Wendy Anne Loughlin

Efficient formal synthesis of (±)-Hyphodermin B (2006)

Henderson, Luke, Loughlin, Wendy Anne, Jenkins, Ian Douglas, Healy, Peter Conrad, Campitelli, Marc Ronald

An efficient formal synthesis of hyphodermin B 1, a metabolite of Hyphoderma radula, has been completed in 15% overall yield. The tricyclic carbon skeleton 3 was rapidly assembled from a novel vinyl...

Efficient formal synthesis of (±)-Hyphodermin B (2006)

Henderson, Luke, Loughlin, Wendy Anne, Jenkins, Ian Douglas, Healy, Peter Conrad, Campitelli, Marc Ronald

An efficient formal synthesis of hyphodermin B 1, a metabolite of Hyphoderma radula, has been completed in 15% overall yield. The tricyclic carbon skeleton 3 was rapidly assembled from a novel vinyl...

(Z,Z)-3,6-Bis[(3,4,5-trimethoxyphenyl)-methylene]piperazine-2,5-dione (2005)

Loughlin, Wendy Anne, Marshall, Raymond Leslie, Fairfull-Smith, Kathryn Elizabeth, Healy, Peter Conrad

The title compound, C24H26N2O8, is a derivative of neihumicin, a cytotoxic antibiotic from Micromonospora neihuensis. The compound crystallizes as discrete molecules with crystallographic inversion...

(Z,Z)-3,6-Bis[(3,4,5-trimethoxyphenyl)-methylene]piperazine-2,5-dione (2005)

Loughlin, Wendy Anne, Marshall, Raymond Leslie, Fairfull-Smith, Kathryn Elizabeth, Healy, Peter Conrad

The title compound, C24H26N2O8, is a derivative of neihumicin, a cytotoxic antibiotic from Micromonospora neihuensis. The compound crystallizes as discrete molecules with crystallographic inversion...

(Z,Z)-3,6-Bis[(3,4,5-trimethoxyphenyl)-methylene]piperazine-2,5-dione (2005)

Loughlin, Wendy Anne, Marshall, Raymond Leslie, Fairfull-Smith, Kathryn Elizabeth, Healy, Peter Conrad

The title compound, C24H26N2O8, is a derivative of neihumicin, a cytotoxic antibiotic from Micromonospora neihuensis. The compound crystallizes as discrete molecules with crystallographic inversion...

Novel polymer-supported coupling/dehydrating reagents for use in organic synthesis (2004)

Fairfull-Smith, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

Two novel dehydrating reagents 3 and 4, based on a phosphonium anhydride and an oxyphosphonium triflate respectively, were prepared by reaction of the corresponding polymer-supported phosphine oxides...

1RS,2RS,6SR.8SR)-2-methyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C15H20O3S, shows a conformational arrangement of the phenyl ring that permits hydrogen-bonded dimers to be disposed about a centre of symmetry.

(1RS,2SR,6SR,8SR)-2,6-dimethyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C16H22O3S, exhibits a conformational arrangement that permits intramolecular O-HO-S hydrogen bonds. Intermolecular bifurcated hydorgen bonding between the hydroxyl H and the...

Novel polymer-supported coupling/dehydrating reagents for use in organic synthesis (2004)

Fairfull-Smith, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

Two novel dehydrating reagents 3 and 4, based on a phosphonium anhydride and an oxyphosphonium triflate respectively, were prepared by reaction of the corresponding polymer-supported phosphine oxides...

1RS,2RS,6SR.8SR)-2-methyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C15H20O3S, shows a conformational arrangement of the phenyl ring that permits hydrogen-bonded dimers to be disposed about a centre of symmetry.

(1RS,2SR,6SR,8SR)-2,6-dimethyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C16H22O3S, exhibits a conformational arrangement that permits intramolecular O-HO-S hydrogen bonds. Intermolecular bifurcated hydorgen bonding between the hydroxyl H and the...

Novel polymer-supported coupling/dehydrating reagents for use in organic synthesis (2004)

Fairfull-Smith, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

Two novel dehydrating reagents 3 and 4, based on a phosphonium anhydride and an oxyphosphonium triflate respectively, were prepared by reaction of the corresponding polymer-supported phosphine oxides...

1RS,2RS,6SR.8SR)-2-methyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C15H20O3S, shows a conformational arrangement of the phenyl ring that permits hydrogen-bonded dimers to be disposed about a centre of symmetry.

(1RS,2SR,6SR,8SR)-2,6-dimethyl-8-(phenylsulfonyl)bicyclo[4.2.0]octan-1-ol (2004)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C16H22O3S, exhibits a conformational arrangement that permits intramolecular O-HO-S hydrogen bonds. Intermolecular bifurcated hydorgen bonding between the hydroxyl H and the...

The Hendrickson reagent and the Mitsunobu reaction: a mechanistic study (2003)

Elson, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

The alkoxytriphenylphosphonium ion intermediate of the Mitsunobu reaction can be generated using the Hendrickson reagent, triphenylphosphonium anhydride trifluoromethanesulfonate, 1. Strangely, while...

The formation of bicyclo[n.2.0]alkan-1-ols from the reaction of the lithium enolates of simple ketones and phenyl vinyl sulfoxide (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela

The enolates generated from cyclopentanone, cycloheptanone or cyclooctanone and LDA at 78 °C in THF react with (±)-phenyl vinyl sulfoxide under controlled conditions of temperature, reaction time,...

Spiro[1,3-dioxolane-2,4'-[8]phenylsulfonylbicyclo[4.2.0]octan-1-ol] (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The structure of the title compound, C16H20O5S, has been determined as part of an investigation into the synthesis of fused carbocyclic ring systems with functionality and containing a cyclobutanol...

Conformational isomerism in 3-(Z)-isobutylidene-1-acetylpiperazine-2,5-dione (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C10H14N2O3, (I), is a key intermediate in the synthesis of the cyclic dehydropeptide albonoursin, which has been found to exhibit useful biological and pharmacological properties....

The Hendrickson reagent and the Mitsunobu reaction: a mechanistic study (2003)

Elson, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

The alkoxytriphenylphosphonium ion intermediate of the Mitsunobu reaction can be generated using the Hendrickson reagent, triphenylphosphonium anhydride trifluoromethanesulfonate, 1. Strangely, while...

The formation of bicyclo[n.2.0]alkan-1-ols from the reaction of the lithium enolates of simple ketones and phenyl vinyl sulfoxide (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela

The enolates generated from cyclopentanone, cycloheptanone or cyclooctanone and LDA at 78 °C in THF react with (±)-phenyl vinyl sulfoxide under controlled conditions of temperature, reaction time,...

Spiro[1,3-dioxolane-2,4'-[8]phenylsulfonylbicyclo[4.2.0]octan-1-ol] (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The structure of the title compound, C16H20O5S, has been determined as part of an investigation into the synthesis of fused carbocyclic ring systems with functionality and containing a cyclobutanol...

Conformational isomerism in 3-(Z)-isobutylidene-1-acetylpiperazine-2,5-dione (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C10H14N2O3, (I), is a key intermediate in the synthesis of the cyclic dehydropeptide albonoursin, which has been found to exhibit useful biological and pharmacological properties....

The Hendrickson reagent and the Mitsunobu reaction: a mechanistic study (2003)

Elson, Kathryn Elizabeth, Jenkins, Ian Douglas, Loughlin, Wendy Anne

The alkoxytriphenylphosphonium ion intermediate of the Mitsunobu reaction can be generated using the Hendrickson reagent, triphenylphosphonium anhydride trifluoromethanesulfonate, 1. Strangely, while...

The formation of bicyclo[n.2.0]alkan-1-ols from the reaction of the lithium enolates of simple ketones and phenyl vinyl sulfoxide (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela

The enolates generated from cyclopentanone, cycloheptanone or cyclooctanone and LDA at 78 °C in THF react with (±)-phenyl vinyl sulfoxide under controlled conditions of temperature, reaction time,...

Spiro[1,3-dioxolane-2,4'-[8]phenylsulfonylbicyclo[4.2.0]octan-1-ol] (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The structure of the title compound, C16H20O5S, has been determined as part of an investigation into the synthesis of fused carbocyclic ring systems with functionality and containing a cyclobutanol...

Conformational isomerism in 3-(Z)-isobutylidene-1-acetylpiperazine-2,5-dione (2003)

Loughlin, Wendy Anne, McCleary, Michelle Angela, Healy, Peter Conrad

The title compound, C10H14N2O3, (I), is a key intermediate in the synthesis of the cyclic dehydropeptide albonoursin, which has been found to exhibit useful biological and pharmacological properties....