglas, Steven D., Wang, Xu, Riedel, Eric, Ho, Wen-Zhe
CCR5, a β-chemokine receptor, plays an important role in human immunodeficiency virus (HIV) infection of human immune cells, as it is a primary coreceptor for HIV entry into macrophages. We have...
Real-Time Reverse Transcription-PCR Quantitation of Substance P Receptor (NK-1R) mRNA
Lai, Jian-Ping, Douglas, Steven D., Wang, Yan-Jian, Ho, Wen-Zhe
The substance P (SP)-preferring receptor, neurokinin-1 receptor (NK-1R), has an important role in inflammation, immune regulation, and viral infection. We applied a newly developed real-time reverse...
Morphine Withdrawal Enhances Hepatitis C Virus Replicon Expression
Wang, Chuan-Qing, Li, Yuan, Douglas, Steven D., Wang, Xu, Metzger, David S., Zhang, Ting, ...
We previously demonstrated that morphine enhances hepatitis C virus (HCV) replication in human hepatic cells. Here we describe the impact of morphine withdrawal (MW), a recurrent event during the...
Wang, Xu, Douglas, Steven D., Peng, Jin-Song, Zhou, Dun-Jin, Wan, Qi, Ho, Wen-Zhe
Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or...
Morphine Enhances Hepatitis C Virus (HCV) Replicon Expression
Li, Yuan, Zhang, Ting, Douglas, Steven D., Lai, Jian-Ping, Xiao, Wei-Dong, Pleasure, David E., ...
Little information is available regarding whether substance abuse enhances hepatitis C virus (HCV) replication and promotes HCV disease progression. We investigated whether morphine alters HCV mRNA...
Molecular Epidemiology of Astrovirus Infection in Infants in Wuhan, China▿
Liu, Man-Qing, Yang, Bei-Fang, Peng, Jin-Song, Zhou, Dun-Jin, Tang, Li, Wang, Bin, ...
We report the molecular epidemiology of astrovirus infection in 335 infants with diarrhea in Wuhan City, China. Astrovirus RNA was detected in the stool specimens of 33 children (9.87%). Genotyping...
Methamphetamine Enhances HIV Infection of Macrophages
Liang, Hao, Wang, Xu, Chen, Hui, Song, Li, Ye, Li, Wang, Shi-Hong, ...
Epidemiological studies have demonstrated that the use of methamphetamine (meth), a sympathomimetic stimulant, is particularly common among patients infected with HIV. However, there is a lack of...
Lambda Interferon Inhibits Human Immunodeficiency Virus Type 1 Infection of Macrophages ▿
Hou, Wei, Wang, Xu, Ye, Li, Zhou, Lin, Yang, Zhan-Qiu, Riedel, Eric, ...
The newly identified type III interferon (IFN-λ) has antiviral activity against a broad spectrum of viruses. We thus examined whether IFN-λ has the ability to inhibit human immunodeficiency virus...