Kulkarni, Diptee A., Vazquez, Alexei, Haffty, Bruce G., Bandera, Elisa V., Hu, Wenwei, Sun, Yvonne Y., ...
Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53. In tumors...
Hu, Wenwei, Feng, Zhaohui, Tang, Moon-shong
Nickel (II), a ubiquitous environmental and industrial contaminant, is a well-known human carcinogen, particularly in human lung cancer. Although by itself it is a weak mutagen, nickel (II) is able...
Hu, Wenwei, Feng, Zhaohui, Tang, Moon-shong
Nickel (II), a ubiquitous environmental and industrial contaminant, is a well-known human carcinogen, particularly in human lung cancer. Although by itself it is a weak mutagen, nickel (II) is able...
Feng, Zhaohui, Hu, Wenwei, Chasin, Lawrence A., Tang, Moon-shong
It has been long recognized that in mammalian cells, DNA damage is preferentially repaired in the transcribed strand of transcriptionally active genes. However, recently, we found that in Chinese...
Feng, Zhaohui, Hu, Wenwei, Rom, William N., Costa, Max, Tang, Moon-Shong
Chromium(VI) [Cr(VI)] is a ubiquitous environmental and industrial contaminant. Cr(VI) exposure is strongly associated with a higher incidence of human lung cancer, but the mechanism of Cr(VI)...
Hu, Wenwei, Feng, Zhaohui, Tang, Moon-shong
Nickel (II), a ubiquitous environmental and industrial contaminant, is a well-known human carcinogen, particularly in human lung cancer. Although by itself it is a weak mutagen, nickel (II) is able...
Hu, Wenwei, Feng, Zhaohui, Eveleigh, Jamie, Iyer, Ganesh, Pan, Jishen, Amin, Shantu, ...
Trans-4-hydroxy-2-nonenal (4-HNE), a major electrophilic by-product of lipid peroxidation, is able to interact with DNA to form exocyclic guanine adducts. 4-HNE is a mutagen and a significant amount...
Feng, Zhaohui, Hu, Wenwei, Rom, William N., Beland, Frederick A., Tang, Moon-shong
4-Aminobiphenyl (4-ABP) is a major etiological agent of human bladder cancer, and its metabolites are able to form DNA adducts that may induce mutation and initiate bladder carcinogenesis. Thirty to...
Preferential DNA Damage and Poor Repair Determine ras Gene Mutational Hotspot in Human Cancer (2002)
Feng, Zhaohui, Hu, Wenwei, Chen, James X., Pao, Annie, Li, Haiying, Rom, William, ...
Background: Mutations in ras genes are commonly found in human cancers and in animal models. Although mutations at codons 12, 13, and 61 of H-, N- and K-ras genes can activate their oncogenic...
Feng, Zhaohui, Hu, Wenwei, Chasin, Lawrence A., Tang, Moon-shong
It has been long recognized that in mammalian cells, DNA damage is preferentially repaired in the transcribed strand of transcriptionally active genes. However, recently, we found that in Chinese...
Feng, Zhaohui, Hu, Wenwei, Tang, Moon-shong
Lipid peroxidation (LPO) is a cellular process that commonly takes place under normal physiological conditions. Under excessive oxidative stress, the level of LPO becomes very significant, and a...
A plausible model for the digital response of p53 to DNA damage
Ma, Lan, Wagner, John, Rice, John Jeremy, Hu, Wenwei, Levine, Arnold J., Stolovitzky, Gustavo A.
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows...
Detection of functional single-nucleotide polymorphisms that affect apoptosis
Harris, Sandra L., Gil, German, Robins, Harlan, Hu, Wenwei, Hirshfield, Kim, Bond, Elisabeth, ...
Human EBV-transformed B lymphocyte cell lines (LCLs) were used to measure the apoptotic response of individuals to γ radiation. The responses form a normal distribution around a median of 35.5%...
Feng, Zhaohui, Hu, Wenwei, Chasin, Lawrence A., Tang, Moon-shong
It has been long recognized that in mammalian cells, DNA damage is preferentially repaired in the transcribed strand of transcriptionally active genes. However, recently, we found that in Chinese...
Feng, Zhaohui, Hu, Wenwei, Tang, Moon-shong
Lipid peroxidation (LPO) is a cellular process that commonly takes place under normal physiological conditions. Under excessive oxidative stress, the level of LPO becomes very significant, and a...
A plausible model for the digital response of p53 to DNA damage
Ma, Lan, Wagner, John, Rice, John Jeremy, Hu, Wenwei, Levine, Arnold J., Stolovitzky, Gustavo A.
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows...
Detection of functional single-nucleotide polymorphisms that affect apoptosis
Harris, Sandra L., Gil, German, Robins, Harlan, Hu, Wenwei, Hirshfield, Kim, Bond, Elisabeth, ...
Human EBV-transformed B lymphocyte cell lines (LCLs) were used to measure the apoptotic response of individuals to γ radiation. The responses form a normal distribution around a median of 35.5%...
Feng, Zhaohui, Hu, Wenwei, Hu, Yu, Tang, Moon-shong
The tumor suppressor gene p53 is frequently mutated in cigarette smoke (CS)-related lung cancer. The p53 binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found in CS coincides...
Feng, Zhaohui, Hu, Wenwei, Teresky, Angelika K., Hernando, Eva, Cordon-Cardo, Carlos, Levine, Arnold J.
Cancer is a disease of aging. The accumulation of mutations in individual cells over a lifetime is thought to be the reason. In this work, we explored an additional hypothesis: could p53 function...
Shi, Hong, Tan, Si-jie, Zhong, Hua, Hu, Wenwei, Levine, Arnold, Xiao, Chun-jie, ...
The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold...